KEGG   Vulpes lagopus (Arctic fox): 121494738
Entry
121494738         CDS       T07435                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
vlg  Vulpes lagopus (Arctic fox)
Pathway
vlg01521  EGFR tyrosine kinase inhibitor resistance
vlg01522  Endocrine resistance
vlg01524  Platinum drug resistance
vlg04012  ErbB signaling pathway
vlg04014  Ras signaling pathway
vlg04015  Rap1 signaling pathway
vlg04024  cAMP signaling pathway
vlg04062  Chemokine signaling pathway
vlg04066  HIF-1 signaling pathway
vlg04068  FoxO signaling pathway
vlg04070  Phosphatidylinositol signaling system
vlg04071  Sphingolipid signaling pathway
vlg04072  Phospholipase D signaling pathway
vlg04081  Hormone signaling
vlg04140  Autophagy - animal
vlg04150  mTOR signaling pathway
vlg04151  PI3K-Akt signaling pathway
vlg04152  AMPK signaling pathway
vlg04210  Apoptosis
vlg04211  Longevity regulating pathway
vlg04213  Longevity regulating pathway - multiple species
vlg04218  Cellular senescence
vlg04360  Axon guidance
vlg04370  VEGF signaling pathway
vlg04380  Osteoclast differentiation
vlg04510  Focal adhesion
vlg04550  Signaling pathways regulating pluripotency of stem cells
vlg04611  Platelet activation
vlg04613  Neutrophil extracellular trap formation
vlg04620  Toll-like receptor signaling pathway
vlg04625  C-type lectin receptor signaling pathway
vlg04630  JAK-STAT signaling pathway
vlg04650  Natural killer cell mediated cytotoxicity
vlg04660  T cell receptor signaling pathway
vlg04662  B cell receptor signaling pathway
vlg04664  Fc epsilon RI signaling pathway
vlg04666  Fc gamma R-mediated phagocytosis
vlg04668  TNF signaling pathway
vlg04670  Leukocyte transendothelial migration
vlg04722  Neurotrophin signaling pathway
vlg04725  Cholinergic synapse
vlg04750  Inflammatory mediator regulation of TRP channels
vlg04810  Regulation of actin cytoskeleton
vlg04910  Insulin signaling pathway
vlg04914  Progesterone-mediated oocyte maturation
vlg04915  Estrogen signaling pathway
vlg04917  Prolactin signaling pathway
vlg04919  Thyroid hormone signaling pathway
vlg04923  Regulation of lipolysis in adipocytes
vlg04926  Relaxin signaling pathway
vlg04929  GnRH secretion
vlg04930  Type II diabetes mellitus
vlg04931  Insulin resistance
vlg04932  Non-alcoholic fatty liver disease
vlg04933  AGE-RAGE signaling pathway in diabetic complications
vlg04935  Growth hormone synthesis, secretion and action
vlg04960  Aldosterone-regulated sodium reabsorption
vlg04973  Carbohydrate digestion and absorption
vlg05010  Alzheimer disease
vlg05017  Spinocerebellar ataxia
vlg05020  Prion disease
vlg05100  Bacterial invasion of epithelial cells
vlg05135  Yersinia infection
vlg05142  Chagas disease
vlg05146  Amoebiasis
vlg05160  Hepatitis C
vlg05161  Hepatitis B
vlg05162  Measles
vlg05163  Human cytomegalovirus infection
vlg05164  Influenza A
vlg05165  Human papillomavirus infection
vlg05166  Human T-cell leukemia virus 1 infection
vlg05167  Kaposi sarcoma-associated herpesvirus infection
vlg05168  Herpes simplex virus 1 infection
vlg05169  Epstein-Barr virus infection
vlg05170  Human immunodeficiency virus 1 infection
vlg05171  Coronavirus disease - COVID-19
vlg05200  Pathways in cancer
vlg05203  Viral carcinogenesis
vlg05205  Proteoglycans in cancer
vlg05206  MicroRNAs in cancer
vlg05207  Chemical carcinogenesis - receptor activation
vlg05208  Chemical carcinogenesis - reactive oxygen species
vlg05210  Colorectal cancer
vlg05211  Renal cell carcinoma
vlg05212  Pancreatic cancer
vlg05213  Endometrial cancer
vlg05214  Glioma
vlg05215  Prostate cancer
vlg05218  Melanoma
vlg05220  Chronic myeloid leukemia
vlg05221  Acute myeloid leukemia
vlg05222  Small cell lung cancer
vlg05223  Non-small cell lung cancer
vlg05224  Breast cancer
vlg05225  Hepatocellular carcinoma
vlg05226  Gastric cancer
vlg05230  Central carbon metabolism in cancer
vlg05231  Choline metabolism in cancer
vlg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vlg05415  Diabetic cardiomyopathy
vlg05417  Lipid and atherosclerosis
vlg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vlg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    121494738 (PIK3R2)
   04014 Ras signaling pathway
    121494738 (PIK3R2)
   04015 Rap1 signaling pathway
    121494738 (PIK3R2)
   04370 VEGF signaling pathway
    121494738 (PIK3R2)
   04630 JAK-STAT signaling pathway
