KEGG   Zalophus californianus (California sea lion): 113917179
Entry
113917179         CDS       T07874                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca01521  EGFR tyrosine kinase inhibitor resistance
zca01522  Endocrine resistance
zca01524  Platinum drug resistance
zca04012  ErbB signaling pathway
zca04014  Ras signaling pathway
zca04015  Rap1 signaling pathway
zca04024  cAMP signaling pathway
zca04062  Chemokine signaling pathway
zca04066  HIF-1 signaling pathway
zca04068  FoxO signaling pathway
zca04070  Phosphatidylinositol signaling system
zca04071  Sphingolipid signaling pathway
zca04072  Phospholipase D signaling pathway
zca04081  Hormone signaling
zca04140  Autophagy - animal
zca04145  Phagocytosis
zca04150  mTOR signaling pathway
zca04151  PI3K-Akt signaling pathway
zca04152  AMPK signaling pathway
zca04210  Apoptosis
zca04211  Longevity regulating pathway
zca04213  Longevity regulating pathway - multiple species
zca04218  Cellular senescence
zca04360  Axon guidance
zca04370  VEGF signaling pathway
zca04380  Osteoclast differentiation
zca04510  Focal adhesion
zca04517  IgSF CAM signaling
zca04518  Integrin signaling
zca04550  Signaling pathways regulating pluripotency of stem cells
zca04611  Platelet activation
zca04613  Neutrophil extracellular trap formation
zca04620  Toll-like receptor signaling pathway
zca04625  C-type lectin receptor signaling pathway
zca04630  JAK-STAT signaling pathway
zca04650  Natural killer cell mediated cytotoxicity
zca04660  T cell receptor signaling pathway
zca04662  B cell receptor signaling pathway
zca04664  Fc epsilon RI signaling pathway
zca04666  Fc gamma R-mediated phagosome formation
zca04668  TNF signaling pathway
zca04670  Leukocyte transendothelial migration
zca04722  Neurotrophin signaling pathway
zca04725  Cholinergic synapse
zca04750  Inflammatory mediator regulation of TRP channels
zca04810  Regulation of actin cytoskeleton
zca04910  Insulin signaling pathway
zca04914  Progesterone-mediated oocyte maturation
zca04915  Estrogen signaling pathway
zca04917  Prolactin signaling pathway
zca04919  Thyroid hormone signaling pathway
zca04923  Regulation of lipolysis in adipocytes
zca04926  Relaxin signaling pathway
zca04929  GnRH secretion
zca04930  Type II diabetes mellitus
zca04931  Insulin resistance
zca04932  Non-alcoholic fatty liver disease
zca04933  AGE-RAGE signaling pathway in diabetic complications
zca04935  Growth hormone synthesis, secretion and action
zca04960  Aldosterone-regulated sodium reabsorption
zca04973  Carbohydrate digestion and absorption
zca05010  Alzheimer disease
zca05017  Spinocerebellar ataxia
zca05020  Prion disease
zca05100  Bacterial invasion of epithelial cells
zca05135  Yersinia infection
zca05142  Chagas disease
zca05146  Amoebiasis
zca05160  Hepatitis C
zca05161  Hepatitis B
zca05162  Measles
zca05163  Human cytomegalovirus infection
zca05164  Influenza A
zca05165  Human papillomavirus infection
zca05166  Human T-cell leukemia virus 1 infection
zca05167  Kaposi sarcoma-associated herpesvirus infection
zca05168  Herpes simplex virus 1 infection
zca05169  Epstein-Barr virus infection
zca05170  Human immunodeficiency virus 1 infection
zca05171  Coronavirus disease
zca05200  Pathways in cancer
zca05203  Viral carcinogenesis
zca05205  Proteoglycans in cancer
zca05206  MicroRNAs in cancer
zca05207  Chemical carcinogenesis - receptor activation
zca05208  Chemical carcinogenesis - reactive oxygen species
zca05210  Colorectal cancer
zca05211  Renal cell carcinoma
zca05212  Pancreatic cancer
zca05213  Endometrial cancer
zca05214  Glioma
zca05215  Prostate cancer
zca05218  Melanoma
zca05220  Chronic myeloid leukemia
zca05221  Acute myeloid leukemia
zca05222  Small cell lung cancer
zca05223  Non-small cell lung cancer
zca05224  Breast cancer
zca05225  Hepatocellular carcinoma
zca05226  Gastric cancer
zca05230  Central carbon metabolism in cancer
zca05231  Choline metabolism in cancer
zca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
zca05415  Diabetic cardiomyopathy
zca05417  Lipid and atherosclerosis
zca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:zca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    113917179 (PIK3R2)
   04014 Ras signaling pathway
    113917179 (PIK3R2)
   04015 Rap1 signaling pathway
    113917179 (PIK3R2)
   04370 VEGF signaling pathway
    113917179 (PIK3R2)
   04630 JAK-STAT signaling pathway
    113917179 (PIK3R2)
   04668 TNF signaling pathway
    113917179 (PIK3R2)
