KEGG   Ursus maritimus (polar bear): 103661921
Entry
103661921         CDS       T03271                                 
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00562  Inositol phosphate metabolism
umr01100  Metabolic pathways
umr01521  EGFR tyrosine kinase inhibitor resistance
umr04068  FoxO signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04071  Sphingolipid signaling pathway
umr04115  p53 signaling pathway
umr04140  Autophagy - animal
umr04150  mTOR signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04218  Cellular senescence
umr04510  Focal adhesion
umr04931  Insulin resistance
umr05165  Human papillomavirus infection
umr05166  Human T-cell leukemia virus 1 infection
umr05200  Pathways in cancer
umr05206  MicroRNAs in cancer
umr05208  Chemical carcinogenesis - reactive oxygen species
umr05213  Endometrial cancer
umr05214  Glioma
umr05215  Prostate cancer
umr05218  Melanoma
umr05222  Small cell lung cancer
umr05224  Breast cancer
umr05225  Hepatocellular carcinoma
umr05230  Central carbon metabolism in cancer
umr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
umr05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103661921
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    103661921
   04070 Phosphatidylinositol signaling system
    103661921
   04071 Sphingolipid signaling pathway
    103661921
   04151 PI3K-Akt signaling pathway
    103661921
   04150 mTOR signaling pathway
    103661921
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103661921
  09143 Cell growth and death
   04115 p53 signaling pathway
    103661921
   04218 Cellular senescence
    103661921
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103661921
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103661921
   05206 MicroRNAs in cancer
    103661921
   05208 Chemical carcinogenesis - reactive oxygen species
    103661921
   05230 Central carbon metabolism in cancer
    103661921
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103661921
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103661921
   05214 Glioma
    103661921
   05218 Melanoma
    103661921
   05215 Prostate cancer
    103661921
   05213 Endometrial cancer
    103661921
   05224 Breast cancer
    103661921
   05222 Small cell lung cancer
    103661921
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103661921
   05165 Human papillomavirus infection
    103661921
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    103661921
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    103661921
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103661921
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:umr01009]
    103661921
Enzymes [BR:umr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     103661921
    3.1.3.48  protein-tyrosine-phosphatase
     103661921
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     103661921
Protein phosphatases and associated proteins [BR:umr01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    103661921
SSDB
Motif
Pfam: PTEN_C2 DUF3256
Other DBs
NCBI-GeneID: 103661921
NCBI-ProteinID: XP_008687806
UniProt: A0A384BYY7
LinkDB
Position
Unknown
AA seq 249 aa
MWEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQ
FVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFW
VNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKAN
RYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDE
DQHTQITKV
NT seq 750 nt   +upstreamnt  +downstreamnt
atgtgggaagtaaggaccagagacaaaaagggagtaactattcccagtcagaggcgctat
gtgtattattatagctacctgttaaagaatcatctggattatagaccagtggcactgttg
tttcacaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaatcctcag
tttgtggtctgccagctaaaggtgaagatctattcctccaattcaggacccacacgacgg
gaagacaagttcatgtacttcgagttccctcagccgttacctgtgtgtggtgacatcaaa
gtagagttcttccacaaacagaacaagatgctaaaaaaggacaaaatgtttcacttttgg
gtaaacacattcttcataccaggaccagaggaaacctcagaaaaagtagaaaatggaagt
ctatgtgatcaagaaattgatagtatttgcagtatagagcgtgcagataatgacaaggaa
tatctagtactcactttaacaaaaaatgatctcgacaaagcaaataaagacaaggccaac
cgatacttttctccaaattttaaggtgaagctgtacttcacgaaaacagtagaggagcca
tcaaatcccgaggctagcagttcaacttctgtaacaccagatgttagtgacaatgaacct
gaccattatcgatattctgacaccactgactctgatccagagaatgaaccttttgatgaa
gatcagcatacacagattacaaaagtctga

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