Tupaia chinensis (Chinese tree shrew): 102475336 Help Entry 102475336         CDS       T02978                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup04020   Calcium signaling pathway tup04371   Apelin signaling pathway tup04713   Circadian entrainment tup04730   Long-term depression tup04921   Oxytocin signaling pathway tup05017   Spinocerebellar ataxia tup05020   Prion disease tup05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:tup00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102475336 (RYR1)    04020 Calcium signaling pathway     102475336 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102475336 (RYR1)   09156 Nervous system    04730 Long-term depression     102475336 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     102475336 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     102475336 (RYR1)    05020 Prion disease     102475336 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     102475336 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:tup01009]     102475336 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:tup04147]     102475336 (RYR1)    04040 Ion channels [BR:tup04040]     102475336 (RYR1) Protein phosphatases and associated proteins [BR:tup01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      102475336 (RYR1) Exosome [BR:tup04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    102475336 (RYR1) Ion channels [BR:tup04040]  Voltage-gated cation channels   Ryanodine receptor    102475336 (RYR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY RR_TM4-6 Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  102475336 NCBI-ProteinID:  XP_006161818 LinkDB All DBs Position Un AA seq 4840 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSC LTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSGCEEGSVTGGHVLRLFHGHMDECLTISPADSED QRRLVFYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLV VIDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDTKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTSGLYNQFIKGLDS FSGKPRGSGPPAGTALPIEGGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQ EEGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCAL FSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKV LDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQY GKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGL HLWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFP VVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHL VGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDD NRRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTY MMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNP RLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEK SYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPF GRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQV GHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVAR MDGTVDTPPCLRLSHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGQQPPA EDEARAAEPDPDYENMRRSAGGWGEAESGKEGTAKEGVAGGAPQAGVEAQPVRAENEKDA TTEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPRDVVPADDRDDPEIILNTTTYYYSVRV FAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGD FVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQ NVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRR AGERLGWAVQCQEPLTMMALHIPEENRCMDVLELSERLDLQRFHSHTLRLYRAVCALGNN RVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLT PETRAITLFPTERSTENGPRHHGLPGVGVTTSLRPPHHFSPPCFVTALPAAGVTEAPVRL SPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGVFGDED VKQILKMIEPEVFTEEEEEDEEEEEEGEEEDEEEKEEDEEEEAQEKEDEEKEEEEAAEGD KEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQGNQRGRY GLLMKAFTMSAAETARRTREFRSPPQEQINMLLHFKDGTDEEDCPLPEEIRQDLLDFHQD LLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVKLVKKEEEKPEEEPPAEESKPQSLQEL VSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVDDTMSLLE CLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGG GESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAA ASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRF AVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGV RRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAIL RSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDF LLHVLDVGFLPDMRAAASLDTATFSTTEMALALXYLCLAVLPLITKCAPLFAGTEHRAIM VDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAK MPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRM AMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKF AEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIA WEWTIEKAREGEEEKTEKKKTRKISQTAQTYDPREGYNPQPPDLSGVTLSRELQAMAEQL AENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVT RGLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFF AKILLPLIKQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFG TDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQA RTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTT KNAYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEE MCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPA GAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLRSHF IPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDN NRAHWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKM AKAGDAQSGGSDQERTKKQRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKT RYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQE VSAVLYHLDQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYK ASWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDE DYLYMAYADIMAKSCHLEEGGENGEGEEEEPEVSFEEKEMEKQRLLYQQARLHNRGAAEM VLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQT CSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNND FQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMAVA KQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLD LQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQ DYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARD IGFNVAVLLTNLSEHMPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEIS ETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEP EEDEDEGAAEAGAEGAEEGAVDGEEEEQPPEPEPEPEPEPEKADAENGEKEEVPEPPPEP SQKTAPPPPPPKKEEAGGAGMEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFIL LFYKVSDSPPGEDDMEGSAAGDLSGAGSGGGSGWGSGAGEEAEGDEDENMVYYFLEESTG YMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDV KGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERK PDPPPGLLTWVMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIA MGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCD DMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLII DAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLIN KDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 14523 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggtgaggacgaggtccagttcctgcggacggacgacgaggtg gtcctgcagtgcagcgccaccgtcctcaaggagcagctcaagctctgcctggccgccgag ggcttcggcaaccgcctctgcttcctggagcccaccagcaatgcccagaatgtgcccccc gatctggccatctgttgcttcgtcctggagcagtcgctgtcggtccgggcattgcaggag atgctggccaacaccgtggaggctggcgtggagtcgtctcagggcgggggacacaggaca ctcctgtatggccatgccatcctgctccggcacgcacacagccgcatgtatctgagctgc ctcactacttcccgctccatgactgacaagctggccttcgacgtgggattgcaggaggat gcaacaggagaggcctgttggtggacaatgcacccagcttccaagcagaggtccgaagga gagaaggtccgtgttggggatgacatcatcctcgtgagtgtctcctcagagcgctacctg cacctgtcgacagccagcggggagctccaggttgacgcctccttcatgcagacactgtgg aacatgaaccccatctgctctggctgtgaagaaggatccgtgacagggggacacgtcctt cgcctctttcatggacacatggatgagtgtctgaccatttcccctgcagacagtgaggac caacgcagactggtcttctatgagggaggagctgtgtgcacccacgcccgctccctctgg aggctggagccgctgagaatcagttggagtgggagccacctgcgctggggccagccgcta cggatccggcatgtgaccactgggcggtacctggcactcaccgaggaccagggcctggtg gtgattgatgccagcaaggcccacaccaaggccacctccttctgcttccgcatctccaag gagaaactggatgtggcccccaagcgggacgtggagggcatgggcccccctgagatcaag tatggggaatccctgtgctttgtgcagcatgtggcctcgggcctgtggctcacgtatgcc gccccggacactaaggccctgaggcttggtgtgctcaagaagaaggccatgctgcaccag gaaggccacatggacgatgcgctgtcactgacccgctgccagcaggaggagtcccaggcg gctcgcatgatccacagcacctccggcctgtacaaccaattcatcaagggcctggacagc ttcagcgggaagccgcggggttcggggccaccggctggcacagcgctgcccatcgagggt ggtgttatcctgagcctgcaggacctcatcggctacttcgagccaccctccgaggagctg cagcacgaggagaagcagagcaagctgcgcagcctgcgcaaccgccagagcctcttccag gaggaggggatgctctccctggtcctgaattgcatcgaccgcctaaatgtctacaccact gctgcccactttgctgaatttgcaggagaggaggcagctgagtcttggaaagagattgtg aacctactctatgaactcctggcatctctgatccgtggcaatcgtaccaactgtgccctc ttctccaccaacttggactggctggtcagcaagctggatcgactggaggcctcgtctggc atcctggaggtgctgtactgtgtcctgattgagagtcctgaggtcctgaacatcatccag gagaaccacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtc ctggatgtgctatgctccctgtgtgtgtgcaatggtgtagccgtacgctccaaccaagat ctcattaccgagaacttgctccccggccgtgagcttctgctgcagacaaacctcatcaac tatgtcaccagcatccgccccaacatttttgtgggccgagcagagggctccacgcagtac ggcaaatggtactttgaggtgatggtggacgaggtggttccattcctgacagctcaggcc acccacctgcgggtaggctgggccctcaccgagggctacagcccctaccctgggggcggc gagggctggggcggcaacggggtcggcgatgacctctattcctacggctttgatggactg catctctggacaggacatgtggcacggccggtgacttccccagggcagcacctcctggct cctgaggatgtggtcagctgctgcctggacctcagcgtgccatccatctccttccgcatc aatggctgccccgtgcagggtgtctttgaggccttcaaccttgacgggctcttcttccct gtcgtcagcttctcagctggtgtcaaggtgcggttcctccttggtggccggcatggtgaa ttcaagttcctgcccccacctggctacgccccatgccatgaggctgtgctccctcgagaa cgactccatctcgaacctatcaaggagtatcgccgggaggggcctcgaggaccccacctg