Ursus arctos (brown bear): 113251536 Help Entry 113251536         CDS       T05909                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism uah  Ursus arctos (brown bear) Pathway uah04022   cGMP-PKG signaling pathway uah04068   FoxO signaling pathway uah04081   Hormone signaling uah04140   Autophagy - animal uah04152   AMPK signaling pathway uah04211   Longevity regulating pathway uah04213   Longevity regulating pathway - multiple species uah04910   Insulin signaling pathway uah04920   Adipocytokine signaling pathway uah04923   Regulation of lipolysis in adipocytes uah04930   Type II diabetes mellitus uah04931   Insulin resistance uah04932   Non-alcoholic fatty liver disease uah04935   Growth hormone synthesis, secretion and action uah05010   Alzheimer disease uah05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     113251536 (IRS2)    04022 cGMP-PKG signaling pathway     113251536 (IRS2)    04152 AMPK signaling pathway     113251536 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     113251536 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     113251536 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     113251536 (IRS2)    04923 Regulation of lipolysis in adipocytes     113251536 (IRS2)    04920 Adipocytokine signaling pathway     113251536 (IRS2)    04935 Growth hormone synthesis, secretion and action     113251536 (IRS2)   09149 Aging    04211 Longevity regulating pathway     113251536 (IRS2)    04213 Longevity regulating pathway - multiple species     113251536 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     113251536 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     113251536 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     113251536 (IRS2)    04932 Non-alcoholic fatty liver disease     113251536 (IRS2)    04931 Insulin resistance     113251536 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  113251536 NCBI-ProteinID:  XP_026349377 LinkDB All DBs Position Unknown AA seq 1327 aa AA seqDB search MASPPLHGPPGPAGGDGPNLNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGDEATATA GGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYF AVAAENEQEQEGWYRALTDLVSEGRAGDAPPAAATAASCSASLPGALGGSAGAAAADDSY GLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMN IRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRS KSQSSGSSSTHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTA SEGDGGAAAGAGAAGGRPVSVAGSPLSPGPVRAPLSRSHTLSGGCGARASKVALAPAGGA LQHSRSMSMPVAHSPPAATSPSSLSSSSGHGSGSYPPPPGPHPHLQHALHHPAGQRPSSG SASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGSGGELYGYMTM DRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATF SGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGVALLGG GSGSCKSDDYMPMSPTSVSAPKQILQPRAAAAALPPTGAAVPAPTPTASRAFPANGGSYK TSSPAESSPEDSGYMRMWCGSKLSMENTDTKLLPNGDYLNMSPSDAGTSGTPPDFFSAAL HGSGEMLRGVPGYCYSSLPRSYKAPYTCNGDNDQYVLMSSPVGRILEEERLEPPAGPGAP STSAFAAGGGHIQPPHPVVPSPSRPSGSSGGRPEGFLNQRCRLVRPTRLSLEGLQTLPSM HEYPLPPEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPG TSSDSRQRSPLSDYMNLDFSSPKSPKPGTQSGDPVGSLDALLSPEASSPYPPLPPRPAAP TSSLQPQPPPPPPPGELYRLPQASTSQGPSAASSSSSETGDNGDYTEMAFGVAATPPQPI AAPPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRH SSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGGSGVLGGGDERPTSPRQL QPPPPQQARPWVPSQPGGLVGCPGGSGSPMRRETSAGFQNGLNYIAIDVRDEPGLSAAPQ QHPHPQPGDKSAWGRTRSLGGLISAVGGSGSGGVCGGPGPGALPSANTYASIDFLSHHLK EATIVKE NT seq 3984 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccaccgctgcatgggccccccgggccggcgggcggcgacggccccaacctc aacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcagaag cacggccacaagcgtttcttcgtgctgcgcgggcccggcgacgaggcgacggcgacagcg ggcggggggccggcgccgcagccgccgcggctcgagtactatgagagcgagaagaagtgg cggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctaaacatcaac