Varanus komodoensis (Komodo dragon): 123025844 Help Entry 123025844         CDS       T07701                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism vko  Varanus komodoensis (Komodo dragon) Pathway vko04020   Calcium signaling pathway vko04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:vko00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123025844 (RYR1)    04020 Calcium signaling pathway     123025844 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:vko01009]     123025844 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:vko04147]     123025844 (RYR1)    04040 Ion channels [BR:vko04040]     123025844 (RYR1) Protein phosphatases and associated proteins [BR:vko01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      123025844 (RYR1) Exosome [BR:vko04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    123025844 (RYR1) Ion channels [BR:vko04040]  Voltage-gated cation channels   Ryanodine receptor    123025844 (RYR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 SecE Motif Other DBs NCBI-GeneID:  123025844 NCBI-ProteinID:  XP_044290863 Ensembl:  ENSVKKG00000012828 LinkDB All DBs Position Unknown AA seq 5021 aa AA seqDB search MAEGGGEGEDDILFLRTDDEVVLQCSATILKEQLKLCLAAEGFGNRLCFLEPTSNAQKVP PDLAICCFSLEQSLSVRALQEMLANTVEVGSESSQGGGHRTLLYGHAILLRHSHSGMYLS CLTTSRSLTDKLAFDVGLQEDATGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERY LHLSTASGELQADASFMQTLWNMNPICSGCEEGYVTGGHVMRLFHGHMDECLTISTTDQN EEQRKVVNYEGGAVCSQARSLWRLEPLRISWSGSHMKWGQPFRVRHVTTGRYLALTEEKG LVVVDAEKANTKATAFCFRISKEKLDVAPKRDVEGMGAPEIKYGESMCFVQHVDSGLWVT YAAADAKALRLGIVKRRAILHQEGHMDDALSLTRCQHEESQAARMIYSTSGLYNQFIKGL DTLSGKVKLSTPVTLPISGMILSLQDLINYFQHPEEELQHEEKQTKLRSLKNRQNLFQEE GMITLVLNCIDRLNVYSTAAHFAEFAGEDAAESWKEIVNLLYELLASLIRGNRSNCALFS NNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTKLINHVTSMRPNIFLGTHEGSTQYKK WYYEMMVDYVEPFMTAQVTHLRVGWAMAEGYSPYPGGGEGWGGNGVGDDLYSFGFDGLHL WSGRVARAVASPGQHSLGADDVVSCCLDLSVPSISFRINGFPVQGMFENFNLDGLFFPVV SFSAGVKVRFLLGGRHGDFKFLPPPGYAPCYEALLPREKMRVEPIKEYKHDFNGFRNLLG PTQSLSHTSFTPYPVDTMQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPIRDDNK RLHPCLLDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEENLKKTKLPKTYTM SNGYKPAPLDLNHVKLTPAQNTLVDKLAENGHNVWARDRVQQGWTYSVMQDIKNKRNPRL VPYILLDERTKKTNRDSLREAVRTLIGYGYNIEPPDQEASQDLTKSRSEKVRIFRAEQFY AVKSGKWYFEFEAVTTGEMRVGWARPNVRPDVDLGADELSYVFNGHRGQRWHVGSEPFGR PWQPGDVVGCMIDLGDNSIMFTLNGEMLISDSGSELAFKEVEIGDGFIPVCSLGLSQVGR LNLGQDVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFSPVPVEHPHYEVSRID GTVDNPPCLKLTHRTFGSQNAVVELLFLRLSMPVEFHEKFKIAAGTTPLTHTLTIPEDEV KDVDLDSEFEQLKKTASRKEAEEAEKEKQGPAPPTTPKEPPKEASKAENEKDASTEKSKA KRGFLFKAKKATTFITPPPVVPTVPRLEEEVVPDDRDDPEIIMNTTTYYYSVRIFAGQEP TCVWVGWVTPDYHQHDMNFDLTKVRNVTVTMGDDKGNIHDSIKRSNCYMVWGGDFVSSTQ QTRVSTVDLVIGCLVDLATGFMSFTANGKEVNTFFQVEPNTKLFPAVFTLPTSQNVIQFE LGKLKNIMPISAAMFRSERKNPEPQCPPRLVIQVLTPMTWSRMPNEFLRVDVARFSERHG WMVECLEPNIMMALHIPEESRCIDILELSERLDLLKFHSHTLKLYCAVCALGNNRVAHAL CSHVDESQLLYTIESNHLPGLLRSGYYDLLISMHLESAKRSRLTMNNEFIVPMTDETKSI TLFPDDTKKPGLPGVGMSTCLRPPLHFADTCFVSTSSELYQLSPSIPLDILKVKAINMLT EAVQDGGQHTRDPVGGSVEFQFVPVLKLICTLLIMGVFEDEDVRHILKMIEPNVFGEPKE EEEEVPAGTEEGEEQVPAEEEEELEEEEMAEAEEEFEEEAEKEDEEGLEEGLLQMKLPES VKLQMCNLLQFFCDRELQHRVEAIIAFSERYVDRMQINQRQRYSTLMQAFTMSAAETARR TREFRSPPQEQINMLLQFKNGADEEDCPVPDEIRDELLEFHTDLLSHCGIQSEGEEEEEE EDTSFRRRLMNLVEKVVSLRKKKADLEEEQPPEDKPKPSTLQELISHTMVHWAQESFIQS PELVRVMFSLLHRQYDGLGELLRALPKAYTINANSVDDTMSLLECLGQIRSLLIVQMGLE EENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPKMVTNCC RFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMRGSTPLDVAAASVIDNNELALALQEQ DLEKVVTYLAGAGLQSCSMLLSKGYPDIGWNPCGGERYLDFLRFTVFVNGESVEENANVV VRLLIRRPECFGPALRGEGGNGLLAAIEEAIQISQDPARDGPTVKKDRRRELFGGEETHE ENRVHLGNAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISL PLQIPSFGKDGSVIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLDVLEVGFLPDMRA AASLDTAAFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTIYRLSRG RSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPILNEFSKMSLKLLTNHYERCW KYYCLPTGWANYGVTSEEELHLTRKLFWGIFESLSHKKFDPDLYKLAMPCLCAIAGAIPP DYVDASYSSKTEKKASVDAEGNFDPKPVETLNVIIPEKLDSFINKYAEYTHEKWAFDKIQ NNWSFGETVDEEAKTSPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEE KTEKKKTRKISQSAQTYDPSHGYNPQPIDLSGVTLSRELQAMAEQLAENYHNTWGRKKKL ELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQLNGYAVTRGLKDMELDTSSIE KRFAYGFLQQLLKWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTN HCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAAAVVNCLHILA RSLDARTVMKSGPEIVKAGLRSFFEGASDDIEKMVENLKLGKVSQSRTQVKGVGQNITYT TVALLPVLTSLFEHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNPYVERQRPQLGE CLARLAAAMPVAFLEPHINEYNPYSVYTTKSPRERAILGLPNCVEEMCPDIPVLERLMKD ISGLAESGARYTEMPHVIEVTLPMLCNYLPRWWERGPETHAQGPWCTEVTSDHLNTLLGN ILKIIVNNLGIDEASWMKRLAVFAQPIVSKAKPELLRSHFIPTMEKLKKRSGKVVAEEEQ LRLEAKTESEDAELLIRDEFSVLCRDLYALYPLLIRYVDNNRAKWLTEPNSDAEELFRMV GEVFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMSKSGEGQSGGSDQERTKKKR RGDRYSVQTSLIVATLKKMLPIGLNMCSPTDQELINMAKNRYALKDTDEEVREYLNNNLH LQGKCENSSSMRWQMALYREMSGKAEDSNNPEKIVRRVQEVSAVLYHLEQTEHPYKSKKA VWHKLLSKQRRRAVVACFRMTPLYNLPRHRACNMFLESYKLLWILTEEHPFEDRMIDDLS KPGEEEEEEEEEAEKKPDPLHQLILHFSRTALTEKTKLEEDYLYMAYADIMAKSCHINEG EEGGYGSPEEEEAEVPFEEKEMEKQKLLYQQSRLHNRGAAEMVLQMISACKGEPGAMVSS TLKLGISILNGGNEEVQQKMLDYLKEKREVGFFQSVQALMQTCSVLDLNAFERQNKAEGL GMVTEEGTIISRENGEKVMADDLFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTNTINII ICTVDYLLRLQESISDFYWYYSGKDVIDDQGKRNFSKAMAVAKQVFNSLTEYIQGPCTGN QQSLAHSRLWDAVIGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVV NGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYITDPRGLISKKDFQKA MDSQKQYTPSEIQFLLSCSEADENEMIDYEEFASRFQEPAKDIGFNIAVLLTNLSEHMPH DNRLKTFLELAECILNYFSPYLGRIEIMGASKRIERIYFEISETNKAQWEMPQVKESKRQ FIFDVVNEGGESEKMELFINFCEDTIFEMQIAAQISEEEGQGEEEEEEEGEGTEGGEAEK ATAPSESSSVFGEFVESVLNFFRLFTYRNVRRQFRKIKKMTIKEMAMAVATFVYTILMGI LFFFYNVFKGIFLLIWNTLFGGGLVEEAKKMTVTELLASMPDPTQDEVHGDVAPSEEVEQ VAEEGEEVEIVEPGKEETPAEVGDVFDLKKEHFRSFAPDAPGGLGDMGDTTPVEPPTPEG SPILKRKLTVEGQEEEPEPEKVEEPSVEAEKVDAENGEKAAKEEGEKKEEAPRQDEPEPP AKQKKVSQREKQQPEEGGSEFWNELEIQKTKFLNYLSRNFYNLRFLALFLAFAINFILLF YKVSDTPPGEEEFEGSGFEGELDAGSGADSGFGGEDDGGDGNGDEDDEDSMVYFFLEEST GYMQPALRILAIIHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDD IKGQWDRLVLNAPSFPSNYWDKFIKRKVLDKYGDIYGRERIAELLGMDLSSLEISAQNEK KPEPDKSFLSWVTSIDIKYKIWKFGVIFTDNSFLYLFWYMVMSVLGHYNNFFFASHLLDI AMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKC DDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVIFDITFFFFVIVILLAIIQGLI IDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFDTHTLEEHNLANYMFFLMYLI NKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15066 nt NT seq  +upstreamnt  +downstreamnt atggccgagggaggcggagagggcgaggatgatatcctcttcctccggaccgatgatgaa gtcgtgcttcagtgttcagccacaatcctaaaggaacagctgaagttatgcctggctgct gaaggctttggaaaccggctatgtttcctggaacctacctccaatgctcagaaagtccct ccagatctggccatatgctgcttcagcctggaacagtccttgtcggtacgagccctgcag gagatgctggccaacaccgtagaggtgggctccgagtcttctcaaggtggcggacaccgg accctcctgtacggacacgctattcttcttcggcattcccacagtggcatgtatttaagc tgcctaaccacatcccgctccctgacggataaacttgcctttgacgtgggccttcaggag gatgccacaggagaagcctgctggtggaccatccaccccgcctccaagcagcgatcggaa ggggagaaggtgcgcgttggtgatgacctcatccttgtgagcgtttcctccgagcggtac ctgcacctgtccacagccagcggagaacttcaggcagatgcctccttcatgcaaacgctt tggaacatgaacccgatctgctcaggctgtgaggaagggtatgtgaccggtggccatgtt atgcgcctcttccacggccacatggatgaatgcctcacgatctccaccacggaccagaat gaagagcagcgcaaagtggtgaactatgaaggtggagctgtctgttcccaagctcgttcg ctgtggcgcctggagcccttgcgcatcagctggagcggcagccacatgaagtggggccag cccttccgtgtccgtcatgtcaccacaggccgctacttggcattgaccgaggagaagggg ctggttgtggtggatgctgagaaagccaacaccaaagccactgctttttgcttccggatc tccaaggaaaagctggacgtggccccaaagcgagatgtggaggggatgggggccccggag atcaagtacggcgagtccatgtgcttcgtgcagcatgtggacagcggcctctgggtgacg tatgcggcggctgatgccaaggcgctgcgcctggggatagtcaagagaagggccattttg catcaggaggggcacatggacgacgccctctcgctgacgcgctgccagcatgaggaatcg caagctgctcggatgatctacagcacttctgggctttacaaccagttcatcaagggcctg gacaccctgagtggaaaggtcaagctgagcaccccggtgactcttcccatcagtgggatg attctcagcttgcaggatctgatcaactacttccagcaccccgaggaagagctgcaacat gaggaaaagcagaccaagctccgctctctcaaaaacaggcaaaatctcttccaggaggag ggcatgatcacgctcgtcctgaactgcatcgaccgtctcaatgtgtatagcactgctgcg cactttgcagagtttgccggcgaggatgcggctgaatcctggaaggagattgtcaacctg ttgtacgagctgctcgcctccttgatccgcgggaaccgctccaactgtgctcttttctcc