gtgggccccagccgctgcctctcacacactgactttgtgccatgccctgtggacaccgtc cagattgtcctgcctccccacttggagcgcattcgggagaagctggccgagaacatccac gagctctgggcactgacccgcatcgagcagggctggacctacggcccggttcgggatgac aacaggcggctgcacccgtgtcttgtggacttccacagtctaccagagcccgagaggaat tacaacctgcagatgtcgggggagacactcaagaccctactggcgctgggctgccatgtg ggcatggcagatgagaaggctgaggacaacctgaagaagacaaaactccctaagacgtac atgatgagcaacgggtacaagccggctccactggacctgagccacgtgcggctgacaccg gcccagacgacgctggtggatcggctggcagagaatggccacaatgtgtgggcacgagac cgcgtggcccagggctggagctacagcgctgtgcaggacatccccgcacgccgaaaccct cgcctcgtgccctaccgcctgctggacgaggccaccaagcgcagcaaccgggacagcctc tgccaggccgtgcgcaccctgctaggctatggctacaacattgagccgcctgaccaggaa cccagtcaggtggagaaccagtctcgctgggaccgagtgcgtatcttccgggcagagaaa tcctatgcagtacagagtggccgctggtacttcgagtttgaggcagtcaccacgggcgag atgcgagtgggctgggcaaggcctgagctgcggcctgacgtagagctgggagctgatgaa ctggcctatgtcttcaatgggcaccgtggccagcgttggcacttgggcagtgagcctttt ggacgtccctggcagtcaggtgatgttgttggctgcatgattgacctcacagagaatacc atcatcttcactctcaacggcgaagtcctcatgtctgactcaggctctgagacagccttc cgggacattgagattggggacggcttcctgcccgtctgcagcctggggcctggccaggtg gggcacctgaacctgggccaggatgtgagctccctacgattctttgccatctgtggcctc caggagggctttgagccatttgctatcaacatgcagcgcccagtcaccacctggttcagc aaaagccttccccagtttgaggccgtgccccttgagcaccctcactatgaggtggcccgc atggacggcactgtggacacgcctccctgcctgcgcctgagtcaccgcacatggggctcc cagaacagcctagtggagatgctctttctccggctcagccttccggtccagttccaccag catttccgctgcactgcaggggccaccccgttggcaccccctggccagcagcccccagct gaggatgaggccagggcagcagaacctgaccctgactatgaaaacatgcgccgctcagct ggaggctggggtgaggccgagagcggcaaagagggcacagccaaggagggtgtggctggg ggtgccccacaggctggggtagaggcccagccagtcagggcggagaatgagaaggatgct accacagagaagaacaagaagagagggttcttattcaaggccaagaaggttgccatgatg actcagccaccagccacaccgactctgccccggcttcctcgtgacgtggtacccgctgat gaccgcgatgaccctgagatcatcctcaacaccaccacgtactattactccgtgagggtc ttcgctggtcaggagccgagctgcgtgtgggtgggctgggtcacccctgactaccatcag cacgacatgagctttgacctcagcaaggtccgggcagtgacggtgaccatgggtgatgag caaggcaacgtccatagcagcctcaagtgcagcaactgctatatggtgtggggcggagac tttgtgagccctgggcagcagggccggatcagccacacggaccttgtcatcggctgtctg gtggacttggccactggcttaatgacctttacggccaatggcaaagagagcaacaccttt ttccaggtggaacccaacacgaagctgtttccggctgtctttgtcctgcccacccaccag aatgtcatccagtttgagctggggaagcagaagaacatcatgccattgtcagctgccatg ttcctgagtgagcgcaagaacccagccccgcagtgcccaccgcggctggaggtgcagatg ctgatgcccgtctcctggagccgcatgcccaaccacttcctgcaggtggagacgcggcgt gccggcgagcggcttggctgggccgtgcagtgccaggagccgctgaccatgatggcgctg cacatcccggaggagaaccgatgcatggacgtcttggagctgtcagaacgtctggacctg cagcgcttccactcgcacactctccgcctgtaccgtgcagtgtgtgccctgggcaacaac cgtgtggcgcatgcgctctgcagtcacgtggaccaggcacagctactgcacgcgctggag gacgcgcacctgccaggcccactgcgagcgggctactacgacctccttatcagcatccac cttgaaagtgcctgccgcagccgccgctccatgctctctgaatatatcgtgcccctcacg cccgagacccgcgccatcacactcttcccaactgaaagaagcacagaaaatggtccccgc caccatggcctgcctggcgttggagtcacaacctcgctgaggcccccacaccatttctca cccccttgttttgtgactgcccttccggccgctggagtaactgaagccccagtccgcctc agccctgccatccctctggaggccctgcgggacaaggcactgagaatgctgggagaggcc gtgcgagatggtgggcagcatgcccgcgaccccgtcgggggttctgtggagttccagttt