KEGG   PATHWAY: zof00908
Entry
zof00908                    Pathway                                
Name
Zeatin biosynthesis - Zingiber officinale (ginger)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
zof00908  Zeatin biosynthesis
zof00908

Other DBs
GO: 0009691
Organism
Zingiber officinale (ginger) [GN:zof]
Gene
121973811  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122003976  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122004617  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122026573  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122026574  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122026575  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122026576  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122026577  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122027893  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122029013  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122029014  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122029015  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122029017  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122029018  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122029019  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121977341  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121977798  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122030262  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121980064  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122031994  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122049032  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122010825  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122049506  adenylate isopentenyltransferase 5, chloroplastic-like isoform X1 [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122034569  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121983285  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121999674  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122013766  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122000428  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122037836  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122053236  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121985840  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122039557  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122040104  adenylate isopentenyltransferase 5, chloroplastic-like isoform X1 [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121973098  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
121987022  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
122027340  cytokinin hydroxylase-like isoform X1 [KO:K10717]
122029704  cytokinin hydroxylase-like isoform X1 [KO:K10717]
122025725  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
121988745  cytokinin dehydrogenase 4-like [KO:K00279] [EC:1.5.99.12]
121989900  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
122005582  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
122019920  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
122043555  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
122043987  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
122043996  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
122044012  cytokinin dehydrogenase 10-like [KO:K00279] [EC:1.5.99.12]
122044023  cytokinin dehydrogenase 10-like [KO:K00279] [EC:1.5.99.12]
122045431  cytokinin dehydrogenase 4-like [KO:K00279] [EC:1.5.99.12]
122007220  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
122007901  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
121992830  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
121979802  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
121993700  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
121980446  cytokinin dehydrogenase 9-like [KO:K00279] [EC:1.5.99.12]
121967385  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
121996797  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
122050720  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
121997678  cytokinin dehydrogenase 4-like [KO:K00279] [EC:1.5.99.12]
121983300  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
122013250  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
122052597  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
121984355  cytokinin dehydrogenase 9-like [KO:K00279] [EC:1.5.99.12]
122021879  cytokinin dehydrogenase 11-like isoform X1 [KO:K00279] [EC:1.5.99.12]
121984891  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
122001289  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
122023396  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
121985948  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
122015854  cytokinin dehydrogenase 7-like isoform X1 [KO:K00279] [EC:1.5.99.12]
122023740  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
122040922  cytokinin dehydrogenase 4-like [KO:K00279] [EC:1.5.99.12]
122005686  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
122010975  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
122000099  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
122014903  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
122056166  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
122056168  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
122051632  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
122036761  tRNA dimethylallyltransferase 2-like [KO:K00791] [EC:2.5.1.75]
122016227  tRNA dimethylallyltransferase 2-like isoform X1 [KO:K00791] [EC:2.5.1.75]
122025569  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
121990316  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
121992834  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
121992836  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
121992839  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
121994161  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
121994163  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
121994986  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
121995004  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
122021443  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
zof00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   
LinkDB

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