Ursus americanus (American black bear): 123795008
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Entry
123795008 CDS
T07931
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar00140
Steroid hormone biosynthesis
uar01100
Metabolic pathways
uar04913
Ovarian steroidogenesis
uar04925
Aldosterone synthesis and secretion
uar04927
Cortisol synthesis and secretion
uar04934
Cushing syndrome
Module
uar_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
uar_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
uar_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
uar_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
123795008
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
123795008
04925 Aldosterone synthesis and secretion
123795008
04927 Cortisol synthesis and secretion
123795008
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
123795008
Enzymes [BR:
uar01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
123795008
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
123795008
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Paralog
GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
NmrA
KR
adh_short
Sacchrp_dh_NADP
Ldh_1_N
Motif
Other DBs
NCBI-GeneID:
123795008
NCBI-ProteinID:
XP_045657344
LinkDB
All DBs
Position
Unknown
AA seq
373 aa
AA seq
DB search
MAGWSCLVTGAGGFLGQRIVRLLVEEKELQEIRALDKVFKPELREEFSKLQSKTKVIMVE
GDILDEQCLKKACQGISVVIHTASVIDVMNILHRETMMNVNLKGTQLLLEACAQASVPIF
IYTSTIEVAGPNSYREIIQNGHEEEHLESTWSTPYPHSKKLAEKAVLAANGWALKNGGTL
HTCALRPMYIYGEGSIFLYNFIYEALRNNHILTHNSKFSIVNPVYVGNVAWAHILALRAL
RDAKKSPSVRGQFYYISDDTPHQSYDDLNYTLSKEWGFSLDSRRSLPLFLTYWLAFLLEI
VSFLLSPIYTYQPSFNRHTVTLLNSVFTFSYKKAQRDLGYKPLFSWEEAKQKTTEWIGSL
VKQHKETLKTKTH
NT seq
1122 nt
NT seq
+upstream
nt +downstream
nt
atggctgggtggagctgccttgtgacaggtgcaggagggtttctgggtcagaggatcgtt
cgcttgttggtggaggagaaggagctgcaggagatccgggcactggacaaagttttcaaa
ccagaactgcgggaggaattttctaagctccagagcaagaccaaggtgatcatggtggaa
ggagacattctggatgagcagtgcctgaagaaagcctgccagggcatctcagttgtcatt
cacaccgcctctgtcattgacgtcatgaatatccttcaccgagagaccatgatgaatgtc
aatctgaagggtacccagctcctgttggaagcctgtgcccaggctagtgtgccgatcttc
atctataccagcaccatagaggtggctgggcccaactcctacagggagatcatccagaat
ggccacgaagaagagcatcttgaatcgacatggtctactccttacccccacagcaaaaag
cttgcagagaaggcggtgttagctgctaatgggtgggctcttaaaaacggtggcaccttg
cacacttgtgccttaaggcccatgtatatttatggggaaggaagcatattcctttataac
tttatatacgaggccctgaggaacaatcacatcctgacgcataatagcaagttctccata
gtcaaccccgtctatgttggcaatgtagcctgggctcacattctggccttgagggcccta
cgggatgccaagaagtccccaagtgtccgaggacagttctattatatctcagatgacaca
cctcaccaaagctatgatgacctcaattacactttgagcaaggaatggggcttctccctt
gattccagaaggagtcttcctttgtttctgacgtactggcttgccttcctgctggaaata
gtaagcttcctgctcagtccaatttacacatatcaaccctccttcaaccgccacacagtg
acattgttgaatagtgtatttaccttctcctataagaaagctcagcgagatctggggtat
aagccactcttcagctgggaggaagccaagcagaaaaccacagagtggattggctccctg
gtgaaacagcacaaagagaccctaaaaacaaagactcattga
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