    121494738 (PIK3R2)
   04668 TNF signaling pathway
    121494738 (PIK3R2)
   04066 HIF-1 signaling pathway
    121494738 (PIK3R2)
   04068 FoxO signaling pathway
    121494738 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    121494738 (PIK3R2)
   04072 Phospholipase D signaling pathway
    121494738 (PIK3R2)
   04071 Sphingolipid signaling pathway
    121494738 (PIK3R2)
   04024 cAMP signaling pathway
    121494738 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    121494738 (PIK3R2)
   04152 AMPK signaling pathway
    121494738 (PIK3R2)
   04150 mTOR signaling pathway
    121494738 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    121494738 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121494738 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    121494738 (PIK3R2)
   04218 Cellular senescence
    121494738 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121494738 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    121494738 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121494738 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121494738 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    121494738 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    121494738 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    121494738 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    121494738 (PIK3R2)
   04660 T cell receptor signaling pathway
    121494738 (PIK3R2)
   04662 B cell receptor signaling pathway
    121494738 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    121494738 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    121494738 (PIK3R2)
   04670 Leukocyte transendothelial migration
    121494738 (PIK3R2)
   04062 Chemokine signaling pathway
    121494738 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121494738 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    121494738 (PIK3R2)
   04929 GnRH secretion
    121494738 (PIK3R2)
   04915 Estrogen signaling pathway
    121494738 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    121494738 (PIK3R2)
   04917 Prolactin signaling pathway
    121494738 (PIK3R2)
   04926 Relaxin signaling pathway
    121494738 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    121494738 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    121494738 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121494738 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    121494738 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    121494738 (PIK3R2)
   04722 Neurotrophin signaling pathway
    121494738 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121494738 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    121494738 (PIK3R2)
   04380 Osteoclast differentiation
    121494738 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    121494738 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    121494738 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121494738 (PIK3R2)
   05206 MicroRNAs in cancer
    121494738 (PIK3R2)
   05205 Proteoglycans in cancer
    121494738 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    121494738 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    121494738 (PIK3R2)
   05203 Viral carcinogenesis
    121494738 (PIK3R2)
   05230 Central carbon metabolism in cancer
    121494738 (PIK3R2)
   05231 Choline metabolism in cancer
    121494738 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121494738 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121494738 (PIK3R2)
   05212 Pancreatic cancer
    121494738 (PIK3R2)
   05225 Hepatocellular carcinoma
    121494738 (PIK3R2)
   05226 Gastric cancer
    121494738 (PIK3R2)
   05214 Glioma
    121494738 (PIK3R2)
   05221 Acute myeloid leukemia
    121494738 (PIK3R2)
   05220 Chronic myeloid leukemia
    121494738 (PIK3R2)
   05218 Melanoma
    121494738 (PIK3R2)
   05211 Renal cell carcinoma
    121494738 (PIK3R2)
   05215 Prostate cancer
    121494738 (PIK3R2)
   05213 Endometrial cancer
    121494738 (PIK3R2)
   05224 Breast cancer
    121494738 (PIK3R2)
   05222 Small cell lung cancer
    121494738 (PIK3R2)
   05223 Non-small cell lung cancer
    121494738 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121494738 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    121494738 (PIK3R2)
   05161 Hepatitis B
    121494738 (PIK3R2)
