Vicugna pacos (alpaca): 102537935 Help Entry 102537935         CDS       T08098                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism vpc  Vicugna pacos (alpaca) Pathway vpc04062   Chemokine signaling pathway vpc04151   PI3K-Akt signaling pathway vpc04217   Necroptosis vpc04550   Signaling pathways regulating pluripotency of stem cells vpc04630   JAK-STAT signaling pathway vpc04658   Th1 and Th2 cell differentiation vpc04659   Th17 cell differentiation vpc05161   Hepatitis B vpc05162   Measles vpc05166   Human T-cell leukemia virus 1 infection vpc05169   Epstein-Barr virus infection vpc05200   Pathways in cancer vpc05203   Viral carcinogenesis vpc05223   Non-small cell lung cancer vpc05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:vpc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102537935 (JAK3)    04151 PI3K-Akt signaling pathway     102537935 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102537935 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102537935 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102537935 (JAK3)    04659 Th17 cell differentiation     102537935 (JAK3)    04062 Chemokine signaling pathway     102537935 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102537935 (JAK3)    05203 Viral carcinogenesis     102537935 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     102537935 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102537935 (JAK3)    05161 Hepatitis B     102537935 (JAK3)    05162 Measles     102537935 (JAK3)    05169 Epstein-Barr virus infection     102537935 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     102537935 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:vpc01001]     102537935 (JAK3) Enzymes [BR:vpc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102537935 (JAK3) Protein kinases [BR:vpc01001]  Non-receptor tyrosine kinases   JAK family [OT]    102537935 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl Kdo ABC1 FERM_C_FAK1 Haspin_kinase Motif Other DBs NCBI-GeneID:  102537935 NCBI-ProteinID:  XP_006199130 UniProt:  A0A6I9I0G0 LinkDB All DBs Position 22 AA seq 1104 aa AA seqDB search MAPPSEEMPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDHSAEELCVRAAKA SGILPVYHSLFALATEDLSCWFPPSHIFSVEDVGTQVLVYRLRFYFPNWFGLEKCHRFGL RKDLACAILDLPVLEHLFAQHRNDLVSGCLPVGLSLKEQGECLSLAVLDLARMALEQAQR PEELLKTISYKVCLPPGLRDLIQGLSFVTRKRIRRTVRRALRRVAACQADRHSLMAKYIM DLERLDPGRAAETFRVGLPGTAGGQDAPGLLRVAGGSGIAWSPGEQEVLQPFCDFPEIVD ISIKQAPRFGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTTDSRHFFC KEVAPPRLLEEVAEQCYGPITLDFAINKLKTGGSLPGSYVLRRSPQDFDSFLLTICVQTP LGPDYKGCLIRCDPSGTLSLAGLGRPHSSLRELLAACWNSGLHVDGIELNLTFCCTPRPK EKSNLIVVRRGCSLPTSCPVQPQSQCQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR HETVDGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ EFVHLGALDMYLRKSGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA DGNPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS GVMMPVSTLDPAKKLQFYEERQQLPAPKWMELALLIQQCMAYEPGQRPSFRAVIRDLNSL ITSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR YDPLGDNTGALVAVKQLQHSGPEQQKDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL VMEYLPSGCLRDFLQRHRARLDAGRLLLFASQICKGMEYLGSRRCVHRDLAARNILVESE THVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL FTYSDKSCSPSAEFLRMMGCERDVPALCRLLELLAEGQRLPAPPACPGEVHELMKLCWAP SPQDRPPFSALGPQLDALWSGSRG NT seq 3315 nt NT seq  +upstreamnt  +downstreamnt