Ursus americanus (American black bear): 123796994
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Entry
123796994 CDS
T07931
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar00562
Inositol phosphate metabolism
uar01100
Metabolic pathways
uar01521
EGFR tyrosine kinase inhibitor resistance
uar04012
ErbB signaling pathway
uar04014
Ras signaling pathway
uar04015
Rap1 signaling pathway
uar04020
Calcium signaling pathway
uar04062
Chemokine signaling pathway
uar04064
NF-kappa B signaling pathway
uar04066
HIF-1 signaling pathway
uar04070
Phosphatidylinositol signaling system
uar04072
Phospholipase D signaling pathway
uar04360
Axon guidance
uar04370
VEGF signaling pathway
uar04613
Neutrophil extracellular trap formation
uar04650
Natural killer cell mediated cytotoxicity
uar04658
Th1 and Th2 cell differentiation
uar04659
Th17 cell differentiation
uar04660
T cell receptor signaling pathway
uar04664
Fc epsilon RI signaling pathway
uar04666
Fc gamma R-mediated phagocytosis
uar04670
Leukocyte transendothelial migration
uar04722
Neurotrophin signaling pathway
uar04750
Inflammatory mediator regulation of TRP channels
uar04919
Thyroid hormone signaling pathway
uar04933
AGE-RAGE signaling pathway in diabetic complications
uar04935
Growth hormone synthesis, secretion and action
uar05012
Parkinson disease
uar05022
Pathways of neurodegeneration - multiple diseases
uar05135
Yersinia infection
uar05167
Kaposi sarcoma-associated herpesvirus infection
uar05170
Human immunodeficiency virus 1 infection
uar05171
Coronavirus disease - COVID-19
uar05200
Pathways in cancer
uar05205
Proteoglycans in cancer
uar05206
MicroRNAs in cancer
uar05214
Glioma
uar05223
Non-small cell lung cancer
uar05225
Hepatocellular carcinoma
uar05231
Choline metabolism in cancer
uar05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
uar05417
Lipid and atherosclerosis
Module
uar_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
123796994 (PLCG1)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
123796994 (PLCG1)
04015 Rap1 signaling pathway
123796994 (PLCG1)
04064 NF-kappa B signaling pathway
123796994 (PLCG1)
04066 HIF-1 signaling pathway
123796994 (PLCG1)
04070 Phosphatidylinositol signaling system
123796994 (PLCG1)
04072 Phospholipase D signaling pathway
123796994 (PLCG1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
123796994 (PLCG1)
04650 Natural killer cell mediated cytotoxicity
123796994 (PLCG1)
04660 T cell receptor signaling pathway
123796994 (PLCG1)
04658 Th1 and Th2 cell differentiation
123796994 (PLCG1)
04659 Th17 cell differentiation
123796994 (PLCG1)
04664 Fc epsilon RI signaling pathway
123796994 (PLCG1)
04666 Fc gamma R-mediated phagocytosis
123796994 (PLCG1)
04670 Leukocyte transendothelial migration
123796994 (PLCG1)
04062 Chemokine signaling pathway
123796994 (PLCG1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
123796994 (PLCG1)
04919 Thyroid hormone signaling pathway
123796994 (PLCG1)
09156 Nervous system
04722 Neurotrophin signaling pathway
123796994 (PLCG1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
123796994 (PLCG1)
09158 Development and regeneration
04360 Axon guidance
123796994 (PLCG1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123796994 (PLCG1)
05206 MicroRNAs in cancer
123796994 (PLCG1)
05205 Proteoglycans in cancer
123796994 (PLCG1)
05231 Choline metabolism in cancer
123796994 (PLCG1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
123796994 (PLCG1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
123796994 (PLCG1)
05214 Glioma
123796994 (PLCG1)
05223 Non-small cell lung cancer
123796994 (PLCG1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
123796994 (PLCG1)
05171 Coronavirus disease - COVID-19
123796994 (PLCG1)
05167 Kaposi sarcoma-associated herpesvirus infection
123796994 (PLCG1)
09171 Infectious disease: bacterial
05135 Yersinia infection
123796994 (PLCG1)
09164 Neurodegenerative disease
05012 Parkinson disease
123796994 (PLCG1)
05022 Pathways of neurodegeneration - multiple diseases
123796994 (PLCG1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123796994 (PLCG1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
123796994 (PLCG1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123796994 (PLCG1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
uar04131
]
123796994 (PLCG1)
Enzymes [BR:
uar01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