gtgcctgtgctcaagctcgtgtccaccttgctggtgatgggtgtctttggagatgaggat gtaaaacagatcttgaagatgattgagcccgaagtgttcactgaagaagaagaggaagac gaggaggaagaggaagagggggaagaggaagatgaggaggagaaggaagaggatgaggag gaagaggcacaggagaaggaagatgaggaaaaagaggaagaggaggcagcagaaggagac aaagaagaaggcttggaggaggggctgctccagatgaagttgccagagtctgtgaagtta cagatgtgccatctgctggagtacttctgtgaccaggaactgcagcaccgtgtggagtcc ctggcagcctttgcagagcgctatgtggataagctccagggcaaccagcggggccgctat ggcctcctcatgaaagccttcaccatgtccgcagctgagactgcaagacgcacccgcgag ttccgctccccaccccaggagcagatcaacatgctattgcacttcaaagatggtacagat gaggaagattgccctctccctgaagagattcgacaggatttgcttgactttcaccaagac ctgctagcacactgtggaattcagctggatggggaggaggaggaacctgaagaagagacc accctgggcagccgcctaatgagccttttggagaaagtgaaactggtaaagaaggaggag gagaaacctgaagaggagcctccggctgaagagagcaaaccccagtccctgcaggagctg gtatcccacacggtggtgcgctgggcccaggaggacttcgtgcagagccccgagctggtc cgcgccatgttcagcctcctgcaccggcagtacgacggactcggtgagctgctgcgggcg ctgccacgggcgtacaccatctcaccatcctccgtggacgacaccatgagcctgctcgag tgcctcggccagatccgctcgctgctcatcgtgcagatgggcccccaggaggagaacctc atgatccagagcattgggaatatcatgaacaacaaagtcttctaccaacacccgaacctg atgagggcgctgggcatgcacgagaccgtcatggaggtcatggtgaacgtgctcgggggt ggggaatccaaggagatccgcttccccaagatggtgacaagctgctgccgcttcctctgc tacttctgccgcatcagccggcagaaccagcgctccatgtttgaccacctgagctacctg ctggagaacagcggcatcggactgggcatgcagggctccacgcccctggacgtggcagct gcctccgtcatcgacaacaatgagctggccttggcattgcaggagcaagacctggaaaag gttgtgtcctacttggcaggctgcggcctccaaagctgccccatgctgctggccaaaggg tacccagacattggctggaacccctgtggcggtgagcgctacctggacttcctgcgcttc gctgtctttgtcaacggcgagagtgtggaggagaatgccaacgtggtggtgcgcctactc atccgtaagcccgagtgcttcgggcctgcccttcggggtgaggggggctccgggctgctg gctgccattgaagaggccatccgcatctctgaggacccagcgcgggacggcccaggtgtc cgcagggatcggcggcgtgagcacttcggtgaggagcccccggaagaaaaccgggtacac ctgggacatgccatcatgtctttctacgccgccctgattgacctgctgggacgctgtgca ccagagatgcatttaatccaagctggcaagggtgaggccctgcggatccgtgccatccta cgctccctcgtgccgctggatgacctcgtgggcatcatcagcctgccgctgcagatccct accctgggcaaagacggggctctggtacagccgaagatgtcagcatcctttgtgccggac cacaaggcatccatggtgctcttcctggaccgtgtgtacggcattgagaaccaggacttc ttactgcacgtgctggatgtgggcttcctgcccgacatgagggcagctgcctcactggac acggccactttcagcaccacggagatggcgctggcactgnactacctgtgcctggcggtg ctgccgctcatcacaaagtgtgcaccactctttgcgggaactgagcaccgcgccatcatg gtggactccatgcttcacaccgtgtaccgcctgtcccgtggccgctcgctcaccaaggcg cagcgtgacgtcatcgaggactgcctcatggctctctgcaggtatatccgcccatcgatg ctgcagcacctgctgcggcgcctggtgtttgatgtgcccatccttaacgagttcgccaag atgccactcaagctcctcaccaaccactatgagcgctgttggaagtactactgcctcccc acaggctgggccaactttggggtcacctcggaggaagagctgcacctcactcgtaaactc ttctggggcatctttgactctctggcccataagaagtatgaccaggagctgtaccgcatg gccatgccctgtttatgcgccatcgcaggggctctgccccccgactacgtggatgcctca tactcatccaaggctgagaaaaaggccacagtggacgctgaaggcaacttcgatccccgg cctgtggagaccctcaatgtgatcatcccggagaagctcgactccttcattaacaagttt gcagagtacacgcacgagaagtgggccttcgacaagatccagaacaactggtcctatgga gagaacatagatgaggagctgaagacccaccccatgctgaggccctacaagacattttct gagaaggacaaagagatttaccgctggcccatcaaggagtccttgaaggctatgattgcc tgggaatggacaattgagaaggcccgggagggtgaagaggaaaagacggagaagaaaaaa acaaggaagatatcacaaacggcccagacctacgatccacgagaaggctacaaccctcag