Ursus arctos (brown bear): 113256691
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Entry
113256691 CDS
T05909
Symbol
JAK3
Name
(RefSeq) tyrosine-protein kinase JAK3 isoform X1
KO
K11218
Janus kinase 3 [EC:
2.7.10.2
]
Organism
uah
Ursus arctos (brown bear)
Pathway
uah04062
Chemokine signaling pathway
uah04151
PI3K-Akt signaling pathway
uah04217
Necroptosis
uah04550
Signaling pathways regulating pluripotency of stem cells
uah04630
JAK-STAT signaling pathway
uah04658
Th1 and Th2 cell differentiation
uah04659
Th17 cell differentiation
uah05161
Hepatitis B
uah05162
Measles
uah05166
Human T-cell leukemia virus 1 infection
uah05169
Epstein-Barr virus infection
uah05200
Pathways in cancer
uah05203
Viral carcinogenesis
uah05223
Non-small cell lung cancer
uah05340
Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
113256691 (JAK3)
04151 PI3K-Akt signaling pathway
113256691 (JAK3)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
113256691 (JAK3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
113256691 (JAK3)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
113256691 (JAK3)
04659 Th17 cell differentiation
113256691 (JAK3)
04062 Chemokine signaling pathway
113256691 (JAK3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113256691 (JAK3)
05203 Viral carcinogenesis
113256691 (JAK3)
09162 Cancer: specific types
05223 Non-small cell lung cancer
113256691 (JAK3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
113256691 (JAK3)
05161 Hepatitis B
113256691 (JAK3)
05162 Measles
113256691 (JAK3)
05169 Epstein-Barr virus infection
113256691 (JAK3)
09163 Immune disease
05340 Primary immunodeficiency
113256691 (JAK3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113256691 (JAK3)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
113256691 (JAK3)
Protein kinases [BR:
uah01001
]
Non-receptor tyrosine kinases
JAK family [OT]
113256691 (JAK3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
SH2_1
Jak1_Phl
ABC1
Kdo
Kinase-like
SH2
FERM_C_FAK1
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
113256691
NCBI-ProteinID:
XP_057167619
LinkDB
All DBs
Position
Unknown
AA seq
1049 aa
AA seq
DB search
MKNGGQRVCAACPRSCSKSVAQPGLCEVSAGSSTPPYPYSRLLPFPNSFYFPNWFGLEKC
HRFGLRKDLASAILDLPVLEHLFAQHRNDLVSGCLPVGLSLKEQGECLSLAVLDLARMAC
EQAQQPEELLKTVSYKVCLPPDLRDLIQGLSFVTRKRIRRTVRRALRRVTACQADRHSLM
AKYIMDLERLDPARAVETFLVSLPGAADGQDAQGLLRVAGDSGIAWCPGGQEALQPFCDF
PEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTSDS
RHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDCFLLTV
CVQTPLGPDYKGCLIRCDPTGTFSLAGLGRPHSSLRELLAACWDGGLHVDGVALNLTVCC
TPKPKEKSNLIVVRRGCNPPTSSPVQPQSQCQLSQMTFHKIPPESLEWHENLGHGSFTKI
YRGCRHEVVEGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGD
SIMVQEFVHLGALDTYLLKSGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLL
AREGADGNLPFIKLSDPGVSPTVLNREMLTDRIPWVAPECLQEARTLGLEADKWGFGATV
WEVFSGIPMPISTLDPAKKLQFYEEQQQLPAPKWMELATLIQQCMAYESGQRPSFRAIIR
DLNSLITSDYELLSDPTPGALAPRDGLWNGAQLYAYQDPTIFEERHLKYISQLGKGNFGS
VELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFEREIQILKALHSDFIVKYRGVSYGPGR
QSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGSCRCVHRDLAARNI
LVESETHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGV
VLYELFTYGNKSCSPSAEFLRMMECDRDVPALCRLLELLAEGQRLPAPPACPGEVHELMK
LCWAPSSQDRPTFSALGPQLDALWSASRG
NT seq
3150 nt
