Ursus maritimus (polar bear): 121101279 Help Entry 121101279         CDS       T03271                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism umr  Ursus maritimus (polar bear) Pathway umr04022   cGMP-PKG signaling pathway umr04068   FoxO signaling pathway umr04081   Hormone signaling umr04140   Autophagy - animal umr04152   AMPK signaling pathway umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04910   Insulin signaling pathway umr04920   Adipocytokine signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04930   Type II diabetes mellitus umr04931   Insulin resistance umr04932   Non-alcoholic fatty liver disease umr04935   Growth hormone synthesis, secretion and action umr05010   Alzheimer disease umr05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     121101279 (IRS2)    04022 cGMP-PKG signaling pathway     121101279 (IRS2)    04152 AMPK signaling pathway     121101279 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     121101279 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     121101279 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     121101279 (IRS2)    04923 Regulation of lipolysis in adipocytes     121101279 (IRS2)    04920 Adipocytokine signaling pathway     121101279 (IRS2)    04935 Growth hormone synthesis, secretion and action     121101279 (IRS2)   09149 Aging    04211 Longevity regulating pathway     121101279 (IRS2)    04213 Longevity regulating pathway - multiple species     121101279 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     121101279 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     121101279 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     121101279 (IRS2)    04932 Non-alcoholic fatty liver disease     121101279 (IRS2)    04931 Insulin resistance     121101279 (IRS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH MEKK4_N Motif Other DBs NCBI-GeneID:  121101279 NCBI-ProteinID:  XP_040480454 UniProt:  A0A8M1FIK4 LinkDB All DBs Position Unknown AA seq 1327 aa AA seqDB search MASPPLHGPPGPAGGDGPNLNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGDEATATA GGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYF AVAAENEQEQEGWYRALTDLVSEGRAGDAPPAAATAASCSASLPGALGGSAGAAAADDSY GLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMN IRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRS KSQSSGSSSTHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTA SEGDGGAAAGAGAAGGRPVSVAGSPLSPGPVRAPLSRSHTLSGGCGARASKVALAPAGGA LQHSRSMSMPVAHSPPAATSPSSLSSSSGHGSGSYPPPPGPHPHLQHALHHPAGQRPSSG SASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGSGGELYGYMTM DRPLSHCGRPYRRVSGDGGQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATF SGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGVALLGG GSGSCKSDDYMPMSPTSVSAPKQILQPRAAAAALPPTGAAVPAPTPTASRAFPANGGSYK TSSPAESSPEDSGYMRMWCGSKLSMENTDTKLLPNGDYLNMSPSDAGTSGTPPDFFSAAL HGSGEMLRGVPGYCYSSLPRSYKAPYTCNGDNDQYVLMSSPVGRILEEERLEPPAGPGAP STSAFAAGGGHIQPPHPVVPSPSRPSGSSGGRPEGFLNQRCRLVRPTRLSLEGLQTLPSM HEYPLPPEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPG TSSDSRQRSPLSDYMNLDFSSPKSPKPGTQSGDPVGSLDALLSPEASSPYPPLPPRPAAP TSSLQPQPPPPPPPGELYRLPQASTSQGPSAASSSSSETGDNGDYTEMAFGVAATPPQPI AAPPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRH SSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGGSGVLGGGDERPTSPRQL QPPPPQQARPWVPSQPGGLVGCPGGSGSPMRRETSAGFQNGLNYIAIDVRDEPGLSAAPQ QHPHPQPGDKSAWGRTRSLGGLISAVGGSGSGGVCGGPGPGALPSANTYASIDFLSHHLK EATIVKE NT seq 3984 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccaccgctgcatgggccccccgggccggcgggcggcgacggccccaacctc aacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcagaag cacggccacaagcgtttcttcgtgctgcgcgggcccggcgacgaggcgacggcgacagcg ggcggggggccggcgccgcagccgccgcggctcgagtactatgagagcgagaagaagtgg cggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctaaacatcaac aagcgcgccgacgccaaacacaagtacctgatcgcgctctacaccaaggacgagtacttc gcggtggcggccgagaacgagcaggagcaggagggctggtaccgcgcgctcaccgacctg gtcagcgagggccgcgccggcgacgcgccccccgccgccgccaccgccgcgtcctgcagc gcctccctgcccggcgccctgggcggctcggccggcgccgccgcggccgatgacagctac gggctggtggcgcccgccacggccgcctaccgcgaggtgtggcaggtgaacctgaagccc aagggcctgggccagagcaagaacctgacgggcgtgtaccgcctgtgcctgtcggcgcgc accatcggcttcgtgaagctcaactgtgagcagccgtcggtgacgctgcagctcatgaac atccgccgctgcggccactcggacagcttcttcttcatcgaggtgggccggtcggctgtc acgggcccaggtgagctgtggatgcaggccgacgactcggtggtggcgcagaacatccac gagaccatcctggaggccatgaaggcactcaaggagctcttcgagttccggccgcgcagt aagagccagtcgtcgggctcgtcctccacacaccccatcagcgtccccggcgcgcgccgc caccaccacctggtcaacctgccccccagccagacgggcctggtgcgccgctcgcgcacc gacagcctggccgccaccccgccggccgccaagtgcagctcttgtcgggtgcgcacggcc agcgagggagacggcggcgcggcggcgggggcgggggcggcgggcggcaggcctgtgtct gtagccgggagtcccctgagccccgggccggtgcgcgcgcccctgagccgctcacacacc ctgagcggcggctgcggcgcccgcgcgagcaaggtggcgctggcgccggcagggggcgcc ctgcaacacagccgctccatgtccatgccggtggcgcactcgcccccagccgccaccagc cccagcagcctgtcgtccagcagcgggcatggctccggttcttacccgccgccgccaggc ccgcatccgcacctgcagcacgccctgcaccaccccgcgggccagcggccctccagcggc agcgcctcggcctccggctcccccagcgaccctggcttcatgtctctggatgagtatggc tccagccctggggacctgagagccttctgcagccacaggagcaacacgcccgagtccatc gctgagacacctccggccagagacggcagcgggggcgagctgtacgggtacatgactatg gacaggcccctgagccactgtggtcgcccctaccgcagagtctctggggacgggggccag gacttggaccgagggctgaggaagaggacttactccctgaccacacctgcccggcagcgg ccagtgccccagccctcctctgcatccctggatgaatacaccctgatgcgggccacgttc tccggcagctccggccgcctctgcccatcctgtcccgcgtcatctcccaaagtggcctac cacccctatcctgaggactatggcgacatcgagatcgggtcccataggagctctagcagt aacctgggtgccgacgatggctacatgcccatgacccctggcgtggccctcctgggtggt ggcagtggcagctgtaagagtgatgactacatgcccatgagccccactagcgtgtctgcc ccgaagcagatcctgcagcctcgggccgcggccgcagccctgccccccacaggagccgca gtgcccgcacccacccctacggccagtagggcctttccagcgaacgggggcagctacaag acgagctccccagccgagagctcccctgaggacagtgggtacatgcgtatgtggtgtggc tccaagctgtccatggagaacactgacaccaagctgctacccaacggggactacctcaat atgtcccccagcgacgcgggtacctcagggacacctcccgacttcttctcggctgccttg catggcagcggggagatgctcaggggagtccctggctattgctatagctccctgcctcgc tcctacaaggctccctacacgtgcaatggggacaacgaccagtatgtgctcatgagctcc cccgtggggcgcatcctggaagaggagaggctagaaccgcctgccggccctggcgcacca tccactagcgctttcgcggccggaggcggccacatccaacctcctcacccagtagtgcct tcgcccagcaggccgagtggcagcagcggtggccgcccagagggcttcctgaaccagcgc tgccggttagtgcggcccacacgcctgtccctggaggggcttcagaccctgcccagcatg cacgagtaccctctgccgcctgagcccaagagcccgggcgagtacatcaacattgacttt ggtgaagccggaactcgcctgtctccgcccgcgcctccgctgctggcttcggcggcctca tcgtcctcactgctgtccgccagcagcccggcctcgtccctgggctcgggcaccccgggc acgagcagcgacagcaggcagcgctccccactctccgactacatgaaccttgacttcagc tcgcccaagtcacccaagccgggcacccagagcggggaccccgtgggctccctggatgcc ctcctgtcccctgaggcctcgtccccctacccaccgctgcccccccgtcctgcggccccc acctcctccctgcagccgcagccgcccccaccgccccccccaggggagctgtaccgcctg ccccaggcgtcaacttcccagggccccagtgctgcctcctcttcgtcctcggagactggg gacaatggtgactacaccgagatggcctttggcgtggctgccaccccaccacaacccatc gcggcccccccgaagccggaaggtgcccgcgtgaccagccccacctccggcttgaagagg ctgagtctcatggatcaggtgtcgggagtcgaggccttcctgcaggcgagccagccccca gaccctcaccggggagccaaggtcatccgcgcagacccacaggggggccgccgccgccac agctccgagaccttctcctcgaccaccactgtgacccccgtgtccccatccttcgcccat aaccctaagcgccacaactcggcctctgtggaaaacgtctctctcaggaaaagcagcgaa gggggcggcagcggcgtcctgggtgggggcgacgagcgccccacgtccccccgccagttg cagccaccgcccccccagcaggcgcgcccatgggtaccaagtcagcctgggggcttggtt ggctgccctgggggcagtgggtctccaatgcgcagggagacctctgccggcttccagaac ggcctcaactacatcgccatcgacgtgagggacgagcctgggctgtcagcggccccacag cagcatcctcatccgcagcccggagacaagagcgcctggggccggacccgcagcctcggg ggcctcatcagcgctgtggggggcagcggcagcggtggggtatgtggggggccgggccct ggcgccctaccctctgccaacacctatgccagcattgacttcttgtcccatcacctgaag gaggccaccattgtgaaagagtga

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