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Name |
Description |
Object |
Legend |
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map04024
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cAMP signaling pathway |
... G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other sig... |
C00076 (Calcium cation) C00076 (Calcium cation) C00238 (Potassium cation) C01330 (Sodium cation) C00... |
cAMP SIGNALING PATHWAY Sarcoplasmic Reticulum (SR) VDCC RyR2 SERCA2a TnI Calcium signaling pathway... |
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map04931
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Insulin resistance |
...is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alc... |
C00162 (Fatty acid) C00162 (Fatty acid) C02843 (Long-chain acyl-CoA) C00165 (Diacylglycerol) C00031 ... |
JNK1 TNFα FFA ER stress TNFR1 FATPs FFA IKKβ mTOR S6K INSR IRS-1 PI3K AKT2 GSK-3 +py LCFA-CoA DAG PK... |
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map04072
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Phospholipase D signaling pathway |
... is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton r... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4... |
MAPK signaling pathway PHOSPHOLIPASE D SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pat... |
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map04540
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Gap junction |
...s permit the direct transfer of small molecules including ions, amino acids, nucleotides, second mes... |
C00681 (1-Acyl-sn-glycerol 3-phosphate) C00076 (Calcium cation) C01245 (D-myo-Inositol 1,4,5-trispho... |
LPA v-Src cGMP DAG cAMP CK1 PKC Serotonin Glutamate Connexin Connexin Connexin Connexin Connexin Con... |
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map04917
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Prolactin signaling pathway |
...nvolved in a wide range of biological functions including osmoregulation, lactation, reproduction, g... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C05981 (Phosphatidylinositol-3,4,5-trisphosphate) ... |
Jak_STAT signaling pathway MAPK signaling pathway PIP Akt/PKB PI3K PROLACTIN SIGNALING PATHWAY ERK... |
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map04926
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Relaxin signaling pathway |
...w known to exert a range of pleiotropic effects including vasodilatory, anti-fibrotic and angiogenic... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00533 (Nitric oxide) C00575 (3',5'-Cyclic AMP) C0... |
PIP AKT RELAXIN SIGNALING PATHWAY RXFP1 IκB NF κB NFκB signaling pathway eNOS Vasodilation VEGF si... |
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map00512
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Mucin type O-glycan biosynthesis |
...e. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or... |
G00034 G00033 G00032 G00031 G00030 G00029 G00028 G00027 G00026 (Sialyl T antigen) G00025 G00023 (Tn ... |
Keratan sulfate biosynthesis Core 8 Core 7 (F1α) Core 6 Core 5 Core 4 Core 3 (disialyl-T antigen) (s... |
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map00941
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Flavonoid biosynthesis |
...etabolites that serves a multitude of functions including pigments and antioxidant activity. Flavono... |
C16492 (8-C-Glucosylnaringenin) C01460 (Vitexin) C00852 (Chlorogenate) C12208 (p-Coumaroyl quinic ac... |
Flavone and flavonol biosynthesis Flavone and flavonol biosynthesis 8-C-Glucosylnaringenin Vitexin C... |
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map01210
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2-Oxocarboxylic acid metabolism |
...are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate,... |
C17254 (8-Methylthiooctyl glucosinolate) C17232 (2-Oxo-10-methylthiodecanoic acid) C17252 (7-Methylt... |
8-Methylthiooctyl glucosinolate 2-Oxo-10-methylthio-decanoic acid 7-Methylthioheptyl glucosinolate 2... |
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map02025
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Biofilm formation - Pseudomonas aeruginosa |
... of biofilm formation by Pseudomonas aeruginosa include cAMP/Vfr signaling, quorum sensing (QS) syst... |
C00575 (3',5'-Cyclic AMP) C11837 (N-Butyryl-L-homoserine lactone) C20643 (2-Heptyl-4(1H)-quinolone),... |
PilI PilH PilG PilJ ChpA CyaB cAMP CpdA Vfr LasI LasR RhlI PqsA PqsB PqsC PqsD PqsH MvfR BIOFILM FO... |
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map03430
