Ursus maritimus (polar bear): 103682322 Help Entry 103682322         CDS       T03271                                  Symbol TNF Name (RefSeq) tumor necrosis factor   KO K03156   tumor necrosis factor superfamily, member 2 Organism umr  Ursus maritimus (polar bear) Pathway umr01523   Antifolate resistance umr04010   MAPK signaling pathway umr04060   Cytokine-cytokine receptor interaction umr04061   Viral protein interaction with cytokine and cytokine receptor umr04064   NF-kappa B signaling pathway umr04071   Sphingolipid signaling pathway umr04150   mTOR signaling pathway umr04210   Apoptosis umr04217   Necroptosis umr04350   TGF-beta signaling pathway umr04380   Osteoclast differentiation umr04612   Antigen processing and presentation umr04620   Toll-like receptor signaling pathway umr04621   NOD-like receptor signaling pathway umr04622   RIG-I-like receptor signaling pathway umr04625   C-type lectin receptor signaling pathway umr04640   Hematopoietic cell lineage umr04650   Natural killer cell mediated cytotoxicity umr04657   IL-17 signaling pathway umr04660   T cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04668   TNF signaling pathway umr04920   Adipocytokine signaling pathway umr04930   Type II diabetes mellitus umr04931   Insulin resistance umr04932   Non-alcoholic fatty liver disease umr04933   AGE-RAGE signaling pathway in diabetic complications umr04936   Alcoholic liver disease umr04940   Type I diabetes mellitus umr05010   Alzheimer disease umr05014   Amyotrophic lateral sclerosis umr05020   Prion disease umr05022   Pathways of neurodegeneration - multiple diseases umr05132   Salmonella infection umr05133   Pertussis umr05134   Legionellosis umr05135   Yersinia infection umr05140   Leishmaniasis umr05142   Chagas disease umr05143   African trypanosomiasis umr05144   Malaria umr05145   Toxoplasmosis umr05146   Amoebiasis umr05152   Tuberculosis umr05160   Hepatitis C umr05161   Hepatitis B umr05163   Human cytomegalovirus infection umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05168   Herpes simplex virus 1 infection umr05169   Epstein-Barr virus infection umr05170   Human immunodeficiency virus 1 infection umr05171   Coronavirus disease - COVID-19 umr05205   Proteoglycans in cancer umr05310   Asthma umr05321   Inflammatory bowel disease umr05322   Systemic lupus erythematosus umr05323   Rheumatoid arthritis umr05330   Allograft rejection umr05332   Graft-versus-host disease umr05410   Hypertrophic cardiomyopathy umr05414   Dilated cardiomyopathy umr05417   Lipid and atherosclerosis umr05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103682322 (TNF)    04350 TGF-beta signaling pathway     103682322 (TNF)    04064 NF-kappa B signaling pathway     103682322 (TNF)    04668 TNF signaling pathway     103682322 (TNF)    04071 Sphingolipid signaling pathway     103682322 (TNF)    04150 mTOR signaling pathway     103682322 (TNF)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     103682322 (TNF)    04061 Viral protein interaction with cytokine and cytokine receptor     103682322 (TNF)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     103682322 (TNF)    04217 Necroptosis     103682322 (TNF)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     103682322 (TNF)    04620 Toll-like receptor signaling pathway     103682322 (TNF)    04621 NOD-like receptor signaling pathway     103682322 (TNF)    04622 RIG-I-like receptor signaling pathway     103682322 (TNF)    04625 C-type lectin receptor signaling pathway     103682322 (TNF)    04650 Natural killer cell mediated cytotoxicity     103682322 (TNF)    04612 Antigen processing and presentation     103682322 (TNF)    04660 T cell receptor signaling pathway     103682322 (TNF)    04657 IL-17 signaling pathway     103682322 (TNF)    04664 Fc epsilon RI signaling pathway     103682322 (TNF)   09152 Endocrine system    04920 Adipocytokine signaling pathway     103682322 (TNF)   09158 Development and regeneration    04380 Osteoclast differentiation     103682322 (TNF)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     