Tupaia chinensis (Chinese tree shrew): 102496620 Help Entry 102496620         CDS       T02978                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup04022   cGMP-PKG signaling pathway tup04068   FoxO signaling pathway tup04081   Hormone signaling tup04140   Autophagy - animal tup04150   mTOR signaling pathway tup04151   PI3K-Akt signaling pathway tup04152   AMPK signaling pathway tup04211   Longevity regulating pathway tup04213   Longevity regulating pathway - multiple species tup04722   Neurotrophin signaling pathway tup04910   Insulin signaling pathway tup04920   Adipocytokine signaling pathway tup04923   Regulation of lipolysis in adipocytes tup04930   Type II diabetes mellitus tup04931   Insulin resistance tup04932   Non-alcoholic fatty liver disease tup04935   Growth hormone synthesis, secretion and action tup04960   Aldosterone-regulated sodium reabsorption tup05010   Alzheimer disease tup05206   MicroRNAs in cancer tup05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:tup00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     102496620 (IRS1)    04022 cGMP-PKG signaling pathway     102496620 (IRS1)    04151 PI3K-Akt signaling pathway     102496620 (IRS1)    04152 AMPK signaling pathway     102496620 (IRS1)    04150 mTOR signaling pathway     102496620 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     102496620 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102496620 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102496620 (IRS1)    04923 Regulation of lipolysis in adipocytes     102496620 (IRS1)    04920 Adipocytokine signaling pathway     102496620 (IRS1)    04935 Growth hormone synthesis, secretion and action     102496620 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102496620 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     102496620 (IRS1)   09149 Aging    04211 Longevity regulating pathway     102496620 (IRS1)    04213 Longevity regulating pathway - multiple species     102496620 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     102496620 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     102496620 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102496620 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102496620 (IRS1)    04932 Non-alcoholic fatty liver disease     102496620 (IRS1)    04931 Insulin resistance     102496620 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  102496620 NCBI-ProteinID:  XP_006142025 LinkDB All DBs Position Un AA seq 1053 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLTLSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMAGKGASTLTAPN GHYILPRGSNGHRFISGAGLGTSPALVGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPMERRGGHHR TDASSLHTDDGYMPMSPGVAPVPSNRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSSSGSCSPDIGGGPSSGGSSSAAPSGSSYGKLWTNGVGGHHSHALTHPKPPVDSS GGKLLPCTGDYINMSPVGDSNTSSPSDCYYGPEDPQHKPVLSFYSLPRSFKHTQRPGELE EAARHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGGGYCGARPESGLPHLHHQVLQPHL PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPPPPVLHPPEPKSPGEYVN IEFGSDQPGYLSGPVASHSSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRAAWQENA GVEMGRVGPAPPGVASICRPTRAVPTSRGDYMTMQMGCPRQSYVDTSPIAPISYADMRTG IAAEEASLPRATAAAPSSSSAVSASPTAPSGAE NT seq 3162 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagacagacggcttctcggacgtgcgcaaggtgggctacctccgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctcgagtactacgagaatgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggccctctacacccgggacgagcattttgccattgcagcggacagcgag gccgagcaagacagctggtatcaggccctcctgcagctgcacaaccgcgccaagggccac catgatggggccgcagctcctggggcgggaggaggcgggggcagctgcagcggcagctct ggtctcggtgaggctggggaggacctgagctacggggatgtgcccccaggacccgccttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctgtgtctgaccagcaagaccattagcttcgtgaagctgaactcggag gcagcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactccgagaacttc ttcttcatcgaggtgggccgttctgcggtgactggacccggggagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgagggccatg agcgatgagttccgacctcggagcaagagccagtcctcatccaactgctccaaccccatc agcgtccctctgcgcaggcaccatctcaacaacccgccgcccagccaggtggggctgacc cgcagatcgcgcaccgagagcatcaccgccacctccccggcaagcatggtgggcgggaag ccgggttccttccgtgtccgtgcctccagcgatggcgaaggcaccatgtcccgcccggct tcggtggacggcagcccggtgagtcccagcaccaacaggacccacgcccaccggcatcgc ggtagctcccggctgcacccgccgctcaccctcagccgctccatccccatgccttcttct cgctgctcaccttctgccaccagcccggtcagcttgtcctccagcagcaccagtggccac ggctccacctcagactgcctcttcccacggcggtctagcgcatccgtgtctggatcgccc agcgatggcggcttcatttcctcagatgagtatggctccagcccctgcgatttccgaagc tccttccgcagtgtcactccagattccttgggccacaccccaccggcccgaggtgaggaa gagctgagcaactatatctgcatggccggcaaaggcgcctccacgctgaccgcccccaac ggtcactacattttgcctcggggtagcaatggtcaccgcttcatctcgggagcaggctta ggcaccagtcctgcactggttggggacgaagccgctagtgcagcagatttggataatcgg ttccgaaagagaactcactcggcaggcacatcccccaccatttcccaccagaagacccca tcgcagtcctcggtggcttccattgaggagtacacggagatgatgcctgcctacccacca ggaggtggcagtggaggccggctgccgggctaccgacactccgccttcgtgcccacccac tcctaccccgaggagggcctggaaatgcaccccatggagcgccgcgggggccaccaccgc acagatgcctccagcctccacaccgatgatggctacatgcccatgagcccaggggtagcc ccagtgcctagcaacagaaagggcagcggagactatatgcccatgagccccaagagtgtg tctgccccacagcagatcatcaaccccatcagacgccatccccagagggtagaccccaac ggctacatgatgatgtcctctagtggcagctgctcccctgacatcggaggagggcccagc agtggtggcagcagcagtgctgccccttctgggagcagctacggaaagctgtggaccaat ggggtaggaggccaccattctcacgccctgacccaccccaagccccctgtggacagcagc ggtggcaagcttttaccttgcacaggtgactacataaacatgtcgccagtgggggactcc aacaccagcagcccctctgactgctactatgggcctgaggacccccagcacaagccagtc ctctccttctactcgttgccaaggtcctttaagcacacccagcgccctggggagctggag gaggctgcccggcatcagcacctccgcctgtcctcgagctctggtcgccttctctatgct gcaaccgcagaagattcttcctcctccaccagcagtgacagcctgggggggggctactgt ggggccaggccggagtctggccttccgcatctccaccatcaggtcctgcagccgcatctg cctcgaaaggtggacacagctgcccagactaatagccgcctggctcgacccacgaggctg tccctgggggatcccaaggccagcaccttacctcgggcacgagagcagcagcagcagcag cagccgccaccgcctgtgctgcaccctccagagcccaagagcccaggggaatatgtgaat attgaatttgggagtgatcagcctggctacttatctggtcctgtggcttcccacagctcg ccttctgtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcact gaggagtacatgaacatggacctgggaccaggccggagggcagcctggcaggagaatgct ggggttgagatgggcagagtgggtcctgcacctcctggggtggctagcatttgcagacct acccgggcagtgcctaccagccggggcgactacatgaccatgcagatgggctgtcctcgt cagagctacgtggacacctcaccgatcgcccccatcagctatgctgacatgcggacaggc attgctgcagaggaggcgagcttgccaagggccacagcagctgccccttcctcatcctca gcagtctctgcttcccccactgcaccttcaggagcagaatga

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