KEGG   Ursus americanus (American black bear): 123787146
Entry
123787146         CDS       T07931                                 
Symbol
MDM2
Name
(RefSeq) E3 ubiquitin-protein ligase Mdm2 isoform X1
  KO
K06643  E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01522  Endocrine resistance
uar01524  Platinum drug resistance
uar04068  FoxO signaling pathway
uar04110  Cell cycle
uar04115  p53 signaling pathway
uar04120  Ubiquitin mediated proteolysis
uar04144  Endocytosis
uar04151  PI3K-Akt signaling pathway
uar04218  Cellular senescence
uar04625  C-type lectin receptor signaling pathway
uar04919  Thyroid hormone signaling pathway
uar05163  Human cytomegalovirus infection
uar05165  Human papillomavirus infection
uar05169  Epstein-Barr virus infection
uar05200  Pathways in cancer
uar05202  Transcriptional misregulation in cancer
uar05203  Viral carcinogenesis
uar05205  Proteoglycans in cancer
uar05206  MicroRNAs in cancer
uar05214  Glioma
uar05215  Prostate cancer
uar05218  Melanoma
uar05219  Bladder cancer
uar05220  Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:uar00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    123787146 (MDM2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    123787146 (MDM2)
   04151 PI3K-Akt signaling pathway
    123787146 (MDM2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    123787146 (MDM2)
  09143 Cell growth and death
   04110 Cell cycle
    123787146 (MDM2)
   04115 p53 signaling pathway
    123787146 (MDM2)
   04218 Cellular senescence
    123787146 (MDM2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    123787146 (MDM2)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    123787146 (MDM2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123787146 (MDM2)
   05202 Transcriptional misregulation in cancer
    123787146 (MDM2)
   05206 MicroRNAs in cancer
    123787146 (MDM2)
   05205 Proteoglycans in cancer
    123787146 (MDM2)
   05203 Viral carcinogenesis
    123787146 (MDM2)
  09162 Cancer: specific types
   05214 Glioma
    123787146 (MDM2)
   05220 Chronic myeloid leukemia
    123787146 (MDM2)
   05218 Melanoma
    123787146 (MDM2)
   05219 Bladder cancer
    123787146 (MDM2)
   05215 Prostate cancer
    123787146 (MDM2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123787146 (MDM2)
   05169 Epstein-Barr virus infection
    123787146 (MDM2)
   05165 Human papillomavirus infection
    123787146 (MDM2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    123787146 (MDM2)
   01522 Endocrine resistance
    123787146 (MDM2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uar04131]
    123787146 (MDM2)
   04121 Ubiquitin system [BR:uar04121]
    123787146 (MDM2)
Enzymes [BR:uar01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     123787146 (MDM2)
Membrane trafficking [BR:uar04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    123787146 (MDM2)
Ubiquitin system [BR:uar04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   MDM2/MDM4 proteins
    123787146 (MDM2)
SSDB
Motif
Pfam: zf-C3HC4_3 Zn_ribbon_RanBP SWIB zf-RING_2 zf-FPG_IleRS
Other DBs
NCBI-GeneID: 123787146
NCBI-ProteinID: XP_045645578
LinkDB
Position
Unknown
AA seq 487 aa
MCNTNMSVSTDGAVSTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVIFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQHEPSDSGT
SVSENRCHLEGGSDQKEPVQELQEEKPSSSDLVSRPSTSSRRRAISETEEHSDELPGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYRVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPPHCNRCWALRENWLPEDKGKIPEKAKLENSTQVEEGFDVPDCKK
TAVNDSRESCAEENDDKITQASQSQESEDYSQPSTSNSIIYSSQEDVKEFEREETQDKEE
VVESSFPLNAIEPCVICQGRPKNGCIVHGRTGHLMACFTCAKKLKKRNKPCPVCRQPIQM
IVLTYFP
NT seq 1464 nt   +upstreamnt  +downstreamnt
atgtgcaataccaacatgtctgtgtctactgatggtgctgtaagcacctcacagattcca
gcttcggaacaggagaccctggttagaccaaagcctttgcttttgaagttgttaaagtct
gttggtgcacaaaaagacacttatactatgaaagaggttatattttatcttggccagtat
attatgactaaacgattatatgatgagaagcaacagcatattgtgtattgttccaatgat
cttctaggggatttgtttggagtgccaagcttctctgtgaaagagcacaggaaaatatat
acaatgatctacagaaacttggtagtagtcaatcagcatgaaccatcagattcaggcaca
tctgtgagtgaaaataggtgtcaccttgaaggtgggagtgatcaaaaggagccggtgcaa
gagttgcaggaagagaaaccttcatcttcagatttggtttctagaccgtctacctcatct
agaaggagagcaattagtgagacagaagaacattcagatgaattacctggtgaacggcag
agaaagcgccacaaatctgatagtatttccctgtcctttgatgaaagccttgctctgtgt
gtaataagggagatatgctgtgaaagaagcagtagcagtgaatcaacagggacaccatca
aatccggatcttgatgctggtgtaagtgagcattcaggtgactggttggatcaggattca
gtttcagatcaattcagtgtagaatttgaagttgagtctctcgattcagaagattacagt
cttagtgaagaagggcaagaactctcagatgaagatgatgaggtatatcgagtaactgtg
tatcaggcaggggagagtgataccgattcatttgaagaagatcctgaaatttccttagct
gactattggaagtgtacttcgtgcaatgaaatgaatcctcctcttccacctcattgcaac
agatgttgggcccttcgtgagaactggcttcctgaagataaagggaaaatacctgagaaa
gccaaactagaaaactcaacacaagtagaagagggctttgatgtccctgattgtaaaaaa
actgcagtgaatgattccagagaatcatgtgctgaggaaaatgatgataaaatcacacaa
gcctcccaatcccaagaaagtgaggattattctcagccatcaacttctaacagcatcatt
tacagcagccaagaagatgtcaaagagtttgagagggaagaaacacaagacaaagaagag
gttgtggaatctagttttcccctgaatgccattgaaccttgtgtgatttgccagggtcga
cctaaaaacggttgcattgttcatggcagaacaggacatcttatggcgtgctttacgtgt
gcaaagaagctcaagaaaaggaataagccctgcccagtatgtagacagccaattcaaatg
attgtgctaacttatttcccctag

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