KEGG   PATHWAY: uah00531
Entry
uah00531                    Pathway                                
Name
Glycosaminoglycan degradation - Ursus arctos (brown bear)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
uah00531  Glycosaminoglycan degradation
uah00531

Module
uah_M00076  Dermatan sulfate degradation [PATH:uah00531]
uah_M00077  Chondroitin sulfate degradation [PATH:uah00531]
uah_M00078  Heparan sulfate degradation [PATH:uah00531]
uah_M00079  Keratan sulfate degradation [PATH:uah00531]
Other DBs
GO: 0006027
Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113266534  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
113266542  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
113256904  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
113256907  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
113256908  HYAL1; hyaluronidase-1 isoform X2 [KO:K01197] [EC:3.2.1.35]
125282322  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
113267745  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
113241894  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
113245712  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
113255173  ARSB; arylsulfatase B isoform X2 [KO:K01135] [EC:3.1.6.12]
113263199  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
113251812  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
113244537  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
113245550  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
113265417  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
113252143  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
113253756  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
113256327  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
113240939  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
113255209  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00634  Chondroitin 4-sulfate
C00925  Heparan sulfate
G00526   
G00711   
G00872  DWA-2
G01391   
G01945   
G01977   
G02632   
G09660   
G10008   
G10505  Hyaluronic acid
G12336   
G13034   
G13035   
G13036   
G13037   
G13038   
G13039   
G13040   
G13041   
G13042   
G13043   
G13073   
G13074   
Reference
PMID:27570
  Authors
Greiling H, Stuhlsatz HW, Cantz M, Gehler J
  Title
Increased urinary excretion of keratan sulfate in fucosidosis.
  Journal
J Clin Chem Clin Biochem 16:329-34 (1978)
DOI:10.1515/cclm.1978.16.6.329
Reference
PMID:3161730
  Authors
Fuchs W, Beck M, Kresse H
  Title
Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate.
  Journal
Eur J Biochem 151:551-6 (1985)
DOI:10.1111/j.1432-1033.1985.tb09138.x
Related
pathway
uah00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
uah00533  Glycosaminoglycan biosynthesis - keratan sulfate
uah00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
KO pathway
ko00531   
LinkDB

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