KEGG   Vulpes lagopus (Arctic fox): 121477887
Entry
121477887         CDS       T07435                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
vlg  Vulpes lagopus (Arctic fox)
Pathway
vlg00562  Inositol phosphate metabolism
vlg01100  Metabolic pathways
vlg01521  EGFR tyrosine kinase inhibitor resistance
vlg04012  ErbB signaling pathway
vlg04014  Ras signaling pathway
vlg04015  Rap1 signaling pathway
vlg04020  Calcium signaling pathway
vlg04062  Chemokine signaling pathway
vlg04064  NF-kappa B signaling pathway
vlg04066  HIF-1 signaling pathway
vlg04070  Phosphatidylinositol signaling system
vlg04072  Phospholipase D signaling pathway
vlg04360  Axon guidance
vlg04370  VEGF signaling pathway
vlg04613  Neutrophil extracellular trap formation
vlg04650  Natural killer cell mediated cytotoxicity
vlg04658  Th1 and Th2 cell differentiation
vlg04659  Th17 cell differentiation
vlg04660  T cell receptor signaling pathway
vlg04664  Fc epsilon RI signaling pathway
vlg04666  Fc gamma R-mediated phagocytosis
vlg04670  Leukocyte transendothelial migration
vlg04722  Neurotrophin signaling pathway
vlg04750  Inflammatory mediator regulation of TRP channels
vlg04919  Thyroid hormone signaling pathway
vlg04933  AGE-RAGE signaling pathway in diabetic complications
vlg04935  Growth hormone synthesis, secretion and action
vlg05012  Parkinson disease
vlg05022  Pathways of neurodegeneration - multiple diseases
vlg05135  Yersinia infection
vlg05167  Kaposi sarcoma-associated herpesvirus infection
vlg05170  Human immunodeficiency virus 1 infection
vlg05171  Coronavirus disease - COVID-19
vlg05200  Pathways in cancer
vlg05205  Proteoglycans in cancer
vlg05206  MicroRNAs in cancer
vlg05214  Glioma
vlg05223  Non-small cell lung cancer
vlg05225  Hepatocellular carcinoma
vlg05231  Choline metabolism in cancer
vlg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vlg05417  Lipid and atherosclerosis
Module
vlg_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:vlg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121477887 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    121477887 (PLCG1)
   04015 Rap1 signaling pathway
    121477887 (PLCG1)
   04064 NF-kappa B signaling pathway
    121477887 (PLCG1)
   04066 HIF-1 signaling pathway
    121477887 (PLCG1)
   04070 Phosphatidylinositol signaling system
    121477887 (PLCG1)
   04072 Phospholipase D signaling pathway
    121477887 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    121477887 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    121477887 (PLCG1)
   04660 T cell receptor signaling pathway
    121477887 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    121477887 (PLCG1)
   04659 Th17 cell differentiation
    121477887 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    121477887 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    121477887 (PLCG1)
   04670 Leukocyte transendothelial migration
    121477887 (PLCG1)
   04062 Chemokine signaling pathway
    121477887 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    121477887 (PLCG1)
   04919 Thyroid hormone signaling pathway
    121477887 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    121477887 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121477887 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    121477887 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121477887 (PLCG1)
   05206 MicroRNAs in cancer
    121477887 (PLCG1)
   05205 Proteoglycans in cancer
    121477887 (PLCG1)
   05231 Choline metabolism in cancer
    121477887 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121477887 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    121477887 (PLCG1)
   05214 Glioma
    121477887 (PLCG1)
   05223 Non-small cell lung cancer
    121477887 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    121477887 (PLCG1)
   05171 Coronavirus disease - COVID-19
    121477887 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121477887 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    121477887 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    121477887 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    121477887 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121477887 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    121477887 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121477887 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vlg04131]
