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Description |
Object |
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map05224
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Breast cancer |
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breas... |
... (NOTCH4) K07203 (MTOR) K04688 (RPS6KB) K05459 (IGF1) K05087 (IGF1R) K05083 (ERBB2) K09101 (NCOA1), ... |
...gen signaling pathway Jagged Notch mTOR S6K IGF IGF1R HER2 CoR PI3K-Akt signaling pathway Survival P... |
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map04913
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Ovarian steroidogenesis |
The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine ... |
... (ACOT1_2_4) K04526 (INS) K04527 (INSR) K05459 (IGF1) K05087 (IGF1R) K04526 (INS) K04527 (INSR) K054... |
...MP cAMP 17β-HSD PKA DNA DNA ARTISt Insulin INSR IGF1 IGF1R Insulin INSR IGF1 IGF1R LDLR Insulin sign... |
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map04213
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Longevity regulating pathway - multiple species |
Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss... |
...00922 (PIK3CA_B_D), K02649 (PIK3R1_2_3) K05459 (IGF1) K05087 (IGF1R) K16172 (IRS1), K07187 (IRS2), K... |
FOXO S6K mTOR Akt P13K PIP LONGEVITY REGULATING PATHWAY - MULTIPLE SPECIES DNA IGF-I IGF-IR IRS1... |
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map05214
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Glioma |
Gliomas are the most common of the primary brain tumors and account for more than 40% of all central... |
...4 (TGFA) K04359 (PDGFA), K17386 (PDGFB) K05459 (IGF1) K04361 (EGFR) K04363 (PDGFRA), K05089 (PDGFRB)... |
EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR CAM CAMK PKC Shc Grb2 Sos Ra... |
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map05202
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Transcriptional misregulation in cancer |
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged ... |
...CDKN1A) K10138 (IGFBP3) K04388 (TGFBR2) K05459 (IGF1) K10048 (CEBPB) K05405 (IL6) K14242 (NFKBIZ) K1... |
...rowth inhibition, senescence, apoptosis TGFBR2 IGF1 Tumor cell growth Proliferation Interactions ... |
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map05205
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Proteoglycans in cancer |
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... |
... (IL12B) K09108 (TFAP4) K06625 (CDKN1A) K05459 (IGF1) K05087 (IGF1R) K00922 (PIK3CA_B_D), K02649 (PI... |
CD44v3 Tiam1 HER2 RhoA ROCK Ankyrin Cytoskeleton activation PI3K AKT CD44 Lipid Raft IP3R CAMKII Fil... |
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map01522
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Endocrine resistance |
Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast canc... |
...20 (E2F3) K07203 (MTOR) K04688 (RPS6KB) K05459 (IGF1) K05087 (IGF1R) K05083 (ERBB2) K11256 (NCOA3), ... |
... E2F mTOR S6K Androgens ERα loss EGFR, HER2 and IGF1R overexpression, mutation or amplification ERα ... |
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map04068
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FoxO signaling pathway |
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellu... |
...43 (MDM2) K04498 (EP300) K11411 (SIRT1) K05459 (IGF1) K05087 (IGF1R) K07201 (FOXO1), K09408 (FOXO3),... |
...pathway PTEN SKP2 Ubiquitination MDM2 CBP SIRT1 IGF1 IGF1R FOXO Ubiquitin-mediated proteolysis CDK2 ... |
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map04114
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Oocyte meiosis |
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregatio... |
...K04382 (PPP2C) K08556 (PGR) K08557 (AR) K05087 (IGF1R) K04526 (INS) K05459 (IGF1) K08694 (SPDY) K020... |
...ric cohesin Fertilization MPF MPF SMC3 PP2A PGR IGF1R INS IGF1 Ringo Cdc2 Cdk2 Plkk1 Progesterone-me... |
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map04152
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AMPK signaling pathway |
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through ev... |
