KEGG   Ursus americanus (American black bear): 123781964
Entry
123781964         CDS       T07931                                 
Symbol
BRCA1
Name
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01524  Platinum drug resistance
uar03440  Homologous recombination
uar03460  Fanconi anemia pathway
uar04120  Ubiquitin mediated proteolysis
uar04151  PI3K-Akt signaling pathway
uar05206  MicroRNAs in cancer
uar05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:uar00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    123781964 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    123781964 (BRCA1)
   03460 Fanconi anemia pathway
    123781964 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    123781964 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    123781964 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    123781964 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    123781964 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:uar01009]
    123781964 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:uar04121]
    123781964 (BRCA1)
   03036 Chromosome and associated proteins [BR:uar03036]
    123781964 (BRCA1)
   03400 DNA repair and recombination proteins [BR:uar03400]
    123781964 (BRCA1)
Enzymes [BR:uar01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     123781964 (BRCA1)
Protein phosphatases and associated proteins [BR:uar01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     123781964 (BRCA1)
Ubiquitin system [BR:uar04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    123781964 (BRCA1)
  Multi subunit type E3
   BRCC complex
    123781964 (BRCA1)
Chromosome and associated proteins [BR:uar03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     123781964 (BRCA1)
DNA repair and recombination proteins [BR:uar03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     123781964 (BRCA1)
    BRCA1-A complex
     123781964 (BRCA1)
    BRCA1-B complex
     123781964 (BRCA1)
    BRCA1-C complex
     123781964 (BRCA1)
    BRCA complex
     123781964 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     123781964 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-RING_UBOX zf-C3HC4_4 zf-C3HC4_3 zf-RING_5 zf-RING_2 RING_XB3-XBAT31 zf-Nse zf-RING_6 zf-ANAPC11 zf-rbx1 zf-RING_10 Baculo_IE-1 Prok-RING_4
Other DBs
NCBI-GeneID: 123781964
NCBI-ProteinID: XP_045637718
LinkDB
Position
Unknown
AA seq 1863 aa
MDLPADRVEEVQNVLNAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQRKGPSQ
CPLCKNDITKRSLQESTRFSQLVEELLKIIHAFELDTGLQFANSYNFSKKENNSPDHLKE