atggcacctccaagtgaggagatgcccctgatccctcagcgttcctgcagcctctcctct tcagaggctggcgccctgcacgtgctgctgccccctcggggccctggacccccgcagcgc ctatccttctcttttggggaccactcagctgaagagctgtgtgttcgagctgctaaggcc agtggtatcctgcccgtgtaccactccctctttgctctggccacggaggacctatcctgt tggttccccccgagccacatcttctccgtggaagacgtgggcacccaggtccttgtctac aggctccgcttttacttccccaactggtttgggctagaaaagtgccaccgctttgggcta cgaaaggacttagcctgcgccatccttgacctgccagtcctggagcacctatttgctcag caccgaaatgatctggtgagcggctgcctcccagtgggcctcagcctcaaggagcagggt gagtgtctcagcttggccgtgctggacctggcccgcatggctctcgagcaggctcagcgg cccgaggagctgctgaagacaatcagctacaaggtctgcctgccccccggcctgcgcgac ctgatccagggcctgagtttcgtgacacgaaagcgtatccgaaggacagtgcgcagggcc ttgcgccgcgtggccgcctgccaggctgacaggcactcactcatggccaagtacatcatg gatctcgaacggctggacccaggcagggccgccgagaccttccgcgtgggcctccccgga acggctggtggtcaggatgcgccagggctgctccgcgtggctggtggcagcggcatagcc tggagcccaggagaacaagaggtccttcagcccttctgcgactttccagaaattgtggat atcagcatcaagcaggccccgcgctttggcccggctggggagcaccgcctggtcaccgtc accaggacggacaaccagatcctggaggccgagttcccggggctgcctgccgccttgtcc ttcgtggcactcgtggatggctacttcaggctgaccaccgactcccggcacttcttctgc aaggaggtggcgccgccgcggctgctggaggaggtggctgagcagtgctatggccccatc accctggattttgccatcaacaaactcaagactgggggctcgcttcccggctcctacgtt ctccgtcgcagcccccaggattttgacagcttcctcctaactatctgtgtccagaccccc ctgggccctgattacaagggctgcctcattcggtgtgacccttcgggaactttatccctg gctggccttggccgtccccacagcagtcttcgagagctcctggcagcctgttggaatagt gggttgcatgtggatgggattgagctgaacctcaccttctgctgcacccccagacccaaa gaaaaatccaacctgatcgtggtccggagaggttgcagcctgcccacgtcatgccctgtt cagccccaatctcaatgccagctgagtcagatgacgtttcacaagatccctgctgacagc ctggagtggcatgagaatctgggtcacgggtctttcaccaagatttaccgcggctgtcga catgagaccgtggatggggaggcccgggagacagaggtgctgctcaaagtgatggatgcc aagcataagaactgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtca taccagcatcttgtgttgctccatggcgtgtgcatggctggagacagcatcatggtgcag gagtttgtacacctgggagcgctggacatgtatctgcgcaagagtggccacctggtgcct gccagctggaagctacaggtggtcaaacagctggcctatgccctcaactatctggaagat aaaggtctccctcatggcaatgtctcagcccggaaagtgctcctggcccgggagggggct gatgggaacccacccttcatcaaactgagtgaccctggtgtcagccccactgtgctaagt ctggagatgctcactgacaggattccctgggtggcccctgagtgtcttcaggaggcccgg acacttggcttggaagctgacaagtggggctttggtgccacagtctgggaggtgttcagc ggtgtcatgatgcccgtcagtaccctggatccggccaagaagctccagttttacgaggaa cgacagcagctgcccgcccccaagtggatggagctggccctgctgatccaacagtgcatg gcatacgagccgggccagaggccctccttccgtgctgtcatccgtgacctgaacagcctc atcacttcagattatgagctcctctcagatcccacacctggtgccttggcaccccgtgac gggctttggaatggtgcccagctctatgcctgccaggaccctaccatctttgaggagaga cacctcaagtatatctcacagctgggcaagggcaactttggcagcgtggaactatgccgc tacgacccactgggcgacaacacaggcgccctggtggctgtgaagcagctgcagcacagt gggccagaacagcagaaggacttccagcgggagatccagatcctcaaagccctgcacagc gacttcattgtcaagtaccgaggtgtcagctatggtccaggccgccagagcctgcggctg gtcatggagtacctgcccagcggctgtctgcgcgacttcctgcagcggcatcgcgcccgc ctcgacgctggccgcctgctcctctttgcctcgcagatctgcaagggcatggagtacctg ggctcccgccgctgcgtgcaccgcgacctggcagcccgtaacatcctggtggagagcgag acgcacgtcaagatcgcagacttcggcctcgccaagcttctgcccctcgacaaagactac tacgtggtccgcgagcccggccaaagtcccatcttctggtatgccccagagtccctctca gataacatcttctcgcgccagtcggatgtctggagcttcggggtcgtcctgtatgagctc ttcacctacagtgacaagagctgtagcccctcagctgagttcctgcggatgatgggatgt gagcgagatgtcccagccctctgccgcctcctggagctgctggctgagggccagaggctg cccgcacctcctgcctgccctggtgaggttcatgagctcatgaagctatgctgggcccct agcccacaagaccggccaccattcagtgctctgggcccccagctggatgcactgtggagt ggaagccggggatag

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