123796994 (PLCG1)
Membrane trafficking [BR:
uar04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
123796994 (PLCG1)
Endocytosis
Macropinocytosis
Phospholipase C
123796994 (PLCG1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
PH
SH3_1
C2
EF-hand_PLCG1
SH3_9
SH3_2
PH_12
GDPD
EF-hand_6
PH_9
EF-hand_7
Motif
Other DBs
NCBI-GeneID:
123796994
NCBI-ProteinID:
XP_045660581
LinkDB
All DBs
Position
Unknown
AA seq
1290 aa
AA seq
DB search
MAGAASPCANGCAPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFSLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPASLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDVFPAKQENGDLSPFSMSLRERGSDTSGQLFHGRAREGSFEARYQQPFEDF
RISQEQLADHFDSRERRAPRRTRVNGDNRL
NT seq
3873 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgccgcgtccccctgcgccaatggctgcgcgcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgcgaaatcaaggag
atccgcccagggaagacctcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgctttgtcatcctgtatgggatggaattccgcctgaagaccctg
agcctgcaagctacgtctgaggatgaagtaaacatgtggatcaggggtttaacctggttg
atggaggatacattgcaggcagccacgcctctgcagatcgagaggtggctgcggaagcag
ttctactcggtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggct
ggggagcggccagagctctgtcgtgtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcgagaccccttgcgagaaattgaagagccatacttctccctggatgagtttgtcacc
ttcctgttctcgaaagagaacagtgtgtggaactcgcagctggatgcagtgtgcccagat
accatgaacaatcctctctcccactactggatctcttcctcccacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctagaagcctacgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagtcatttaccat
ggacacacccttaccaccaagatcaagttctcggacgttctgcacaccatcaaggagcat
gccttcgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgct
cagcagagaaatatggcacagtatttcaagaaggtgcttggggacacactccttaccaag
cccgtggacatcgctgccgacgggctcccctcgcccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcggagggcagcgcctacgaagaggtgcctacgtcggtgatg
tactccgagaatgatatcagcaactccatcaagaatggcatcctctacctggaggacccc
gtgaaccatgaatggtacccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagcgaccagggcaatgaggatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccagtgagaagtggttccatgggaagctcggggcgggacgggac
ggacggcacatcgctgagcgcctgctcaccgagtactgcatcgagaccggggcccctgat
ggctccttcctcgtgcgggagagcgagaccttcgtgggcgactacaccctctctttctgg
aggaacggaaaagtccagcactgccggatccactcccggcaggacgctggggcccccaag
ttcttcttgacagacaacttggtctttgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagcctgtcccgcagacg
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggctgagcac
atgctgatgcgtgtcccccgggatggggccttcctggtgagaaaacggaatgagcccaac
tcctacgccatctccttccgggccgagggcaagatcaagcattgccgcgtccagcaggag
ggccagacggtgatgctgggcaactcggagtttgacagcctcgtggacctcatcagctac
tatgagaagcacccgctgtaccgcaagatgaagctgcgctaccccatcaacgaggaggcg
ctagagaagatcggcaccgctgagcctgactatggagccttgtatgagggacgcaaccct
ggcttctacgtggaggcaaatcctatgccgactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagggaggacgagctgacgttcacaaagagcgccatcatccagaac
gtggagaagcaagaaggcggctggtggcggggggactacggggggaagaagcagctgtgg
ttcccgtcaaactacgtggaggagatggtcagccctgcatccctggagccggagagggag
cacttggacgagaacagccccctgggggacttgctccggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacagccggctcttcgtcttctccatcagc
atggcttcagtggcgcactggtccttggacgtcgctgctgactcacaggaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagatgccaggctcacggagggg
aagatgatggagcgcaggaagaagattgccctggagctctccgagctggttgtctactgt
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtcctttccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccgcctgcagctctcccgcatctaccccaagggccagcggctagactcc
tccaattacgaccccttgcccatgtggatctgcggcagtcagctggtggccctcaacttc
cagacgccagacaagcctatgcagatgaaccaggcgctcttcatggccggcggccactgc
ggctacgtgctgcagcccagcaccatgcgggatgaggcctttgacccctttgacaagagc
agcctccgaggcctagagccatatgccatctgcattgaggtgctgggggcccggcacctg
ccaaagaatggccgaggcatcgtgtgtccttttgtggagattgaggtggccggagcggaa
tatgacagcatcaagcagaagacagagtttgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagtaacccggaattcgcctttttgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctaccttcccggtg
aaaggcctgaagacaggatacagagctgtgcctttgaagaacaactacagtgaggacttg
gagctggcctccctgctcgtcaagatcgatgttttccctgccaagcaggagaacggggac
ctcagtcccttcagtatgtctctgcgggagcggggctccgatacctcaggccagctgttt
catggccgggcccgggaaggttcctttgaagcccgctaccagcagccatttgaggacttt
cgtatctcccaggagcagctggcagaccattttgacagtcgggaacggagggccccacga
aggactcgggtcaacggagacaaccgcctctag
DBGET
integrated database retrieval system
