Ursus arctos (brown bear): 113260807 Help Entry 113260807         CDS       T05909                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism uah  Ursus arctos (brown bear) Pathway uah00230   Purine metabolism uah01100   Metabolic pathways uah01522   Endocrine resistance uah04015   Rap1 signaling pathway uah04020   Calcium signaling pathway uah04022   cGMP-PKG signaling pathway uah04024   cAMP signaling pathway uah04062   Chemokine signaling pathway uah04072   Phospholipase D signaling pathway uah04081   Hormone signaling uah04082   Neuroactive ligand signaling uah04114   Oocyte meiosis uah04211   Longevity regulating pathway uah04213   Longevity regulating pathway - multiple species uah04261   Adrenergic signaling in cardiomyocytes uah04270   Vascular smooth muscle contraction uah04371   Apelin signaling pathway uah04540   Gap junction uah04611   Platelet activation uah04713   Circadian entrainment uah04714   Thermogenesis uah04723   Retrograde endocannabinoid signaling uah04724   Glutamatergic synapse uah04725   Cholinergic synapse uah04727   GABAergic synapse uah04750   Inflammatory mediator regulation of TRP channels uah04911   Insulin secretion uah04912   GnRH signaling pathway uah04913   Ovarian steroidogenesis uah04914   Progesterone-mediated oocyte maturation uah04915   Estrogen signaling pathway uah04916   Melanogenesis uah04918   Thyroid hormone synthesis uah04921   Oxytocin signaling pathway uah04922   Glucagon signaling pathway uah04923   Regulation of lipolysis in adipocytes uah04925   Aldosterone synthesis and secretion uah04926   Relaxin signaling pathway uah04927   Cortisol synthesis and secretion uah04928   Parathyroid hormone synthesis, secretion and action uah04934   Cushing syndrome uah04935   Growth hormone synthesis, secretion and action uah04970   Salivary secretion uah04971   Gastric acid secretion uah04972   Pancreatic secretion uah04976   Bile secretion uah05032   Morphine addiction uah05163   Human cytomegalovirus infection uah05166   Human T-cell leukemia virus 1 infection uah05200   Pathways in cancer uah05207   Chemical carcinogenesis - receptor activation uah05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:uah00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     113260807 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     113260807 (ADCY2)    04371 Apelin signaling pathway     113260807 (ADCY2)    04020 Calcium signaling pathway     113260807 (ADCY2)    04072 Phospholipase D signaling pathway     113260807 (ADCY2)    04024 cAMP signaling pathway     113260807 (ADCY2)    04022 cGMP-PKG signaling pathway     113260807 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     113260807 (ADCY2)    04081 Hormone signaling     113260807 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     113260807 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     113260807 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     113260807 (ADCY2)    04062 Chemokine signaling pathway     113260807 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     113260807 (ADCY2)    04922 Glucagon signaling pathway     113260807 (ADCY2)    04923 Regulation of lipolysis in adipocytes     113260807 (ADCY2)    04912 GnRH signaling pathway     113260807 (ADCY2)    04913 Ovarian steroidogenesis     113260807 (ADCY2)    04915 Estrogen signaling pathway     113260807 (ADCY2)    04914 Progesterone-mediated oocyte maturation     113260807 (ADCY2)    04921 Oxytocin signaling pathway     113260807 (ADCY2)    04926 Relaxin signaling pathway     113260807 (ADCY2)    04935 Growth hormone synthesis, secretion and action     113260807 (ADCY2)    04918 Thyroid hormone synthesis     113260807 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     113260807 (ADCY2)    04916 Melanogenesis     113260807 (ADCY2)    04925 Aldosterone synthesis and secretion     113260807 (ADCY2)    04927 Cortisol synthesis and secretion     113260807 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     113260807 (ADCY2)    04270 Vascular smooth muscle contraction     113260807 (ADCY2)   09154 Digestive system    04970 Salivary secretion     113260807 (ADCY2)    04971 Gastric acid secretion     113260807 (ADCY2)    04972 Pancreatic secretion     113260807 (ADCY2)    04976 Bile secretion     113260807 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     113260807 (ADCY2)    04727 GABAergic synapse     113260807 (ADCY2)    04725 Cholinergic synapse     113260807 (ADCY2)    04723 Retrograde endocannabinoid signaling     113260807 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     113260807 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     113260807 (ADCY2)    04213 Longevity regulating pathway - multiple species     113260807 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     113260807 (ADCY2)    04714 Thermogenesis     113260807 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     113260807 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     113260807 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     113260807 (ADCY2)    05163 Human