aacaacctggactggctggtcagcaagctggaccgactggaggcttcctctggcatcttg gaagtgttgtactgtgtgctcatcgaaagccccgaagtgctgaacatcatccaggaaaat cacatcaagtctatcatctcactgctggacaaacacgggcgcaaccacaaggtcctggac gtcctctgttctttgtgtgtgtgcaatggcgtggccgtccgttccaaccaaaatcttatc actgaaaacttgctccccgggcgggatctgctcttgcagaccaaactcatcaaccatgtc accagcatgcgccccaacatcttcctgggcacgcatgagggctccacccagtacaagaag tggtactatgaaatgatggtggattacgtggagccatttatgactgcccaggtcacccac ctgcgggttggctgggccatggcagagggctacagcccctaccctgggggcggggaaggc tggggaggcaacggcgttggagatgacctctactccttcggatttgacggcctgcacctg tggtcagggcgtgtggctcgggctgtggcgtcaccagggcagcacagcttgggggcggac gacgtggtgagctgctgcctcgacctgagcgttcccagcatctccttccgcatcaacggc ttcccggtgcagggcatgtttgagaacttcaacctggatggtctcttcttccccgtggtc agcttctctgcgggcgtcaaggtgcggttcctcctgggagggcgccatggggacttcaag ttcctgcccccaccgggctacgctccctgctatgaggccctcttgccccgggagaagatg cgtgtggagcccatcaaggagtataagcacgacttcaacgggttccggaatctcctaggc cctacacagtccctgtcccacacctccttcacgccctacccagttgacaccatgcagatc gtattgcccccacaccttgagcggatccgggagaaattggccgagaatattcatgagctt tgggccctgacccgcatagaacaagggtggacttacggacctatccgagatgataacaag cgcttgcacccgtgtttgctggattttcatagcctgcctgaaccagaacgtaattacaac ctgcagatgtcgggagagacactcaagaccttgcttgctctgggctgccatgtggggatg gcagacgaaaaagctgaagagaacctcaagaaaaccaagcttcccaaaacatacacgatg tccaacggctataaaccagcaccgctggatctcaaccatgtcaagctaactccagcccag aataccctggtggacaagttggctgagaacgggcacaacgtctgggcaagggatcgtgtc cagcagggctggacctatagtgtcatgcaggacatcaaaaacaagcgcaacccccgcctg gtgccgtacatcctgttagacgaacggaccaagaaaacaaaccgggacagcttgcgtgag gcggtgcgcaccctcattggctacggatacaacattgagccgccagaccaggaagccagt caagacctgaccaaaagccggtcagagaaggtccgcatcttccgggctgagcagttctat gcagtgaagtcgggcaaatggtactttgagtttgaggcagtcaccaccggcgagatgcgt gtgggctgggcgcggccgaatgtgcggcccgacgtggacctgggagcggacgagctctcc tatgttttcaacgggcatcggggccaacgctggcatgtgggcagcgagccttttgggcgc ccgtggcaaccaggtgatgtggttggctgcatgatagatctcggcgacaacagcatcatg ttcacgctcaatggggagatgctgatcagcgactcggggtcggaactggccttcaaagag gtcgagattggagatggcttcatccccgtttgtagcttgggcctgtcccaggttgggcgt ctgaacttgggccaggatgtcagcagccttcgctacttcaccatctgcggcctgcaggaa ggctttgagccctttgccatcaacatgaagcgggacatcaccatgtggttcagcaagagc ttgccccagttttcccctgtgccagtggagcaccctcactatgaggtgtcgcggatcgac ggcaccgtggacaacccgccgtgcctgaagctgactcaccggacctttggctcccagaac gcagtggtggagcttctcttcttgcgcctcagcatgcctgtggagttccacgagaagttc aaaatcgccgccggaacaacgcctctcacccacacgctcaccatccctgaggacgaggtc aaggacgtcgacctggattcggagttcgagcagctgaagaaaactgccagccgcaaagag gctgaggaggcggagaaggagaagcaaggccccgctccgcccaccactcccaaggagcct cccaaggaggcctccaaggctgagaacgagaaggacgcctccacggaaaaaagcaaggcc aagcgcggcttcctgttcaaagccaagaaggccaccacttttatcaccccgcctcccgta gtacccacagttccgcgactggaagaagaggttgttccagatgatagagatgaccctgag atcatcatgaacaccacaacgtactactactcggtgcggatctttgcaggccaggagccg