Peptidases and Inhibitors

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 Aspartic peptidases
 
 Cysteine peptidases
 
 Glutamic peptidases
 
 Metallo peptidases
 
 Asparagine peptide lyases
 
 Mixed peptidases
 
 Serine peptidases
   Family S1: chymotrypsin family
   Family S3: togavirin family
   Family S6
   Family S7: flavivirin family
   Family S8: subtilisin family
   Family S9: prolyl oligopeptidase family
   Family S10
   Family S11: D-Ala-D-Ala carboxypeptidase A family
   Family S12: D-Ala-D-Ala carboxypeptidase B family
   Family S13: D-Ala-D-Ala peptidase C family
   Family S14: ClpP endopeptidase family
   Family S15
   Family S16: lon protease family
   Family S21: assemblin family
   Family S24: LexA family
   Family S26: signal peptidase I family
   Family S28
   Family S31
   Family S32
   Family S33
   Family S41: C-terminal processing peptidase family
   Family S45
   Family S49: protease IV family
   Family S50
   Family S51
   Family S53
   Family S54: Rhomboid family
     K23461  RHO; rhomboid [EC:3.4.21.105]
     K02857  RHBDL1_2_3; rhomboid-related protein 1/2/3 [EC:3.4.21.105]
     K09651  RHBDD1, RHBDL4; rhomboid-related protein 4 [EC:3.4.21.105]
     K09652  RHBDD2, RHBDL7; rhomboid domain-containing protein 2
     K09650  PARL, PSARL, PCP1; rhomboid-like protein [EC:3.4.21.105]
     K19225  gluP; rhomboid protease GluP [EC:3.4.21.105]
     K02441  glpG; rhomboid protease GlpG [EC:3.4.21.105]
     K27605  RBL; rhomboid-like protein, plant [EC:3.4.21.105]
     K28166  ydcA; rhomboid protease YdcA [EC:3.4.21.-]
     K28165  rrtA; rhombosortase
     K28366  rho1; rhomboid family protease [EC:3.4.21.105]
     K07059  rho2; rhomboid family protease [EC:3.4.21.105]
   Family S55: SpoIVB peptidase family
   Family S62
   Family S66
   Family S77: phage prohead processing peptidase family
   Family S78
 
 Threonine peptidases
 
 Peptidases of unknown catalytic type
 
 Peptidase inhibitors
   Family I1: Kazal family
     K23417  SPINK1; serine protease inhibitor Kazal-type 1
     K23418  SPINK2; serine protease inhibitor Kazal-type 2
     K23419  SPINK4; serine protease inhibitor Kazal-type 4
     K23420  SPINK5; serine protease inhibitor Kazal-type 5
     K23603  SPINK6_7_9; serine protease inhibitor Kazal-type 6/7/9
     K23604  SPINK8; serine protease inhibitor Kazal-type 8
     K23606  SPINK10_11; serine protease inhibitor Kazal-type 10/11
     K19924  SPINK13; serine protease inhibitor Kazal-type 13
     K23613  SPINK14; serine protease inhibitor Kazal-type 14
     K23615  SPIK5; ovoinhibitor
     K23614  SPIK7; ovomucoid
     K04661  FST; follistatin
     K23912  FSTL1; follistatin-related protein 1
     K23913  FSTL3; follistatin-related protein 3
     K23914  FSTL4; follistatin-related protein 4
     K23915  FSTL5; follistatin-related protein 5
     K23607  TMEFF1; tomoregulin-1
     K23608  TMEFF2; tomoregulin-2
   Family I2: Kunitz - BPTI family
   Family I4: serpin family
   Family I11: ecotin family
   Family I17: WAP-type family
   Family I25: cystatin family
   Family I27: calpastatin family
   Family I32: IAP family
   Family I34: IA3 family
   Family I35: timp family
   Family I39: alpha2M family
   Family I47: latexin family
   Family I49: proSAAS family
   Family I51: IC family
   Family I57: staphostatin B family
   Family I63
   Family I80
   Family I87
   Family I93
     K23599  SZL; secreted Xwnt8 inhibitor sizzled
     K02222  SFRP5; secreted frizzled-related protein 5

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Last updated: September 2, 2026
Classification taken and modified from MEROPS