+E	RModule
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; KEGG Reaction Modules</h2>
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A<b>Reaction modules</b>
B
B  <b>Carboxylic acid metabolism</b>
C    2-Oxocarboxylic acid chain extension
D      RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
E        M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
E        M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
E        M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
E        M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate
E        M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
C    2-Oxocarboxylic acid chain modification
D      RM002  Carboxyl to amino conversion using protective N-acetyl group (basic amino acid synthesis)
E        M00028  Ornithine biosynthesis, glutamate => ornithine
E        M00763  Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
E        M00031  Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine
D      RM032  Carboxyl to amino conversion without using protective group
E        M00033  Ectoine biosynthesis, aspartate => ectoine
D      RM033  Branched-chain addition (branched-chain amino acid synthesis)
E        M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
D      RM030  Glucosinolate synthesis
E        M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin
D      RM044  2-Oxocarboxylic acid conversion to its CoA derivative
E        M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
E        M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
E        M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
D      RM901  Reductive amination of 2-oxocarboxylic acid (aminotransferase reaction)
D      RM903  Oxidative decarboxylation of 2-oxoacid to form its CoA derivative
C    Fatty acid synthesis and degradation
D      RM018  Beta oxidation in acyl-CoA degradation
E        M00087  beta-Oxidation
E        M00861  beta-Oxidation, peroxisome, VLCFA
E        M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
D      RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
E        M00085  Fatty acid elongation in mitochondria
D      RM021  Fatty acid synthesis using malonyl-CoA
E        M00083  Fatty acid biosynthesis, elongation
E        M00572  Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP
E        M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
E        M00886  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
E        M00415  Fatty acid elongation in endoplasmic reticulum
C    Acyl-CoA metabolism
D      RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
E        M00013  Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA
E        M00375  Hydroxypropionate-hydroxybutylate cycle
E        M00376  3-Hydroxypropionate bi-cycle
B
B  <b>Nucleotide sugar metabolism</b>
C    Nucleotide sugar biosynthesis
D      RM022  Nucleotide sugar biosynthesis, type 1
D      RM023  Nucleotide sugar biosynthesis, type 2
D      RM039  Nucleotide sugar biosynthesis, type 3
D      RM042  Nucleotide sugar biosynthesis, type 4
E        M00955  CMP-Neu5Ac/Neu5Gc biosynthesis, animals, UDP-GlcNAc => CMP-Neu5Ac => CMP-Neu5Gc
E        M00954  CMP-KDN biosynthesis, Man-6P => CMP-KDN
E        M00063  CMP-KDO biosynthesis, ribulose-5P => CMP-KDO
E        M00922  CMP-Neu5Ac biosynthesis, bacteria, UDP-GlcNAc => CMP-Neu5Ac
E        M01011  CMP-Leg5Ac7Ac biosynthesis, UDP-BacNAc4NAc => CMP-Leg5Ac7Ac
E        M01012  CMP-Leg5Ac7Ala biosynthesis, UDP-GlcNAc => CMP-Leg5Ac7Ala
E        M01008  CMP-8eLeg5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-8eLeg5Ac7Ac
E        M01007  CMP-Pse5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-Pse5Ac7Ac
C    Deoxy sugar metabolism
D      RM035  Transamination and N,N-dimethylation in polyketide biosynthesis
E        M00796  dTDP-D-mycaminose biosynthesis
E        M00797  dTDP-D-desosamine biosynthesis
E        M00802  dTDP-D-forosamine biosynthesis
E        M00803  dTDP-D-angolosamine biosynthesis
E        M00800  dTDP-L-megosamine biosynthesis
E        M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
E        M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
D      RM043  Transamination and N-acetylation in deoxysugar biosynthesis
E        M01024  dTDP-Qui3NAc biosynthesis, Glc-1P => dTDP-Qui3NAc
E        M01023  dTDP-D-Fuc3NAc biosynthesis, Glc-1P => dTDP-D-Fuc3NAc
E        M01026  dTDP-Qui4NAc biosynthesis, Glc-1P => dTDP-Qui4NAc
E        M01025  dTDP-D-Fuc4NAc biosynthesis, Glc-1P => dTDP-D-Fuc4NAc
E        M01020  GDP-D-Rha4NAc biosynthesis, GDP-Man => GDP-D-Rha4N => GDP-D-Rha4NAc