aagcgcgccgacgccaaacacaagtacctgatcgcgctctacaccaaggacgagtacttc gcggtggcggccgagaacgagcaggagcaggagggctggtaccgcgcgctcaccgacctg gtcagcgagggccgcgccggcgacgcgccccccgccgccgccaccgccgcgtcctgcagc gcctccctgcccggcgccctaggcggctcggccggcgccgccgcggccgatgacagctac gggctggtggcgcccgccacggccgcctaccgcgaggtgtggcaggtgaacctgaagccc aagggcctgggccagagcaagaacctgacgggcgtgtaccgcctgtgcctgtcggcgcgc accatcggcttcgtgaagctcaactgtgagcagccgtcggtgacgctgcagctcatgaac atccgccgctgcggccactcggacagcttcttcttcatcgaggtgggccggtcggctgtc acgggcccaggtgagctgtggatgcaggccgacgactcggtggtggcgcagaacatccac gagaccatcctggaggccatgaaggcactcaaggagctcttcgagttccggccgcgcagt aagagccagtcgtcgggctcgtcctccacacaccccatcagcgtccccggcgcgcgccgc caccaccacctggtcaacctgccccccagccagacgggcctggtgcgccgctcgcgcacc gacagcctggccgccaccccgccggccgccaagtgcagctcttgtcgggtgcgcacggcc agcgagggagacggcggcgcggcggcgggggcgggggcggcgggcggcaggcctgtgtct gtagccgggagtcccctgagccccgggccggtgcgcgcgcccctgagccgctcacacacc ctgagcggcggctgcggcgcccgcgcgagcaaggtggcgctggcgccggcagggggcgcc ctgcaacacagccgctccatgtccatgccggtggcgcactcgcccccagccgccaccagc cccagcagcctgtcgtccagcagcgggcatggctccggttcttacccgccgccgccaggc ccgcatccgcacctgcagcacgccctgcaccaccccgcgggccagcggccctccagcggc agcgcctcggcctccggctcccccagcgaccctggcttcatgtctctggatgagtatggc tccagccctggggacctgagagccttctgcagccacaggagcaacacgcccgagtccatc gctgagacacctccggccagagacggcagcgggggcgagctgtacgggtacatgactatg gacaggcccctgagccactgtggtcgcccctaccgcagagtctctggggacggggcccag gacttggaccgagggctgaggaagaggacttactccctgaccacacctgcccggcagcgg ccagtgccccagccctcctctgcatccctggatgaatacaccctgatgcgggccacgttc tccggcagctccggccgcctctgcccatcctgtcccgcgtcatctcccaaagtggcctac cacccctatcctgaggactatggcgacatcgagatcgggtcccataggagctctagcagt aacctgggtgccgacgatggctacatgcccatgacccctggcgtggccctcctgggtggt ggcagtggcagctgtaagagtgatgactacatgcccatgagccccactagcgtgtctgcc ccgaagcagatcctgcagcctcgggccgcggccgcagccctgccccccacaggagccgca gtgcccgcacccacccctacggccagtagggcctttccagcgaacgggggcagctacaag acgagctccccagccgagagctcccctgaggacagtgggtacatgcgtatgtggtgtggc tccaagctgtccatggagaacactgacaccaagctgctacccaacggggactacctcaat atgtcccccagcgacgcgggtacctcagggacacctcccgacttcttctcggctgccttg catggcagcggggagatgctcaggggagtccctggctattgctatagctccctgcctcgc tcctacaaggctccctacacgtgcaacggggacaacgaccagtatgtgctcatgagctcc cccgtggggcgcatcctggaagaggagaggctagaaccgcctgccggccctggcgcacca tccactagcgctttcgcggccggaggcggccacatccaacctcctcacccagtagtgcct tcgcccagcaggccgagtggcagcagcggtggccgcccagagggcttcctgaaccagcgc tgccggttagtgcggcccacacgcctgtccctggaggggcttcagaccctgcccagcatg cacgagtaccctctgccgcctgagcccaagagcccgggcgagtacatcaacattgacttt ggtgaagccggaactcgcctgtctccgcccgcgcctccgctgctggcttcggcggcctca tcgtcctcactgctgtccgccagcagcccggcctcgtccctgggctcgggcaccccgggc acgagcagcgacagcaggcagcgctccccactctccgactacatgaaccttgacttcagc tcgcccaagtcacccaagccgggcacccagagcggggaccccgtgggctccctggatgcc ctcctgtcccctgaggcctcgtccccctacccaccgctgcccccccgtcctgcggccccc acctcctccctgcagccgcagccgcccccaccgccccccccaggggagctgtaccgcctg ccccaggcgtcaacttcccagggccccagcgctgcctcctcttcgtcctcggagactggg gacaatggtgactacaccgagatggcctttggcgtggctgccaccccgccacaacccatc gcggcccccccgaagccggaaggtgcccgcgtgaccagccccacctccggcttgaagagg ctgagtctcatggatcaggtgtcgggagtcgaggccttcctgcaggcgagccagccccca gaccctcaccggggagccaaggtcatccgcgcagacccacaggggggccgccgccgccac agctccgagaccttctcctcgaccaccactgtgacccccgtgtccccatccttcgcccat aaccctaagcgccacaactcggcctctgtggaaaacgtctctctcaggaaaagcagcgaa gggggcggcagtggcgtcctgggtgggggcgacgagcgccccacgtccccccgccagttg cagccaccgcccccccagcaggcgcgcccatgggtaccaagtcagcctgggggcttggtt ggctgccctgggggcagtgggtctccaatgcgcagggagacctctgccggcttccagaac ggcctcaactacatcgccatcgacgtgagggacgagcctgggctgtcagcggccccacag cagcatcctcatccgcagcccggagacaagagcgcctggggccggacccgcagcctcggg ggcctcatcagcgctgtggggggcagcggcagcggtggggtatgtggggggccgggccct ggcgccctaccctctgccaacacctatgccagcattgacttcttgtcccatcacctgaag gaggccaccattgtgaaagagtga

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