Ursus americanus (American black bear): 123788217
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Entry
123788217 CDS
T07931
Symbol
ACACB
Name
(RefSeq) acetyl-CoA carboxylase 2 isoform X1
KO
K01946
acetyl-CoA carboxylase / biotin carboxylase 2 [EC:
6.4.1.2
6.3.4.14
2.1.3.15
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar00061
Fatty acid biosynthesis
uar00620
Pyruvate metabolism
uar00640
Propanoate metabolism
uar01100
Metabolic pathways
uar04152
AMPK signaling pathway
uar04910
Insulin signaling pathway
uar04920
Adipocytokine signaling pathway
uar04922
Glucagon signaling pathway
uar04931
Insulin resistance
uar04936
Alcoholic liver disease
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
123788217 (ACACB)
00640 Propanoate metabolism
123788217 (ACACB)
09103 Lipid metabolism
00061 Fatty acid biosynthesis
123788217 (ACACB)
09110 Biosynthesis of other secondary metabolites
00254 Aflatoxin biosynthesis
123788217 (ACACB)
09130 Environmental Information Processing
09132 Signal transduction
04152 AMPK signaling pathway
123788217 (ACACB)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
123788217 (ACACB)
04922 Glucagon signaling pathway
123788217 (ACACB)
04920 Adipocytokine signaling pathway
123788217 (ACACB)
09160 Human Diseases
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
123788217 (ACACB)
04931 Insulin resistance
123788217 (ACACB)
Enzymes [BR:
uar01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.3 Carboxy- and carbamoyltransferases
2.1.3.15 acetyl-CoA carboxytransferase
123788217 (ACACB)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.4 Other carbon-nitrogen ligases
6.3.4.14 biotin carboxylase
123788217 (ACACB)
6.4 Forming carbon-carbon bonds
6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
6.4.1.2 acetyl-CoA carboxylase
123788217 (ACACB)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ACC_central
Carboxyl_trans
CPSase_L_D2
ACCA_BT
Biotin_carb_N
Biotin_carb_C
Biotin_lipoyl
ATP-grasp
Dala_Dala_lig_C
Motif
Other DBs
NCBI-GeneID:
123788217
NCBI-ProteinID:
XP_045647444
LinkDB
All DBs
Position
Unknown
AA seq
2431 aa
AA seq
DB search
MMDSKQVTKSKSEGSCIPSQEPFPASDCSGEPPQKNGDRSPLPETPNQAEPASHKGPKDA
CGQRTSRPPPHQNAPGNPCSSDDAPAALQANGTGTEGLRTPDTNGLSSPARPQGQRTRPL
SKEDEKQEHLKRQLMTNFVLGSFDDNSSDEDPGAGLFRESSRKSSRASLGTLSLEAALAV
GESESPIPAMRPSMSGLHLVKRGRELKKVDLHRDFTVASPAEFVTRFGGDRVIEKVLIAN
NGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGPNNN
NYANVELVVDIAKRIPVQAVWAGWGHASENPKLPELLCKHEIAFLGPPSEAMWALGDKIA
STIVAQTLQIPTLPWSGSGLTVEWAEEDLQWGKRITVPEDVYNQGCVKDIDEGLQMAEKI
GFPLMIKASEGGGGKGIRKAESPEDFPILFRQVQSEIPGSPVFLMKLAEHARHLEVQILA
DQYGNAVSLFGRDCSIQRRHQKIIEEAPATIAIPVVFEIMEQCAVRLAKTVGYVSTGTVE
YLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESP
WGVTPISFDTPANPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVA
AAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETERFQ
NNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPAA
SLLNIVDVELIYGGVKYILKVARQSLTMFVLIMNDCHIEIDAHRLSDGGLLLSYNGNSYT
TYMKEEFDSYRITIGNKTCVFEKENDPTVLRAPSAGKLLQYTVEDGGHVEAGSSYADMEV