cytomegalovirus infection     113260807 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     113260807 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     113260807 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     113260807 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     113260807 (ADCY2) Enzymes [BR:uah01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      113260807 (ADCY2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  113260807 NCBI-ProteinID:  XP_026362458 LinkDB All DBs Position Unknown AA seq 1093 aa AA seqDB search MWREAMRRRRYLRDRAEAAAAAAGGGDGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGA CLALLAVFFALRLDVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSVVIWICL VAMGYLFLCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCL SATPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEK RQQERLLLSLLPAHIAMEMKAEIIRRLQGPRAGQMENTNNFHNLYVKRHTNVSILYADIV GFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME AGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPHLFR PRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNR TLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYRATALP AFKYYVTCACLIFFCVFIVQILVLPKTSILGISFGAAFLLLAFILFICFAGQLLQCSKKA SASLLWLLKSSGIIADRPWPRVSLTVLTTAIILTMAVFNMFFLSDPEETIPPTANSSNTS LSALSNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILL HTHAHVLDDYSQVLFQRPGIWKDLKTMGSVSLFIFFVTLLVLGRQNEYYCRLDFLWKNKF KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKE FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE HAQEPERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY DIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGELKTYFVNT EMSRSLSQGNLAS NT seq 3282 nt NT seq  +upstreamnt  +downstreamnt atgtggcgggaggcgatgcggcgccgccgctacctgcgggaccgcgccgaggcggcggcg gcggcggcgggcggcggcgacgggctgcagcggtcccgggactggctgtacgagtcctac tactgcatgagccagcagcacccgctcatcgtcttcctgctgctgatcgtcatgggcgcc tgcctcgccctgctcgccgtcttcttcgcgctccggctggacgttgaagaccacgtggca tttttaataacggtcccgacagccctggcgatcttcttcgcgatcttcatcctcgtctgc atcgagtccgtgttcaagaagctcctgcgccttttctccgtcgtgatatggatctgcctc gtggccatgggctacctgttcctgtgcttcggaggcaccgtctccccctgggaccaggtg tcgttcttcctcttcatcatctttgtggtgtacaccatgctgcccttcaacatgcgggac gccatcatcgccagcgtgctcacctcctcctcccacaccatcgtgctgagcgtctgcctg tctgcgacgccgggggccaaggagcacctggtctggcagatcctggccaatgtgatcatt ttcatctgtgggaacctggcgggagcgtaccacaagcacctcatggagctggccttgcag cagacgtatcaggacacctgcaactgtatcaagtctcggatcaagctggaatttgaaaag cgtcagcaggagcggcttctgctctccctgctgccggctcacatagccatggaaatgaaa gccgagatcatccggaggctgcagggccccagagccggccaaatggaaaacacaaacaac ttccacaacctgtacgtcaagcgccataccaacgtgagcatcctgtatgctgatattgtt ggcttcacccggctggccagtgactgctccccaggagaactggtccacatgctgaacgag ctctttggaaagttcgaccaaattgcaaaggagaatgaatgcatgagaataaaaattttg ggagactgctactactgtgtgtccggacttcctatatctctcccgaaccatgccaagaac tgtgtgaaaatggggctggacatgtgtgaagccataaagaaagtgagggatgccactgga gtggatatcaacatgcgcgtgggagtgcattctgggaacgtcctctgcggggtgattggt ctgcagaagtggcagtacgacgtgtggtcacatgacgttaccttggccaatcacatggaa gctggaggggtccctggacgtgttcacatttcttccgtcaccctggaacacttgaacggc gcttacaaagtggaggaaggagacggtgacatcagagacccgtatttaaaacagcacctg gtgaaaacctactttgtcatcaaccccaagggagaacgaaggagtcctcacctcttcaga cctcgccacaccctcgatggagccaagatgagggcctctgtgcgcatgacccggtacctg gagtcctggggggcggccaagccctttgcacacctgcatcaccgagacagcatgaccacg gagaatggcaaaatcagcaccacggatgtgccaatgggtcagcataattttcaaaatcgt accttaagaaccaagtcccaaaagaagagatttgaagaagaattaaatgaaaggatgatt caagcaattgatggaattaacgcacaaaagcagtggctcaagtctgaagacattcagaga atctcactcctgttctacaataaaatactagaaaaagaataccgagccaccgccctgcca gcgtttaagtactacgtgacctgcgcgtgtctcatattcttctgcgtcttcattgtacag attctggtattaccaaaaacgtccattctggggatctcctttggagctgcgtttctcttg ctcgcctttatcctcttcatctgctttgccgggcagcttctgcaatgcagcaagaaggcc tccgcctctctcctgtggctgttgaagtcgtcgggcatcatcgcggaccggccctggcct cgtgtctccctcactgtcctcaccacggccatcattctgaccatggccgtgttcaacatg tttttcctgagtgacccagaggaaacaattcctccaactgccaattcatccaacacaagt ctttctgccttaagtaatcaggcagcgattctacgggcacaaaatctgtttttcctcccg tactttatctacagctgcatcctgggactgatctcctgctcggttttcctgagggtgaat tacgagctgaagatgttgatcatgatggtggcgttggtgggttacaacaccatccttcta cacacgcacgcccacgtcctggacgactatagccaggtcttattccagagaccaggcatt tggaaagacctgaagaccatgggctcagtgtctctctttatattcttcgtcacactgctt gttctgggtagacagaatgaatattactgtaggttagacttcttatggaagaacaagttc aaaaaagagcgggaggagatagaaaccatggaaaacctgaaccgcgtgctgctggagaac gtgctgcccgcgcacgtggcggagcatttcctggcccggagcctgaagaacgaggagtta taccaccagtcctatgactgtgtctgcgtcatgtttgcctctattccggatttcaaagaa ttctacacagaatcagatgtgaacaaggagggcttggaatgccttcggctcctgaatgag atcatcgccgactttgatgatctgctgtccaagccgaagttcagtggagttgaaaagatc aagaccattggcagcacatacatggcggcgaccggtctgagcgccgtgcccagccaggag cacgcccaggagccggagaggcagtacatgcacattggcaccatggtggagtttgccttc gcgctggtggcgaagctggacgccatcaacaagcactccttcaacgacttcaagctgcga gtgggtattaaccacggacctgtgatagccggtgtgattggagctcagaagccgcagtat gatatctggggcaacactgtaaacgtggccagcaggatggacagcaccggcgtgctggac aagatacaggtcaccgaggagacaagcctcatcctccagacgctggggtacacgtgcacg tgtcgaggaataattaacgtgaaaggcaagggggagctgaagacgtactttgtaaacaca gaaatgtcaaggtccctttcccagggcaacttggcatcctga

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