ccccccgaccttagtggcgtcaccctatcccgagagctgcaggccatggcagaacaactg gcagaaaattatcacaacacatgggggcggaagaagaaacaggagctggaggccaaagga ggtgggacccaccctctgctggtcccctatgacactctcacggccaaggagaaggcgcga gatcgcgagaaggcccaggagctgctgaagttcctacagatgaacggctatgcggtcact agaggccttaaggacatggagttggatacatcttccatcgagaagcggtttgcctttggt tttttgcagcagttgcttcgatggatggacatttcccaggagttcatcgcccacctggag gctgtggtgagcagtggacgtgtggaaaagtccccacacgagcaggagattaaattcttt gccaagatcctgcttcctttgatcaagcagtacttcaccaaccactgcctctatttcctg tccacaccagccaaagtgctgggcagtggtggccacgcctccaacaaggagaaagaaatg atcaccagcctcttctgcaaactcgctgctcttgtccgccaccgagtctctctcttcggg acggatgccccagccgtggtcaactgtcttcacatcctggcgcgctccctggacgccagg acggtaatgaagtctggccctgagattgtgaaggctggcctccgttccttctttgagagc gcctcagaggacatcgagaagatggtggagaacctacggctaggcaaggtgtcccaggca cgcacgcaggtgaagggcgtgggccagaacctcacctacaccactgtggccctgctgccg gtcctcaccaccctcttccagcacatcgcccagcaccagtttggagatgatgtcatcctg gacgacgtccaggtgtcttgctaccgaacgctatgcagcatctactccttgggaaccacc aagaacgcttatgtggaaaagctacggcccgccctcggggagtgcctggcccgactagca gcggccatgcctgtggcgttcctggagcctcagctgaacgagtacaatgcctgctctgtg tacaccaccaagtctccccgggagcgggccatcctggggctccccaacagtgtggaggag atgtgtcctgacatccctgtgctggagcggctcatggcagacattggggggctggccgag tcgggggcccgctacacagagatgccacacgtcatcgagatcacgctgcccatgctgtgc agctacctgccccgctggtgggagcgtgggcctgaggcgcccccacccgccctgcctgct ggtgcccccccgccctgcacagccgtcacctctgaccacctcaactccctgctggggaat atcctgcgaatcattgtcaacaacctgggcatcgatgaggcctcgtggatgaagcggctt gcagtgttcgcccagcccatcgtgagcagggcccggccagagctcctgcgctcacacttc atccccaccattggccggctgcgcaagcgggcagggaaggtggtggccgaggaggagcag ctgcgcctggaggccaaggccgaagccgaggagggcgagcttctggtgcgggacgagttc tctgtgctctgccgggacctgtacgccctgtacccgctgctgattcgctacgtggacaac aaccgggcgcactggctgacagagcccaaccccagtgcagaggagctgttcaggatggtg ggcgagatcttcatctactggtccaagtcccacaactttaagcgggaggagcagaacttc gtggtccagaatgagatcaacaacatgtccttcctgaccgccgacaacaagagcaaaatg gccaaggcaggagacgcacagtcaggtggctcggaccaggaacgcaccaagaagcagcgc cggggggaccggtactccgtacagacgtcgctgatcgtggccacactcaagaagatgctg cccatcggcctgaacatgtgtgcccccaccgaccaggacctcatcacgctggccaagacc cgctatgccctgaaagacacagatgaggaggtccgggaatttctgcaaaacaaccttcac cttcagggaaaggttgaaggttccccatctctgcgctggcagatggccctgtaccggggc gtcccaggccgcgaagaggacgccgacgaccccgagaaaatcgtgcgcagagtccaggaa gtgtccgcggtgctctatcacctggaccagatcgaacacccttacaaatccaaaaaggct gtgtggcacaagctcctatccaagcaacgccggagggcagtcgtggcctgtttccgtatg acgcccctctacaacctgcccacgcaccgagcatgtaacatgttcctggaaagctacaag gcctcatggatcctgactgaagaccacagttttgaggaccgcatgatagacgatctttca aaagctggggagcaggaggaggaggaggaagaggtggaggagaagaagccagatcccctg caccagctggtcctgcacttcagccgcactgccctgactgaaaagagcaagctagacgag gattacctgtacatggcgtatgcagacatcatggcaaagagctgccacctggaggaggga ggggagaatggtgaaggtgaagaagaggagcctgaagtttcctttgaggagaaagagatg gagaagcagaggctcctgtaccagcaggcgcggctacacaaccgaggggccgccgagatg gtgctgcagatgatcagcgcctgcaaaggagagacgggcgccatggtgtcctccaccctg aagctgggcatctccatcctcaatggaggcaatgccgaggtgcagcagaaaatgctggac tatctgaaggacaagaaggaagttggcttcttccagagtatccaggcactgatgcaaaca tgcagcgtcctggacctcaatgccttcgagagacagaacaaggcagaggggctgggcatg