Ursus americanus (American black bear): 123782388
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Entry
123782388 CDS
T07931
Symbol
LCK
Name
(RefSeq) tyrosine-protein kinase Lck isoform X1
KO
K05856
lymphocyte cell-specific protein tyrosine kinase [EC:
2.7.10.2
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar04064
NF-kappa B signaling pathway
uar04380
Osteoclast differentiation
uar04650
Natural killer cell mediated cytotoxicity
uar04658
Th1 and Th2 cell differentiation
uar04659
Th17 cell differentiation
uar04660
T cell receptor signaling pathway
uar05135
Yersinia infection
uar05166
Human T-cell leukemia virus 1 infection
uar05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
uar05340
Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
123782388 (LCK)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
123782388 (LCK)
04660 T cell receptor signaling pathway
123782388 (LCK)
04658 Th1 and Th2 cell differentiation
123782388 (LCK)
04659 Th17 cell differentiation
123782388 (LCK)
09158 Development and regeneration
04380 Osteoclast differentiation
123782388 (LCK)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
123782388 (LCK)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
123782388 (LCK)
09171 Infectious disease: bacterial
05135 Yersinia infection
123782388 (LCK)
09163 Immune disease
05340 Primary immunodeficiency
123782388 (LCK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uar01001
]
123782388 (LCK)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
uar03036
]
123782388 (LCK)
Enzymes [BR:
uar01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
123782388 (LCK)
Protein kinases [BR:
uar01001
]
Non-receptor tyrosine kinases
SRC family
123782388 (LCK)
Chromosome and associated proteins [BR:
uar03036
]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
123782388 (LCK)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_2
SH3_9
ABC1
SH2_1
Haspin_kinase
SH3_16
SH3_3
Motif
Other DBs
NCBI-GeneID:
123782388
NCBI-ProteinID:
XP_045638524
LinkDB
All DBs
Position
Unknown
AA seq
520 aa
AA seq
DB search
MGDGDLTISGTMGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPIRNGSDVRDPLV
TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEG
FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD
FDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKP
QKPWWEDEWEVPRETLKLEERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEA
NLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLAINKLLDMAAQIA
EGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAP
EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEEL
YHLMMLCWKERPEERPTFDYLRSVLEDFFTATEGQYQPQP
NT seq
1563 nt
NT seq
+upstream
nt +downstream
nt
atgggggatggggacctgacaatctcagggaccatgggctgtagctgcagctcaaacccc
gaagatgactggatggaaaacatcgatgtttgtgagaactgccattaccccatagtccca
ctggatggcaaggccacgctgcccatccggaatggctctgatgtgcgggatccactggtt
acctacgaaggctccaaccccccggcctcacccttgcaagacaacctggttatcgctctg
cacagctatgagccctctcacgatggagacttgggcttcgagaagggtgaacagctccgc
atcctggagcagagcggcgagtggtggaaggcacagtccctgaccacgggccaggaaggt
ttcattcccttcaacttcgtggccaaagcgaacagcctagagcccgaaccctggttcttc
aagaacctgagccgcaaggacgctgagcggcagctcctggcgcccgggaacacgcacggc
tcctttctgatccgggaaagcgagagcaccgcgggatcgttttcactgtccgtgcgggac
ttcgaccagaaccagggagaggtggtgaaacattacaaaatccgtaacctggacaacggc
ggcttctacatctcccctcgcatcacttttcctggcctgcacgagctggtccgccattac
accaatgcttcggacgggctgtgcacgcgattgagtcgcccctgccagacccagaagccc
cagaagccttggtgggaggacgagtgggaggttcccagggagacgctgaagctggaggag
cggctgggagctggccagttcggggaggtgtggatggggtactacaacgggcacacaaag
gtggcagtgaagagcctgaagcagggcagcatgtcccccgacgccttcctggccgaggcc
aacctcatgaagcagctgcaacaccagagactggtccggctctacgcggtggtcacccag
gagcccatctacatcatcacggaatacatggagaacgggagcctggtggatttcctcaag
acccccccgggcatcaagctggccatcaacaaactcttggatatggcagcccaaattgca
gagggcatggcattcattgaagagcggaattatatccaccgtgacctgagggctgccaac
atcctggtgtctgacaccctgagctgcaagatcgcagactttggcctagcacgcctcatc
gaggacaacgagtacacagccagggagggagccaagtttcccattaagtggacagcacca
gaagccattaactatgggacgttcaccatcaagtcggatgtgtggtcttttgggatcctg
ctgacggagattgtcacccatggccgcatcccttacccagggatgaccaatcccgaggtg
atccagaacctggagcgaggctaccgcatggtgcgacctgacaactgtcccgaggagttg
taccacctcatgatgctgtgctggaaggagcgcccagaggaacggcccaccttcgactac
ctgcgcagtgtgctggaggacttcttcacggccacagagggccagtaccagccccagccc
tga
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