Vulpes lagopus (Arctic fox): 121496830 Help Entry 121496830         CDS       T07435                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism vlg  Vulpes lagopus (Arctic fox) Pathway vlg04022   cGMP-PKG signaling pathway vlg04068   FoxO signaling pathway vlg04081   Hormone signaling vlg04140   Autophagy - animal vlg04150   mTOR signaling pathway vlg04151   PI3K-Akt signaling pathway vlg04152   AMPK signaling pathway vlg04211   Longevity regulating pathway vlg04213   Longevity regulating pathway - multiple species vlg04722   Neurotrophin signaling pathway vlg04910   Insulin signaling pathway vlg04920   Adipocytokine signaling pathway vlg04923   Regulation of lipolysis in adipocytes vlg04930   Type II diabetes mellitus vlg04931   Insulin resistance vlg04932   Non-alcoholic fatty liver disease vlg04935   Growth hormone synthesis, secretion and action vlg04960   Aldosterone-regulated sodium reabsorption vlg05010   Alzheimer disease vlg05206   MicroRNAs in cancer vlg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:vlg00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     121496830 (IRS1)    04022 cGMP-PKG signaling pathway     121496830 (IRS1)    04151 PI3K-Akt signaling pathway     121496830 (IRS1)    04152 AMPK signaling pathway     121496830 (IRS1)    04150 mTOR signaling pathway     121496830 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     121496830 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     121496830 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     121496830 (IRS1)    04923 Regulation of lipolysis in adipocytes     121496830 (IRS1)    04920 Adipocytokine signaling pathway     121496830 (IRS1)    04935 Growth hormone synthesis, secretion and action     121496830 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     121496830 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     121496830 (IRS1)   09149 Aging    04211 Longevity regulating pathway     121496830 (IRS1)    04213 Longevity regulating pathway - multiple species     121496830 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     121496830 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     121496830 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     121496830 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     121496830 (IRS1)    04932 Non-alcoholic fatty liver disease     121496830 (IRS1)    04931 Insulin resistance     121496830 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  121496830 NCBI-ProteinID:  XP_041621503 LinkDB All DBs Position 8:11722246..11786317 Genome browser AA seq 1239 aa AA seqDB search MASPPEADGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGASAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTTRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN GHYILPRGGNGHRYAPGAGLGTSPALAADEAAGAAELDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR PDAAALHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPGSSSSGSAAPSGSSYGKLWTNGVGGHHPHALPHPKLPVESG SGKLLSCTGDYMNMSPVGDSNTSSPSDGYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE ESARHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGGGYCGVRPDPGLPHIHHQVLQPHL PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQHPPPLLHPPEPKSPGEYVNIEFG SDQPGYLSGPVAARSSPSVRCPPQLQPAPREEETGTEEYMNMDLGPGRRAAWQEGAGVQP GRVGPAPPGAASVCRPTRAVPSGRGDYMTMQVGCPGQGYVDTSPVAPISYADMRTGIVVE EASLPGATAAAPSSSSAASASPTAPPKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNRN QSAKVIRADPQGCRRRHSSETFSSTPSATRAGNAVPFGGGAALGGSGGGSSAEDMKRHSS ASFENVWLRPGELGGAPKEPAPHAGAAGGLENGLNYIDLDLVKDFKQRSQERPPQPQPPP PPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ NT seq 3720 