Ursus maritimus (polar bear): 103679770 Help Entry 103679770         CDS       T03271                                  Symbol IRS4 Name (RefSeq) insulin receptor substrate 4   KO K17446   insulin receptor substrate 4 Organism umr  Ursus maritimus (polar bear) Pathway umr04022   cGMP-PKG signaling pathway umr04068   FoxO signaling pathway umr04081   Hormone signaling umr04140   Autophagy - animal umr04152   AMPK signaling pathway umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04910   Insulin signaling pathway umr04920   Adipocytokine signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04930   Type II diabetes mellitus umr04935   Growth hormone synthesis, secretion and action umr05010   Alzheimer disease Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     103679770 (IRS4)    04022 cGMP-PKG signaling pathway     103679770 (IRS4)    04152 AMPK signaling pathway     103679770 (IRS4)   09133 Signaling molecules and interaction    04081 Hormone signaling     103679770 (IRS4)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103679770 (IRS4)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     103679770 (IRS4)    04923 Regulation of lipolysis in adipocytes     103679770 (IRS4)    04920 Adipocytokine signaling pathway     103679770 (IRS4)    04935 Growth hormone synthesis, secretion and action     103679770 (IRS4)   09149 Aging    04211 Longevity regulating pathway     103679770 (IRS4)    04213 Longevity regulating pathway - multiple species     103679770 (IRS4)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     103679770 (IRS4)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103679770 (IRS4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH_11 PH Motif Other DBs NCBI-GeneID:  103679770 NCBI-ProteinID:  XP_040483427 UniProt:  A0A8M1FMZ7 LinkDB All DBs Position X AA seq 1325 aa AA seqDB search MASGSFARDQATRRLRAAAAATAAALAAVATTPLLSSGTPTALIGTGSSCPGAMWLSAAS GSRSDSESDEEDLPVGDEVCKRGYLRKQKHGHWRYFVLKLETADAPARLEYYENARKFRH SVRAAAAAAAAAASGASVPALIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV AENESEQESWYLLLSRLILESKRRRCGTPGAQPDGEPGALAAAAAAEPPFYKDVWQVIIK PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISVGAHLLTLLSTRRH LETLPREPGGWLRRSRFDQFYHLRAVGDGEDETLLTRRHITPSEPVPPSRRGRLHLPRAR RTRRAISAPASCFRRLPPSPVRVPHPAEVPSDRACLSPEASGSGNSGEEGSPQGQEGQEG NGGDYMPMNGWGSGNGQGSGGGQGSSGQGSSSQGSGGNQCSGGGQGSGGGGQGSGGGQGS SGGQGSGGGQGSSGGQGSRGQGAGGNQRSGDGQGTAGGHGSGSDQGAAGGGRGHGSGGGR GPGDGHGSGGGKNSGGAKGSGSGKTSDGNGERGKSLKKRSYFGKLTQSKQHMPPPPPLPP PPPTAGATGGKGKSGGRFRLYFCADRGAPKERKEAKEVKDLETPEGAAQGPHRARAFDED EDDPYMPMRPGVAAPLTSSSDYMPMAPQNFSASKRHSRSPFEDSRGYMMMFPTVSPPPVP SPPKEPDPEKEDESKDNDSESDYMFMAPGAGAIPKNPQNPQGGSSSKSWSSYFSLPNAFQ GSPLGQSEHSEYVPMLPGKVLGKGLDKEASSNGGPKDALSKPSAQGSFSKPGDGGSPSKP SDDGPPKNKAKRPNRLSFITKGSKIKPKSQKPTHEQRGAVSSSDYVNIDFTKRESNVPAP FIYGLPGSWGIIAGPRPSAFSNYVNIEFGLPFPNAAHRLSNLLRAIPGANPLYLEGARWP LAPLLRSATGGSASEEEGDYIEVIFNPAMTPIVPFGDSAIRYDAQTGRIYVVDPFSECCM DISLSPGRYSEPPPVARLLQEEQRLERRRPQSRSQSFFGSARAAVSAFPTDSLERDLSAP FASAAAASAAVPALALSRAVAAASASALAVAPGIGAAARGLDAAAGFDSASVRWFRPVAG AAASEAVRGAQNVAGGSNPRAPNPSADLAGGENGAAAAAPPPPPRRPVPSPPELEESDND DDDDETYVRMDFARPDYKKFDSPRRGYIARNLECSFPVTSSDRQVTFAVPHFLHVTSRKE GMVTT NT seq 3978 nt NT seq  +upstreamnt  +downstreamnt atggcgagtggctccttcgctcgcgaccaagcgacgaggagactgagagctgcagcagcg gcaacagcggcggctctagctgcggtagcgaccaccccacttctttcctcgggcaccccg accgcactcattgggaccgggtcgtcttgtccgggagccatgtggctctccgcggcctct ggctcccggtccgactcggagtccgatgaggaggacctccccgtcggggacgaagtctgc aaacgcggctacctgcggaagcagaagcatgggcactggcgctacttcgtgctcaaactc gagaccgccgacgccccggctcggctggaatactacgaaaacgccaggaagttccggcac agtgtccgcgccgcggcagcggcggcggcggcggccgcctccggcgcctcggtccccgcg