Tupaia chinensis (Chinese tree shrew): 102490973
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Entry
102490973 CDS
T02978
Symbol
ITCH
Name
(RefSeq) itchy E3 ubiquitin protein ligase
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
tup
Tupaia chinensis (Chinese tree shrew)
Pathway
tup04120
Ubiquitin mediated proteolysis
tup04144
Endocytosis
tup04330
Notch signaling pathway
tup04668
TNF signaling pathway
tup04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
tup00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
102490973 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
102490973 (ITCH)
04668 TNF signaling pathway
102490973 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
102490973 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
102490973 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
tup04131
]
102490973 (ITCH)
04121 Ubiquitin system [BR:
tup04121
]
102490973 (ITCH)
Enzymes [BR:
tup01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
102490973 (ITCH)
Membrane trafficking [BR:
tup04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
102490973 (ITCH)
Ubiquitin system [BR:
tup04121
]
Ubiquitin ligases (E3)
HECT type E3
102490973 (ITCH)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
102490973
NCBI-ProteinID:
XP_006144084
LinkDB
All DBs
Position
Un
AA seq
860 aa
AA seq
DB search
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVAVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLNFRVWSHQTLKSDVLLGAAALDIYETLKSNNMKLEEVVVTL
QLVGDKEPAETIGDLSVCLDGLQLESEVVTNGETTCSESASQNDDGSRPKEESRVNTNGS
DDPEDAGSGENRRLNGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
GSSTGSLPPTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVY
YVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQ
RSQLQGAMQQFNQRFIYGNQDLFATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRI
TQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIA
YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSAQDLRRRLWVIFPG
EEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGR
FIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGLEM
YFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNE
ILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEK
RMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSY
EQLKEKLLFAIEETEGFGQE
NT seq
2583 nt
NT seq
+upstream
nt +downstream
nt
atgtctgacagtggatcacagctcggttcaatgggtagcctgaccatgaaatcacaactt
cagatcactgtcatctcagcaaaacttaaagaaaataaaaagaattggtttggaccaagc
ccttatgtggaagtagcagtagatggacagtcaaagaagacagaaaaatgcaacaacacg
aacagtcccaaatggaagcaaccccttacagttatcgttacccctgtgagtaaattaaat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggagctgccgcatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtggttgtgactttg
caacttgtaggtgacaaagagccagcagagacaataggagacttatcagtttgtcttgat
ggactgcagttagagtctgaagttgttactaatggtgaaactacatgttcagaaagtgct
tcacagaatgatgatggctccagacctaaggaagaatcaagagtgaacacaaatggatca
gatgaccctgaggatgcagggtctggtgaaaatagaaggctcaatggaaataattctcct
tcactctcaaatggtggttttaaaccttctagacctccaagaccttctagaccacctccg
ccaaccccacgtagaccagcatctgtcaatggttcaccatctgccacttctgaaagtgat
ggatctagtacaggctctctaccaccaacaaatacgaatacatctgaaggtgcaacatct
ggattaattattcctcttactatatctggaggctcgggccctcgaccattaaatcctgta
actcaagctcctctaccacctggctgggagcaaagagtggaccagcatgggcgagtttat
tatgtagatcacgttgaaaaaagaacaacatgggatagaccagaacctctacctcctggc
tgggaacggcgggttgacaacatgggacgtatttattatgttgaccattttacaagaaca
acaacatggcaaaggccaacgttggaatctgtccggaactatgaacagtggcagctacaa
cgtagtcaacttcaaggagcaatgcagcaatttaaccagagatttatttatgggaatcaa
gatttgttcgctacatcacaaaacaaagaatttgaccctctaggtcctttaccacctgga
tgggagaagagaacagacagcaatggcagagtatattttgtcaaccataacactcgaatt
acacaatgggaagaccctagaagtcaaggtcagttaaatgaaaagcctttacctgaaggc
tgggaaatgagattcacagtggatggaattccatattttgtggaccacaatagaagaaca
accacatatatagatcctcgcacaggaaaatctgccctagacaatggaccccagatagcc
tatgttcgggacttcaaggcaaaggttcagtatttccgtttctggtgtcagcaactggcc
atgccgcagcatataaagattacagtgacaagaaaaacactgtttgaggattcctttcaa
cagataatgagcttcagtgcccaagatctgcgaagacgtttgtgggtgatttttccagga
gaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtcacatgaa
gtgttgaacccaatgtattgcctatttgaatatgcagggaaggataactactgcttgcag
ataaatcccgcttcatacatcaatccagatcacctgaaatattttcgttttattggcagg
tttattgccatggcgctgttccatgggaagttcatagacacagggttttctttgccattc
tataagcgtatcttgaacaagccagttgggctcaaggatttagaatctattgatccagaa
ttttacaattctctcatctgggttaaagaaaacaatattgaggaatgtggcttggaaatg
tacttctctgttgataaagaaattctaggtgaaattaagagtcatgatttgaaacccaat
ggtggcaatattcttgtaacagaagaaaataaagaggaatatatcagaatggtagctgaa
tggagattgtctcgaggtgttgaagaacagacacaagctttctttgagggctttaatgaa
attctccctcagcagtatttgcagtactttgatgcaaaggaattagaggtccttttatgt
ggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgtcattacact
aggacgagcaaacaaatcatgtggttttggcagttcgttaaagaaattgataatgagaag
agaatgagactactgcagtttgttactggaacttgccgattgccagtaggaggatttgct
gaccttatggggagcaacggaccacagaaattctgcattgaaaaagttgggaaagagaat
tggttaccaagaagtcatacatgttttaaccgcctagacctgccaccttacaagagctat
gagcaactgaaagaaaagctgttgtttgccattgaagaaacagaaggatttggacaagag
taa
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