Ursus arctos (brown bear): 113252326 Help Entry 113252326         CDS       T05909                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism uah  Ursus arctos (brown bear) Pathway uah00230   Purine metabolism uah01100   Metabolic pathways uah01522   Endocrine resistance uah04015   Rap1 signaling pathway uah04022   cGMP-PKG signaling pathway uah04024   cAMP signaling pathway uah04062   Chemokine signaling pathway uah04072   Phospholipase D signaling pathway uah04081   Hormone signaling uah04082   Neuroactive ligand signaling uah04114   Oocyte meiosis uah04211   Longevity regulating pathway uah04213   Longevity regulating pathway - multiple species uah04261   Adrenergic signaling in cardiomyocytes uah04270   Vascular smooth muscle contraction uah04371   Apelin signaling pathway uah04540   Gap junction uah04611   Platelet activation uah04713   Circadian entrainment uah04714   Thermogenesis uah04723   Retrograde endocannabinoid signaling uah04724   Glutamatergic synapse uah04725   Cholinergic synapse uah04726   Serotonergic synapse uah04727   GABAergic synapse uah04728   Dopaminergic synapse uah04750   Inflammatory mediator regulation of TRP channels uah04911   Insulin secretion uah04912   GnRH signaling pathway uah04913   Ovarian steroidogenesis uah04914   Progesterone-mediated oocyte maturation uah04915   Estrogen signaling pathway uah04916   Melanogenesis uah04918   Thyroid hormone synthesis uah04921   Oxytocin signaling pathway uah04923   Regulation of lipolysis in adipocytes uah04924   Renin secretion uah04925   Aldosterone synthesis and secretion uah04926   Relaxin signaling pathway uah04927   Cortisol synthesis and secretion uah04928   Parathyroid hormone synthesis, secretion and action uah04934   Cushing syndrome uah04935   Growth hormone synthesis, secretion and action uah04970   Salivary secretion uah04971   Gastric acid secretion uah04972   Pancreatic secretion uah04976   Bile secretion uah05012   Parkinson disease uah05030   Cocaine addiction uah05031   Amphetamine addiction uah05032   Morphine addiction uah05034   Alcoholism uah05163   Human cytomegalovirus infection uah05166   Human T-cell leukemia virus 1 infection uah05200   Pathways in cancer uah05207   Chemical carcinogenesis - receptor activation uah05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:uah00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     113252326 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     113252326 (ADCY5)    04371 Apelin signaling pathway     113252326 (ADCY5)    04072 Phospholipase D signaling pathway     113252326 (ADCY5)    04024 cAMP signaling pathway     113252326 (ADCY5)    04022 cGMP-PKG signaling pathway     113252326 (ADCY5)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     113252326 (ADCY5)    04081 Hormone signaling     113252326 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     113252326 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     113252326 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     113252326 (ADCY5)    04062 Chemokine signaling pathway     113252326 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     113252326 (ADCY5)    04923 Regulation of lipolysis in adipocytes     113252326 (ADCY5)    04912 GnRH signaling pathway     113252326 (ADCY5)    04913 Ovarian steroidogenesis     113252326 (ADCY5)    04915 Estrogen signaling pathway     113252326 (ADCY5)    04914 Progesterone-mediated oocyte maturation     113252326 (ADCY5)    04921 Oxytocin signaling pathway     113252326 (ADCY5)    04926 Relaxin signaling pathway     113252326 (ADCY5)    04935 Growth hormone synthesis, secretion and action     113252326 (ADCY5)    04918 Thyroid hormone synthesis     113252326 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     113252326 (ADCY5)    