MKMIMTLSVQESGRVKYMKRPGAMLEAGCVVARLELDDPSKVHPAKPFTGELPSQQTLPI
VGEKLHQVFHNVLENLTNVMSGYCLPEPIFSTKLKEWVQKLMMTLRHPSLPLLELQEIMT
SVSGRIPAPVEKSVRRVMAQYASNITSVLCQFPSQQIATILDCHAATLQRRAEREVFFMN
TQSIVQLVQRYRRGTRGYMKAVVLDLLRRYLRVEHHFQQAHYDKCVINLRERLKPDMSQV
LDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSEELTSILNELTQLSKSEHCKVALRARQV
LIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENLKKLILSETTIFDVLPTFFYHTNKV
VCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMAVPISVTNPDLL
RHSTELFMDSGFSPLCQRMGAMVAFRRFEDFIRNFDEVISCFANVPREAPLFGKACTSLY
CEEDSKNPREEPIHILNVALQYADHLEDEELVPIFRKFVQSKKNILVDYGLRRITFLIAQ
EKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELSRMRSFDLTAVPCANHKMHLYLGAA
KVKEGAEVTDHRFFIRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRT
DCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPI
RLFITNESGYYLDISLYKEVTDPRSGNIMFHSFGNKQGPQHGMLINTPYVTKDLLQAKRF
QAQSLGTTYVYDFPELFRQALFKLWGTPDKYPKDILTYTELVLDPQGQLVEMNRLPGGNE
VGMVAFKMRFKTPEYPEGRDVIVISNDITFRIGSFGMGEDLLYLRASEMARAEGIPKIYL
AANSGACIGLAEEIKHIFQVAWVDPGDPHKGLKYLYLTPQDYTTISSLNSVHCRHIEEDG
ESRYVITDIIGKDSGVGIENLRGSGMIAGESSLAYDEIVTISLVTCRAVGIGAYLVRLGQ
RVIQVENSHIILTGVSALNKVLGREVYTSNNQLGGVQIMHYNGISHITVPDDFEGVCTIL
EWLSYMPKDNHSPVPIITPTDPIDREIGFFPTRAPYDPRWLLAGRPHPTLKGSWQSGFFD
HGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVVVPADPANLDSEAKIIQQAGQ
VWLPDSAYKTAQAIKDFNRERLPLMIFANWRGFSGGMKDMYDQMLKFGAYIVDSLRQYKQ
PVLIYIPPSAELRGGSWVVVDSSINPLCIEMYADKESRANILEPEGTVEIKYRKKDLIKT
MRRIDPAYKKLVEQLGMSGLSDKDRKDLEGQLKAREDLLLPIYHQVAVQFADLHDSPTCL
LEKGAISDILEWKTARSFLYWRLRRLLLEDQVKQEILRASGELSHVHIQSMLRRWFVETE
GAVKAYLWDNNQMVVQWLEQHWQGEDSLRSTVRENIRCLKRDSVLKAIRGLVQDNPEVAV
DCIVYMSQHISPAERAQVIHLLSTMDSAAST
NT seq
7296 nt
NT seq
+upstream
nt +downstream
nt
atgatggactctaagcaagtcaccaagagtaaatcagaagggagctgtatcccaagccag
gagccctttccagcctcagactgctcaggggagccaccacaaaaaaatggtgaccgcagc
cctctgccagagactcctaaccaggctgagccagcctcccacaaaggtcccaaagatgcc
tgtgggcaaagaacttccaggccacccccacaccagaatgccccaggaaacccctgttcc
tctgatgacgcccccgcagcgctccaagccaatgggacggggactgaaggcctgaggacc
ccggataccaatggcctgtcatctccagccaggcctcagggccagcgaaccagaccgctc
tccaaagaagacgagaagcaggagcacctcaagaggcagctgatgaccaacttcgtcttg
ggctcctttgatgacaactcgtccgatgaggaccctggtgcgggcttgttccgagagtcc
tcccggaagagcagccgggccagcctggggaccctgtccctggaggccgctctggctgta
ggcgagtctgagagccccatccccgctatgagacctagcatgtcgggactccacctggtg
aagaggggccgagaactgaagaaggtggacctgcacagagactttaccgtggcctcccca
gctgagtttgtcacgcgctttgggggggaccgggtcattgagaaggtgctcatcgccaac
aatggcatcgccgccgtgaagtgcatgcgctccatccgcaggtgggcctatgagatgttc
cgcaacgagcgggccatccggtttgtagtcatggtgaccccagaggacctgaaggccaat
gcagagtatatcaagatggcagatcagtatgtccctgtcccaggagggcccaacaacaac
aattatgccaacgtggagctggttgtggacattgccaagagaatccccgtgcaggcggtg
tgggctggctggggccatgcttctgaaaaccccaaactgccggagctcctgtgcaagcat
gagattgctttcttaggccctcccagtgaggccatgtgggccttgggagataagatcgcc
tccaccattgtagcccagacgctgcagatcccaacactgccctggagtggaagcggtctg
acggtggaatgggcagaagaggatctgcagtgggggaagaggatcactgtcccagaagat
gtttacaaccagggttgtgtgaaagatatagatgagggcttacagatggcagaaaaaatt
ggttttcccttgatgatcaaagcatctgaaggcggcggagggaaaggaatccggaaggca