acctgtgtctgggtcggctgggtcacacctgactatcaccagcacgacatgaactttgac ctcaccaaagtgcgcaatgtcactgtcaccatgggcgacgataagggaaacatccatgac agcatcaagcgaagcaactgctacatggtctggggaggggactttgtcagcagcacgcag cagacccgcgtcagcaccgtggacctggtgatcggctgccttgttgatttggccacaggc ttcatgagcttcacagccaatgggaaagaggtcaacactttctttcaggtggagccaaac accaagctgtttcctgctgtttttactctcccaacaagccagaacgtcatccagtttgaa ctaggcaagctgaagaacatcatgcccatctcagctgccatgttccgcagtgagaggaag aaccccgaaccccagtgcccgcctcggcttgtcatccaggtgctgacacctatgacctgg agccgcatgcccaacgagttcctgcgggtagacgtggcccgtttcagcgaacggcacggc tggatggtcgagtgccttgagcctaacatcatgatggccctccacatccccgaggaaagc cggtgcatcgacatcctggagctgtccgagcgtctggacctgctgaagttccactcgcac accctgaagctgtactgcgccgtgtgtgccctgggcaacaaccgagtggcgcacgccttg tgcagccacgtggatgagtcgcagctgctgtacaccatcgagagcaaccacctgccgggc ctcctgcgcagcggctactacgacctgctcatcagcatgcacctcgagtcggccaagcgc tcccgcctcacgatgaacaacgaattcatcgtccccatgacggacgagaccaagagcatc acgctcttcccggacgacacgaagaagcccggtttgcccggcgtgggcatgagcacctgc ctccgcccccctctgcattttgcagacacctgcttcgtcagcaccagctctgagctgtac cagttgagcccttccatccccttggacatcctgaaggtgaaggccatcaacatgctgacc gaggctgtccaggatggcgggcagcacacccgggacccggtgggaggcagcgtggagttc cagtttgtgcccgtcctcaagctgatctgcaccctcctcatcatgggtgtctttgaggat gaggacgtgcgccacatcctcaagatgatcgagcccaacgtatttggggagcccaaggaa gaggaggaagaggtgccggcggggactgaagaaggagaggagcaggtgcctgcggaggag gaggaggagctggaggaggaagagatggccgaggcagaggaggagtttgaagaggaagca gagaaggaggacgaagaagggctagaggaaggcctgctgcagatgaagcttcctgaatct gtcaagctgcagatgtgcaatctgctgcagttcttctgcgatcgtgagctgcagcaccgc gtggaagccatcatcgccttttctgagcgctatgtggacaggatgcagatcaaccagcgc cagcgctacagcaccctgatgcaggccttcaccatgtccgctgctgagacggcccggcgc actcgggagttccgatcccctccacaggagcagattaacatgctgctacagtttaagaat ggtgctgacgaagaggactgcccggtaccggacgagatccgtgatgagctgctggagttc cacacagacttgctgtcacactgtggtatccagtcagagggtgaggaggaggaggaggag gaagatacatccttccgccggcggttgatgaacctggtggagaaggtggtgagcctccgc aagaagaaggcggacctggaagaggaacagcctccggaagacaagccaaagcccagcact ctgcaggagctgatctctcacaccatggttcactgggcccaagagtccttcatccagagc ccagagctggtccgggtcatgttcagccttctccacaggcagtacgacggcctcggcgag ttactccgtgccctgccgaaggcctacaccatcaacgccaactccgtggacgacactatg agcctgctggagtgcctgggccagatccgttcactgctcatcgtccagatggggcttgaa gaggagaacctgatgattcagagtattggcaatattatgaacaacaaagttttctaccag caccccaacttgatgagggccctgggcatgcacgagaccgtcatggaggtgatggtgaat gtgctgggcggaggggattccaaggagatccgcttccccaagatggtgaccaactgctgc cgcttcctgtgctacttctgccgcatcagccgccagaaccagcgctccatgttcgaccat ctcagctacctgctggagaacagcggcattgggctgggcatgcgtggatccacccccttg gacgtggccgctgcgtctgtcattgacaacaacgagctggccctggctctgcaggagcaa gacctggagaaggtggtgacctacctggccggggctggccttcagagctgctccatgctg ctctccaaggggtacccggacatcggctggaacccctgcgggggcgagcgctacctggac ttcctgcgcttcactgtctttgtcaacggtgagagcgtagaagagaacgccaacgtggtt