   04066 HIF-1 signaling pathway
    113917179 (PIK3R2)
   04068 FoxO signaling pathway
    113917179 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    113917179 (PIK3R2)
   04072 Phospholipase D signaling pathway
    113917179 (PIK3R2)
   04071 Sphingolipid signaling pathway
    113917179 (PIK3R2)
   04024 cAMP signaling pathway
    113917179 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    113917179 (PIK3R2)
   04152 AMPK signaling pathway
    113917179 (PIK3R2)
   04150 mTOR signaling pathway
    113917179 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    113917179 (PIK3R2)
   04517 IgSF CAM signaling
    113917179 (PIK3R2)
   04518 Integrin signaling
    113917179 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    113917179 (PIK3R2)
   04140 Autophagy - animal
    113917179 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    113917179 (PIK3R2)
   04218 Cellular senescence
    113917179 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113917179 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    113917179 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113917179 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113917179 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    113917179 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    113917179 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    113917179 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    113917179 (PIK3R2)
   04660 T cell receptor signaling pathway
    113917179 (PIK3R2)
   04662 B cell receptor signaling pathway
    113917179 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    113917179 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    113917179 (PIK3R2)
   04670 Leukocyte transendothelial migration
    113917179 (PIK3R2)
   04062 Chemokine signaling pathway
    113917179 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113917179 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    113917179 (PIK3R2)
   04929 GnRH secretion
    113917179 (PIK3R2)
   04915 Estrogen signaling pathway
    113917179 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    113917179 (PIK3R2)
   04917 Prolactin signaling pathway
    113917179 (PIK3R2)
   04926 Relaxin signaling pathway
    113917179 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    113917179 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    113917179 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    113917179 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    113917179 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    113917179 (PIK3R2)
   04722 Neurotrophin signaling pathway
    113917179 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    113917179 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    113917179 (PIK3R2)
   04380 Osteoclast differentiation
    113917179 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    113917179 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    113917179 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113917179 (PIK3R2)
   05206 MicroRNAs in cancer
    113917179 (PIK3R2)
   05205 Proteoglycans in cancer
    113917179 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    113917179 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    113917179 (PIK3R2)
   05203 Viral carcinogenesis
    113917179 (PIK3R2)
   05230 Central carbon metabolism in cancer
    113917179 (PIK3R2)
   05231 Choline metabolism in cancer
    113917179 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113917179 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113917179 (PIK3R2)
   05212 Pancreatic cancer
    113917179 (PIK3R2)
   05225 Hepatocellular carcinoma
    113917179 (PIK3R2)
   05226 Gastric cancer
    113917179 (PIK3R2)
   05214 Glioma
    113917179 (PIK3R2)
   05221 Acute myeloid leukemia
    113917179 (PIK3R2)
   05220 Chronic myeloid leukemia
    113917179 (PIK3R2)
   05218 Melanoma
    113917179 (PIK3R2)
   05211 Renal cell carcinoma
    113917179 (PIK3R2)
   05215 Prostate cancer
    113917179 (PIK3R2)
   05213 Endometrial cancer
    113917179 (PIK3R2)
   05224 Breast cancer
    113917179 (PIK3R2)
   05222 Small cell lung cancer
    113917179 (PIK3R2)
   05223 Non-small cell lung cancer
    113917179 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113917179 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    113917179 (PIK3R2)
   05161 Hepatitis B
    113917179 (PIK3R2)
   05160 Hepatitis C
    113917179 (PIK3R2)
   05171 Coronavirus disease