   05160 Hepatitis C
    121494738 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    121494738 (PIK3R2)
   05164 Influenza A
    121494738 (PIK3R2)
   05162 Measles
    121494738 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    121494738 (PIK3R2)
   05163 Human cytomegalovirus infection
    121494738 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121494738 (PIK3R2)
   05169 Epstein-Barr virus infection
    121494738 (PIK3R2)
   05165 Human papillomavirus infection
    121494738 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    121494738 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    121494738 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121494738 (PIK3R2)
   05142 Chagas disease
    121494738 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121494738 (PIK3R2)
   05017 Spinocerebellar ataxia
    121494738 (PIK3R2)
   05020 Prion disease
    121494738 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121494738 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    121494738 (PIK3R2)
   05415 Diabetic cardiomyopathy
    121494738 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121494738 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    121494738 (PIK3R2)
   04931 Insulin resistance
    121494738 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121494738 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121494738 (PIK3R2)
   01524 Platinum drug resistance
    121494738 (PIK3R2)
   01522 Endocrine resistance
    121494738 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vlg04131]
    121494738 (PIK3R2)
Membrane trafficking [BR:vlg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    121494738 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 121494738
NCBI-ProteinID: XP_041617468
LinkDB
Position
7:13283130..13295581
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPAPRTDWSLSDVEQWDAAALTDGVKSFLLA
LPAPLVTPEAAAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPVLLVEKLLHEHLEEQEVTPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPATR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggtgctgagggcttccagtaccgagcactgtacccattccgccgggagcggccg
gaggacctggagctgctgccgggcgacgtgctggtggtgagccgggcagccctgcaggtg
ctgggcgtggctgagggcaacgagcgctgcccacagagcgtgggctggatgcctggcctc
aatgaacgcacgcggcaacgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcccggccctcgtccacgtggcccccgcccactgcccgccaggccc
cgggatgggccccctgagccaggcctcacactccccgacctgccagagcagttctcccca
cctgatgttgctcctccactcctggtgaagctggtggaggccattgaacggacagggcta
gacagcgagtccctctacaggcctgagctgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccgcggccctgacggacggcgtcaagagcttcctgctggcg
ctgcccgcgcccctcgtgacgcccgaggccgcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagcccccgacgctgccactgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgccgcgcccccgctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcctccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttccctgtgctg
ctggtggagaagttgctccacgaacacctggaggagcaggaggtcacacccccagcgctg
ccacctaaacctcccaaggcaaagccagcccctgcaggcctcgccaacggagggagtccg
ccctccctgcaggacgctgagtggtactggggtgacatctctagggaggaagtgaatgag
aaactccgggacacacctgatggcacctttctggtccgggatgcatctagcaagatccag
ggagagtacacactgaccctcaggaaaggcgggaataacaagctgattaaggtcttccac
cgagacgggcactatggcttctcagagccactcaccttctgctctgtcgtggacctcatc
acccactaccgccatgagtcgctggcccagtacaacgccaaactggacacacgcctcctc
tacccagtgtccaagtaccagcaggaccagattgtcaaggaggacagcgtggaggcggtg
ggtgcccagctcaaagtctatcaccagcagtaccaggacaaaagccgcgagtatgaccag
ctctatgaggagtacacccgcacctcccaggaactgcagatgaagcgcacagcaattgag
gccttcaatgagaccatcaagatctttgaagaacagggccagacgcaagagaagtgtagc
aaggagtatttggagcgcttccgacgtgagggcaatgagaaagaaatgcagaggatccta
ctgaactcagagcggctcaagtctcgcatcgctgagatccatgagagccgcacaaagctg
gagcaggagctgcgggcacaggcttcagacaaccgggagattgacaagcgcatgaacagc
ctcaagccagacctcatgcagctgcgcaagatccgagaccaatacctagtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagactgag
gaccagtatgcgctgatggaggacgaggacgacctcccccaccacgaggaacgcacgtgg
tatgtgggcaagatcaaccggacacaggctgaggaaatgctgagtggcaagcgggatggt
accttcctcatccgtgagagcagccagcggggctgctatgcctgctctgtggtggtggac
ggcgacaccaagcactgcgtcatctaccgcacagccactggcttcggcttcgcggagccc
tacaacctatacgggtctctgaaggagctggtgctgcactaccagcacgcctccctggtg
caacacaacgacgcgctcacggtcacgctcgcccaccccgtgcgggcccccggccccggg
cctccgcccgccacccgctga

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