Ursus americanus (American black bear): 123776714 Help Entry 123776714         CDS       T07931                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism uar  Ursus americanus (American black bear) Pathway uar04022   cGMP-PKG signaling pathway uar04068   FoxO signaling pathway uar04081   Hormone signaling uar04140   Autophagy - animal uar04152   AMPK signaling pathway uar04211   Longevity regulating pathway uar04213   Longevity regulating pathway - multiple species uar04910   Insulin signaling pathway uar04920   Adipocytokine signaling pathway uar04923   Regulation of lipolysis in adipocytes uar04930   Type II diabetes mellitus uar04931   Insulin resistance uar04932   Non-alcoholic fatty liver disease uar04935   Growth hormone synthesis, secretion and action uar05010   Alzheimer disease uar05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     123776714 (IRS2)    04022 cGMP-PKG signaling pathway     123776714 (IRS2)    04152 AMPK signaling pathway     123776714 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     123776714 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     123776714 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     123776714 (IRS2)    04923 Regulation of lipolysis in adipocytes     123776714 (IRS2)    04920 Adipocytokine signaling pathway     123776714 (IRS2)    04935 Growth hormone synthesis, secretion and action     123776714 (IRS2)   09149 Aging    04211 Longevity regulating pathway     123776714 (IRS2)    04213 Longevity regulating pathway - multiple species     123776714 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     123776714 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     123776714 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     123776714 (IRS2)    04932 Non-alcoholic fatty liver disease     123776714 (IRS2)    04931 Insulin resistance     123776714 (IRS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  123776714 NCBI-ProteinID:  XP_045628852 LinkDB All DBs Position Unknown AA seq 1327 aa AA seqDB search MASPPLHGPPGPAGGDGPNLNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGDEATATA GGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYF AVAAENEQEQEGWYRALTDLVSEGRAGDAPPAAATAASCSASLPGALGGSAGAAAADDSY GLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMN IRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRS KSQSSGSSSTHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTA SEGDGGAAAGAGAAGGRPVSVAGSPLSPGPVRAPLSRSHTLSGGCGARASKVALAPAGGA LQHSRSMSMPVAHSPPAATSPSSLSSSSGHGSGSYPPPPGPHPHLQHALHHPAGQRPSSG SASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGSGGELYGYMTM DRPLSHCGRPYRRVSGDGGQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATF SGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGVALLGG GSGSCKSDDYMPMSPTSVSAPKQILQPRAAAAALPPTGAAVPAPTPTASRAFPANGGSYK TSSPAESSPEDSGYMRMWCGSKLSMENTDTKLLPNGDYLNMSPSDAGTSGTPPDFFSAAL HGSGEMLRGVPGYCYSSLPRSYKAPYTCNGDNDQYVLMSSPVGRILEEERLEPPAGPGAP STSAFAAGGGHIQPPHPVVPSPSRPSGSSGGRPEGFLNQRCRLVRPTRLSLEGLQTLPSM HEYPLPPEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPG TSSDSRQRSPLSDYMNLDFSSPKSPKPGTQSGDPVGSLDALLSPEASSPYPPLPPRPAAP TSSLQPQPPPPPPPGELYRLPQASTSQGPSAASSSSSETGDNGDYTEMAFGVAATPPQPI AAPPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRH SSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGGSGVLGGGDERPTSPRQL QPPPPQQARPWVPSQPGGLVGCPGGSGSPMRRETSAGFQNGLNYIAIDVRDEPGLSAAPQ QHPHPQPGDKSAWGRTRSLGGLISAVGGSGSSGVCGGPGPGALPSANTYASIDFLSHHLK EATIVKE NT seq 3984 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccaccgctgcatgggccccccgggccggcgggcggcgacggccccaacctc aacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcagaag cacggccacaagcgtttcttcgtgctgcgcgggcccggcgacgaggcgacggcgacagcg ggcggggggccggcgccgcagccgccgcggctcgagtactatgagagcgagaagaagtgg cggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctaaacatcaac aagcgcgccgacgccaaacacaagtacctgatcgcgctctacaccaaggacgagtacttc gcggtggcggccgagaacgagcaggagcaggagggctggtaccgcgcgctcaccgacctg gtcagcgagggccgcgccggcgacgcgccccccgccgccgccaccgccgcgtcctgcagc gcctccctgcccggcgccctgggcggctcggccggcgccgccgcggccgatgacagctac gggctggtggcgcccgccacggccgcctaccgcgaggtgtggcaggtgaacctgaagccc aagggcctgggccagagcaagaacctgacgggcgtgtaccgcctgtgcctgtcggcgcgc accatcggcttcgtgaagctcaactgtgagcagccgtcggtgacgctgcagctcatgaac atccgccgctgcggccactcggacagcttcttcttcatcgaggtgggccggtcggctgtc acgggcccaggtgagctgtggatgcaggccgacgactcggtggtggcgcagaacatccac gagaccatcctggaggccatgaaggcactcaaggagctcttcgagttccggccgcgcagt aagagccagtcgtcgggctcgtcctccacacaccccatcagcgtccccggcgcgcgccgc caccaccacctggtcaacctgccccccagccagacgggcctggtgcgccgctcgcgcacc gacagcctggccgccaccccgccggccgccaagtgcagctcttgtcgggtgcgcacggcc agcgagggagacggcggcgcggcggcgggggcgggggcggcgggcggcaggcctgtgtct gtagccgggagtcccctgagccccgggccggtgcgcgcgcccctgagccgctcacacacc ctaagcggcggctgcggcgcccgcgcgagcaaggtggcgctggcgccggcagggggcgcc ctgcaacacagccgctccatgtccatgccggtggcgcactcgcccccagccgccaccagc cccagcagcctgtcgtccagcagcgggcatggctccggttcttacccgccgccgccaggc ccgcatccgcacctgcagcacgccctgcaccaccccgcgggccagcggccctccagcggc agcgcctcggcctccggctcccccagcgaccctggcttcatgtctctggatgagtatggc tccagccctggggacctgagagccttctgcagccacaggagcaacacgcccgagtccatc gctgagacacctccggccagagacggcagcgggggcgagctgtacgggtacatgactatg gacaggcccctgagccactgtggtcgcccctaccgcagagtctctggggacgggggccag gacttggaccgagggctgaggaagaggacttactccctgaccacacctgcccggcagcgg ccagtgccccagccctcctctgcatccctggatgaatacaccctgatgcgggccacgttc tccggcagctccggccgcctctgcccatcctgtcccgcgtcatctcccaaagtggcctac cacccctatcctgaggactatggcgacatcgagatcgggtcccataggagctctagcagt aacctgggtgccgacgatggctacatgcccatgacccctggcgtggccctcctgggtggt ggcagtggcagctgtaagagtgatgactacatgcccatgagccccactagcgtgtctgcc ccgaagcagatcctgcagcctcgggctgcggccgcagccctgccccccacaggagccgca gtgcccgcacccacccctacggccagtagggcctttccagcgaacgggggcagctacaag acgagctccccagccgagagctcccctgaggacagtgggtacatgcgtatgtggtgtggc tccaagctgtccatggagaacactgacaccaagctgctacccaacggggactacctcaat atgtcccccagcgacgcgggtacctcagggacacctcccgacttcttctcggctgccttg catggcagcggggagatgctcaggggagtccctggctattgctatagctccctgcctcgc tcctacaaggctccctacacgtgcaacggggacaacgaccagtatgtgctcatgagctcc cccgtggggcgcatcctggaagaggagaggctagaaccgcctgccggccctggcgcacca tccactagcgctttcgcggccggaggcggccacatccaacctcctcacccagtagtgcct tcgcccagcaggccgagtggcagcagcggtggccgcccagagggcttcctgaaccagcgc tgccggttagtgcggcccacacgcctgtccctggaggggcttcagaccctgcccagcatg cacgagtaccctctgccgcctgagcccaagagcccgggcgagtacatcaacattgacttt ggtgaagccggaactcgcctgtctccgcccgcgcctccgctgctggcttcggcggcctca tcgtcctcactgctgtccgccagcagcccggcctcgtccctgggctcgggcaccccgggc acgagcagcgacagcaggcagcgctccccactctccgactacatgaaccttgacttcagc tcgcccaagtcacccaagccgggcacccagagcggggaccctgtgggctccctggatgcc ctcctgtcccctgaggcctcgtccccctacccaccgctgcccccccgtcctgcggccccc acctcctccctgcagccgcagccgcccccaccgccccccccaggggagctgtaccgcctg ccccaggcgtcaacttcccagggccccagcgctgcctcctcttcgtcctcggagactggg gacaatggtgactacaccgagatggcctttggcgtggctgccaccccgccacaacccatc gcggcccccccgaagccggaaggtgcccgcgtgaccagccccacctccggcttgaagagg ctgagtctcatggatcaggtgtcgggagtcgaggccttcctgcaggcgagccagccccca gaccctcaccggggagccaaggtcatccgcgcagacccacaggggggccgccgccgccac agctccgagaccttctcctcgaccaccactgtgacccccgtgtccccatccttcgcccat aaccctaagcgccacaactcggcctctgtggaaaacgtctctctcaggaaaagcagcgaa gggggcggcagcggcgtcctgggtgggggtgacgagcgccccacgtccccccgccagttg cagccaccgcccccccagcaggcgcgcccatgggtaccaagtcagcctgggggcttggtt ggctgccctgggggcagtgggtctccaatgcgcagggagacctctgccggcttccagaac ggcctcaactacatcgccatcgacgtgagggacgagcctgggctgtcagcggccccacag cagcatcctcatccgcagcccggagacaagagcgcctggggccggacccgcagcctcggg ggcctcatcagcgctgtggggggcagcggcagcagtggggtatgtggggggccgggccct ggcgccctaccctctgccaacacctatgccagcattgacttcttgtcccatcacctgaag gaggccaccattgtgaaagagtga

DBGET integrated database retrieval system