gtgaggttgctgatccggcgtcctgagtgctttggccctgccctacggggtgagggtggc aacgggctgttggcggcaatagaggaggccatccagatctcccaggatccggcccgggat gggcctaccgtcaagaaagaccgccgtcgggagctgtttgggggagaggaaacacacgag gagaaccgggtgcacttgggcaatgcgatcatgtccttctatgctgccctcatcgatttg ctggggcgttgtgcccccgagatgcatctcatccaggccggaaaaggcgaagccctccgg atcagggccatcttgcgatccttggtgcccattgaggacctggttggcgtcatcagcctc ccgctgcagattccttcattcggcaaagatggcagcgtcatcgagcccaagatgtctgcg agcttcgtgcccgatcacaaggcccccatggtgttgttccttgaccgggtctacggcatc gacaaccaggacttcctgcttgacgtgctggaggtcggattcttgcctgacatgagggca gcggcctcgctggacacggcggccttcagcaccacggagatggcgctggccttgaaccgc tacctgtgcctggccgtgctgccgctcatcaccaagtgtgcgccgctcttcgcgggcact gagcaccgggccatcatggtggactccatgctgcacaccatctaccggctctcccgcggg cgctccctcaccaaggcgcagcgggacgtcatcgaggagtgcctcatggccctgtgcagg tacatccggccctccatgctccagcacctcctgcgccggctggtgtttgatgtgcccatc ctcaacgaattttcaaagatgtcgctcaagctcctgaccaatcattatgagcgttgctgg aagtattactgccttcccactggctgggctaactatggagtcacctctgaggaagagctc cacctgacccgcaagctcttctggggcatctttgagtccttgtcccacaagaaatttgac cctgacctgtacaagcttgccatgccctgcctgtgtgccatcgcgggcgccatcccccct gactatgtggacgccagctactcctccaagaccgagaagaaggcttccgtggacgccgag ggcaacttcgaccccaagccagtggaaacgcttaatgtgatcattcctgagaagctggac tcctttatcaacaagtatgccgagtacactcatgagaagtgggccttcgacaagatccag aataactggtcctttggggagacagtcgacgaggaggccaagacaagccccatgttgcgg ccctacaaaacgttctcggaaaaggacaaggaaatttaccggtggcctatcaaggaatcc ctgaaggccatgattgcttgggagtggactattgagaaggcacgtgaaggtgaagaagag aagacggagaagaaaaagactcgcaagatctcgcagtccgcccagacctatgaccccagc catggctacaacccccagcccatagacctgtctggagtgaccctttccagggaactgcag gccatggcagagcagttggctgagaattatcacaacacctgggggcgcaagaaaaaacta gagctggaagccaaagggggtggcacccatcctctgctggtgccttacgatacactcacg gccaaggagaaggcacgcgaccgagaaaaggctcaagagctgctcaaattcctgcagctt aatggctatgcggtgacaaggggattgaaggacatggaactggacacgtcatccatcgag aaacgctttgcttatgggttcctgcagcagctgctgaaatggatggacatctctcaggag ttcattgcccacctggaggccgtggtgagcagcggacgggtggagaaatctccccatgaa caagagatcaagttctttgccaagatcctgctgcccctgatcaaccagtacttcaccaac cactgtctttacttcttgtccacgccggccaaagtcttgggcagtgggggccatgcctcc aacaaggagaaggagatgatcacaagccttttctgcaaactggcagccctggtcagacac cgggtctccctctttggcaccgatgccgcggctgtggttaactgcctgcatatccttgct cgctctttggatgccaggacagtgatgaagtccggcccggagattgtgaaggcagggctg cgctctttctttgaaggagcctctgacgacatcgagaagatggtggagaaccttaagctg ggcaaggtgtctcagtcccgcacccaggtcaagggggtgggccagaacatcacctacacc acggtggccctcctgcctgtgctcacctccctcttcgagcacattgcacagcaccagttt ggcgacgacgtcatcttggatgacgtgcaggtgtcctgctaccgaacgctctgcagcatc tattccttgggcacaaccaagaatccctacgtggagaggcagcgcccacaacttggggag tgcctggcccggctggcggcagcgatgcccgtggccttcctggagccccatatcaatgag tacaacccctactccgtctacaccaccaagtcaccgagggagcgagccatcctaggcctg ccgaactgcgtggaggagatgtgcccagacataccagtcctggagcggctcatgaaagac