Vibrio cholerae O1 O395: VC395_0434
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Entry
VC395_0434 CDS
T02099
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate--homocysteine methyltransferase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
vcr
Vibrio cholerae O1 O395
Pathway
vcr00270
Cysteine and methionine metabolism
vcr00450
Selenocompound metabolism
vcr00670
One carbon pool by folate
vcr01100
Metabolic pathways
vcr01110
Biosynthesis of secondary metabolites
vcr01230
Biosynthesis of amino acids
vcr04981
Folate transport and metabolism
Module
vcr_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
vcr00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
VC395_0434 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
VC395_0434 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
VC395_0434 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
VC395_0434 (metH)
04980 Cobalamin transport and metabolism
VC395_0434 (metH)
Enzymes [BR:
vcr01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
VC395_0434 (metH)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ACP08455
UniProt:
A0A0H3AM09
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Position
I:458471..462151
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AA seq
1226 aa
AA seq
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MGKEVRQQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLT
QPQIIKEIHSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWT
AKDPSRPRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLIL
IETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVR
PISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWA
QAGFLNLVGGCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNV
GERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNL
CASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAA
VIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYA
LDFINAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNA
GQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPV
AKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVV
KSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIID
LGVMVPCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSK
AHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTP
KSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMG
KYPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDES
RTQVAHVLYNLRQQTEKPKGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKA
QGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPG
YPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPD
QLHSYAERKGWRLEEAEKWLAPNLDA
NT seq
3681 nt
NT seq
+upstream
nt +downstream
nt
gtgggaaaagaagtaagacaacaactcgaacagcaattgaaacaacgtatcctactgatt
gatggtggtatgggtaccatgattcagagttataagttacaagaggaagactatcgcggt
gcacgatttgtcgattggcactgtgatttgaaaggaaataacgacctcttagtgcttact
cagccgcaaattattaaagagattcactccgcttaccttgaagcgggggcggatattctt
gagaccaacacctttaactcaaccacgattgccatggcagactatgacatgcaatcgctc
agtgctgaaattaactttgccgcggctaagcttgcacgtgaagtcgcggatgagtggacg
gctaaagatccaagtcggccacgctatgtggctggtgtgcttgggccaaccaaccgtact
tgctctatttcgccagatgtgaacgatccaggatttcgtaacgtcacttttgatgggctt
gttgaagcctattccgaatcgacgcgcgctttgatcaaaggtggcagcgatctgatcctc