gtgaatgaggatggaactgtcatcaatcgccagaacggagagaaggtcatggcagatgat gaattcacacaagatctgttccggttcctgcagttgctctgcgaggggcacaataacgat ttccaaaactacctacggacacagacggggaacacgaccactattaacatcatcatctgc acagtggactacctcctgcggctgcaggagtccatcagtgacttctactggtactactcg ggcaaggatgtcatcgaggagcagggcaagaggaacttctccaaggccatggcggtggcc aaacaggtgttcaacagtctcaccgagtacatccagggcccctgtaccgggaaccagcag agcctggcgcacagccgcctctgggatgccgtggtgggattcctgcacgtgtttgcccac atgatgatgaagctcgctcaggactcgagccagatagagctgttgaaggagctgctggac cttcagaaggacatggtggtgatgttgctgtcactactagaagggaacgtggtgaacggc atgatcgcccggcagatggtggatatgctcgtggaatcctcatccaacgtggagatgatc ctcaagttctttgacatgttcctgaaactcaaggacatcgtgggctccgaggccttccag gactacgtcaccgatccccgtggcctcatctccaagaaggacttccagaaggccatggac agccagaagcagttcactggcccagaaatccagttcctgctttcctgctccgaagcagat gagaacgagatgatcaactgtgaggagttcgccaaccgcttccaggagcctgcccgtgac attggcttcaacgtggcggtgctgctgaccaacctgtcggagcacatgccacatgaccca cgcctgcgcaacttcctggagctagccgagagcatcctggagtacttccggccttacctg ggtcgcatcgagatcatgggtgcctcccgccgcatcgagcggatctactttgagatctcg gaaaccaaccgcgcgcagtgggagatgccccaggtgaaagagtccaagcgccagttcatc ttcgacgtggtgaacgagggcggcgaggccgagaagatggagctcttcgtgagcttctgc gaggacaccatcttcgagatgcagatcgccgcgcagatctccgagcccgagggcgagccc gaggaggacgaggacgagggggcggccgaggcgggcgccgagggcgcggaggagggcgcg gtggatggtgaagaggaggagcagcctccagagcccgagcccgaaccggagccggagcct gagaaagctgatgctgagaatggggagaaagaagaagtccccgagcccccaccagagccc tcccagaagacagcaccccctccaccccctccaaagaaggaggaagctggaggtgccggc atggagttctggggcgaactggaagtgcagagggtgaagttcttgaactacctctcccgg aacttctacaccctgcgattcctcgccctcttcctagcgtttgccatcaacttcatcttg ctgttttataaggtctcagactctccaccaggagaggacgacatggagggctctgcagct ggggacctgtcaggtgcagggtctggtggcggttctggctggggctcaggggccggtgag gaagcagagggcgacgaggatgagaacatggtgtactacttcctggaggagagcacgggc tacatggagcctgcgctgcggtgtttgagcctgctgcataccctggtggccttcctttgc atcatcggctacaactgtctcaaggtgcccctggtgatctttaagcgggagaaggagctg gcccgaaagttggagtttgacggcctctacatcaccgagcagcccgaggacgacgatgtg aaggggcagtgggaccgactggtgctcaacacaccgtctttccccagcaactactgggac aagtttgtcaagcggaaggtcctggacaaacatggggacatctacgggcgggagcgaatc gccgaactgctgggcatggacctggccactctggagatcacagcccacaacgagcgcaag cccgacccgccgcctgggctgctgacctgggtcatgtccattgatgtcaagtaccagatt tggaagtttggcgtcatcttcacagacaactccttcctgtacctgggctggtacatggtg atgtccctcctggggcactacaacaacttcttcttcgccgctcacctccttgacattgcc atgggggtcaagacgctgcgcaccatcctctcctccgtcacccacaacgggaagcagctg gtgatgactgtgggcctcctggcggtggtggtctacctgtacactgtggtggccttcaac ttcttccgcaagttctacaacaagagtgaggatgaggatgagcctgacatgaagtgcgat gacatgatgacgtgttacctgtttcacatgtacgtgggcgtccgggctggtggaggcatt ggcgacgagattgaggaccccgcgggcgatgaatatgagctctaccgggtggtcttcgac atcaccttcttcttcttcgtcattgtcatcctgctggccatcatccagggtctgatcatc gacgcttttggtgagctccgagaccaacaggaacaagtgaaggaggatatggagaccaag tgcttcatctgcggaatcggcagtgactacttcgacacaacaccgcacggatttgagacc cacacgctggaggaacacaacctggccaattacatgtttttcctgatgtatctgataaac aaggacgagacggaacacactggtcaggagtcgtatgtctggaagatgtaccaggagaga tgctgggatttcttcccggctggcgattgtttccggaagcagtatgaggaccagctgagc tga

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