Ursus maritimus (polar bear): 103661704 Help Entry 103661704         CDS       T03271                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04081   Hormone signaling umr04082   Neuroactive ligand signaling umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05207   Chemical carcinogenesis - receptor activation umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103661704 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103661704 (ADCY8)    04371 Apelin signaling pathway     103661704 (ADCY8)    04020 Calcium signaling pathway     103661704 (ADCY8)    04072 Phospholipase D signaling pathway     103661704 (ADCY8)    04024 cAMP signaling pathway     103661704 (ADCY8)    04022 cGMP-PKG signaling pathway     103661704 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     103661704 (ADCY8)    04081 Hormone signaling     103661704 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103661704 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     103661704 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103661704 (ADCY8)    04062 Chemokine signaling pathway     103661704 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     103661704 (ADCY8)    04923 Regulation of lipolysis in adipocytes     103661704 (ADCY8)    04912 GnRH signaling pathway     103661704 (ADCY8)    04913 Ovarian steroidogenesis     103661704 (ADCY8)    04915 Estrogen signaling pathway     103661704 (ADCY8)    04914 Progesterone-mediated oocyte maturation     103661704 (ADCY8)    04921 Oxytocin signaling pathway     103661704 (ADCY8)    04926 Relaxin signaling pathway     103661704 (ADCY8)    04935 Growth hormone synthesis, secretion and action     103661704 (ADCY8)    04918 Thyroid hormone synthesis     103661704 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     103661704 (ADCY8)    04916 Melanogenesis     103661704 (ADCY8)    04925 Aldosterone synthesis and secretion     103661704 (ADCY8)    04927 Cortisol synthesis and secretion     103661704 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103661704 (ADCY8)    04270 Vascular smooth muscle contraction     103661704 (ADCY8)   09154 Digestive system    04970 Salivary secretion     103661704 (ADCY8)    04971 Gastric acid secretion     103661704 (ADCY8)    04972 Pancreatic secretion     103661704 (ADCY8)    04976 Bile secretion     103661704 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     103661704 (ADCY8)    04727 GABAergic synapse     103661704 (ADCY8)    04725 Cholinergic synapse     103661704 (ADCY8)    04720 Long-term potentiation     103661704 (ADCY8)    04723 Retrograde endocannabinoid signaling     103661704 (ADCY8)   09157 Sensory system    04742 Taste transduction     103661704 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     103661704 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     103661704 (ADCY8)    04213 Longevity regulating pathway - multiple species     103661704 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     103661704 (ADCY8)    04714 Thermogenesis     103661704 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103661704 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     103661704 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103661704 (ADCY8)    05163 Human cytomegalovirus infection     103661704 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     103661704 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103661704 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103661704 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103661704 (ADCY8) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103661704 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  103661704 NCBI-ProteinID:  XP_040481981 UniProt:  A0A8M1FF37 LinkDB All DBs Position Unknown AA seq 1252 aa AA seqDB search MELSDVRYLTGPEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG SGRRGSGKASNPAGGGPNHHAAPLSGDSALPLYSLGPGDRAHSTGGTKVFPERSGSGSCS GSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT SLLQVVLQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPE DIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLAFNSSAVFTDICSYPEYFVFT GVLAMVTCAVFLRLNSVLKLAVLLIMTAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKE ASLLLMAVFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL VQSLNRQRQKQLLNEDNNTGIIKAHYNRRTLLAPSGPEPGAPAEGTDKSDLP NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt atggagctctcagatgtgcgctacctgaccggccccgaggaactctacaccatccacccg acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcagacg gcggtgaggcacatcaccgagcagcgcttcattcacggacaccggggcagcggcggcggc agcgggaggagaggctccggcaaagcctcgaaccctgcaggcggcggccccaaccatcac gcggcgccgctgtccggcgactcggcgctgcccctctactcgctgggccccggggacaga gcgcacagcaccggtggcactaaagtcttcccggaacgcagcgggagcggcagctgcagc ggcagcgggggcgggggcgatctgggcttcctgcacctcgactgcgccccgagcaactcg gatttcttcctcaatgggggctacagctaccgaggggtcattttccccactctgcgcaac tccttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgc aaatccgaggtggtgatgaacgtgttggatgtgctgaccaaactcaccctcttggtcctg cacttgagcctggcctcggcccccatggacccgctcaagggcatcctcctgggcttcttc actggcatcgaggtggtgatctgcgccctggtggtggtcaggaaggacaccacctcgcac acgtacctgcagtacagcggcgtggtcacttgggtggccatgaccacccagatcttggca gcaggcctcggctacgggcttttgggtgatggcatcggctacgttctcttcacgctgttc gccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcttgggcacc tcgctgctgcaggtggtcctgcaggtggtcatcccccggctagcggtcatttccatcaac caggtcgtggcccaggcagtattattcatgtgtatgaacacagctggaatcttcatcagt tacctgtcagaccgggcccagcgccaagccttcctggagacgcggaggtgtgtggaggcc aggctccgcctggagacggaaaaccaaagacaggagcgtctcgtgctatctgtgctcccc cgctttgtcgtcctggaaatgatcaatgacatgaccaatgttgaagacgagcacttgcag caccagttccatcggatctacatccatcgctatgagaacgtcagtattctttttgcagat gttaaaggatttaccaacctctccacaaccttgtccgcccaggagctggtccggatgctc aacgagctctttgccagatttgatcgactggcccatgagcatcactgccttcgcattaaa atcctgggggactgttactactgtgtttcagggcttcctgagccccgccaggaccacgcc cactgctgtgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgaggtcgagg acgaagcatgatgtggacatgcggatcggaatccactctggctcagtgctatgtggcgtg ttgggcctgcggaagtggcagtttgatgtctggtcttgggatgtggacattgcaaacaaa ctcgaatctggaggaatccccgggaggattcacatttccaaagccacgctggactgcctc aacggcgactataacgtggaagagggtcatggtaaagagagaaacgaattcttgaggaag cataatattgagacctacttgattaagcagcctgaggaaagtctgctgtcgttgcccgaa gacatcgtcaaggagtcggtgagctcctcagacaggagaaacagtggggcaacattcaca gaaggatcctggagccccgaactgccctttgataacatagtggggaaacagaacactctg gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc ctggagcacaagtattctcaaatgagggatgaagtattcaagtcaaacttggtctgtgca tttatcgttcttctatttatcacggcgatacaaagtttgcttccttcctcaagggtgatg ccaatggccatccagttttccatcctgattatgctgcactcggctctggtcctcatcacc acggcggaggattataagtgtttgcccctcgtcctccggaaaacttgctgttggattaac gagacctatttggcccggaacgtcatcatctttgcatccatcttgattaacttcctgggc gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctggct ttcaattcctcagctgtgtttacagatatctgctcctacccagagtacttcgtcttcacc ggggtgctggccatggtgacctgtgcggttttcctccgcctgaactctgtcctgaagctg gccgtgctgctgattatgaccgccatctacgccctgctcaccgagaccatctacgcgggc ctcttcctgcgctacgacaacctgaaccacagtggagaagatttcctggggaccaaggag gcgtcactgctcctgatggccgtgttcctccttgccgtgttctaccatggacagcagctg gagtatacagcccgccttgacttcctttggcgagtacaggccaaagaggagatcaacgag atgaaggagctgagggaacacaacgagaacatgctccggaacattctacccagccacgtg gcccgccacttcctggagaaagaccgagacaacgaggagctgtattctcaatcctacgat gccgtcggggtgatgtttgcctccatcccggggttcgcagacttctactctcagaccgaa atgaataaccagggagtggaatgcctgcgcctgctgaatgagatcatcgctgacttcgat gagctgctcggcgaagaccggtttcaagacattgaaaagattaagaccattggcagcacc tacatggccgtgtcaggcctgtcacccgaaaaacagcaatgcgaagacaagtggggacat ttgtgcgccctggccgacttctccctcgccctgaccgagagcatacaggagatcaacaag cattccttcaacaatttcgaactccggatcggcatcagccacggctcggtggtagctggc gttatcggcgctaagaaaccgcagtatgacatttggggcaaaaccgtgaacctggcaagt cgaatggacagcacgggggtcagcggcaggatccaagtccccgaggagacctatctcatc ctgaaggaccagggctttgcctttgactaccgaggggagatctacgtgaagggcatcagt gaacaggaaggaaaaatcaaaacatactttctgctgggaagagtccaacccaacccattc atcctgcccccgagaagactgcccgggcagtactccctggccgcggtcgtcctgggcctt gtccagtccctcaacaggcaaaggcagaagcagctgcttaacgaggacaacaacacgggg atcatcaaggctcattacaaccggcggactttgctggcacccagcgggccagagcccgga gccccagccgaaggcaccgacaagtccgatttgccatga

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