attgaaaccatcttcgatacacttaacgccaaagcctgtgcgtttgcggtcgatagcgta
tttgaagagctgggcatcagcttacctgtgatgatttccggcacgattaccgatgcctct
gggcgaactctgtcaggacagacaacggaagctttctacaacgccttgcgtcatgtacgg
ccgatttcgtttggcttgaactgtgcgttaggtcctgatgagctgcgccagtacgtggaa
gagctttcacgcatttcagaatgctatgtttccgcgcacccaaatgccggactgcccaat
gcgtttggtgaatacgatctctctgccgaggaaatggcagaacatattgcggaatgggca
caagctggctttttgaatttggtcggtggttgctgtggaactacacctgagcatatcgcc
gccattgccaaagccgtcgagggtgtaaaaccaagggctctgccagatctgaaagtagaa
tgtcgtctctcgggtttagagccgctcaatattggccctgaaaccttgtttgttaacgtg
ggcgaacgtactaacgtcaccggttctgcgcgttttaagcgtttaattaaagaagagcaa
tacgacgaagcgctcgatgtggcgcgtgagcaagtcgaaaacggcgcgcagatcattgat
atcaacatggatgaaggcatgttggacgccgaggcgtgtatggtgcgctttttgaatcta
tgcgcctctgaaccagaaatatccaaagttccggtgatggtcgactcctctaaatgggaa
gtcattgaagcgggtctgaaatgcattcagggtaaaggcatcgtcaactctatctctcta
aaagaagggaaagagaagtttattgcccaagccaaattggtgcgccgctacggtgccgcg
gtgattgtgatggcatttgacgaagtgggccaagccgatacccgtgagcgcaaattagag
atctgtcgtcgggcttaccatattttggtcgatgaggtgggcttcccaccggaagatatt
atttttgacccgaacatctttgctgttgcgaccggaattgatgagcacaataactacgca
ctggatttcattaatgcagtggcggacattaagcgtgagctgccgcatgcgatgatttct
ggcggtgtttctaacgtttccttctctttccgcggcaacaactatgtgcgtgaagcgatc
catgctgttttcctttatcactgcttcaaacacggcatggacatggggattgtcaacgca
gggcagcttgaaatctacgataacgttccgctgaaactgcgtgaggcagtggaagatgtg
atcctcaatcgacgtagcgatggcacggaaagactgcttgagatcgccgaagcgtatcgc
gaaaacagtgttggtaaagaagaggatgcttctgcattagagtggcgcgcatggcctgtg
gctaagcgcctagagcacgctttagtcaaaggcatcaccgaatttatcgtccaagacact
gaagaagcacgtcagcaagccagtaaaccactggaagtgattgaagggccgctgatggat
ggtatgaacgtggtcggtgacttgttcggggaagggaaaatgttcctaccgcaagtcgta
aaatcagcgcgtgtcatgaaacaagccgttgcgtatcttgagcctttcattaatgcgcaa
aaaagtggtagcacttcaaatggtaagattttgctggcgaccgtaaaaggcgatgtgcat
gacattggtaagaacattgttggcgtcgtgctgcagtgtaataacttcgagatcatcgat
cttggtgtgatggtgccttgcgagcagatcctcaaagtcgcacgcgagcaaaatgtcgat
atcatcggtctctctgggcttatcacgccgtctttggatgagatggtacacgtggcgaaa
gagatggagcgacaagggtttgaactgccacttttgattggtggggcaacaacgtctaaa
gcgcatactgcggtgaagattgaacagaattatcatgcgcctgtagtgtacgtgaataac
gcgtcgcgcgcggtaggggtgtgcacatcattattgtctgatgaacagcgccccggattt
atcgaacgtttggatctcgattatgagcgcacgcgtgatcagcatgctcgtaaaacgccc
aaatcgcgcccagtcacgttagagcaggcacgtgctaataaagcggcgctggattgggca
aattacacgccgcccgctcctgcgaaaccgggtgtgcatgtgtttgaaaacattgcgtta
gccacactacgtccttatatcgattggacgcctttttttatgacttggtcgcttatgggc
aaataccctgccattttggagcatgaagaggtcggtgaagaggccaaacgtctgtttcat
gatgccaatgccttacttgataaagtagagcgagaaggactactgaaagccagtggtatg
tgtgcactgtttccagcagccagcgtgggcgatgacattgaggtgtacagtgatgaatcg
cgtacgcaagtcgcgcatgtgctgtacaacttgcgtcagcagactgagaaaccgaaaggg
gccaactactgtttgtcggactatgttgctccgaaagagagcggtaaacgtgattggatt
ggcgcgtttgcagtaactggtggcattggtgagcgagccttggccgatgcttataaagct
cagggtgatgattacaatgcgatcatgatccaagcggtagccgatcgtttggcggaagcc
tttgcggaatatctgcatgaaaaagtgcgtaaagagatttggggttatgcgagcgatgaa
aatctctccaatgatgacctgatccgtgagcgttatcagggcattcgacccgcgccgggg
tatcccgcgtgtcctgagcataccgagaaagcgactttgtggcagatgctaaatgtcgaa
gagaccataggtatgtcactgaccacaagctatgcgatgtggccgggcgcttcggtatcc
ggttggtatttctcgcatcccgattctcgctattttgcggtagcgcagatccaaccagat
caactgcacagctacgctgagcgtaaaggttggcgtttggaagaagctgaaaagtggcta
gcgcctaaccttgatgcttaa
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