gagagtcccgaggacttcccaatccttttcagacaagtgcagagtgagatccctggctcc
cccgtcttcctcatgaagctggccgagcatgcccgacacctggaggtccagatcctcgcc
gaccagtatgggaacgccgtgtccctgttcgggcgtgactgctccatccagcggcggcat
cagaagatcattgaggaggcgccggccaccatcgccataccggttgtgttcgagatcatg
gagcagtgtgccgtccgcctggccaagacggtgggctacgtgagcacggggacggtggag
tatctctacagccaggatggcagcttccacttcttggagctgaatccccgtctgcaggtg
gagcacccctgcacagagatgatcgccgacgtcaacctgcctgccgcccagttacagatt
gccatgggggtgcccctgcaccggctgaaggatatccggcttctgtatggagagtcgccg
tggggggtgacacccatttcgttcgacactcctgccaaccctccactcgcccgaggccat
gtcattgcggctagaatcaccagtgagaaccccgatgaggggtttaagccaagctctgga
acggttcaggagctgaatttccggagcaacaagaacgtgtggggttacttcagcgtagcg
gctgccggcggcttacacgagtttgctgattcccagttcgggcactgcttctcctgggga
gagaaccgggaagaggccatttcgaacatggtggtggctttgaaggaactgtccatccgg
ggcgacttcagaaccaccgtggagtatctcattaacctgctggagactgagcgcttccag
aacaatgacatcgacacaggctggttggattacctcatcgccgagaaagtgcaggcggag
aagccggatatcatgctcggggtggtgtgcggagccttgaacgtggccgatgcgatgttc
agaacgtgcatgacggatttcttacactcgctggaaaggggccaggtccttcctgcagct
tctctgctgaacatcgtggatgtggaactaatttatggaggtgttaagtacattctcaag
gtggcccggcaatctctgaccatgttcgtcctcatcatgaacgactgtcacatcgagatc
gacgcccaccggctaagcgacggggggttgctgctgtcctataatggtaacagctatacc
acctacatgaaagaagagtttgacagttaccgtattaccatcggcaacaagacgtgtgtg
tttgagaaagagaacgatcccacggtcctgagagccccttcggctgggaagctgctgcag
tacacggtggaggacgggggccacgttgaggctgggagcagctacgctgacatggaggtg
atgaagatgatcatgaccttgagcgtgcaggaaagtggccgggtgaagtacatgaagcgc
ccgggggccatgctggaggcaggctgtgtggtggccaggctggagctcgatgacccttcc
aaagtgcacccggccaagccattcacaggagagctcccttcccagcaaactctgcccatc
gtgggagagaaactgcaccaggttttccacaatgtcctggaaaacctgaccaacgtcatg
agtggctactgtctgccggaacctatttttagcacaaagctgaaggagtgggtgcaaaag
ctcatgatgaccctccggcacccatcactgccgctgctggagctgcaggaaatcatgacc
agtgtgtccggccgtatccccgcccccgtggagaagtcggtccgcagggtgatggctcag
tacgccagcaacatcacctcggtgctgtgccagttccccagccagcagatagccaccatc
ctggactgccacgcggccaccctgcagcggagggccgaacgggaggtcttcttcatgaac
acccagagcattgtgcagctggtccagaggtaccgcagagggacccgcggctacatgaag
gcagtggtgttggacctcctgcggagatacttgcgggtggagcatcatttccagcaagct
cactacgacaagtgcgtgataaacctcagggagcggctgaagccagacatgtcccaggtg
ctggactgcatcttctcccacgcgcaggtggccaagaagaaccagctggtgatcatgttg
attgatgagctctgtggcccagacccttccctgtcggaagagctgacctccatcctcaat
gagctcactcagctgagcaaaagcgagcattgcaaagtggccctcagagccagacaggtc
ctgattgcctcccacctcccgtcctacgagctgaggcacaaccaggtggagtccattttc
ctgtctgccatcgacatgtacggccaccagttctgcccagaaaacctcaagaaattaata
ctctcagaaacaaccatatttgatgtcctgcccactttcttctaccacactaacaaagtc
gtctgcatggcatccttggaggtttacgtgcggaggggctatatcgcctatgagttaaac
agcttgcagcaccggcagctcccggacggcacctgcgtggtggaattccagttcatgctg
ccctcctcccacccaaacaggatggccgtgcccatcagcgtcaccaaccccgacctgctg
aggcacagcaccgagctcttcatggacagcggcttctccccactgtgccagcggatggga
gccatggtcgccttcaggagattcgaggacttcataaggaacttcgacgaggtcatctcc
tgctttgccaacgtgccccgggaagcccccctcttcggcaaggcctgcacttccctgtac
tgtgaggaagacagcaagaaccccagagaagagccgatccacatcctgaatgtggccctc
cagtacgcggaccacctggaagatgaggagctggtgccaattttccggaagttcgtacag
tccaagaaaaacatccttgtggattacggactccgaagaatcacattcctgattgcccaa
