Xenopus laevis (African clawed frog): 734818
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Entry
734818 CDS
T01010
Symbol
hsd3b1.L, hsd3b1
Name
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 L homeolog
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
xla
Xenopus laevis (African clawed frog)
Pathway
xla00140
Steroid hormone biosynthesis
xla01100
Metabolic pathways
Module
xla_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
xla_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
xla_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
xla_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
xla00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
734818 (hsd3b1.L)
Enzymes [BR:
xla01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
734818 (hsd3b1.L)
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
734818 (hsd3b1.L)
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GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
Polysacc_synt_2
GDP_Man_Dehyd
NAD_binding_10
RmlD_sub_bind
KR
NmrA
Motif
Other DBs
NCBI-GeneID:
734818
NCBI-ProteinID:
NP_001089754
Xenbase:
XB-GENE-995101
UniProt:
Q3KPY4
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Position
2L:complement(1491308..1494371)
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AA seq
380 aa
AA seq
DB search
MAGSLAGINCLLTGASGFLGHRILQLLLEEEGDLAEIRLMDKEFSSDLLGTCDRFQGKAM
LSLLQGDIQDQEFLLQSCRGVDLVIHTAAIIDTVGKISKDVLVAVNVTGTERLLEACVQN
NVHSFVYTSSVEVVGPNMRGDPVVNGDEELVYNSKLSFTYGQSKRLAENSVLRANGRALK
DGGTLITCSLRSMYIYGENSQFLLLHLDQAIMNGGVFHRLSKKEALVNPVYVGNVAWAHI
QASRAMRDPERAKKMAGNFYFISDDTPHLSYSDLNHALGKDLGLGVEPKLALPFPLLYFV
AFLLEMMSFMLKPLVKFVPPFTRHLLRLLNTPFTFSYRKAQRDMGYKPRYSWEQCKQLTT
GWMESVLPLRQELLKDNRKL
NT seq
1143 nt
NT seq
+upstream
nt +downstream
nt
atggccggctccttggctgggattaactgtctgctgactggggccagtggcttcctggga
cacaggattctgcagcttttgttggaggaagagggggacctggccgagattcggctcatg
gataaagaattcagctctgacctgctgggcacctgtgacagattccaaggaaaggcgatg
ctgagcctcctccagggagatattcaggatcaggaatttttgctccagtcctgtcggggg
gtggacctggtcattcacacggcggccattattgatacagttggaaagatcagcaaagac
gtcctggtggccgttaatgtaactgggacagagcgcctcctggaggcctgtgtgcagaac
aacgtgcactcttttgtctacaccagcagcgtggaggtggtaggacccaacatgcggggg
gatcctgttgttaatggggatgaggagctggtgtacaacagcaagctgagcttcacctat
gggcagagcaagaggttggctgagaacagtgttcttagggccaatgggcgggcccttaaa
gatggaggaacactcatcacctgctctcttcggtcaatgtacatctatggggaaaactcc
cagttcctcctcttgcaccttgaccaggccataatgaatggtggcgtcttccaccgattg
tccaagaaggaagctctggtcaaccctgtgtacgtggggaacgttgcgtgggctcacatc
caagcctcgcgggcaatgagggaccctgagagggccaagaagatggcaggaaatttctac
ttcatctctgatgacactccccacctcagctactctgatctcaatcatgctctggggaag
gatctgggactgggggtggagcccaagctcgctctgcccttccctcttctttactttgtg
gcctttttattagaaatgatgagtttcatgttaaagcctcttgtgaagtttgtgccacca
tttacccgccatctcctgcgcctcctgaacaccccattcaccttctcctaccgcaaggcc
cagagggacatgggctacaagccgcgctatagctgggagcagtgcaaacaactgaccact
ggatggatggagtccgtgctccccctaaggcaggagcttctcaaggataaccgcaaactg
tga
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