EVSIIQSMGYRNRAKRLRQSEPENPALQETSLSVHLSDLGIVRSLRTKQQIQPQNKSVYI
ELGSDSSEDTVNKASYCSVGDDELLQITPQGARAEASLNPAKKAACEISEDITNIEHHQS
GNKDLTTTEKHATEKHPEKYQGISVSNLHVEPCGTNTHTSSLQHENSSLLLTKDRMNVEK
AEFCNKSKQLGLARSQQSRWAGSKETCNDRQTPSTEKKVLLNADPLHGRKELRKQKPACS
DSPRDSQDVPWITLNSSVQKVNEWFSRSDGMLPSDDSHDGGSDSNTGVAGAVEVPNEVDG
YSGSSEKVDLMASDPQVALIRGSERVHPKSVESNIEDKIFGKTYRRRASLPSHTNEDLII
GFRAIEPQTTRAHPLTNKAKCKRRTTSGLLPEDFIKKVDLAVVPKTPEKLVEGTNQIARN
GHVMNITNNGPENEAKGDYVQNEKNANPTESLEKESAFRSKAEPISSSISNMELELNSSS
SKAPKKNRLRRKSSTRHACALEFVVSRNPSPPDHGELQIDSCSSSEEMKKQHLDQMPVRH
SKMLQLMEGKEPATGARRGSKPGEQINKRLASHTFPELNLTNVPGFFANCSSSNKPQELV
NPSLQREEPEESLGRIQVSDSTRDPKELLLGGGRGLQTERSVESTRISLVPDTDYGTQDS
ISLLEADTLRKTKTAPNRRANLCAATENPKEPIHGCSKDTRNDTEGFADPLTCEDNHTQE
TRIAMEESELDTQYLYNTFKVSKRQSFALFSNPEDPEKDCAMVCAHSGALRKQSPKVTLE
GGQKEENQGKKESEIKHVQAVHATAGFSAVSQQAKKPGDYAKCSIKGGSGLCQSSLFRGK
EAELLIANNHGISQNPYHIPPLSPIRSSVKTLCKKNPSEERFEQHSMSPERAMGNESVIQ
STVSTISQNNIRESTLKEVSSSSVNEVGSSTNEVGSSGENIQAELGRHRGPKLNAMLRLG
LMQPEVYKQSPPVSNCKHPEMKRQGENEGVVLSVNADFSPCLISDNPEQPMGSTCASQVC
SETPDDLLNGDKIKGKSSFAESDIRERSAVFSKSVQKGAFRRSPLDETRLAQGHQRGARK
LESSEENTSSEEEELPCFQHLLFGKVTNTPSQPTSHNAVATEGLSKKTEENLDSRKSSLS
DLSNQGPSAKASQEHYLSEEARCSGSLFSSQHSALEDLTVTTNSQDPFLMFDPPSKQVRH
QSENLDVLSDKELVSDDDDERELGLDEDNHEEQSVDSDLGEVASGYQSETSLSEDRSGLS
SQSDILTTQQRDTMQDNLIKLQQEMAELEAVLEQHGSQPSRSSPSLLAGSGAPEDLLNPE
QNTSEKAILTSEKSSDYPISQNPESLSADKFQVSLDSSTSKNKEPGTRRSSPSPSRLLDT
RWYVHSGPRNLQNTNCPSQKELIKVISVEEQAPTKSEAQEVVEQSLLRPDLEGTPYLESG
ISLFSDDPESDPSADRTPEPAHVSSMPTSTSALKLPQFQVEESAKSTAAVHVANTAGYNK
REDTVGREKPEVISSVKRINRTISMVASGLTPKEFMLVEKFAKKHHIALTNQISEETTHV
IMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKILDEHDFEVRGDVVNGRNHQ
GPKRARESRDRKIFRGLEVCCYGPFTNMPTDQLEWMVHLCGASVVREPSSFTLSKGTHPV
VVVQPDAWADDSGFHAIGQMCEALVVTREWVLDSVALYQCQELDTYLIPQIRRAAAHASQ
PCP
NT seq 5592 nt   +upstreamnt  +downstreamnt
atggatttacctgcggatcgtgttgaagaagtacaaaatgtccttaatgccatgcagaaa
atcttagagtgtccaatctgtctggagttgatcaaagagcctgtttccacgaagtgtgat
cacatattttgcaagttttgtatgctgaaacttctcaaccagaggaaaggaccttcacaa
tgtcctttgtgtaagaatgatataaccaaaagaagcctacaagaaagtacaagatttagt
caacttgttgaagagctgttgaaaatcattcatgctttcgagctggacacaggattgcag
tttgcaaacagctataatttttcaaaaaaggaaaataactctcctgaccatctaaaggag
gaagtttctattatccaaagtatgggctatcgaaaccgtgccaaaagacttcgacagagt
gagcctgaaaaccctgccttgcaggaaaccagtcttagtgtccacctctctgaccttgga
attgtgagatctctgaggacaaagcagcagatacagcctcagaataagtctgtctacatt
gaattgggatctgattcttctgaagatacagttaataaggcaagttattgcagtgtggga
gacgacgagttgttacaaatcacccctcaaggagccagggctgaagccagtttgaatcct