atcagcgggctggctgagtcgggggcccgctacacggagatgccccacgtgattgaggtc accttgccgatgctttgcaactacctgccccgctggtgggagcggggcccggagacccac gcccaaggtccctggtgcaccgaggtcacctctgaccacctcaacaccttgctgggcaac atcctgaagatcatcgtcaacaacctgggcatagacgaggcttcgtggatgaagcggctg gcagtctttgcccagcctatcgtcagcaaggccaagccggaactgcttcgctcccacttc atccccactatggagaagctgaagaagcgctccgggaaggtggtggcggaggaggagcag ctgcggttggaggcgaagacggagtcagaggatgctgagctgctgatccgagatgagttc tcagtgctctgtcgggacctctatgccctctaccccctgctcatccgatacgtcgacaac aacagggccaagtggttgacagaaccaaactcggatgctgaggagctcttccggatggtt ggggaggtgttcatctactggtccaaatcgcacaacttcaaacgagaagagcagaacttc gtggtgcagaatgaaatcaacaacatgtccttcctgacggcggacagcaagagcaaaatg tcgaagtctggagaaggccagtcgggtggatcggaccaggagaggaccaagaagaagcgc cggggggaccgatactccgtgcagacgtcgcttattgtggctaccctgaaaaagatgctt cccattgggttgaacatgtgctctcccacggaccaggagctgataaacatggccaagaat cgttatgccttgaaagacactgatgaggaggtccgtgaatacctcaacaacaacctgcac cttcagggcaagtgtgagaattcctcttcgatgcgttggcagatggctctctacagggag atgtccggcaaagccgaagacagcaacaacccagagaagatcgtcaggcgcgttcaggaa gtctctgcggtgctctaccacctggaacagacagagcacccctacaagtccaagaaggcc gtgtggcacaagctgctctccaagcaacgccggcgcgccgtggtggcctgcttccgcatg acgcctctctacaacttgcccaggcaccgggcttgcaacatgttcctagagagctacaag ctgttgtggatcctcactgaagagcacccctttgaagacaggatgatcgatgatctgtct aaaccaggagaggaggaggaggaggaggaggaagaggcagaaaagaagccagaccccctg caccaactcatcttgcatttcagcaggacagcactgacggagaagacaaaattggaagaa gactatctctacatggcatatgctgacatcatggcaaagagctgccacatcaatgaaggt gaagaaggaggttatggcagcccggaagaagaagaggctgaagtcccctttgaggagaag gagatggagaaacagaaactgctgtatcaacagtcccgactgcacaaccgaggtgcagcc gagatggtccttcaaatgattagtgcctgtaaaggagagccgggtgccatggtatcctct actctgaaactgggcatttccatcctgaacggtggcaatgaggaagtgcagcagaaaatg ttggattatctaaaggagaaacgggaagttggattcttccagagtgttcaggctctaatg cagacgtgcagcgtgctggacctgaacgcctttgagaggcaaaacaaagctgaaggactg gggatggtgacggaggaaggaacgatcatcagtcgtgaaaatggagaaaaggtgatggcg gacgatttgtttacacaggacctcttccggttcctgcagctcctttgtgaaggacacaac aatgatttccagaactacctgcggacacagaccggcaacacaaacaccatcaatataatc atctgcaccgtcgactacctcctgcgtcttcaggaatctatcagtgatttctactggtat tactccggcaaggatgtgattgatgatcagggtaagcgcaacttctccaaagccatggcc gtggccaagcaggtcttcaacagcctcactgagtacatccaggggccatgcactgggaac cagcaaagcttagcgcacagccggctgtgggacgccgtcatcggcttcctccacgtcttt gcccacatgatgatgaagctggctcaggattccagccaaatcgggctcctgaaagaactg ctggatctgcagaaggacatggtggtgatgctgctgtccttgctggaaggaaacgtggtt aatggtaccattgctcggcagatggtggatatgttggtggaatcttccagtaacgtggag atgattctcaagttctttgatatgttcttgaagctgaaggacattgtagcctcagatgcc ttccgagattacattacagacccacggggcctcatctccaagaaggatttccagaaggcc atggacagccagaagcaatacacaccatctgagatccagttcttgctctcttgctctgaa gccgatgagaatgagatgatagactacgaggagtttgccagccgtttccaggagcctgcc aaagacatcggcttcaacatcgctgtgctgctgaccaacctctccgagcacatgcctcac