E        M01010  UDP-BacNAc4NAc biosynthesis, UDP-GlcNAc => UDP-BacNAc4NAc
E        M01012  CMP-Leg5Ac7Ala biosynthesis, UDP-GlcNAc => CMP-Leg5Ac7Ala
E        M01033  UDP-yelosamine biosynthesis, UDP-GlcNAc => UDP-yelosamine
E        M01008  CMP-8eLeg5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-8eLeg5Ac7Ac
E        M01007  CMP-Pse5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-Pse5Ac7Ac
E        M01035  UDP-ManNAc3NAcA biosynthesis, UDP-GlcNAc => UDP-ManNAc3NAcA
D      RM036  Epimerization and reduction in deoxysugar biosynthesis
E        M00793  dTDP-L-rhamnose biosynthesis
E        M00801  dTDP-L-olivose biosynthesis
E        M00794  dTDP-6-deoxy-D-allose biosynthesis
E        M00800  dTDP-L-megosamine biosynthesis
E        M00798  dTDP-L-mycarose biosynthesis
D      RM037  Deoxygenation (transamination and deamination) in deoxysugar biosynthesis
E        M00797  dTDP-D-desosamine biosynthesis
D      RM038  Deoxygenation (dehydration and reduction) in deoxysugar biosynthesis
E        M00798  dTDP-L-mycarose biosynthesis
E        M00799  dTDP-L-oleandrose biosynthesis
E        M00801  dTDP-L-olivose biosynthesis
E        M00802  dTDP-D-forosamine biosynthesis
C    Sugar conversion
D      RM040  Sugar activation and nucleotide sugar interconversion
D      RM041  Inversion of the carbon chain
B
B  <b>Aromatics degradation</b>
C    Methyl to carboxyl conversion on aromatic ring
D      RM003  Methyl to carboxyl conversion on aromatic ring
E        M00538  Toluene degradation, toluene => benzoate
E        M00537  Xylene degradation, xylene => methylbenzoate
E        M00419  Cymene degradation, p-cymene => p-cumate
D      RM015  Methyl to carboxyl conversion on aromatic ring, anaerobic
E        M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
C    Dihydroxylation of aromatic ring
D      RM004  Dihydroxylation of aromatic ring, type 1 (dioxygenase and dehydrogenase reactions)
E        M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
D      RM005  Dihydroxylation of aromatic ring, type 1a (dioxygenase and decarboxylating dehydrogenase reactions)
E        M00551  Benzoate degradation, benzoate => catechol
D      RM902  Dihydroxylation of aromatic ring, type 1b (single dioxygenase reaction)
D      RM006  Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)
E        M00548  Benzene degradation, benzene => catechol
D      RM007  Dihydroxylation of aromatic ring, type 3 (dealkylation and monooxygenase reactions)
C    Cleavage of aromatic ring
D      RM008  Ortho-cleavage of dihydroxylated aromatic ring
E        M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate
D      RM009  Meta-cleavage of dihydroxylated aromatic ring
E        M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
E        M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
D      RM013  Ortho-cleavage of halogenated aromatic ring
D      RM016  Ring cleavage via beta oxidation, anaerobic
E        M00540  Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA
D      RM017  Ring cleavage via Baeyer-Villiger oxidation
C    Dihydroxylation and cleavage of aromatic ring
D      RM010  Dihydroxylation and meta-cleavage of aromatic ring, type 1
E        M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate
E        M00545  Trans-cinnamate degradation, trans-cinnamate => 2-oxopent-4-enoate + fumarate
E        M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
D      RM011  Dihydroxylation and meta-cleavage of aromatic ring, type 1b
E        M00544  Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate
D      RM012  Dihydroxylation and meta-cleavage of aromatic ring, type 3a
E        M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate
D      RM014  Ring removal from polycyclic aromatic ring
E        M00534  Naphthalene degradation, naphthalene => salicylate
B
B  <b>Other</b>
C    Amino acid metabolism
D      RM025  Conversion of amino acid moiety to carboxyl group (biogenic amine metabolism)
C    Nucleotide metabolism
D      RM045  Conversion of base / nucleoside / nucleotide
D      RM024  Pyrimidine degradation
E        M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
C    Sugar metabolism
D      RM034  Sugar degradation to aldehyde and pyruvate
E        M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
C    Aromatics metabolism
D      RM027  Hydroxylation and methylation motif
D      RM026  Hydroxylation and decarboxylation motif
D      RM028  Flavonoid synthesis
D      RM029  Pterocarpan synthesis
D      RM031  Oxime to acetate conversion
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#Last updated: August 14, 2025