gagaaagaatttcccaagtttttcacgttcagagcaagagacgagttcgcggaagatcgc
atttaccgtcatctggagcccgccctggccttccagctggagctcagccgcatgcgcagc
tttgacctgaccgccgtgccctgcgccaaccacaagatgcacctgtacctgggcgccgcc
aaagtgaaggagggcgcggaagtgacggaccaccgcttcttcatccgcgccatcatccgc
cactcagacctcgttacaaaggaagcctcctttgagtacctgcagaacgagggcgagcgt
ctgctcctggaggccatggacgagctggaggtggcattcaacaacacgagcgtacgcacc
gactgcaaccacatcttcctgaacttcgtgcccaccgtcatcatggacccctccaagatc
gaggagtccgtgcgttccatggttatgcgctatggcagccggctgtggaaactgcgcgtg
ctgcaggctgaggtcaagatcaacatccgccagaccaccactggcagcgctgttcccatc
cgcctgttcatcaccaatgagtcgggctactacctggacatcagcctctacaaagaagtc
accgaccccagatccggaaacatcatgtttcactcctttggcaacaagcagggaccccag
cacgggatgctgatcaacaccccgtatgtcaccaaggatctgcttcaggccaagcggttc
caggcccagtccctgggcaccacctatgtctacgacttcccggagctgttcagacaggct
ctctttaaactgtggggcaccccggacaagtaccccaaagacatcctgacatataccgaa
ctcgtgctggaccctcagggccagctcgtggagatgaaccgccttcctggaggaaatgag
gtgggcatggtggccttcaaaatgaggttcaagaccccagaatatccggaaggacgggac
gtgatcgtaatcagcaatgacatcacgttccgcataggatcctttggcatgggagaagac
ctcttgtacctgcgggcctccgagatggcccgggcagagggtatccccaaaatctacctc
gcagccaacagcggggcctgtatcggccttgcagaggagatcaagcacatattccaggtg
gcttgggtggacccaggagacccccacaaaggacttaagtacttgtacctgacgccccaa
gactacaccacaatcagctccctgaactctgtccattgtaggcacatcgaggaagacggg
gaatccaggtatgtcatcacggatatcatcgggaaggacagtggtgtgggcatagagaat
ctcaggggctccggcatgatcgcgggggagtcctccctggcttacgacgagattgtcacc
atcagcttggtgacttgccgagccgtggggatcggggcctacttggtgaggctgggtcag
cgagtgatccaggtggagaactctcatatcatcctgacgggagtcagcgctctcaacaag
gtgctgggcagagaggtctacacgtccaacaaccagctgggcggcgtgcagatcatgcat
tacaatggcatctcccacatcactgtgccagatgacttcgagggcgtttgtaccatcctg
gagtggctgtcctatatgccaaaggataatcacagcccagtccccatcatcacacccacg
gaccccattgacagagaaattggattcttcccgacccgggctccctatgacccccggtgg
ctgctggcaggaaggcctcacccgactctgaagggatcctggcagagtggattctttgac
catggcagtttcaaggaaatcatggcgccctgggcccagaccgtggtgacaggacgagca
aggctaggggggatccctgttggcgtgatcgccgtggagacacggactgtggaggtggtg
gtgcctgcggaccctgccaacctggactcagaggccaagataatccagcaggcaggccag
gtgtggctcccagactccgcctacaagacggcccaggccatcaaggatttcaaccgagag
aggttgcccctgatgatctttgccaactggagggggttctccggtggcatgaaagacatg
tacgaccagatgctaaagttcggagcctacatcgtggacagtctcaggcagtacaagcag
cccgtcctgatctacatcccaccctccgcggagctccgggggggctcctgggtggtcgtg
gactcctccatcaaccccctgtgcatagaaatgtacgcggacaaggagagcagggcgaat
attctggagccggagggcacggtggagattaagtaccgaaagaaagatctgataaagacc
atgagaaggattgacccagcttacaagaagctcgtggaacagctaggaatgtcggggctc
tccgacaaggaccgcaaggacctggagggccagctgaaggcccgggaggacctgctgctg
cccatctaccaccaggtggcggtgcagttcgccgacctccacgacagccccacctgcctg
ctggagaagggcgccatctccgacatcctggagtggaagaccgcgcgctccttcctgtac
tggcgcctgcgccgcctcctgctggaggaccaggtcaagcaggagatcctgcgggccagc
ggcgagctgagccacgtgcacatccagtccatgctgcgccgctggttcgtggagacggag
ggcgccgtcaaggcctacctgtgggacaacaatcagatggtggtgcagtggctggaacag
cactggcagggggaggacagcctgcgctccactgtccgcgagaacatcaggtgcttgaag
cgagactccgtcctcaaggccatcagaggcctggttcaggacaaccctgaagtggccgtg
gactgcatcgtgtacatgagccagcacatcagcccggccgagcgggcccaagtcattcac
ctcctgtccaccatggacagcgcagcctccacctga
DBGET
integrated database retrieval system