    121477887 (PLCG1)
Enzymes [BR:vlg01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     121477887 (PLCG1)
Membrane trafficking [BR:vlg04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    121477887 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    121477887 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 121477887
NCBI-ProteinID: XP_041588345
LinkDB
Position
18:complement(18586410..18622648)
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEDKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDVFPAKQENGDLSPFGMSLRERGSDASGQLFHGRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcttccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccagggaagacctcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgcttcgtcatcctgtatgggatggaattccgcctgaagactctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaagggtttaacttggctg
atggaggatactttgcaggcagccacacctctgcagattgagaggtggctgcggaagcag
ttctactcagtggatcggaatcgtgaggatcgtatatcagccaaggacttgaagaacatg
ctgtcccaggtcaactaccgggttcccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcaactgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggca
ggggagcgcccggagctctgtcgtgtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcgagatcctttgcgagaaattgaagagccttacttcttcctggacgagtttgtcacc
ttcttgttctccaaagagaacagcgtgtggaattcacagctggatgcagtgtgcccagac
accatgaacaaccctctgtcccactactggatctcctcctcccacaacacgtacctgact
ggggaccagttctccagtgagtcctccctggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat
gggcacacccttaccaccaagatcaagttctcagatgttctacataccatcaaggagcat
gccttcgtggcttcagagtatccggtcatcctgtccatcgaggaccactgcagcatcgcc
cagcagagaaacatggcacagtacttcaagaaggtgcttggggacacactcctcaccaag
cctgtggacatcgctgctgacgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagagggcagtgcctacgaagaggtgcctacgtcagtgatg
tactctgagaacgatatcagcaactccatcaagaatggcatcctctacctggaggacccg
gtgaaccatgagtggtacccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaggaggaacccaaggaggccagtggc
agcacagagctgcactccagtgagaagtggttccacgggaagcttggggcaggacgggat
ggacggcacatcgccgagcgcctgctcaccgagtattgcattgagaccggggcccctgat
ggctccttcctcgtgcgggagagcgagaccttcgtgggcgactataccctctctttctgg
aggaacgggaaagtccagcactgtcggatccattcccggcaggatgctggggcccccaag
ttcttcttgacagacaacctggtctttgattcgctctatgacctcatcacgcactaccag
caagtgcccctgcgctgcaacgaatttgagatgcgcctttcagagccggtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggccgagcac
atgctgatgcgtgttccccgggatggggccttcctggtgaggaaacggaatgagcccaac
tcctatgccatctctttccgggccgagggcaagatcaaacattgccgcgtccagcaggag
ggccagactgtgatgctgggcaactctgagtttgacagcctcgtggacctcatcagctac
tatgagaagcacccgctataccgcaaaatgaagctgcgctatcccatcaatgaggaagcg
ctggagaagataggcacagctgagcctgactatggagccctgtatgagggacgcaaccct
ggcttctatgtggaggcaaatcctatgccaacttttaagtgtgccgtcaaagccctcttt
gactacaaggctcagagggatgacgagctgacattcacgaagagtgccatcattcagaat
gtggagaagcaagaaggcggctggtggcggggggactacggggggaaaaagcagctctgg
ttcccgtcaaactacgtagaagagatggtcagccctgcagccctggagcctgagagggag
cacttggatgagaacagccccctgggggacttgctccgtggggtcttggatgtgccagcc
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcttcagtggcacactggtccttggatgtcgctgctgattcacaggaagagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagacgccaggctcacggagggg
aagatgatggagcgcaggaagaagatcgccctggagctctccgagctggttgtctactgc
aggccggttcccttcgatgaagacaagattggcacagaacgtgcgtgctaccgggacatg
tcatcctttccggaaaccaaggctgagaaatatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctcgcgcatctaccccaagggccagcggctggactcc
tccaattatgaccccctgcccatgtggatctgtggcagtcagctcgtagccctcaacttc
cagaccccagacaagcccatgcagatgaaccaggccctcttcatggctggcggccactgc
ggctacgtgctgcagccgagcaccatgcgggacgaggcctttgatccctttgacaagagc
agcctccgaggcctggaaccatatgccatctgcattgaggtgctgggggctcggcacctg
ccaaagaacggccgaggcatcgtgtgccctttcgtggagattgaagtggccggagcagag
tacgacagcatcaagcagaagacagagttcgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagtaacccggaattcgcctttttgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcctggctcaggctacattcccggtg
aaaggcctgaagacaggatacagagctgtgcctttgaagaacaactacagtgaggaccta
gagctggcctccctgctcgtcaagatcgatgtgttccctgccaagcaggagaatggggac
ctcagtcccttcgggatgtctcttcgggagcggggctctgatgcctcaggccagctgttc
catggccgggcccgtgaaggttcctttgaggcccgctaccagcagccatttgaggacttt
cgtatctcccaggagcacctggcagaccattttgacagtcgggaacggagggccccacgg
aggacacgggtcaacggagacaaccgcctctag

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