    113917179 (PIK3R2)
   05164 Influenza A
    113917179 (PIK3R2)
   05162 Measles
    113917179 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    113917179 (PIK3R2)
   05163 Human cytomegalovirus infection
    113917179 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113917179 (PIK3R2)
   05169 Epstein-Barr virus infection
    113917179 (PIK3R2)
   05165 Human papillomavirus infection
    113917179 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    113917179 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    113917179 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    113917179 (PIK3R2)
   05142 Chagas disease
    113917179 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113917179 (PIK3R2)
   05017 Spinocerebellar ataxia
    113917179 (PIK3R2)
   05020 Prion disease
    113917179 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113917179 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    113917179 (PIK3R2)
   05415 Diabetic cardiomyopathy
    113917179 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    113917179 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    113917179 (PIK3R2)
   04931 Insulin resistance
    113917179 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    113917179 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113917179 (PIK3R2)
   01524 Platinum drug resistance
    113917179 (PIK3R2)
   01522 Endocrine resistance
    113917179 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:zca04131]
    113917179 (PIK3R2)
Membrane trafficking [BR:zca04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    113917179 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 ODF2_C Ribosomal_L22e SH3_9 ATG11
Other DBs
NCBI-GeneID: 113917179
NCBI-ProteinID: XP_027440622
UniProt: A0A6J2CDA2
LinkDB
Position
1:13649044..13661440
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPILVKLVEAIERTGLDSESLYRPELPALRTDWSLSDVEQWDIAALTDGVKGFLLA
LPAPLVTPEAAAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTESSPDFPVLLVEKLLLEHLEEQEVAPPAL
PPKPPKAKPASAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EHELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALAVTLAHPVRAPGPG
PPPAAR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggctggtgctgagggcttccagtaccgcgcgctgtacccattccgccgggagcggcca
gaagacctggagctgctgccaggcgacgtgttggtggtgagccgggcagccctgcaggtg
ctgggcgtggccgagggcaacgagcgctgcccacagagcgtgggctggatgcctggcctc
aatgagcgcacgcggcaacgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcctggccctcgtccacgtggcccccgcccactgcccgccaggccc
cgggatgggccccctgagccaggcctcacactccccgacctgccagagcagttctcccca
cctgatgtggctccccccatcctggtgaagctggtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgcccgccctgcgtacagactggtccctgagc
gacgtggagcagtgggacatcgcagccctgacagacggcgtcaagggcttcctgctggca
ctgcccgcgcccctcgtgactcccgaggccgcagccgaggcgcgccgggccctgcgggag
gccgcggggccggtggggccggcgctggagcccccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccggcgcgcccccgccccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcctccc
tcgccgccgccagggggcgcgcctgacgggactgagtccagccctgacttcccggtgctg
ctggtggagaagttgcttctggaacatctggaggagcaggaggtcgcacccccagcgctg
ccgcctaaaccccccaaggcaaagcctgcctctgcaggcctggctaatggggggagcccg
ccctccctgcaggacgctgagtggtactggggtgacatctccagagaggaggtgaatgag
aagctccgggacacgcctgatggcacctttctggtccgagatgcgtctagcaagatccag
ggggagtacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccac
cgcgacgggcactatggcttctcagagccactcaccttctgctccgttgtggacctcatc
acccactaccgccatgagtcgctggcgcagtacaatgccaagctggacacccggctcctc
taccccgtgtccaagtaccagcaggaccagatcgtcaaggaggacagtgtggaggcggtg
ggtgcccagctcaaagtctaccaccagcagtaccaggataagagccgcgaatatgaccag
ctctatgaggagtacacccgcacctcccaggaactgcagatgaagcgcacagcaattgag
gccttcaatgagaccattaagatctttgaagagcagggccagacgcaagagaagtgtagc
aaggaatatctggagcgcttccgacgcgagggcaatgagaaagagatgcagaggatcctg
ctgaactccgagcggctcaagtctcgcatcgccgagatccacgagagccgcacaaagctg
gagcacgagctgcgggcacaggcctcagacaaccgagagatcgacaagcgcatgaatagc
ctcaagccagacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggcttacc
cagaagggcgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagactgag
gaccagtatgcgctgatggaggatgaggatgacctcccccaccatgaggagcgcacgtgg
tacgtgggcaagatcaaccggacccaggctgaggaaatgctgagcggcaagcgggatggt
accttcctcatccgtgagagcagccagcggggctgctatgcctgctccgtggtggtggac
ggcgacaccaagcactgcgtcatctaccgcacggccacgggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctggtg
cagcacaacgatgcgctcgccgtcacgctcgcccacccggtgcgcgcccccgggcccggg
cccccacccgctgcccgctga

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