KEGG   Ursus maritimus (polar bear): 103669754
Entry
103669754         CDS       T03271                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00562  Inositol phosphate metabolism
umr01100  Metabolic pathways
umr01521  EGFR tyrosine kinase inhibitor resistance
umr04012  ErbB signaling pathway
umr04014  Ras signaling pathway
umr04015  Rap1 signaling pathway
umr04020  Calcium signaling pathway
umr04062  Chemokine signaling pathway
umr04064  NF-kappa B signaling pathway
umr04066  HIF-1 signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04072  Phospholipase D signaling pathway
umr04360  Axon guidance
umr04370  VEGF signaling pathway
umr04517  IgSF CAM signaling
umr04613  Neutrophil extracellular trap formation
umr04650  Natural killer cell mediated cytotoxicity
umr04658  Th1 and Th2 cell differentiation
umr04659  Th17 cell differentiation
umr04660  T cell receptor signaling pathway
umr04664  Fc epsilon RI signaling pathway
umr04666  Fc gamma R-mediated phagocytosis
umr04670  Leukocyte transendothelial migration
umr04722  Neurotrophin signaling pathway
umr04750  Inflammatory mediator regulation of TRP channels
umr04919  Thyroid hormone signaling pathway
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr04935  Growth hormone synthesis, secretion and action
umr05012  Parkinson disease
umr05022  Pathways of neurodegeneration - multiple diseases
umr05135  Yersinia infection
umr05167  Kaposi sarcoma-associated herpesvirus infection
umr05170  Human immunodeficiency virus 1 infection
umr05171  Coronavirus disease - COVID-19
umr05200  Pathways in cancer
umr05205  Proteoglycans in cancer
umr05206  MicroRNAs in cancer
umr05214  Glioma
umr05223  Non-small cell lung cancer
umr05225  Hepatocellular carcinoma
umr05231  Choline metabolism in cancer
umr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
umr05417  Lipid and atherosclerosis
Module
umr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103669754 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103669754 (PLCG1)
   04014 Ras signaling pathway
    103669754 (PLCG1)
   04015 Rap1 signaling pathway
    103669754 (PLCG1)
   04370 VEGF signaling pathway
    103669754 (PLCG1)
   04064 NF-kappa B signaling pathway
    103669754 (PLCG1)
   04066 HIF-1 signaling pathway
    103669754 (PLCG1)
   04020 Calcium signaling pathway
    103669754 (PLCG1)
   04070 Phosphatidylinositol signaling system
    103669754 (PLCG1)
   04072 Phospholipase D signaling pathway
    103669754 (PLCG1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    103669754 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103669754 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    103669754 (PLCG1)
   04660 T cell receptor signaling pathway
    103669754 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    103669754 (PLCG1)
   04659 Th17 cell differentiation
    103669754 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    103669754 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    103669754 (PLCG1)
   04670 Leukocyte transendothelial migration
    103669754 (PLCG1)
   04062 Chemokine signaling pathway
    103669754 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    103669754 (PLCG1)
   04919 Thyroid hormone signaling pathway
    103669754 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103669754 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103669754 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    103669754 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103669754 (PLCG1)
   05206 MicroRNAs in cancer
    103669754 (PLCG1)
   05205 Proteoglycans in cancer
    103669754 (PLCG1)
   05231 Choline metabolism in cancer
    103669754 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103669754 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103669754 (PLCG1)
   05214 Glioma
    103669754 (PLCG1)
   05223 Non-small cell lung cancer
    103669754 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103669754 (PLCG1)
   05171 Coronavirus disease - COVID-19
    103669754 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103669754 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103669754 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    103669754 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    103669754 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103669754 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103669754 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103669754 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103669754 (PLCG1)
