Ursus arctos (brown bear): 113250592 Help Entry 113250592         CDS       T05909                                  Symbol CASP8 Name (RefSeq) caspase-8   KO K04398   caspase 8 [EC:3.4.22.61] Organism uah  Ursus arctos (brown bear) Pathway uah01524   Platinum drug resistance uah04115   p53 signaling pathway uah04210   Apoptosis uah04215   Apoptosis - multiple species uah04217   Necroptosis uah04620   Toll-like receptor signaling pathway uah04621   NOD-like receptor signaling pathway uah04622   RIG-I-like receptor signaling pathway uah04623   Cytosolic DNA-sensing pathway uah04625   C-type lectin receptor signaling pathway uah04657   IL-17 signaling pathway uah04668   TNF signaling pathway uah04932   Non-alcoholic fatty liver disease uah04936   Alcoholic liver disease uah05010   Alzheimer disease uah05016   Huntington disease uah05022   Pathways of neurodegeneration - multiple diseases uah05132   Salmonella infection uah05134   Legionellosis uah05142   Chagas disease uah05145   Toxoplasmosis uah05152   Tuberculosis uah05160   Hepatitis C uah05161   Hepatitis B uah05162   Measles uah05163   Human cytomegalovirus infection uah05164   Influenza A uah05165   Human papillomavirus infection uah05167   Kaposi sarcoma-associated herpesvirus infection uah05168   Herpes simplex virus 1 infection uah05169   Epstein-Barr virus infection uah05170   Human immunodeficiency virus 1 infection uah05200   Pathways in cancer uah05203   Viral carcinogenesis uah05416   Viral myocarditis uah05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     113250592 (CASP8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     113250592 (CASP8)    04215 Apoptosis - multiple species     113250592 (CASP8)    04217 Necroptosis     113250592 (CASP8)    04115 p53 signaling pathway     113250592 (CASP8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     113250592 (CASP8)    04621 NOD-like receptor signaling pathway     113250592 (CASP8)    04622 RIG-I-like receptor signaling pathway     113250592 (CASP8)    04623 Cytosolic DNA-sensing pathway     113250592 (CASP8)    04625 C-type lectin receptor signaling pathway     113250592 (CASP8)    04657 IL-17 signaling pathway     113250592 (CASP8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     113250592 (CASP8)    05203 Viral carcinogenesis     113250592 (CASP8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     113250592 (CASP8)    05161 Hepatitis B     113250592 (CASP8)    05160 Hepatitis C     113250592 (CASP8)    05164 Influenza A     113250592 (CASP8)    05162 Measles     113250592 (CASP8)    05168 Herpes simplex virus 1 infection     113250592 (CASP8)    05163 Human cytomegalovirus infection     113250592 (CASP8)    05167 Kaposi sarcoma-associated herpesvirus infection     113250592 (CASP8)    05169 Epstein-Barr virus infection     113250592 (CASP8)    05165 Human papillomavirus infection     113250592 (CASP8)   09171 Infectious disease: bacterial    05132 Salmonella infection     113250592 (CASP8)    05134 Legionellosis     113250592 (CASP8)    05152 Tuberculosis     113250592 (CASP8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     113250592 (CASP8)    05142 Chagas disease     113250592 (CASP8)   09164 Neurodegenerative disease    05010 Alzheimer disease     113250592 (CASP8)    05016 Huntington disease     113250592 (CASP8)    05022 Pathways of neurodegeneration - multiple diseases     113250592 (CASP8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     113250592 (CASP8)    05416 Viral myocarditis     113250592 (CASP8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     113250592 (CASP8)    04932 Non-alcoholic fatty liver disease     113250592 (CASP8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     113250592 (CASP8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:uah01002]     113250592 (CASP8) Enzymes [BR:uah01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      113250592 (CASP8) Peptidases and inhibitors [BR:uah01002]  Cysteine peptidases   Family C14: caspase family    113250592 (CASP8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C14 DED PYRIN Motif Other DBs NCBI-GeneID:  113250592 NCBI-ProteinID:  XP_026347970 LinkDB All DBs Position Unknown AA seq 486 aa AA seqDB search MNFSKCLYNIGEQLDSDELASLKFLSMDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLS FLKELLFRINRLDLLVTYLDTSKEEMEQELQIPGRAQISAYRVMLFQISEDVSKLELRSF KFFLSQEISRCKLHDDLNLFDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE LSREQTLSPQRSLDEISNDMSQLLVGEESLRVPPMSDSPGEQDCEPETSDKVYRMESKPR GYCLIFNNYDFSIARKEVPKLQSIKDRNGTDLDADALCQTFSELHFEIVPFKDCTAKKIC EVLKSYQSMDHSSRDCFICCILSHGDKGIIYGSDGQEVPIYELTSYFTGSKCPSLAGKPK IFFIQACQGDNYQKGIAVETDSEQKEAYLEMDSSYQKRYIPEDADFLLGMATVNNCVSYR NPMEGTWYIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDRKNMGKQMPQPTFTLRKK LFFPLN NT seq 1461 nt NT seq  +upstreamnt  +downstreamnt atgaatttcagcaaatgcctctataatattggagaacagctggacagtgatgagctggcc tccctcaagttcctgagcatggactacatcccacagaagaagcaggaacccatcaaggat cccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgtcc ttcttgaaggagctgcttttccgaattaacagactggacctgctggttacctacctggac accagcaaggaggagatggagcaggagcttcaaataccaggcagagcccagatctctgcc tacagggtcatgctttttcagatttcagaagatgtaagcaaattggaattgaggtccttt aagttttttttgagccaggagatctccagatgtaaactgcacgatgacttgaacttgttt gatattttcatagagatggagaagagggtcatcctcggggaaagaaatctggataccctg aaaagaatctgtgaccaaattaacaagagcctgctgaagaaaatcacggattatgaagaa ttaagcagagagcaaacactgagccctcaaagaagtctagatgaaatttcaaatgatatg tctcagttgcttgtaggggaggaatccctgagggtaccgccaatgtcggactctccagga gaacaggactgtgaaccagagacatcggacaaagtttaccgaatggaaagcaaacctcga ggatattgtttgatctttaacaattacgactttagcatagcacggaaggaagtgcccaaa cttcagagcattaaggataggaatggaacagacttggatgcagatgctttgtgtcagacc tttagtgagcttcattttgagatcgtgcctttcaaagactgtacagccaagaaaatctgt gaggttctgaaatcctaccaaagcatggaccactctagcagggattgcttcatctgctgc atcctctcccatggagacaagggcatcatctatggctctgatgggcaagaagtccccatc tatgagctgacttcttacttcactggttcaaagtgcccttcccttgcaggcaagcccaaa atcttttttattcaggcttgtcaaggggataactaccagaaaggtatagctgttgagact gactctgaacagaaggaagcctatttagaaatggactcatcctatcagaagagatatatc ccagaagatgctgactttctgctggggatggccactgtgaataattgtgtttcctaccga aaccccatggaggggacctggtatatccagtcactttgccagagcctgagagaaagatgt cctaggggcgaagatattctcaccatccttaccgaggtgaactttgaagtgagcaataag gatgacaggaaaaacatggggaaacaaatgccacaacctactttcacactgaggaaaaaa ctctttttccctcttaattga

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