04916 Melanogenesis     113252326 (ADCY5)    04924 Renin secretion     113252326 (ADCY5)    04925 Aldosterone synthesis and secretion     113252326 (ADCY5)    04927 Cortisol synthesis and secretion     113252326 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     113252326 (ADCY5)    04270 Vascular smooth muscle contraction     113252326 (ADCY5)   09154 Digestive system    04970 Salivary secretion     113252326 (ADCY5)    04971 Gastric acid secretion     113252326 (ADCY5)    04972 Pancreatic secretion     113252326 (ADCY5)    04976 Bile secretion     113252326 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     113252326 (ADCY5)    04727 GABAergic synapse     113252326 (ADCY5)    04725 Cholinergic synapse     113252326 (ADCY5)    04728 Dopaminergic synapse     113252326 (ADCY5)    04726 Serotonergic synapse     113252326 (ADCY5)    04723 Retrograde endocannabinoid signaling     113252326 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     113252326 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     113252326 (ADCY5)    04213 Longevity regulating pathway - multiple species     113252326 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     113252326 (ADCY5)    04714 Thermogenesis     113252326 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     113252326 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     113252326 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     113252326 (ADCY5)    05163 Human cytomegalovirus infection     113252326 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     113252326 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     113252326 (ADCY5)    05031 Amphetamine addiction     113252326 (ADCY5)    05032 Morphine addiction     113252326 (ADCY5)    05034 Alcoholism     113252326 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     113252326 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     113252326 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     113252326 (ADCY5) Enzymes [BR:uah01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      113252326 (ADCY5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC PEN-2 Motif Other DBs NCBI-GeneID:  113252326 NCBI-ProteinID:  XP_026350697 LinkDB All DBs Position Unknown AA seq 1264 aa AA seqDB search MSGSKSVSPPGYAAQTAAAPASRGGPEHRSAWGEADSRANGYPHAPGGSTRGCTKKPGGA VTPQQRQQQQQQRLANRWRGDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGS RRQRRGAAGGGSTRAPPAGGGGGSAAAAAAAGGTEVRPRSVELGLEERRGKGRAVDELEA GAVDGDEGSGDGGSSAESGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRL NQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDH MGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLL SALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQA RLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEG FTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC VEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA GGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIA KMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVD EFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICF VQITIVPHSVFMLSFYLTCFLLLTLVVFVSVIYSCVKLFPTPLQTLSRKIVRSKMNSTLV GVFTITLVFLSAFVNMFTCNSNDLFGCLADEHNISTSQVNACHVVESAANYSLGDERGFC SSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELTYVLIVEVPRVTLFDN ADLLVTANAIDFNNNGTSQCPEHATKVALKVMTPIVISVFVLALYLHAQQVESTARLDFL WKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASI ANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFKQLEKIKTIGSTYMAASGLND STYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYD IWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGG PPLS NT seq 3795 nt NT seq  +upstreamnt  +downstreamnt atgtccggctccaaaagcgtgagccccccgggctacgcggcgcagacagcagcggcgccg gcgtcccggggaggcccggaacaccgctcggcgtggggggaggcagattcccgcgccaat