NT seq
+upstream
nt +downstream
nt
atgaagaacggaggccagagagtgtgcgctgcttgcccaaggtcatgtagcaagtcggtg
gcacaacctgggctctgtgaggtctcggcagggtcttccacccctccatatccctactcc
aggcttctccccttccccaacagcttttacttccccaactggtttgggctagagaagtgc
caccgctttgggctacgaaaggacttggccagcgccatccttgacctgcccgtcctggag
cacctcttcgcccagcaccgaaatgacctggtgagcggctgcctccccgtgggcctcagt
ctcaaggagcagggtgaatgtctcagcctggcggtgctggacctggcccggatggcctgc
gagcaggctcagcagcctgaggagctgctaaagactgtcagctacaaggtctgcctcccc
cccgacctgcgcgacctgatccaaggcctgagcttcgtgacgcggaagcgcatccggagg
accgtgcgtcgggccctgcgccgcgtgaccgcctgccaggctgacaggcactcgctcatg
gccaagtacattatggacctggagaggctcgacccggccagggcggtcgagaccttcctc
gtgagcctccctggggctgctgatggtcaagatgcgcaggggctgctccgagtggctggt
gacagcggcatcgcatggtgtccaggaggacaagaggccctccagcccttctgcgacttt
ccagaaattgtggacatcagcatcaagcaggctccgcgtgttggcccggccggggagcac
cgcctggtcaccgtcaccaggacagacaaccagatcctggaggccgagttcccggggctg
ccggccgcgttgtccttcgtggcgctcgtcgacggctacttccggctgacctccgactcc
aggcacttcttctgcaaggaggttgctccgccgcggctgctggaggaggtggcagagcag
tgccacggccccatcaccctggattttgccatcaacaagctcaagactgggggttcacgt
ccgggctcctacgttctccgccgcagtccccaggattttgactgcttcctcctcactgtc
tgtgtccagacccccctgggtcctgattacaagggctgcctcatccggtgtgaccccacg
gggaccttctccctggctggcctaggccgtccccacagcagtcttcgagagctcttggca
gcctgctgggacggcgggctgcacgtggatggggttgcgctgaacctcacagtctgctgc
acccccaaacccaaagaaaagtccaacctgattgtggtgcggaggggttgcaaccccccc
acgtcgtcccctgttcagccccaatcccaatgccagctgagtcagatgacgtttcacaag
atccctcctgagagcctggagtggcatgagaacttgggtcacgggtccttcaccaagatt
taccggggttgtcgccatgaggtcgtggagggcgaggcccgggagacggaggtgctgctc
aaagtgatggatgccaagcataaaaactgcatggagtcatttctggaagcagcgagtttg
atgagccaagtgtcataccagcatcttgtgttgctccatggcgtgtgcatggctggagac
agtatcatggtgcaggagtttgtacacctgggagctctggacacgtacctgctcaagtct
ggccacctggtgccagccagctggaagctgcaggtgatcaagcagctggcctacgccctc
aactacctggaagacaaaggcctcccccatggcaatgtctcagcccggaaggtgctcctg
gctcgcgaaggggctgatgggaacctgcccttcatcaagctgagtgaccctggtgtcagc
cccactgtgctaaaccgggagatgctcactgacaggatcccctgggtggcccctgagtgt
ctccaggaggcccggacacttggcttggaagccgacaagtggggttttggtgccacagtc
tgggaggtgttcagcgggatcccgatgcccatcagcaccctggatcctgccaagaagctc
cagttttatgaggaacagcagcagctgcctgcccccaagtggatggagctggccacactg
atccaacagtgcatggcctatgagtcaggccagaggccctccttccgcgccatcatccgt
gacctgaacagcctcatcacttcagattatgagctcctctcagaccccacgcccggtgcc
ttggcgccccgtgacgggctatggaatggcgcccagctctacgcctaccaggaccctacc
atttttgaggagagacacctcaagtacatctcacagctgggcaagggtaacttcggcagc
gtggaactgtgccgctatgacccgctgggtgacaacacgggcgccctagtggcagtgaag
cagctgcagcacagcgggccagaccagcagagggactttgagagggagatccagatcctc
aaagcccttcacagcgacttcatcgtcaagtaccgcggtgtcagctatggcccaggccgt
cagagcttgcggctggtgatggagtacctgcccagcggctgcctgcgcgacttcctgcag
cggcaccgcgcgcgcctcgacgccagccgcctgctcctctacgcctcgcagatctgcaag
ggcatggagtacctgggctcctgccgctgcgtgcaccgcgacctggcagcgcgtaacatc
ctggtggagagcgagacgcacgtcaagatcgccgactttggcctcgccaagctgctgcca
ctcgacaaagactactacgtggtccgcgagcccggccagagccccatcttctggtatgcc
ccagagtccctctctgacaacatcttctcgcgccagtcggatgtctggagcttcggggtc
gtcctgtacgagcttttcacctacggcaacaagagttgcagcccctcagccgagttcctg
cggatgatggaatgtgatcgagatgtccccgccctctgccgcctcctggagctgctggct
gagggccagaggctgcccgcgcctcctgcctgccctggtgaggttcatgagctcatgaag
ctatgctgggcccctagctcgcaagaccggccaacattcagtgccctgggcccccagctg
gatgcgctatggagtgccagccgggggtag
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