KEGG   PATHWAY: ypb03070
Entry
ypb03070                    Pathway                                
Name
Bacterial secretion system - Yersinia pseudotuberculosis PB1/+ (serotype 1B)
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
ypb03070  Bacterial secretion system
ypb03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Yersinia pseudotuberculosis PB1/+ (serotype 1B) [GN:ypb]
Gene
YPTS_3541  type I secretion outer membrane protein, TolC family [KO:K12340]
YPTS_4211  type III secretion system needle protein [KO:K03221]
YPTS_0340  type III secretion system needle protein [KO:K03221]
YPTS_4286  type III secretion YscO fmaily protein [KO:K04056]
YPTS_4287  type III secretion system needle length determinant [KO:K04057]
YPTS_4281  type III secretion protein, YscX family [KO:K04059]
YPTS_4208  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
YPTS_0336  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
YPTS_4284  type III secretion regulator YopN/LcrE/InvE/MxiC [KO:K04058]
YPTS_0343  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
YPTS_4215  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
YPTS_4289  Yop virulence translocation R [KO:K03226]
YPTS_0351  Yop virulence translocation R [KO:K03226]
YPTS_4290  type III secretion protein, HrpO family [KO:K03227]
YPTS_0352  type III secretion protein, HrpO family [KO:K03227]
YPTS_4291  type III secretion protein SpaR/YscT/HrcT [KO:K03228]
YPTS_0353  type III secretion protein SpaR/YscT/HrcT [KO:K03228]
YPTS_4292  type III secretion protein, YscU/HrpY family [KO:K03229]
YPTS_0354  type III secretion protein, YscU/HrpY family [KO:K03229]
YPTS_4279  type III secretion protein, HrcV family [KO:K03230]
YPTS_0346  type III secretion protein, HrcV family [KO:K03230]
YPTS_4285  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
YPTS_0347  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
YPTS_0350  type III secretion system apparatus protein YscQ/HrcQ [KO:K03225]
YPTS_4288  type III secretion system apparatus protein YscQ/HrcQ [KO:K03225]
YPTS_4217  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
YPTS_3187  general secretion pathway protein D [KO:K02453]
YPTS_3176  conserved hypothetical protein [KO:K02465]
YPTS_3188  general secretion pathway protein C [KO:K02452]
YPTS_3185  type II secretion system protein [KO:K02455]
YPTS_3184  general secretion pathway protein G [KO:K02456]
YPTS_3183  general secretion pathway protein H [KO:K02457]
YPTS_3182  type II secretion system protein I/J [KO:K02458]
YPTS_3181  general secretion pathway protein J [KO:K02459]
YPTS_3180  general secretion pathway protein K [KO:K02460]
YPTS_3179  general secretion pathway protein L [KO:K02461]
YPTS_3186  type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
YPTS_3177  peptidase A24A domain protein [KO:K02464] [EC:3.4.23.43 2.1.1.-]
YPTS_0971  protein-export membrane protein SecD [KO:K03072]
YPTS_0972  protein-export membrane protein SecF [KO:K03074]
YPTS_0297  preprotein translocase, SecE subunit [KO:K03073]
YPTS_0507  preprotein translocase, SecG subunit [KO:K03075]
YPTS_3870  preprotein translocase, SecY subunit [KO:K03076]
YPTS_0970  preprotein translocase, YajC subunit [KO:K03210]
YPTS_4202  60 kDa inner membrane insertion protein [KO:K03217]
YPTS_0724  preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
YPTS_0723  secretion monitor family proten [KO:K13301]
YPTS_0236  signal recognition particle-docking protein FtsY [KO:K03110]
YPTS_0065  protein-export protein SecB [KO:K03071]
YPTS_0869  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
YPTS_0274  twin-arginine translocation protein, TatA/E family subunit [KO:K03116]
YPTS_0275  twin-arginine translocation protein, TatB subunit [KO:K03117]
YPTS_0276  Sec-independent protein translocase, TatC subunit [KO:K03118]
YPTS_1147  twin-arginine translocation protein, TatA/E family subunit [KO:K03425]
YPTS_2085  Hemolysin activator HlyB domain protein [KO:K11017]
YPTS_3837  Hemolysin activator HlyB domain protein [KO:K11017]
YPTS_3838  filamentous haemagglutinin family outer membrane protein [KO:K11016]
YPTS_4238  YadA domain protein [KO:K12341]
YPTS_1513  Haemagluttinin domain protein [KO:K12342]
YPTS_1514  conserved hypothetical protein [KO:K12342]
YPTS_3421  type VI secretion system Vgr family protein [KO:K11904]
YPTS_3379  type VI secretion system Vgr family protein [KO:K11904]
YPTS_1600  type VI secretion system Vgr family protein [KO:K11904]
YPTS_2756  type VI secretion system Vgr family protein [KO:K11904]
YPTS_3807  type VI secretion system Vgr family protein [KO:K11904]
YPTS_0671  type VI secretion system Vgr family protein [KO:K11904]
YPTS_1597  type VI secretion system Vgr family protein [KO:K11904]
YPTS_3823  type VI secretion system effector, Hcp1 family [KO:K11903]
YPTS_2761  type VI secretion system effector, Hcp1 family [KO:K11903]
YPTS_1595  type VI secretion system effector, Hcp1 family [KO:K11903]
YPTS_0666  protein of unknown function DUF796 [KO:K11903]
YPTS_3381  type VI secretion system effector, Hcp1 family [KO:K11903]
YPTS_3816  lipoprotein [KO:K11906]
YPTS_1612  conserved hypothetical protein [KO:K11906]
YPTS_2760  conserved hypothetical protein [KO:K11906]
YPTS_0676  putative lipoprotein [KO:K11906]
YPTS_2757  type VI secretion protein IcmF [KO:K11891]
YPTS_3809  type VI secretion protein IcmF [KO:K11891]
YPTS_1606  ImcF domain protein [KO:K11891]
YPTS_0679  type VI secretion protein IcmF [KO:K11891]
YPTS_3814  membrane protein [KO:K11892]
YPTS_2758  type VI secretion system OmpA/MotB family protein [KO:K11892]
YPTS_3383  possibly conserved membrane protein [KO:K11892]
YPTS_1593  conserved hypothetical protein [KO:K11892]
YPTS_0678  type IV / VI secretion system protein, DotU family [KO:K11892]
YPTS_3380  type VI secretion ATPase, ClpV1 family [KO:K11907]
YPTS_2768  type VI secretion ATPase, ClpV1 family [KO:K11907]
YPTS_3813  type VI secretion ATPase, ClpV1 family [KO:K11907]
YPTS_0670  type VI secretion ATPase, ClpV1 family [KO:K11907]
YPTS_1596  type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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