ggctacccccacgcccctgggggttcgacccgtggctgcaccaagaaacccgggggggcg gtgaccccgcagcagcggcagcagcagcagcagcagcgcctggccaaccgctggcgcggc gacgacgacgacgatcctccgctgagtggcgacgaccccctggccgggggcttcggcttc agcttccgctccaagtcggcttggcaggagcgcggcggcgacgactgcggtcgcggcagc cgccggcagcggcggggcgcggccggcgggggtagcacccgggcgccccctgcgggcggc ggtggcggctcggcggcggcggcggccgcggccggcgggacggaggtgcgccctcggtcg gtggagctgggcctggaggagcggcggggcaagggccgcgcggtggacgagctggaggcc ggcgccgtcgacggcgacgaagggtccggggatggcggcagctcggcagaatcaggcgcg gggcccggcgcagtgctgtcgctgggtgcctgctgcctggcgctgctgcagatattccgt tccaagaagttcccgtcggacaagctggagcggctgtaccagcgctacttcttccgtctg aaccagagcagcctcactatgctcatggccgtgctggtgctcgtgtgcctcgtcatgttg gccttccacgcggcgcggcccccgctccagctgccctacctggcagtgctggcggctgcg gtaggtgtcatcctcgtcatggctgtgctctgcaaccgcgccgccttccaccaggaccac atgggcctggcctgctacgcgctcatcgccgtggtgctggccgtccaggtggtgggcctg ctgctgccccagccgcgcagcgcctccgagggcatctggtggaccgtgttcttcatctac accatctacacgttgctgcctgtgcgcatgcgggccgcggtactcagtggagtgctcctt tctgcactccacctggccatcgccctgcgcaccaacgcccaggaccagttcctgctcaag cagcttgtctccaatgtcctcattttctcctgcaccaacattgtgggtgtttgcacccac tacccggctgaagtctcccagagacaggccttccaggagacccgggagtgcatccaggca cggctccactcacaacgggagaaccaacaacaggagcggctcctgctgtctgtcctgccc cgtcatgttgccatggagatgaaagcagacatcaatgccaagcaggaggatatgatgttc cataagatttacatccagaaacacgacaacgtgagcatcctgtttgctgacatcgagggc ttcaccagcctggcatcccagtgcactgcccaggagctggtcatgaccctcaacgagctc ttcgcccgcttcgacaagctggctgcggagaatcactgtttacgtattaagatcctgggg gattgttattactgtgtctctgggctgcctgaagcgagggctgaccacgcccactgctgc gtggagatgggcatggacatgattgaggccatctcgttggtccgggaggtgacaggggtg aacgtgaacatgcgcgtgggaattcacagcgggcgagtacactgcggtgtccttggtctc aggaagtggcaattcgacgtctggtctaatgacgtcacgctggccaaccacatggaagct ggaggcaaggcagggcgcatccacatcaccaaggccacactcaactacctgaacggggac tacgaggtggagccgggctgtgggggcgagcgcaacgcctacctcaaggagcacagtatc gagaccttcctcatcctgcgctgcacccagaagcggaaagaagaaaaggccatgatcgcc aagatgaatcgccagagaaccaactccattgggcacaacccgccccactggggggccgag cgtcccttctacaaccacctggggggcaaccaggtgtccaaggagatgaagcggatgggc ttcgaagaccccaaggacaagaacgcccaagaaagcgcaaaccctgaggacgaagtggac gaatttctgggccgtgccattgacgccaggagcatcgacaggctgcggtctgagcatgtc cgcaagttcctcttgaccttcagggagcctgacttagagaagaagtactccaagcaggtg gatgaccgattcggtgcctacgtggcatgtgcctcgcttgtcttcctcttcatctgcttt gtccagatcaccatcgtgccccactccgtgttcatgttgagtttctacctaacctgtttc ctgctgctgacgttagtggtatttgtgtccgtgatctattcctgcgtgaagctgttcccc accccactgcagaccctctccaggaagattgtgcggtccaagatgaacagcactctggtt ggcgtgttcaccatcaccctcgtgttcctctcggcttttgtcaacatgttcacgtgtaac tccaacgacctgttcggctgcctggcggatgagcacaacatcagcaccagccaggtcaac gcgtgccacgtggtggagtcggccgccaactacagcctgggggacgagcggggcttctgc agcagcccgtggcccaactgcaacttccctgagtacttcacctacagcgtgctgctcagc ctgctggcctgctccgtgttcctgcagatcagctgcattgggaagctggtgctcatgctg gccattgagctcacatacgtgctcatcgtcgaggtgccccgagtcacgctctttgacaat gccgacctgctggtcaccgccaatgccatagacttcaacaacaacgggacctcccagtgc cctgagcatgcgaccaaggtggcgctgaaggtgatgacgcccatcgtcatctccgtcttt gtgctggccctgtacctgcacgcccagcaagtggagtccaccgcccgcctggacttcctc tggaaactgcaggccacggaggagaaggaggagatggaggagctgcaggcctacaaccgg cggctgctgcacaacatcctgcccaaggacgtggctgcccacttcctggcccgcgagcgg cgcaacgacgagctctactaccagtcgtgcgagtgcgtggccgtcatgtttgcctccatc gccaacttctccgagttctatgtggagctggaggccaacaatgagggcgtcgagtgcctg cggctgctcaatgagatcatcgccgactttgacgagatcatcagtgaggatcggttcaag cagctggagaagatcaagaccattggcagcacctacatggccgcctcaggcctcaacgac tctacgtatgacaaggtgggcaagacccacatcaaagccctggccgacttcgccatgaag ctcatggaccaaatgaagtacatcaatgaacactccttcaacaacttccagatgaagatc gggctcaacatcggccctgtggtggccggggtgatcggggctcgcaagccgcagtacgac atctggggcaatacggtgaacgtggccagccgcatggacagcaccggtgtgcccgaccgc atccaggtcaccacggacatgtaccaggtgctggctgccaacacataccagctggagtgc aggggtgtggtcaaggtcaagggcaaaggcgagatgatgacctacttcctcaacgggggc cccccgctcagttag

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