Ursus arctos (brown bear): 113250390 Help Entry 113250390         CDS       T05909                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism uah  Ursus arctos (brown bear) Pathway uah04022   cGMP-PKG signaling pathway uah04068   FoxO signaling pathway uah04081   Hormone signaling uah04140   Autophagy - animal uah04150   mTOR signaling pathway uah04151   PI3K-Akt signaling pathway uah04152   AMPK signaling pathway uah04211   Longevity regulating pathway uah04213   Longevity regulating pathway - multiple species uah04722   Neurotrophin signaling pathway uah04910   Insulin signaling pathway uah04920   Adipocytokine signaling pathway uah04923   Regulation of lipolysis in adipocytes uah04930   Type II diabetes mellitus uah04931   Insulin resistance uah04932   Non-alcoholic fatty liver disease uah04935   Growth hormone synthesis, secretion and action uah04960   Aldosterone-regulated sodium reabsorption uah05010   Alzheimer disease uah05206   MicroRNAs in cancer uah05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     113250390 (IRS1)    04022 cGMP-PKG signaling pathway     113250390 (IRS1)    04151 PI3K-Akt signaling pathway     113250390 (IRS1)    04152 AMPK signaling pathway     113250390 (IRS1)    04150 mTOR signaling pathway     113250390 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     113250390 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     113250390 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     113250390 (IRS1)    04923 Regulation of lipolysis in adipocytes     113250390 (IRS1)    04920 Adipocytokine signaling pathway     113250390 (IRS1)    04935 Growth hormone synthesis, secretion and action     113250390 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     113250390 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     113250390 (IRS1)   09149 Aging    04211 Longevity regulating pathway     113250390 (IRS1)    04213 Longevity regulating pathway - multiple species     113250390 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     113250390 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     113250390 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     113250390 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     113250390 (IRS1)    04932 Non-alcoholic fatty liver disease     113250390 (IRS1)    04931 Insulin resistance     113250390 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  113250390 NCBI-ProteinID:  XP_026347600 LinkDB All DBs Position Unknown AA seq 1237 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGASAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN GHYILPRGGNGHRYIPGAGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR PDTSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSSSAAPSGSSYGKLWTNGVGGHHAHALPHPKLPAESGSGK LLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEESA RHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGGGYCGVRPDPGLPHIHHQVLQPHLPRK VDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQPSLLHAPEPKSPGEYVNIEFGSDQ PCYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQESAGVQAGRE GPAPPGAASMCRPTRAVPSSRGDYMTMQMGCPAQSYVDTSPVAPISYADMRTGLAVEEAS LPGATAAAPSSSSVASASPTAPQKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNRNQSA KVIRADPQGCRRRHSSETFSSTPSATRMGNTVPFGGGAAVGGGGGGSSSTEDMKRHSSAS FENVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKPRPQERPPQPQLPLPP PPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ NT seq 3714 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggttacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcagggggg ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcagactccaagaac aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaggacagctggtaccaagccctcctgcagctgcacaatcgggccaagggccac cacgacggggcctcggcccccggggcaggaggcggtgggggcagctgcagcggcagctcc ggcctcggggaggctggggaggacttgagctacggggacgtgcccccaggacctgcgttc aaggaggtctggcaggtgatcctgaaacccaaaggtctgggtcagacaaagaacctgatt ggcatctaccgactctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcagacgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacaggacctggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agcgatgagttccgtcctcgaagtaagagccagtcctcctccaactgctccaaccccatc agcgtccccttgcgcaggcatcacctcaacaaccccccacccagccaggtggggctgacg cgccgctctcgcaccgagagcatcaccgccacctctccggccagcatggtgggcggcaag cagggctccttccgtgtgcgagcgtccagcgatggcgaaggcaccatgtcccgcccggcc tcggtggacgggagccctgtgagtcccagcaccaacaggacccacgcccaccgtcatcgc ggcagctcccggctgcacccccctctcaaccacagccgctccatccccatgccttcttct cgctgctcaccttccgccaccagcccggtcagtctgtcgtccagcagcaccagtggccac ggctccacctcggactgtctcttcccacggcggtctagtgcttctgtgtccggttccccc agcgatggcggcttcatctcctccgatgagtatggctccagcccttgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacaccccaccggcccgcggtgaggag gagctgagcaactacatctgcatgggaggcaaggggtcctccaccctcaccgcccccaat ggtcactatattttgcctcggggtggcaacggtcaccgctacatcccaggagctggcttg ggcacgagccctgccctggctggggatgaagcggccagtgctgcagatctggataatcgg ttccgaaagcggactcactctgctggcacatcccctaccatttcccaccagaagacccca tcccagtcctctgtggcttccattgaggaatacacggagatgatgcctgcctacccgcca ggaggtggcagtggaggccgactgcctggctaccggcactctgccttcgtgcccacccac tcctaccctgaggagggtctggaaatgcaccctttggacaggcgtgggggccaccaccgc ccagacacatccactctccacactgatgacggctacatgcccatgtccccaggagtggca ccagtgcccagcagccgaaagggcagtggggactacatgcccatgagccccaagagcgtg tctgcgccgcagcagatcatcaacccgatcagacgccatcctcagagagtggaccccaat ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggcgggcccagc agcagcagcgccgccccttctgggagcagctatggcaagctatggacaaatggggtaggg ggccaccacgctcatgccctgccgcaccccaaactgcccgcagagagcgggagtggcaag ctcttgtcttgtactggtgactacatgaacatgtcgccagtgggggactccaacaccagc agcccctccgactgctactacggcccagaggacccccagcacaagccagttctctcctac tactcattgccaaggtcctttaagcacacccagcgccctggggagctggaggagagtgcc cggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcaacggca gaggattcctcctcctccaccagcagcgacagcctgggcgggggatactgtggggtgagg ccggatcctggcctcccacatatccaccatcaggtcctgcagccccatctgcctcgaaag gtggacacagctgcccagaccaacagccgcctggctcggcccacgaggctgtccctgggg gatcccaaggccagcaccttacctcgggtccgagagcagcagcaacagccgtccctgctg cacgctccggagcccaagagcccaggggagtatgtgaatattgaatttgggagtgatcag ccgtgttacttatctggtcctgtggcttcccgcagctcgccttctgtcaggtgtccatcc cagctccagccagctcccagagaggaagagactggcactgaggaatacatgaacatggac ctggggccaggccgaagggcgacctggcaggagagtgccggggtccaggcaggcagagag ggccctgcaccccctggggctgctagcatgtgcaggcctacccgggcagtgcccagcagc cggggggactacatgaccatgcagatgggctgtccggcacagagctacgtggacacctca ccagttgcccccatcagctatgctgacatgcggacaggccttgctgtggaggaggccagc cttccaggagccaccgcggcggctccctcctcatcctctgtagcctctgcttcccccact gcgcctcaaaaagcaggggagctggtggcccgctcttccctgctggggggcccacaggga cctgggggcatgagcgccttcacccgggtgaacctcagtcccaaccgtaaccagagtgcc aaagtgatccgtgcggacccacaagggtgccggaggcggcatagctctgagaccttctcc tccacacctagtgccacccggatgggcaacacggtgccctttggagggggggctgctgta gggggcggtggtggtggcagcagcagcacagaggatatgaaacgccacagttctgcttcc tttgagaatgtgtggctgaggcctggggagctcgggggagcccccaaggagccggcccaa gtgtgtggggctgctgggggtttggagaacgggcttaactacatagacctggatttggtc aaggacttcaaaccgcgccctcaggagcgcccccctcaaccgcagctgcccctgcccccg ccccctcatcagcctctgggcagcagtgagagcagctcaaccagccgctccagcgaggat ttaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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