Enzymes [BR:umr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103669754 (PLCG1)
Membrane trafficking [BR:umr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103669754 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103669754 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG PH SH3_1 C2 EF_HAND_1_PLCG SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 103669754
NCBI-ProteinID: XP_040494248
UniProt: A0A8M1GF12
LinkDB
Position
Unknown
AA seq 1290 aa
MAGAASPCANGCAPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFSLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPASLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDVFPAKQENGDLSPFSMSLRERGSDTSGQLFHGRAREGSFEARYQQPFEDF
RISQEQLADHFDIRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgcgcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgcgaaatcaaggag
atccgcccagggaagacctcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgctttgtcatcctgtatgggatggaattccgcctgaagaccctg
agcctgcaagctacgtctgaggatgaagtaaacatgtggatcaggggtttaacctggttg
atggaggatacattgcaggcagccacgcctctgcagatcgagaggtggctgcggaagcag
ttctactcggtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggct
ggggagcggccagagctctgtcgtgtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcgagaccccttgcgagaaattgaagagccatacttctccctggatgagtttgtcacc
ttcctgttctcgaaagagaacagtgtgtggaactcgcagctggatgcagtgtgcccagat
accatgaacaatcctctctcccactactggatctcttcctcccacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctagaagcctacgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagtcatttaccat
ggacacacccttaccaccaagatcaagttctcggacgttctgcacaccatcaaggagcat
gccttcgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgct
cagcagagaaatatggcacagtatttcaagaaggtgcttggggacacactccttaccaag
cccgtggacatcgctgccgacgggctcccctcgcccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcggagggcagcgcctacgaagaggtgcctacgtcggtgatg
tactccgagaatgatatcagcaactccatcaagaatggcatcctctacctggaggacccc
gtgaaccatgaatggtacccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagcgaccagggcaatgaggatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccagtgagaagtggttccatgggaagctcggggcgggacgggac
ggacggcacatcgctgagcgcctgctcaccgagtactgcatcgagaccggggcccctgat
ggctccttcctcgtgcgggagagcgagaccttcgtgggcgactacaccctctctttctgg
aggaacggaaaagtccagcactgccggatccactcccggcaggacgctggggcccccaag
ttcttcttgacagacaacttggtctttgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagcctgtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggctgagcac
atgctgatgcgtgtcccccgggatggggccttcctggtgagaaaacggaatgagcccaac
tcctacgccatctccttccgggccgagggcaagatcaagcattgccgcgtccagcaggag
ggccagacggtgatgctgggcaactcggagtttgacagcctcgtggacctcatcagctac
tatgagaagcacccgctgtaccgcaagatgaagctgcgctaccccatcaacgaggaggcg
ctagagaagatcggcaccgctgagcctgactatggagccttgtatgagggacgcaaccct
ggcttctacgtggaggcaaatcctatgccgactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagggaggacgagctgacgttcacaaagagcgccatcatccagaac
gtggagaagcaagaaggcggctggtggcggggggactacggggggaagaagcagctgtgg
ttcccgtcaaactacgtggaggagatggtcagccctgcatccctggagccggagagggag
cacttggacgagaacagccccctgggggacttgctccggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacagccggctcttcgtcttctccatcagc
atggcttcagtggcgcactggtccttggacgtcgctgctgactcacaggaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagatgccaggctcacggagggg
aagatgatggagcgcaggaagaagattgccctggagctctccgagctggttgtctactgt
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtcctttccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccgcctgcagctctcccgcatctaccccaagggccagcggctagactcc
tccaattacgaccccttgcccatgtggatctgcggcagtcagctggtggccctcaacttc
cagacgccagacaagcctatgcagatgaaccaggcgctcttcatggccggcggccactgc
ggctacgtgctgcagcccagcaccatgcgggatgaggcctttgacccctttgacaagagc
agcctccgaggcctagagccatatgccatctgcattgaggtgctgggggcccggcacctg
ccaaagaatggccgaggcatcgtgtgtccttttgtggagattgaggtggccggagcggaa
tatgacagcatcaagcagaagacagagtttgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagtaacccggaattcgcctttttgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctaccttcccggtg
aaaggcctgaagacaggatacagagccgtgcctttgaagaacaactacagtgaggacttg
gagctggcctccctgctcgtcaagatcgatgttttccctgccaagcaggagaacggggac
ctcagtcccttcagtatgtctctgcgggagcggggctccgatacctcaggccagctgttt
catggccgggcccgggaaggttcctttgaagcccgctaccagcagccatttgaggacttt
cgtatctcccaggagcagctggcagaccattttgacattcgggaacggagggccccacga
aggactcgggtcaacggagacaaccgcctctag

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