gcaaaaaaggctgcctgtgaaatttctgaggacataacaaatattgaacatcatcaatcc
ggtaataaagatttgaccaccactgagaagcatgcaactgagaagcatccagaaaagtat
cagggtatttctgtttcaaacttgcatgtggagccatgtggcacaaatactcataccagc
tcattacagcatgagaacagcagtttattactcactaaagacagaatgaatgtagaaaag
gctgaattctgtaataaaagcaaacagcttggcttagcaaggagccaacagagcagatgg
gctggaagtaaggaaacatgtaatgataggcagactcccagcacagagaaaaaggtactt
ctgaatgctgatcccctgcatgggagaaaagaactgaggaagcagaaacctgcatgctct
gacagtcctagagattcccaagatgttccttggataacgctgaatagtagcgtacagaaa
gttaatgagtggttttccagaagtgatggaatgttaccttctgatgactcacatgacggg
ggctctgactcgaatactggagtagctggtgcggtagaagttccaaatgaagtggacgga
tattctggttcttctgagaaagtagatttaatggccagtgatcctcaggttgctttgata
cgtggaagtgaaagagtccaccccaagtcagtagagagtaatatcgaagataaaatattt
gggaaaacctaccggaggagggcgagcctccctagccacacgaatgaagacctaattata
ggatttcgtgctatagaacctcagacaacgcgagcccatcccctcacaaataaagcaaag
tgtaaaaggagaactacatcaggccttcttcctgaggattttatcaagaaagtagatttg
gccgttgttccaaagactcctgaaaagctagttgagggaaccaaccaaatcgcacgaaat
ggtcacgtgatgaatattacaaataacggtcctgagaatgaagcaaaaggtgattatgtt
cagaacgagaaaaatgctaacccaacagaatcattggaaaaagaatctgcttttagaagc
aaagctgaaccgataagcagcagtataagcaatatggaactggaattaaatagctccagt
tcgaaagcccctaagaagaacaggctgaggaggaagtcctccaccaggcacgcttgtgca
cttgaattcgtagtcagtagaaatccaagcccgcctgatcatggcgaactacagatcgat
agttgttctagcagtgaagagatgaagaaacagcatttggaccaaatgccagtcagacac
agcaaaatgcttcagctcatggaaggtaaagaacctgcaactggagccaggaggggcagt
aagccaggggaacagataaataagagacttgccagtcatactttcccagagctaaatttg
acaaacgtgcctggtttttttgctaactgttcaagttctaataaacctcaagagcttgtc
aaccctagccttcaaagagaagaaccagaagagagcctaggaaggattcaagtgtctgat
agtaccagagatcccaaagagctgctcttgggtggaggaagaggtttgcaaactgaaaga
tctgtggagagtacccgtatttcactggtacctgatactgattacggcactcaggacagt
atctcgttgctggaagctgacaccctaaggaagacaaaaacagcaccaaatcgacgtgcg
aatctgtgcgcagcaactgaaaaccccaaggaacctatccacggttgttctaaagatact
agaaatgacacagagggttttgcagatccactgacatgtgaagataaccacactcaggag
acaagaatagcaatggaagagagtgaacttgacacacagtatttatacaacacattcaag
gtttcaaagcgtcagtcatttgctctgttttcaaatccagaagatccagaaaaggactgt
gcaatggtctgtgcccactccggggccttaaggaaacaaagtccaaaagtcactcttgaa
ggtggacaaaaagaagaaaatcagggaaagaaagagtctgaaatcaagcatgtgcaggca
gttcatgcaactgcaggcttttctgcagttagtcagcaagctaagaagccaggtgattat
gccaaatgtagcataaaaggaggctctgggctttgtcagtcatctctgttcagaggcaag
gaagctgaactccttattgcaaataaccatggaatttcccagaacccttaccatatacca
ccactttctcccatcagatcatctgttaaaactctatgtaagaaaaacccgtcagaggaa
aggtttgagcagcattcaatgtcacctgaaagagcaatgggaaatgagagcgtcattcaa
agtacagtgagcacaattagccaaaataacattagagaaagcactttgaaggaagtcagc
tcaagcagtgttaatgaagtgggttccagtactaatgaagtgggttccagtggtgaaaac
