Ursus maritimus (polar bear): 103659742 Help Entry 103659742         CDS       T03271                                  Symbol CASP8 Name (RefSeq) caspase-8 isoform X1   KO K04398   caspase 8 [EC:3.4.22.61] Organism umr  Ursus maritimus (polar bear) Pathway umr01524   Platinum drug resistance umr04115   p53 signaling pathway umr04210   Apoptosis umr04215   Apoptosis - multiple species umr04217   Necroptosis umr04620   Toll-like receptor signaling pathway umr04621   NOD-like receptor signaling pathway umr04622   RIG-I-like receptor signaling pathway umr04623   Cytosolic DNA-sensing pathway umr04625   C-type lectin receptor signaling pathway umr04657   IL-17 signaling pathway umr04668   TNF signaling pathway umr04932   Non-alcoholic fatty liver disease umr04936   Alcoholic liver disease umr05010   Alzheimer disease umr05016   Huntington disease umr05022   Pathways of neurodegeneration - multiple diseases umr05132   Salmonella infection umr05134   Legionellosis umr05142   Chagas disease umr05145   Toxoplasmosis umr05152   Tuberculosis umr05160   Hepatitis C umr05161   Hepatitis B umr05162   Measles umr05163   Human cytomegalovirus infection umr05164   Influenza A umr05165   Human papillomavirus infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05168   Herpes simplex virus 1 infection umr05169   Epstein-Barr virus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05416   Viral myocarditis umr05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     103659742 (CASP8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     103659742 (CASP8)    04215 Apoptosis - multiple species     103659742 (CASP8)    04217 Necroptosis     103659742 (CASP8)    04115 p53 signaling pathway     103659742 (CASP8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     103659742 (CASP8)    04621 NOD-like receptor signaling pathway     103659742 (CASP8)    04622 RIG-I-like receptor signaling pathway     103659742 (CASP8)    04623 Cytosolic DNA-sensing pathway     103659742 (CASP8)    04625 C-type lectin receptor signaling pathway     103659742 (CASP8)    04657 IL-17 signaling pathway     103659742 (CASP8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103659742 (CASP8)    05203 Viral carcinogenesis     103659742 (CASP8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     103659742 (CASP8)    05161 Hepatitis B     103659742 (CASP8)    05160 Hepatitis C     103659742 (CASP8)    05164 Influenza A     103659742 (CASP8)    05162 Measles     103659742 (CASP8)    05168 Herpes simplex virus 1 infection     103659742 (CASP8)    05163 Human cytomegalovirus infection     103659742 (CASP8)    05167 Kaposi sarcoma-associated herpesvirus infection     103659742 (CASP8)    05169 Epstein-Barr virus infection     103659742 (CASP8)    05165 Human papillomavirus infection     103659742 (CASP8)   09171 Infectious disease: bacterial    05132 Salmonella infection     103659742 (CASP8)    05134 Legionellosis     103659742 (CASP8)    05152 Tuberculosis     103659742 (CASP8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     103659742 (CASP8)    05142 Chagas disease     103659742 (CASP8)   09164 Neurodegenerative disease    05010 Alzheimer disease     103659742 (CASP8)    05016 Huntington disease     103659742 (CASP8)    05022 Pathways of neurodegeneration - multiple diseases     103659742 (CASP8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     103659742 (CASP8)    05416 Viral myocarditis     103659742 (CASP8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     103659742 (CASP8)    04932 Non-alcoholic fatty liver disease     103659742 (CASP8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     103659742 (CASP8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:umr01002]     103659742 (CASP8) Enzymes [BR:umr01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      103659742 (CASP8) Peptidases and inhibitors [BR:umr01002]  Cysteine peptidases   Family C14: caspase family    103659742 (CASP8) SSDB OrthologParalogGFIT Motif Pfam:  Peptidase_C14 DED Motif Other DBs NCBI-GeneID:  103659742 NCBI-ProteinID:  XP_008685574 UniProt:  A0A384BTK5 LinkDB All DBs Position Unknown AA seq 486 aa AA seqDB search MNFSKCLYNIGEQLDSDELASLKFLSMDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLS FLKELLFRINRLDLLVTYLDTSKEEMEQELQIPGRAQISAYRVMLFQISEDVSKLELRSF KFFLSQEISRCKLHDDLNLFDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE LSREQTLSPQRSLDEISNDMSQLLVGEESLRVPPMSDSPGEQDCEPETSDKVYRMESKPR GYCLIFNNYDFSIARKEVPKLQSIKDRNGTDLDADALCQTFSELHFEIVPFKDCTAKKIC EVLKSYQSMDHSSRDCFICCILSHGDKGIIYGSDGQEVPIYELTSYFTGSKCPSLAGKPK IFFIQACQGDNYQKGIAVETDSEQKEAYLEMDSSYQKRYIPEDADFLLGMATVNNCVSYR NPMEGTWYIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDRKNMGKQMPQPTFTLRKK LFFPLN NT seq 1461 nt NT seq  +upstreamnt  +downstreamnt atgaatttcagcaaatgcctctataatattggagaacagctggacagtgatgagctggcc tccctcaagttcctgagcatggactacatcccacagaagaagcaggaacccatcaaggat cccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgtcc ttcttgaaggagctgcttttccgaattaacagactggacctgctggttacctacctggac accagcaaggaggagatggagcaggagcttcaaataccaggcagagcccagatctctgcc tacagggtcatgctttttcagatttcagaagatgtaagcaaattggaattgaggtccttt aagttttttttgagccaggagatctccagatgtaaactgcacgatgacttgaacttgttt gatattttcatagagatggagaagagggtcatcctcggggaaagaaatctggataccctg aaaagaatctgtgaccaaattaacaagagcctgctgaagaaaatcacggattatgaagaa ttaagcagagagcaaacactgagccctcaaagaagtctagatgaaatttcaaatgatatg tctcagttgcttgtaggggaggaatccctgagggtaccgccaatgtcggactctccagga gaacaggactgtgaaccagagacatcggacaaagtttaccgaatggaaagcaaacctcga ggatattgtttgatctttaacaattacgactttagcatagcacggaaggaagtgcccaaa cttcagagcattaaggataggaatggaacagacttggatgcagatgctttgtgtcagacc tttagtgagcttcattttgagatcgtgcctttcaaagactgtacagccaagaaaatctgt gaggttctgaaatcctaccaaagcatggaccactctagcagggattgcttcatctgctgc atcctctcccatggagacaagggcatcatctatggctctgatgggcaagaagtccccatc tatgagctgacttcttacttcactggttcaaagtgcccttcccttgcaggcaagcccaaa atcttttttattcaggcttgtcaaggggataactaccagaaaggtatagctgttgagact gactctgaacagaaggaagcctatttagaaatggactcatcctatcagaagagatatatc ccagaagatgctgactttctgctggggatggccactgtgaataattgtgtttcctaccga aaccccatggaggggacctggtatatccagtcactttgccagagcctgagagaaagatgt cctaggggcgaagatattctcaccatccttaccgaggtgaactttgaagtgagcaataag gatgacaggaaaaacatggggaaacaaatgccacaacctactttcacactgaggaaaaaa ctctttttccctcttaattga

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