nt NT seq  +upstreamnt  +downstreamnt atggcgagccccccggaggccgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag gcggagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagggccac cacgacggcgcctcggcccccggggcgggaggcggcgggggcagctgcagcggcagctcg ggcctcggggaggccggcgaggacttgagctacggggacgtgcccccgggacctgcgttc aaggaggtctggcaggtgatcctgaagcccaagggcctggggcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactccgag gcggcggccgtggtgctgcagctgatgaacatccgacgttgcggccactcggagaacttc ttcttcatcgaagtgggccggtccgcagtgacggggcccggcgagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agcgacgagttccgccctcggagtaagagccagtcctcctccaactgctccaaccccatc agcgtccccctgcgccggcaccacctcaacaacccccctcccagccaggtggggctgacg cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggtgggcggcaag cagggctccttccgcgtgcgcgcgtccagcgatggcgagggcaccatgtcccgcccggcc tcggtggacggcagccccgtgagcccgagcaccaccaggacccacgcgcaccggcaccgc ggcagctcgcggctgcaccccccgctcaaccacagccgctccatccccatgccctcctct cgctgctcgccttccgccaccagcccggtcagcctgtcgtccagcagcaccagtggccac ggctccacctcggactgcctcttcccccggcgctctagcgcctcggtgtcgggttccccc agcgacggtgggttcatctcctctgacgagtacggctccagcccctgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacacccccccggcccgcggcgaggag gagctgagcaactacatctgcatgggaggcaaagggtcctccaccctcaccgcccccaac ggtcactacattttgcctcggggtggcaatggccaccgctacgccccgggggctggcttg ggcaccagcccggccctggctgcggatgaggcggccggtgcggccgagctggataaccgg ttccgaaagcggactcactctgcgggcacgtcccccaccatttcccaccagaagaccccg tcccagtcttccgtggcttccattgaggagtacacggagatgatgcctgcctacccgcca ggaggtggcagtggaggccgactgcctggctaccggcactctgccttcgtgcccacccac tcctaccccgaggagggtctggaaatgcaccccctggacaggcgtgggggccaccaccgg ccggacgccgccgctctccacacggatgatggctacatgcccatgtccccgggagtggca ccggtgcccagcggccggaagggcagtggggactatatgcccatgagccccaagagcgtg tcggcgccgcagcagatcatcaaccctattagacgccatccccagagggtggaccccaat ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccggc agcagcagcagcggcagcgccgccccttctgggagcagctatggcaagctgtggacaaac ggggtagggggccaccaccctcacgccctgccgcaccccaaactccccgtggagagcggg agtggcaagctcctgtcttgtaccggcgactacatgaacatgtcgccggtgggggactcc aacaccagcagcccctccgacggctactacggcccagaggacccccagcacaagccagtt ctctcctactactcattgccaaggtcctttaagcacacccagcgccctggggagctggag gagagcgcccggcaccagcacctccgcctctcctccagctcgggtcgtctcctgtacgcc gcgacggcggaagattcctcttcctccaccagcagcgacagcctgggcgggggatactgt ggggtcaggccggatcccggcctcccgcatatccaccatcaggtcctgcagcctcacctg cctcggaaggtggacaccgcggcgcagaccaacagccgcctggctcggcccacgaggctg tccctgggggaccccaaggccagcaccttaccacgggttcgagaacagcagcacccgccg cccctgctgcaccctccggagcccaagagccccggggaatatgtgaatattgagttcggg agcgatcagccgggctacttatcggggcccgtggccgcccgcagctcgccttctgtcagg tgcccaccgcagctccagccagctccccgggaggaagagactggcaccgaggagtacatg aacatggacctggggcctggccggagggcagcctggcaggagggtgctggggtccagcca ggcagggtgggccccgcgccccccggggccgctagcgtgtgcaggcccacccgggcagtg cccagcggccgcggcgactacatgaccatgcaggtgggctgccccggccagggctacgtg gacacctcgccagtggcccccatcagctacgctgacatgcggacaggcattgtcgtggag gaggccagcctgccgggggccacagcggccgccccctcctcgtcctcggcggcctcggct tcccccacggcgcctccaaaagcgggggagctggtggcccgctcctccctgctggggggc ccgcagggaccggggggcatgagcgccttcacccgggtgaacctcagtcccaaccgcaac cagagtgccaaagtgatccgcgccgacccgcaggggtgtcggaggcggcatagctctgag accttctcctccacgcccagtgccacccgggcgggcaacgcagtgcccttcggcgggggg gcggccctggggggcagcggtggcggcagcagcgcggaggatatgaaacgccacagttcg gcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagccg gccccgcacgctggggccgccgggggtttggagaatgggcttaactacatagacctggat ttggtcaaggacttcaaacagcgctctcaggagcgcccccctcaaccgcagccgcccccg cccccggcccctcatcagcctctgggcagcagcgagagcagctcaaccagccgctccagc gaggatctaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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