103682322 (TNF)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103682322 (TNF)    05170 Human immunodeficiency virus 1 infection     103682322 (TNF)    05161 Hepatitis B     103682322 (TNF)    05160 Hepatitis C     103682322 (TNF)    05171 Coronavirus disease - COVID-19     103682322 (TNF)    05164 Influenza A     103682322 (TNF)    05168 Herpes simplex virus 1 infection     103682322 (TNF)    05163 Human cytomegalovirus infection     103682322 (TNF)    05169 Epstein-Barr virus infection     103682322 (TNF)    05165 Human papillomavirus infection     103682322 (TNF)   09171 Infectious disease: bacterial    05132 Salmonella infection     103682322 (TNF)    05135 Yersinia infection     103682322 (TNF)    05133 Pertussis     103682322 (TNF)    05134 Legionellosis     103682322 (TNF)    05152 Tuberculosis     103682322 (TNF)   09174 Infectious disease: parasitic    05146 Amoebiasis     103682322 (TNF)    05144 Malaria     103682322 (TNF)    05145 Toxoplasmosis     103682322 (TNF)    05140 Leishmaniasis     103682322 (TNF)    05142 Chagas disease     103682322 (TNF)    05143 African trypanosomiasis     103682322 (TNF)   09163 Immune disease    05310 Asthma     103682322 (TNF)    05322 Systemic lupus erythematosus     103682322 (TNF)    05323 Rheumatoid arthritis     103682322 (TNF)    05321 Inflammatory bowel disease     103682322 (TNF)    05330 Allograft rejection     103682322 (TNF)    05332 Graft-versus-host disease     103682322 (TNF)   09164 Neurodegenerative disease    05010 Alzheimer disease     103682322 (TNF)    05014 Amyotrophic lateral sclerosis     103682322 (TNF)    05020 Prion disease     103682322 (TNF)    05022 Pathways of neurodegeneration - multiple diseases     103682322 (TNF)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     103682322 (TNF)    05418 Fluid shear stress and atherosclerosis     103682322 (TNF)    05410 Hypertrophic cardiomyopathy     103682322 (TNF)    05414 Dilated cardiomyopathy     103682322 (TNF)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103682322 (TNF)    04940 Type I diabetes mellitus     103682322 (TNF)    04936 Alcoholic liver disease     103682322 (TNF)    04932 Non-alcoholic fatty liver disease     103682322 (TNF)    04931 Insulin resistance     103682322 (TNF)    04933 AGE-RAGE signaling pathway in diabetic complications     103682322 (TNF)   09176 Drug resistance: antineoplastic    01523 Antifolate resistance     103682322 (TNF)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:umr04052]     103682322 (TNF)    00536 Glycosaminoglycan binding proteins [BR:umr00536]     103682322 (TNF) Cytokines and neuropeptides [BR:umr04052]  Cytokines   Tumor necrosis fators    103682322 (TNF) Glycosaminoglycan binding proteins [BR:umr00536]  Heparan sulfate / Heparin   Cytokines    103682322 (TNF) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  TNF Motif Other DBs NCBI-GeneID:  103682322 NCBI-ProteinID:  XP_008710131 UniProt:  A0A384DSV1 LinkDB All DBs Position Unknown AA seq 233 aa AA seqDB search MSTESMIRDVELAEEALPKKAGGPQGSRRCLCLSLFSFLLVAGATTLFCLLHFGVIGPQR EELPDGLQLINPLAQTVKSSSRTPSDKPVAHVVANPEAEGQLQWLSRRANALLANGVELT DNQLIVPSDGLYLIYSQVLFKGQGCPSTHVLLTHTISRFAVSYQTKVNLLSAIKSPCQRE TPEGTEAKPWYEPIYLGGVFQLEKGDRLSAEINLPDYLDFAESGQVYFGIIAL NT seq 702 nt NT seq  +upstreamnt  +downstreamnt atgagcactgaaagcatgatccgggacgtggagctggccgaggaggcactccccaagaag gcagggggcccccagggctccagaaggtgcttgtgcctcagcctcttctccttcctcctc gtcgcaggagccaccacgctcttctgcctgctgcacttcggcgtgatcggcccccagagg gaagagctcccagatggactccaactaatcaaccctctggcccagacagtcaaatcatct tctcgaactccaagtgacaagcctgtagctcatgttgtagcaaaccccgaagctgagggg caactccagtggctgagccggcgtgccaatgccctcctggccaatggtgtggagctgaca gacaaccagctaatagtgccatcagacgggctgtacctcatctactcccaggtcctcttc aagggccaaggatgcccttccacccatgtgctcctcacccacaccatcagccgcttcgct gtctcttaccagaccaaggtcaacctcctctctgccatcaagagcccttgccaaagggag accccagaggggactgaggccaagccctggtacgagcccatctacctgggaggggtcttc caactggagaagggtgatcgactcagcgctgagatcaacctgcctgactacctcgacttt gccgagtctgggcaggtctactttggaatcattgccctgtga

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