Ursus maritimus (polar bear): 103679250 Help Entry 103679250         CDS       T03271                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04081   Hormone signaling umr04082   Neuroactive ligand signaling umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04922   Glucagon signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05207   Chemical carcinogenesis - receptor activation umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103679250 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103679250 (ADCY2)    04072 Phospholipase D signaling pathway     103679250 (ADCY2)    04024 cAMP signaling pathway     103679250 (ADCY2)    04022 cGMP-PKG signaling pathway     103679250 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     103679250 (ADCY2)    04081 Hormone signaling     103679250 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103679250 (ADCY2)    04062 Chemokine signaling pathway     103679250 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     103679250 (ADCY2)    04922 Glucagon signaling pathway     103679250 (ADCY2)    04923 Regulation of lipolysis in adipocytes     103679250 (ADCY2)    04913 Ovarian steroidogenesis     103679250 (ADCY2)    04915 Estrogen signaling pathway     103679250 (ADCY2)    04921 Oxytocin signaling pathway     103679250 (ADCY2)    04926 Relaxin signaling pathway     103679250 (ADCY2)    04935 Growth hormone synthesis, secretion and action     103679250 (ADCY2)    04918 Thyroid hormone synthesis     103679250 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     103679250 (ADCY2)    04925 Aldosterone synthesis and secretion     103679250 (ADCY2)    04927 Cortisol synthesis and secretion     103679250 (ADCY2)   09154 Digestive system    04970 Salivary secretion     103679250 (ADCY2)    04971 Gastric acid secretion     103679250 (ADCY2)    04972 Pancreatic secretion     103679250 (ADCY2)    04976 Bile secretion     103679250 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     103679250 (ADCY2)    04727 GABAergic synapse     103679250 (ADCY2)    04725 Cholinergic synapse     103679250 (ADCY2)    04723 Retrograde endocannabinoid signaling     103679250 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103679250 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     103679250 (ADCY2)    04213 Longevity regulating pathway - multiple species     103679250 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     103679250 (ADCY2)    04714 Thermogenesis     103679250 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103679250 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     103679250 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103679250 (ADCY2)    05163 Human cytomegalovirus infection     103679250 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     103679250 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103679250 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103679250 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103679250 (ADCY2) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103679250 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  103679250 NCBI-ProteinID:  XP_040486493 UniProt:  A0A8M1FSZ7 LinkDB All DBs Position Unknown AA seq 1093 aa AA seqDB search MWREAMRRRRYLRDRAEAAAAAAGGGDGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGA CLALLAVFFALRLDVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSVVIWICL VAMGYLFLCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCL SATPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEK RQQERLLLSLLPAHIAMEMKAEIIRRLQGPRAGQMENTNNFHNLYVKRHTNVSILYADIV GFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME AGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPHLFR PRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNR TLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYRATALP AFKYYVTCACLIFFCVFIVQILVLPKTSILGISFGAAFLLLAFILFICFAGQLLQCSKKA