...87 (IRS2), K17445 (IRS3), K17446 (IRS4) K05459 (IGF1) K05087 (IGF1R) K07201 (FOXO1), K09408 (FOXO3) ... |
... Gluconeogenesis DNA PI3K-Akt signaling pathway IGF1 IGF1R FOXO Cell cycle Insulin signaling pathway... |
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map04730
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Long-term depression |
Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar l... |
...(PRKCA), K19662 (PRKCB), K19663 (PRKCG) K05087 (IGF1R) K04578 (CRHR1) K05256 (CRH) K05459 (IGF1) K12... |
...PLA2 PLA2 NOS DAG PLC mGluR1 Glutamate PKC cGMP IGF1R CRFR1 DAG Glutamate CRF IGF1 GUCY δ2R PKG VGCC... |
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map04914
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Progesterone-mediated oocyte maturation |
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the s... |
...3',5'-Cyclic AMP) C00410 (Progesterone) K05087 (IGF1R) K05459 (IGF1) K04526 (INS) K04367 (MOS) K0260... |
IGF1R IGF-1 Insulin Mos CPEB CycB1/B4 Cdc2 Ras PI3K Cdc2 PIP , PIP Akt/PKB PDE3 APC/C Fizzy Mad1/2/3... |
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map01521
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EGFR tyrosine kinase inhibitor resistance |
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also ser... |
...K01110 (PTEN) K08052 (NF1) K05099 (MET) K05087 (IGF1R) K04363 (PDGFRA), K05089 (PDGFRB) K05098 (KDR)... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |
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map04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...(NTRK1), K04360 (NTRK2), K04527 (INSR), K05087 (IGF1R), K04363 (PDGFRA), K05089 (PDGFRB), K05090 (CS... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
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map04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...56 (NTF3), K12457 (NTF4), K04526 (INS), K05459 (IGF1), K13769 (IGF2), K04359 (PDGFA), K17386 (PDGFB)... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
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map04015
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Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
...51 (NGFA), K02582 (NGFB), K04526 (INS), K05459 (IGF1), K04359 (PDGFA), K17386 (PDGFB), K05450 (PDGFC... |
MAPK signaling pathway RAP1 SIGNALING PATHWAY ERK MEK Raf-1 Rap1 RIAM RTK RalGDS Rac RapL MEK3,6 p... |
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map04066
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HIF-1 signaling pathway |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... |
...99 (SLC2A1) K04526 (INS), K04357 (EGF), K05459 (IGF1) K04527 (INSR), K04361 (EGFR), K05087 (IGF1R), ... |
CUL2 Rbx1 ElonginB ElonginC VEGF PHD VHL HIF-1β p300/CBP HIF-1α Glut1 HIF-1 SIGNALING PATHWAY mTOR... |
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map04150
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mTOR signaling pathway |
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protei... |
... C00123 (L-Leucine) C00062 (L-Arginine) K05087 (IGF1R), K04527 (INSR) K16172 (IRS1) K00922 (PIK3CA_B... |
mTOR SIGNALING PATHWAY IRS1 PI3K Raf MAPK signaling pathway ERK1/2 Ras MEK PTEN PDK1 Akt TSC1/2 Rh... |
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map04151
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PI3K-Akt signaling pathway |
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellul... |
...(NTRK1), K04360 (NTRK2), K04527 (INSR), K05087 (IGF1R), K04363 (PDGFRA), K05089 (PDGFRB), K05090 (CS... |
PIP eIF4E 4EBPs eIF4B S6K1/2 Raptor mTOR GβL Rheb TSC2 TSC1 AKT PDK1 PI3K p53 signaling pathway mTOR... |
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map04211
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Longevity regulating pathway |
Regulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that... |
...00922 (PIK3CA_B_D), K02649 (PIK3R1_2_3) K05459 (IGF1) K05087 (IGF1R) K16172 (IRS1), K07187 (IRS2), K... |
FOXO S6K mTOR Akt P13K PIP LONGEVITY REGULATING PATHWAY DNA IGF-I IGF-IR IRS1-4 Ras cAMP PKA AMPK ... |