ctcatcccgccgcggcgcgtgatcaccctgtaccagtgcttctccgtgagccagcgggcc gacgcaaggtatcgacacctcatcgccctcttcacccaggacgagtacttcgcgatggtg gccgagaacgagtcggagcaggagagctggtacttgctgctcagccgcctcatcctcgag agcaagcgccgccgctgcggcacgccaggcgcgcagccggatggggagccgggcgcgctg gcggctgcagcggcggcggagccacccttctacaaagatgtgtggcaggtaataatcaaa cccagggggctggggcacagaaaagagctgagcggcgtgttccggctctgtcttaccgac gaggaggtggtatttgtgaggctgaataccgaagtggccagcgtggtcgtccagctcctg agcatccgtcgctgcgggcactcggagcagtatttcttcttggaagtgggtaggtccacc gtcatcggtcccggggagctctggatgcaggtcgatgactgtgtggtggcccaaaacatg cacgagctgtttctggagaagatgagagccctgtgcgcagacgagtaccgagcccgatgc cgcagctacagcatcagcgtcggcgcccacctgttaaccctgctgtccactaggaggcac ctggaaacgctgccgcgcgagcccggcggctggctgagaaggtcccgcttcgaccagttt taccacctcagggccgtcggtgatggggaagacgagacgctcctcaccaggcgccacata acacccagcgaacccgtgcccccctccaggcgaggaagactgcacctgcccagagcgcgc aggaccagaagagcgatttccgcgcccgccagctgttttcgccgcctaccacccagccca gtgcgcgtcccgcatcctgcagaagtcccgagtgacagagcttgcctgtctcctgaagct tctggctctggcaactctggggaagaaggcagtcctcagggccaagaaggtcaggaagga aacggaggtgactacatgcccatgaacggatgggggtcgggaaacggccagggttccgga ggtggccagggctcgagtggccaaggctccagtagccagggttcaggaggaaaccagtgc tctggcggggggcagggctccggaggaggcggccagggctccggtggcggtcagggctca agcggtggccagggctccggtggcggccagggctcaagcggtggccagggctcacggggc cagggtgcaggaggaaaccaacgttcaggagatggccagggcaccgcaggtgggcacggc tcgggcagtgaccagggagccgctggcggcggcaggggacatggctcaggcggtgggcgg ggacctggagatggccacggctcaggcgggggcaagaactctggaggggccaaaggctca ggaagtgggaaaacctccgatggcaatggtgaacgcggaaaatctctgaagaaaaggtcc tactttggcaaattaactcaaagcaagcagcacatgccaccaccaccacctcttccccct ccacccccaacagctggagcaactggcggtaaagggaagtctgggggaaggttccgactc tatttttgtgcggacaggggagccccaaaagaacgcaaagaggccaaggaggtcaaagac ttagagaccccagaaggtgcagctcagggtccccacagagccagagcttttgacgaagat gaggatgacccatacatgccaatgaggccaggggtggctgctcctctcacaagctccagt gattatatgccaatggctcctcaaaacttctctgcttcaaaacgccactctcgatcacct tttgaagattcaagaggttacatgatgatgtttcccacagtgagcccaccacctgtccca agtcccccaaaagagccggatcctgaaaaggaggatgagtcaaaggacaatgacagtgag agtgactatatgtttatggctcctggagccggtgcaattccaaaaaacccccaaaatcct cagggtggctcttcctctaaaagttggagctcctacttttccctgccaaatgcttttcag ggctccccgttgggacagagtgagcacagtgagtatgtacccatgttacctggaaaagtc ctggggaagggcctagacaaggaagcctcatctaacgggggccccaaagatgcactttca aagccttcagcccaggggtcattctcaaagcctggagatggggggtcaccctcaaagcct tcagatgatgggcctcccaagaacaaggctaagagacctaaccgcctctctttcatcaca aaaggaagtaaaatcaagccaaaatcacaaaagcccacacatgagcagagaggagctgtc agctctagtgactacgtcaacattgacttcaccaagagagagagcaatgtgccagccccc tttatttacggactgccaggttcgtggggcatcattgctggacccagaccatccgccttt tccaactatgtgaatattgagttcggactgccatttccaaacgcagcacacaggctctcg aatcttttaagagccattccaggtgccaaccccctttatctggaaggtgctaggtggcca cttgcacctctacttcgcagcgctacaggtggcagtgcaagtgaggaagagggtgactat atcgaagtgattttcaatccagcaatgacaccgatcgtgccttttggtgacagtgccatc cgctatgatgctcaaacaggtcgcatctatgtggtcgacccgttttccgagtgctgtatg gacatttctctttcccccggccgctattccgaaccaccacctgtagccaggctgctgcag gaagaacagcggctagagcgaagacgcccgcaaagccgttcgcaaagtttctttgggtcc gccagggccgcggtctcggctttcccaaccgacagcctcgagagagacctctcggccccc tttgcctcggccgccgccgcctcggcagccgtgccagccttagccttgagccgggcggta gccgccgcctcggcctccgccctcgccgtggccccgggcatcggggcagccgccaggggc ttggatgccgccgcagggtttgactccgcctccgtccgctggttccgacctgttgctggc gccgcggcctcagaagcggtcaggggggcacaaaacgttgccggtggctcgaacccgaga gcccccaacccgtctgcagacctagccggaggtgagaacggggccgccgcggccgcgccc ccaccaccacctcgccgccctgtgccgagtccccccgagctcgaggagtctgacaacgac gacgacgacgacgaaacgtacgtgagaatggactttgccagacccgactacaagaagttc gactctccccgcagaggatacattgccagaaaccttgagtgttcctttcctgtcactagt agtgacaggcaagtcaccttcgctgtgcctcattttcttcatgtaacttcccgcaaagag ggaatggtgacaacttga

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