Ursus americanus (American black bear): 123778092 Help Entry 123778092         CDS       T07931                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism uar  Ursus americanus (American black bear) Pathway uar04022   cGMP-PKG signaling pathway uar04068   FoxO signaling pathway uar04081   Hormone signaling uar04140   Autophagy - animal uar04150   mTOR signaling pathway uar04151   PI3K-Akt signaling pathway uar04152   AMPK signaling pathway uar04211   Longevity regulating pathway uar04213   Longevity regulating pathway - multiple species uar04722   Neurotrophin signaling pathway uar04910   Insulin signaling pathway uar04920   Adipocytokine signaling pathway uar04923   Regulation of lipolysis in adipocytes uar04930   Type II diabetes mellitus uar04931   Insulin resistance uar04932   Non-alcoholic fatty liver disease uar04935   Growth hormone synthesis, secretion and action uar04960   Aldosterone-regulated sodium reabsorption uar05010   Alzheimer disease uar05206   MicroRNAs in cancer uar05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     123778092 (IRS1)    04022 cGMP-PKG signaling pathway     123778092 (IRS1)    04151 PI3K-Akt signaling pathway     123778092 (IRS1)    04152 AMPK signaling pathway     123778092 (IRS1)    04150 mTOR signaling pathway     123778092 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     123778092 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     123778092 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     123778092 (IRS1)    04923 Regulation of lipolysis in adipocytes     123778092 (IRS1)    04920 Adipocytokine signaling pathway     123778092 (IRS1)    04935 Growth hormone synthesis, secretion and action     123778092 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     123778092 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     123778092 (IRS1)   09149 Aging    04211 Longevity regulating pathway     123778092 (IRS1)    04213 Longevity regulating pathway - multiple species     123778092 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     123778092 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     123778092 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     123778092 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     123778092 (IRS1)    04932 Non-alcoholic fatty liver disease     123778092 (IRS1)    04931 Insulin resistance     123778092 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  123778092 NCBI-ProteinID:  XP_045631223 LinkDB All DBs Position Unknown AA seq 1237 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGASAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN GHYILPRGGNGHRYIPGAGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR PDTSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSSSAAPSGSSYGKLWTNGVGGHHAHALPHPKLPAESGSGK LLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEESA RHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGGGYCGVRPDPGLPHIHHQVLQPHLPRK VDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQPSLLHAPEPKSPGEYVNIEFGSDQ PCYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQESAGVQAGRA GPAPPGAASMCRPTRAVPSSRGDYMTMQMGCPAQSYVDTSPVAPISYADMRTGLAVEEAS LPGATAAAPSSSSVASASPTARQKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNRNQSA KVIRADPQGCRRRHSSETFSSTPSATRMGNTVPFGGGAAVGGGGGGSSSTEDMKRHSSAS FENVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKPRPQERPPQPQPPLPP PPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ NT seq 3714 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggttacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcagggggg ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcagactccaagaac aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaggacagctggtaccaagccctcctgcagctgcacaatcgggccaagggccac cacgacggggcctcggcccccggggcaggaggcggtgggggcagctgcagcggcagctcc ggcctcggggaggctggggaggacttgagctacggggacgtgcccccaggacctgcgttc aaggaggtctggcaggtgatcctgaaacccaaaggtctgggtcagacaaagaacctgatt ggcatctaccgactctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcagacgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacaggacctggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agcgatgagttccgtcctcgaagtaagagccagtcctcctccaactgctccaaccccatc agcgtccccttgcgcaggcatcacctcaacaaccccccacccagccaggtggggctgacg cgccgctctcgcaccgagagcatcaccgccacctctccggccagcatggtgggcggcaag cagggctccttccgtgtgcgagcgtccagcgatggcgaaggcaccatgtcccgcccggcc tcggtggacgggagccctgtgagtcccagcaccaacaggacccacgcccaccgtcatcgc ggcagctcccggctgcacccccctctcaaccacagccgctccatccccatgccttcttct cgctgctcaccttccgccaccagcccggtcagtctgtcgtccagcagcaccagtggccac ggctccacctcggactgtctcttcccacggcggtctagtgcttctgtgtccggttccccc agcgatggcggcttcatctcctccgatgaatatggctccagcccttgcgatttccgaagt tccttccgcagtgtcaccccagattccctgggccacaccccaccggcccgcggtgaggag gagctgagcaactacatctgcatgggaggcaaggggtcctccaccctcaccgcccccaat ggtcactatattttgcctcggggtggcaacggtcaccgctacatcccaggagctggcttg ggcacgagccctgccctggctggggatgaagcggccagtgctgcagatctggataatcgg ttccgaaagcggactcactctgctggcacatcccctaccatttcccaccagaagacccca tcccagtcctctgtggcttccattgaggaatacacggagatgatgcctgcctacccgcca ggaggtggcagtggaggccgactgcctggctaccggcactctgccttcgtgcccacccac tcctaccctgaggagggtctggaaatgcaccctttggacaggcgtgggggccaccaccgc ccagacacatccactctccacactgatgacggctacatgcccatgtccccaggagtggcg ccagtgcccagcagccgaaagggcagtggggactacatgcccatgagccccaagagcgtg tctgcgccgcagcagatcatcaacccgatcagacgccatcctcagagagtggaccccaat ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggcgggcccagc agcagcagtgccgccccttctgggagcagctatggcaagctatggacaaatggggtaggg ggccaccacgctcatgccctgccgcaccccaaactgcccgcagagagcgggagtggcaag ctcttgtcttgtactggtgactacatgaacatgtcgccagtgggggactccaacaccagc agcccctccgactgctactacggcccagaggacccccagcacaagccagttctctcctac tactcattgccaaggtcctttaagcacacccagcgccctggggagctggaggagagtgcc cggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcaacggca gaagattcctcctcctccaccagcagcgacagcctgggcgggggatactgtggggtgagg ccggatcctggcctcccacatatccaccatcaggtcctgcagccccatctgcctcgaaag gtggacacagctgcccagaccaacagccgcctggctcggcccacgaggctgtccctgggg gatcccaaggccagcaccttacctcgggtccgagagcagcagcaacagccgtccctgctg cacgctccggagcccaagagcccaggggagtatgtgaatattgaatttgggagtgatcag ccgtgttacttatctggtcctgtggcttcccgcagctcgccttctgtcaggtgtccatcc cagctccagccagctcccagagaggaagagactggcactgaggaatacatgaacatggac ctggggccaggccgaagggcgacctggcaggagagtgccggggtccaggcaggcagagcg ggccctgcaccccctggggctgctagcatgtgcaggcctacccgggcagtgcccagcagc cggggggactacatgaccatgcagatgggttgtccggcgcagagctacgtggacacctca ccagttgcccccatcagctatgctgacatgcggacaggccttgctgtggaggaggccagc cttccaggagccaccgcggcggctccctcctcatcctctgtagcctctgcttcccccact gcgcgtcaaaaagcaggggagctggtggcccgctcttccctgctggggggcccacaggga cctgggggcatgagcgccttcacccgggtgaacctcagtcccaaccgtaaccagagtgcc aaagtgatccgtgcggacccacaagggtgccggaggcggcatagctctgagaccttctcc tccacacctagtgccacccggatgggcaacacggtgccctttggagggggggctgccgta gggggcggcggtggtggcagcagcagcacagaggatatgaaacgccacagttctgcttcc tttgagaatgtgtggctgaggcctggggagctcgggggagcccccaaggagccggcccaa gtgtgtggggctgctgggggtttggagaacgggcttaactacatagacctggatttggtc aaggacttcaaaccgcgccctcaggagcgcccccctcaaccgcagccacccctgcccccg ccccctcatcagcctctgggcagcagtgagagcagctcaaccagccgctccagcgaggat ttaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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