attcaggcagaactaggtagacaccgaggacctaaattaaatgctatgctcagattaggt
cttatgcaacctgaagtctataagcaaagccctcctgtaagtaattgtaaacatccggaa
atgaaaaggcaaggagaaaatgaaggcgtagttctgtctgttaatgcagatttctctcca
tgtctaatttcagataaccccgaacaaccgatgggaagcacttgcgcttctcaggtttgt
tcggagacacctgatgacctattaaatggtgacaaaataaagggaaaaagcagctttgct
gaaagtgacattagggaaagatctgctgtttttagcaaaagtgtccagaaaggagccttc
agaagaagccctttagacgaaacacgtttggcccagggtcaccaaagaggggccaggaaa
ttagagtcctcggaagagaacacatccagtgaagaggaagagcttccatgcttccaacac
ttactatttggtaaagtaaccaacacaccttctcagcctaccagtcacaatgctgttgcc
acagagggtctgtctaagaaaacagaggagaacctagactcacggaagagtagtttaagt
gacctcagtaaccagggaccatcagcaaaggcatcccaggaacattatcttagtgaggaa
gcaaggtgttctgggagcttattttcttcacagcacagtgcattggaagacttgacagtg
actacaaacagccaggaccctttcttgatgttcgatcccccttccaaacaagtgaggcat
cagtctgaaaacctggatgttctgagcgacaaggaattggtttcagatgatgatgatgaa
agggagcttggcctggacgaagataatcacgaagaacagagtgtggattcagacttaggt
gaagtggcatccgggtatcagagtgaaacaagcctctctgaagaccgttcagggttgtcc
tctcagagtgatattctaaccactcagcagagggataccatgcaagataacctgataaag
ctccagcaggaaatggccgaactggaagccgtgttagagcagcacgggagccagccttct
cgcagctccccttccctcctagcaggttctggtgccccggaggatctgctaaatccggaa
caaaacacatcagaaaaagcaatattaacttcagagaaaagtagtgactatcctataagc
cagaatcccgaaagcctttctgctgacaaatttcaagtatctctggatagttccaccagt
aaaaataaagaaccaggaacaagaaggtcttccccttctccatcccggttgttagatacc
aggtggtatgtgcacagcggcccaaggaatcttcagaacacaaactgcccgtctcaaaag
gagctcattaaggtcatcagtgtggaggaacaagcaccgactaagtcagaggcccaagag
gtcgtggagcagtctttgttaagaccagatctggagggaaccccttacctcgagtctgga
atcagcctcttctctgatgaccctgagtctgacccctctgcagacagaaccccagagcca
gctcatgttagcagcatgccaacttcaacctctgctttgaaattaccccaatttcaagtt
gaagaatcagccaagagtacagctgctgtccatgttgctaatactgctgggtataataag
agggaagacactgtgggcagggagaagccagaagttatatcttcagtaaaaagaatcaac
agaacaatatctatggtggcatcaggcttaaccccaaaagaatttatgcttgtggagaag
tttgccaaaaaacaccacatcgctttaacgaatcaaatttctgaagagactactcatgtc
atcatgaaaacagatgctgagtttgtgtgtgaacggacactgaaatattttctgggtatc
gcaggaggaaaatgggtagttagctatttctgggtgacccagtctattaaagaaagaaag
atactagatgagcatgattttgaagtcagaggagatgttgtgaatggaagaaaccaccaa
ggtccgaagcgagcaagagaatcccgggacagaaagatcttcaggggcctagaagtctgt
tgctatgggccctttaccaacatgcccacagatcagctagagtggatggtgcacctctgt
ggggcttctgtggtgagggagccttcatcattcactctcagcaagggtactcacccagtg
gtggtcgtgcagccggacgcctgggcggacgacagtggcttccatgcaattggacagatg
tgtgaggcacttgtggtgacccgagagtgggtgttggacagtgtggccctctaccagtgc
caggagctggacacctacctgatcccgcagattcgcagagctgctgctcacgccagccag
ccatgtccgtag

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