KEGG   Vulpes vulpes (red fox): 112935820
Entry
112935820         CDS       T05911                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp01521  EGFR tyrosine kinase inhibitor resistance
vvp01522  Endocrine resistance
vvp01524  Platinum drug resistance
vvp04012  ErbB signaling pathway
vvp04014  Ras signaling pathway
vvp04015  Rap1 signaling pathway
vvp04024  cAMP signaling pathway
vvp04062  Chemokine signaling pathway
vvp04066  HIF-1 signaling pathway
vvp04068  FoxO signaling pathway
vvp04070  Phosphatidylinositol signaling system
vvp04071  Sphingolipid signaling pathway
vvp04072  Phospholipase D signaling pathway
vvp04081  Hormone signaling
vvp04140  Autophagy - animal
vvp04145  Phagocytosis
vvp04150  mTOR signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04152  AMPK signaling pathway
vvp04210  Apoptosis
vvp04211  Longevity regulating pathway
vvp04213  Longevity regulating pathway - multiple species
vvp04218  Cellular senescence
vvp04360  Axon guidance
vvp04370  VEGF signaling pathway
vvp04380  Osteoclast differentiation
vvp04510  Focal adhesion
vvp04517  IgSF CAM signaling
vvp04518  Integrin signaling
vvp04550  Signaling pathways regulating pluripotency of stem cells
vvp04611  Platelet activation
vvp04613  Neutrophil extracellular trap formation
vvp04620  Toll-like receptor signaling pathway
vvp04625  C-type lectin receptor signaling pathway
vvp04630  JAK-STAT signaling pathway
vvp04650  Natural killer cell mediated cytotoxicity
vvp04660  T cell receptor signaling pathway
vvp04662  B cell receptor signaling pathway
vvp04664  Fc epsilon RI signaling pathway
vvp04666  Fc gamma R-mediated phagosome formation
vvp04668  TNF signaling pathway
vvp04670  Leukocyte transendothelial migration
vvp04722  Neurotrophin signaling pathway
vvp04725  Cholinergic synapse
vvp04750  Inflammatory mediator regulation of TRP channels
vvp04810  Regulation of actin cytoskeleton
vvp04910  Insulin signaling pathway
vvp04914  Progesterone-mediated oocyte maturation
vvp04915  Estrogen signaling pathway
vvp04917  Prolactin signaling pathway
vvp04919  Thyroid hormone signaling pathway
vvp04923  Regulation of lipolysis in adipocytes
vvp04926  Relaxin signaling pathway
vvp04929  GnRH secretion
vvp04930  Type II diabetes mellitus
vvp04931  Insulin resistance
vvp04932  Non-alcoholic fatty liver disease
vvp04933  AGE-RAGE signaling pathway in diabetic complications
vvp04935  Growth hormone synthesis, secretion and action
vvp04960  Aldosterone-regulated sodium reabsorption
vvp04973  Carbohydrate digestion and absorption
vvp05010  Alzheimer disease
vvp05017  Spinocerebellar ataxia
vvp05020  Prion disease
vvp05100  Bacterial invasion of epithelial cells
vvp05135  Yersinia infection
vvp05142  Chagas disease
vvp05146  Amoebiasis
vvp05160  Hepatitis C
vvp05161  Hepatitis B
vvp05162  Measles
vvp05163  Human cytomegalovirus infection
vvp05164  Influenza A
vvp05165  Human papillomavirus infection
vvp05166  Human T-cell leukemia virus 1 infection
vvp05167  Kaposi sarcoma-associated herpesvirus infection
vvp05168  Herpes simplex virus 1 infection
vvp05169  Epstein-Barr virus infection
vvp05170  Human immunodeficiency virus 1 infection
vvp05171  Coronavirus disease
vvp05200  Pathways in cancer
vvp05203  Viral carcinogenesis
vvp05205  Proteoglycans in cancer
vvp05206  MicroRNAs in cancer
vvp05207  Chemical carcinogenesis - receptor activation
vvp05208  Chemical carcinogenesis - reactive oxygen species
vvp05210  Colorectal cancer
vvp05211  Renal cell carcinoma
vvp05212  Pancreatic cancer
vvp05213  Endometrial cancer
vvp05214  Glioma
vvp05215  Prostate cancer
vvp05218  Melanoma
vvp05220  Chronic myeloid leukemia
vvp05221  Acute myeloid leukemia
vvp05222  Small cell lung cancer
vvp05223  Non-small cell lung cancer
vvp05224  Breast cancer
vvp05225  Hepatocellular carcinoma
vvp05226  Gastric cancer
vvp05230  Central carbon metabolism in cancer
vvp05231  Choline metabolism in cancer
vvp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vvp05415  Diabetic cardiomyopathy
vvp05417  Lipid and atherosclerosis
vvp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112935820 (PIK3R1)
   04014 Ras signaling pathway
    112935820 (PIK3R1)
   04015 Rap1 signaling pathway
    112935820 (PIK3R1)
   04370 VEGF signaling pathway
    112935820 (PIK3R1)
   04630 JAK-STAT signaling pathway
    112935820 (PIK3R1)
   04668 TNF signaling pathway
    112935820 (PIK3R1)
