KEGG   Ursus arctos (brown bear): 113244637
Entry
113244637         CDS       T05909                                 
Symbol
GRB2
Name
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
uah  Ursus arctos (brown bear)
Pathway
uah01521  EGFR tyrosine kinase inhibitor resistance
uah01522  Endocrine resistance
uah04010  MAPK signaling pathway
uah04012  ErbB signaling pathway
uah04014  Ras signaling pathway
uah04062  Chemokine signaling pathway
uah04068  FoxO signaling pathway
uah04072  Phospholipase D signaling pathway
uah04150  mTOR signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04380  Osteoclast differentiation
uah04510  Focal adhesion
uah04517  IgSF CAM signaling
uah04540  Gap junction
uah04550  Signaling pathways regulating pluripotency of stem cells
uah04630  JAK-STAT signaling pathway
uah04650  Natural killer cell mediated cytotoxicity
uah04660  T cell receptor signaling pathway
uah04662  B cell receptor signaling pathway
uah04664  Fc epsilon RI signaling pathway
uah04714  Thermogenesis
uah04722  Neurotrophin signaling pathway
uah04910  Insulin signaling pathway
uah04912  GnRH signaling pathway
uah04915  Estrogen signaling pathway
uah04917  Prolactin signaling pathway
uah04926  Relaxin signaling pathway
uah04935  Growth hormone synthesis, secretion and action
uah05034  Alcoholism
uah05160  Hepatitis C
uah05161  Hepatitis B
uah05163  Human cytomegalovirus infection
uah05165  Human papillomavirus infection
uah05200  Pathways in cancer
uah05203  Viral carcinogenesis
uah05205  Proteoglycans in cancer
uah05206  MicroRNAs in cancer
uah05207  Chemical carcinogenesis - receptor activation
uah05208  Chemical carcinogenesis - reactive oxygen species
uah05210  Colorectal cancer
uah05211  Renal cell carcinoma
uah05213  Endometrial cancer
uah05214  Glioma
uah05215  Prostate cancer
uah05220  Chronic myeloid leukemia
uah05221  Acute myeloid leukemia
uah05223  Non-small cell lung cancer
uah05224  Breast cancer
uah05225  Hepatocellular carcinoma
uah05226  Gastric cancer
uah05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113244637 (GRB2)
   04012 ErbB signaling pathway
    113244637 (GRB2)
   04014 Ras signaling pathway
    113244637 (GRB2)
   04630 JAK-STAT signaling pathway
    113244637 (GRB2)
   04068 FoxO signaling pathway
    113244637 (GRB2)
   04072 Phospholipase D signaling pathway
    113244637 (GRB2)
   04151 PI3K-Akt signaling pathway
    113244637 (GRB2)
   04150 mTOR signaling pathway
    113244637 (GRB2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    113244637 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113244637 (GRB2)
   04540 Gap junction
    113244637 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    113244637 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    113244637 (GRB2)
   04660 T cell receptor signaling pathway
    113244637 (GRB2)
   04662 B cell receptor signaling pathway
    113244637 (GRB2)
   04664 Fc epsilon RI signaling pathway
    113244637 (GRB2)
   04062 Chemokine signaling pathway
    113244637 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113244637 (GRB2)
   04912 GnRH signaling pathway
    113244637 (GRB2)
   04915 Estrogen signaling pathway
    113244637 (GRB2)
   04917 Prolactin signaling pathway
    113244637 (GRB2)
   04926 Relaxin signaling pathway
    113244637 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    113244637 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    113244637 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    113244637 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    113244637 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113244637 (GRB2)
   05206 MicroRNAs in cancer
    113244637 (GRB2)
   05205 Proteoglycans in cancer
    113244637 (GRB2)
   05207 Chemical carcinogenesis - receptor activation
    113244637 (GRB2)
   05208 Chemical carcinogenesis - reactive oxygen species
    113244637 (GRB2)
   05203 Viral carcinogenesis
    113244637 (GRB2)
   05231 Choline metabolism in cancer
    113244637 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113244637 (GRB2)
   05225 Hepatocellular carcinoma
    113244637 (GRB2)
   05226 Gastric cancer
    113244637 (GRB2)
   05214 Glioma
    113244637 (GRB2)
   05221 Acute myeloid leukemia
    113244637 (GRB2)
   05220 Chronic myeloid leukemia
    113244637 (GRB2)
   05211 Renal cell carcinoma
    113244637 (GRB2)
   05215 Prostate cancer
    113244637 (GRB2)
   05213 Endometrial cancer
    113244637 (GRB2)
   05224 Breast cancer
    113244637 (GRB2)
   05223 Non-small cell lung cancer
    113244637 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    113244637 (GRB2)
   05160 Hepatitis C
    113244637 (GRB2)
   05163 Human cytomegalovirus infection
    113244637 (GRB2)
   05165 Human papillomavirus infection
    113244637 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    113244637 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113244637 (GRB2)
   01522 Endocrine resistance
    113244637 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uah04131]
    113244637 (GRB2)
Membrane trafficking [BR:uah04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    113244637 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH3_3 SH2_2 DUF5093 DUF7145 hSH3 SH3_4
Other DBs
NCBI-GeneID: 113244637
NCBI-ProteinID: XP_026339949
LinkDB
Position
Unknown
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgctgacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagaa
ctcaatgggaaagatggcttcattcccaagaattatatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcatgac
ggggcctttcttatccgagagagtgagagtgccccgggggacttctccctctctgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggagctgggaagtatttcctc
tgggtggtgaaattcaattctctgaacgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatattcctccgggacatagaacaggtgccacagcaaccgacgtac
gtccaggccctctttgactttgatccccaggaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcctgccacggg
cagaccggcatgtttccccgcaattacgtcacccccgtgaaccggaacgtctaa

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