SASLLWLLKSSGIIADRPWPRVSLTVLTTAIILTMAVFNMFFLSDPEETIPPTANSSNTS LSALSNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILL HTHAHVLDDYSQVLFQRPGIWKDLKTMGSVSLFIFFVTLLVLGRQNEYYCRLDFLWKNKF KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKE FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE HAQEPERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY DIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGELKTYFVNT EMSRSLSQGNLAS NT seq 3282 nt NT seq  +upstreamnt  +downstreamnt atgtggcgggaggcgatgcggcgccgccgctacctgcgggaccgcgccgaggcggcggcg gcggcggcgggcggcggcgacgggctgcagcggtcccgggactggctgtacgagtcctac tactgcatgagccagcagcacccgctcatcgtcttcctgctgctgatcgtcatgggcgcc tgcctcgccctgctcgccgtcttcttcgcgctccggctggacgttgaagaccacgtggca tttttaataacggtcccgacagccctggcgatcttcttcgcgatcttcatcctcgtctgc atcgagtccgtgttcaagaagctcctgcgccttttctccgtcgtgatatggatctgcctc gtggccatgggctacctgttcctgtgcttcggaggcaccgtctccccctgggaccaggtg tcgttcttcctcttcatcatctttgtggtgtacaccatgctgcccttcaacatgcgggac gccatcatcgccagcgtgctcacctcctcctcccacaccatcgtgctgagcgtctgcctg tctgcgacgccgggggccaaggagcacctggtctggcagatcctggccaatgtgatcatt ttcatctgtgggaacctggcgggagcgtaccacaagcacctcatggagctggccttgcag cagacgtatcaggacacctgcaactgtatcaagtctcggatcaagctggaatttgaaaag cgtcagcaggagcggcttctgctctccctgctgccggctcacatagccatggaaatgaaa gccgagatcatccggaggctgcagggccccagagccggccaaatggaaaacacaaacaac ttccacaacctgtacgtcaagcgccataccaacgtgagcatcctgtatgctgatattgtt ggcttcacccggctggccagtgactgctccccaggagaactggtccacatgctgaacgag ctctttggaaagttcgaccaaattgcaaaggagaatgaatgcatgagaataaaaattttg ggagactgctactactgtgtgtccggacttcctatatctctcccgaaccatgccaagaac tgtgtgaaaatggggctggacatgtgtgaagccataaagaaagtgagggatgccactgga gtggatatcaacatgcgcgtgggagtgcattctgggaacgtcctctgcggggtgattggt ctgcagaagtggcagtacgacgtgtggtcacatgacgttaccttggccaatcacatggaa gctggaggggtccctggacgtgttcacatttcttccgtcaccctggaacacttgaacggc gcttacaaagtggaggaaggagacggtgacatcagagacccgtatttaaaacagcacctg gtgaaaacctactttgtcatcaaccccaagggagaacgaaggagtcctcacctcttcaga cctcgccacaccctcgatggagccaagatgagggcctctgtgcgcatgacccggtacctg gagtcctggggggcggccaagccctttgcacacctgcatcaccgagacagcatgaccacg gagaatggcaaaatcagcaccacggatgtgccaatgggtcagcataattttcaaaatcgt accttaagaaccaagtcccaaaagaagagatttgaagaagaattaaatgaaaggatgatt caagcaattgatggaattaacgcacaaaagcagtggctcaagtctgaagacattcagaga atctcactcctgttctacaataaaatactagaaaaagaataccgagccaccgccctgcca gcgtttaagtactacgtgacctgcgcgtgtctcatattcttctgcgtcttcattgtgcag attctggtattaccaaaaacgtccattctggggatctcctttggagctgcgtttctcttg ctcgcctttatcctcttcatctgctttgccgggcagcttctgcaatgcagcaagaaggcc tccgcctctctcctgtggctgttgaagtcgtcgggcatcatcgcggaccggccctggcct cgtgtctccctcactgtcctcaccacggccatcattctgaccatggccgtgttcaacatg tttttcctgagtgacccagaggaaacaattcctccaactgccaattcatccaacacaagt ctttctgccttaagtaatcaggcagcgattctacgggcacaaaatctgtttttcctcccg tactttatctacagctgcatcctgggactgatctcctgctcggttttcctgagggtgaat tacgagctgaagatgttgatcatgatggtggcgttggtgggttacaacaccatccttcta cacacgcacgcccacgtcctggacgactatagccaggtcttattccagagaccaggcatt tggaaagacctgaagaccatgggctcagtgtctctctttatattcttcgtcacactgctt gttctgggtagacagaatgaatattactgtaggttagacttcttatggaagaacaagttc aaaaaagagcgggaggagatagaaaccatggaaaacctgaaccgcgtgctgctggagaac gtgctgcccgcgcacgtggcggagcatttcctggcccggagcctgaagaacgaggagtta taccaccagtcctatgactgtgtctgcgtcatgtttgcctctattccggatttcaaagaa ttctacacagaatcagatgtgaacaaggagggcttggaatgccttcggctcctgaatgag atcatcgccgactttgatgatctgctgtccaagccgaagttcagtggagttgaaaagatc aagaccattggcagcacatacatggcggcgaccggtctgagcgccgtgcccagccaggag cacgcccaggagccggagaggcagtacatgcacattggcaccatggtggagtttgccttc gcgctggtggcgaagctggacgccatcaacaagcactccttcaacgacttcaagctgcga gtgggtattaaccacggacctgtgatagccggtgtgattggagctcagaagccgcagtat gatatctggggcaacactgtaaacgtggccagcaggatggacagcaccggcgtgctggac aagatacaggtcaccgaggagacaagcctcatcctccagacgctggggtacacgtgcacg tgtcgaggaataattaacgtgaaaggcaagggggagctgaagacgtactttgtaaacaca gaaatgtcaaggtccctttcccagggcaacttggcatcctga

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