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Mismatch repair |
...lity, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeu... |
K06223 (dam) K03555 (mutS), K07456 (mutS2) K08735 (MSH2) K08739 (MLH3) K08734 (MLH1) K03573 (mutH) K... |
Dam MutS MSH2 MLH3 MLH1 Colorectal cancer MutH MutL Lig UVRD MLH1 LigI PCNA DpoIII ExoI Polδ RPA Exo... |
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map04012
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ErbB signaling pathway |
...pathways regulating diverse biologic responses, including proliferation, differentiation, cell motil... |
C00076 (Calcium cation) C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C05981 (... |
Non-small cell lung cancer Grb2 Elk ErbB-4 ErbB-4 ErbB-3 ErbB-3 STAT5 ErbB-2 ErbB-2 ErbB-2 ErbB-2... |
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map04061
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Viral protein interaction with cytokine and cytokine receptor |
...detection and destruction by the immune system, including copying and repurposing host cytokine and ... |
K12499 (CCL5), K05408 (CCL3), K16596 (CCL8), K22671 (CCL9), K21092 (CCL14), K21093 (CCL16), K05511 (... |
Chemokines CCL CCR1 vCCI CCL3 vav US28 U12 CCL3 hcmv hhv6 vCCI CCL7 vav CCL7 US28 hcmv MC148 CCR1 vC... |
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map04068
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FoxO signaling pathway |
...ssion of genes in cellular physiological events including apoptosis, cell-cycle control, glucose met... |
C00031 (D-Glucose) C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C00008 (ADP) C00020 (AMP) C0002... |
IKKα/β JNK ERK1/2 AMPK INS Glucose FOXO SOS Ras MEK1/2 INSR Raf PEPCK G6PC Akt P13K PDK1/2 IRS PIP F... |
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map04510
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Focal adhesion |
...sential roles in important biological processes including cell motility, cell proliferation, cell di... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) C04637 (1-Phosphatidyl-D-myo-inositol 4,5-bisphosp... |
ECM-receptor interaction Cytokine-cytokine receptor interaction MAPK signaling pathway ITGB ITGA Fil... |
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map04550
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Signaling pathways regulating pluripotency of stem cells |
...erminal layers. The types of PSCs known to date include embryonic stem (ES) and induced pluripotent ... |
K03209 (WNT1), K00182 (WNT2), K00312 (WNT3), K00408 (WNT4), K00444 (WNT5), K00445 (WNT6), K00572 (WN... |
Wnt APC Axin Dvl Frizzled SIGNALING PATHWAYS REGULATING PLURIPOTENCY OF STEM CELLS β-catenin G... |
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map04668
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TNF signaling pathway |
...e a wide range of intracellular signal pathways including apoptosis and cell survival as well as inf... |
K03156 (TNF) K03158 (TNFRSF1A) K03171 (TRADD) K03173 (TRAF2), K09849 (TRAF5) K02861 (RIPK1) K16060 (... |
TNF SIGNALING PATHWAY TNF TNFR1 TRADD TRAF2/5 RIP1 cIAP1/2 TAK1 MKK4/7 MKK3/6 p38 JNK1/2 IKKγ IKK... |
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map04672
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Intestinal immune network for IgA production |
...microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's... |
C00777 (Retinoate), C15493 (9-cis-Retinoic acid) K13375 (TGFB1) K05428 (IL5) K05405 (IL6) K05475 (TN... |
TGFβ Gut lumen M cell Antigen processing and presentation T cell receptor signaling pathway B c... |
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map04726
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Serotonergic synapse |
...ne secretion, as well as in pathological states including abnormal mood and cognition. Once released... |
C00643 (5-Hydroxy-L-tryptophan) C00780 (Serotonin) C00780 (Serotonin) C00575 (3',5'-Cyclic AMP) C012... |
SEROTONERGIC SYNAPSE Glial cell Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) 5-HT 4, 6... |
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map04910
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Insulin signaling pathway |
... signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade includin... |
C00369 (Starch) C00575 (3',5'-Cyclic AMP) C00031 (D-Glucose) C05981 (Phosphatidylinositol-3,4,5-tris... |
TSC1 SKIP SHIP2 IKK JNK LAR PTP1B SOCS Elk1 MNK ERK1/2 FAS AMPK Glycogen cAMP INS Glucose HSL PP1 PY... |