   04066 HIF-1 signaling pathway
    112935820 (PIK3R1)
   04068 FoxO signaling pathway
    112935820 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    112935820 (PIK3R1)
   04072 Phospholipase D signaling pathway
    112935820 (PIK3R1)
   04071 Sphingolipid signaling pathway
    112935820 (PIK3R1)
   04024 cAMP signaling pathway
    112935820 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    112935820 (PIK3R1)
   04152 AMPK signaling pathway
    112935820 (PIK3R1)
   04150 mTOR signaling pathway
    112935820 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    112935820 (PIK3R1)
   04517 IgSF CAM signaling
    112935820 (PIK3R1)
   04518 Integrin signaling
    112935820 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    112935820 (PIK3R1)
   04140 Autophagy - animal
    112935820 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    112935820 (PIK3R1)
   04218 Cellular senescence
    112935820 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112935820 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112935820 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112935820 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112935820 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    112935820 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    112935820 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    112935820 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    112935820 (PIK3R1)
   04660 T cell receptor signaling pathway
    112935820 (PIK3R1)
   04662 B cell receptor signaling pathway
    112935820 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    112935820 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    112935820 (PIK3R1)
   04670 Leukocyte transendothelial migration
    112935820 (PIK3R1)
   04062 Chemokine signaling pathway
    112935820 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112935820 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    112935820 (PIK3R1)
   04929 GnRH secretion
    112935820 (PIK3R1)
   04915 Estrogen signaling pathway
    112935820 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    112935820 (PIK3R1)
   04917 Prolactin signaling pathway
    112935820 (PIK3R1)
   04926 Relaxin signaling pathway
    112935820 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    112935820 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    112935820 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112935820 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112935820 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    112935820 (PIK3R1)
   04722 Neurotrophin signaling pathway
    112935820 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112935820 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    112935820 (PIK3R1)
   04380 Osteoclast differentiation
    112935820 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    112935820 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    112935820 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112935820 (PIK3R1)
   05206 MicroRNAs in cancer
    112935820 (PIK3R1)
   05205 Proteoglycans in cancer
    112935820 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    112935820 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112935820 (PIK3R1)
   05203 Viral carcinogenesis
    112935820 (PIK3R1)
   05230 Central carbon metabolism in cancer
    112935820 (PIK3R1)
   05231 Choline metabolism in cancer
    112935820 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112935820 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112935820 (PIK3R1)
   05212 Pancreatic cancer
    112935820 (PIK3R1)
   05225 Hepatocellular carcinoma
    112935820 (PIK3R1)
   05226 Gastric cancer
    112935820 (PIK3R1)
   05214 Glioma
    112935820 (PIK3R1)
   05221 Acute myeloid leukemia
    112935820 (PIK3R1)
   05220 Chronic myeloid leukemia
    112935820 (PIK3R1)
   05218 Melanoma
    112935820 (PIK3R1)
   05211 Renal cell carcinoma
    112935820 (PIK3R1)
   05215 Prostate cancer
    112935820 (PIK3R1)
   05213 Endometrial cancer
    112935820 (PIK3R1)
   05224 Breast cancer
    112935820 (PIK3R1)
   05222 Small cell lung cancer
    112935820 (PIK3R1)
   05223 Non-small cell lung cancer
    112935820 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112935820 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    112935820 (PIK3R1)
   05161 Hepatitis B
    112935820 (PIK3R1)