gacaaccggctcaagaccttcctggagctggcagaatgcatcctcaactacttcagtccg tacttgggccgtatcgagatcatgggcgccagcaaacgcattgagcgcatctactttgag atcagtgagaccaacaaggcccagtgggagatgccccaggtcaaggagtccaagcggcag ttcatctttgatgtggtcaatgaggggggcgagtcagaaaaaatggagctcttcatcaac ttctgtgaggacaccatctttgagatgcagattgcagcacagatttcggaggaagagggg cagggggaggaagaagaggaggaggaaggagaagggacagaaggtggggaagctgagaag gcaacagcaccgtcagagtcatcctcggtctttggggagtttgtggaaagtgtcctgaac ttcttccgcctgttcacttaccgcaacgtccgccggcagttccgcaaaatcaagaagatg accatcaaggagatggccatggccgtggccacctttgtttacaccattttgatgggcatc ctcttcttcttctataacgtcttcaagggcatcttccttctcatttggaacacgctcttt gggggtggcctggtggaggaggccaaaaagatgacggtcactgaactgctggccagcatg cctgacccaactcaggatgaggtgcatggagatgtggccccctcagaggaggtagaacag gtggcggaggaaggggaagaagtggaaatagtggaacctggcaaggaggaaacacctgct gaagttggggacgtcttcgacctgaagaaagagcacttccgatccttcgcacctgacgca cctggtgggcttggagatatgggggacacaactccagtggaacctcctacccctgaggga tcacccatcctcaaaagaaaactgacagtagaagggcaggaggaggagcccgaacctgag aaggtggaggagccttccgtggaagcagagaaagtagatgctgaaaatggggagaaggca gcaaaggaggagggagaaaagaaggaggaagcgccccggcaggacgagccggagccgcca gccaagcagaagaaggtgtcgcagcgggagaagcagcagcctgaggaagggggctccgag ttttggaacgagctggagatccagaagacaaagttcttgaattatctgtccaggaacttc tacaacctccgcttcctcgccctcttcctggccttcgccatcaacttcatcctgctgttc tacaaggtgtcagacacgccaccaggcgaggaggaatttgaaggctccgggttcgaagga gagctggatgctggctccggtgcggactctggctttggcggggaagatgacggcggagac ggcaacggggacgaggacgacgaggacagcatggtttacttcttcctggaggagagcacg ggctacatgcagccggccttgcggatcttggccatcatccacacgctggtggccttcctc tgcatcatcggctacaactgcctcaaggtgccgctggtcatcttcaagcgcgagaaggag ctggcccgcaagctggagtttgacggcctctacatcacggagcagccggaggacgacgac atcaagggccagtgggaccgcctggtgctcaacgcgccgtcattcccaagcaattactgg gataaattcatcaagagaaaggtgctagataaatatggcgacatctatggacgggagagg attgcagaactgctggggatggatttgtccagtctggaaatctcggcgcagaatgagaaa aaaccagagccagacaaatctttccttagttgggtcacctccattgacatcaagtacaag atctggaaatttggggtgatcttcacagataactctttcctgtatctcttctggtacatg gtgatgtctgtcctcggacactacaacaacttcttctttgcctcccacctcctggacatc gccatgggcgtcaagacgttgcggaccatcctctcctccgtcacccacaacggcaagcag ctggtgatgacggtggggctgctggccgtcgtcgtgtacctgtacacggtggttgccttc aacttcttccgcaagttctacaacaagagcgaggatgaggatgagcccgacatgaaatgc gacgacatgatgacgtgctacctgttccacatgtatgtcggggtgcgtgctggtggtggc atcggagacgagatcgaggacccggcgggcgacgagtacgagctttaccgcgtcatcttt gacatcaccttcttcttcttcgtcatcgtcattctgctggccatcatccaaggtttgatc attgacgcctttggggagctgcgagaccagcaggagcaggtgaaggaggatatggagacc aaatgcttcatctgtggaatcggcagtgactattttgacacgacgccccacggctttgat acccacacgctggaggagcacaacttggctaattatatgttcttcctcatgtacctcatc aacaaggacgaaacggagcacactggccaggagtcctacgtctggaagatgtaccaggag cgctgctgggacttcttccctgccggcgactgcttccgcaagcagtacgaagaccagctc agctag

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