   05160 Hepatitis C
    112935820 (PIK3R1)
   05171 Coronavirus disease
    112935820 (PIK3R1)
   05164 Influenza A
    112935820 (PIK3R1)
   05162 Measles
    112935820 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    112935820 (PIK3R1)
   05163 Human cytomegalovirus infection
    112935820 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112935820 (PIK3R1)
   05169 Epstein-Barr virus infection
    112935820 (PIK3R1)
   05165 Human papillomavirus infection
    112935820 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    112935820 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    112935820 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112935820 (PIK3R1)
   05142 Chagas disease
    112935820 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112935820 (PIK3R1)
   05017 Spinocerebellar ataxia
    112935820 (PIK3R1)
   05020 Prion disease
    112935820 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112935820 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    112935820 (PIK3R1)
   05415 Diabetic cardiomyopathy
    112935820 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112935820 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    112935820 (PIK3R1)
   04931 Insulin resistance
    112935820 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112935820 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112935820 (PIK3R1)
   01524 Platinum drug resistance
    112935820 (PIK3R1)
   01522 Endocrine resistance
    112935820 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vvp04131]
    112935820 (PIK3R1)
Membrane trafficking [BR:vvp04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112935820 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 CEP135_TSGA10_CC SH3_9 CCDC113_CCDC96_CC ODF2_C Laminin_I ACDC Exonuc_VII_L
Other DBs
NCBI-GeneID: 112935820
NCBI-ProteinID: XP_025875527
UniProt: A0A3Q7UQL5
LinkDB
Position
Unknown
AA seq 725 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALALPDLA
EQFAPPDIAPPLLVKLLEAIEKKGLECSTLYRTPSSSNPAELRQLLDCDAASTDLEMIDV
QVLGDAFKRYLMDLPNPVIPVAVYNEMIYLAQEVQSSEEYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLSQTSSKNLLSARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgggcgctgtatgattacaagaaggaacgagaggaa
gatattgacctgcacttgggtgacgtcttgactgtgaataaagggtccttagtagctctt
ggattcagtgacggacaggaagccaggcctgaggagattggctggttaaatggttataat
gaaacaacgggggaaagaggggactttccgggaacttatgttgaatatattggaaggaag
aaaatctcccctcccacaccaaagccccgaccccctcgaccccttcccgtggcaccaggt
tcttcgaaagctgaagcagacagtgagcaacagcaagccttggcccttccggatcttgca
gagcagtttgcccctcccgacatcgctccgcctctgctggtgaagctcctggaagccatt
gaaaagaaaggtctggaatgttcaactctatacaggacaccgagctccagcaacccggct
gagttacgacagctccttgattgtgatgccgcctccacggacttggagatgatcgatgtg
caagtcttgggagacgctttcaaacgctatcttatggacttaccgaatcctgtcattcca
gtagccgtttacaatgagatgatttatttagcccaagaagtgcaaagctctgaagaatat
atccagttgttgaagaagctcattagggcacctaacatacctcatcagtattggcttacg
cttcagtatttgctcaaacatttcttcaagctctcgcaaacctccagcaagaatcttctg
agtgcaagagtactctctgaactcttcagccctctgcttttccgattcccagcagccagc
tctgagaatactgaacacctcataaaagttatagaaatcttaatctcaacggagtggaat
gaacgacagcctgcaccagcattgcctcctaaaccaccgaaacccaccactgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagccgatgggacctttttggtacgagac
gcatctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaa
ttaatcaaaatatttcaccgagatgggaaatatggcttctctgacccactgaccttcaac
tctgtggttgaactaataaaccactaccggaatgagtctctagctcagtataaccccaaa
ctggacgtgaaattactctatccagtatccaaataccaacaggatcaggttgtcaaagag
gataatattgaagctgtagggaaaaaattacacgaatataacactcaatttcaagaaaaa
agtcgggaatacgataggttatatgaagattatacccgtacttcccaggaaattcaaatg
aagagaacagctattgaagcatttaatgaaaccataaaaatatttgaagagcagtgccaa
agccaggaacggtacagcaaagaatacatagaaaaatttaagcgtgaaggcaacgaaaaa
gaaatacaaaggattatgcataattatgaaaagttaaagtcccgaattagtgagattgtg
gacagtagaaggcgcctggaggaagacctgaagaagcaagcagctgagtaccgggagatc
gacaagcgcatgaacagcattaagcccgacctcattcagctgaggaagacgagagaccag
tacttgatgtggttgactcagaaaggtgttcggcaaaagaagttgaatgagtggctgggc
aacgagaatacggaagaccaatactcgctggtggaagatgatgaggacctgcctcaccac
gacgagaagacctggaacgtgggcagtagcaacaggaacaaagccgagaaccttctacgg
gggaaacgggacggcaccttcctggtccgggagagcagtaaacagggctgctatgcttgc
tccgtggtggtggatggcgaggtcaagcattgcgtcatcaacaaaacggccactggctac
ggctttgccgagccctataacctgtacagctccctgaaagaactggtgctccattaccaa
cacacctccctggtgcagcacaacgactctctcaacgtcacactagcctacccggtatat
gcacagcagaggcgatga

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