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Description |
Object |
Legend |
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map04926
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Relaxin signaling pathway |
Human relaxin-2 ("relaxin"), originally identified as a peptidic hormone of pregnancy, is now known ... |
...(RXFP1) K04734 (NFKBIA) K02580 (NFKB1), K04735 (RELA) K13242 (NOS3) K04371 (ERK) K00922 (PIK3CA_B_D)... |
PIP AKT RELAXIN SIGNALING PATHWAY RXFP1 IκB NF κB NFκB signaling pathway eNOS Vasodilation VEGF si... |
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map04122
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Sulfur relay system |
... Ubiquitin, MoaD, and ThiS are all structurally related proteins whose C-termini are activated throu... |
C00097 (L-Cysteine) C00041 (L-Alanine) C00868 (tRNA uridine) C17322 (tRNA containing 2-thiouridine) ... |
SULFUR RELAY SYSTEM E1-like urm1 -COOH ATP PPi -COAMP Protein modification Prokaryote Ahp1 -NHCO-... |
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map04270
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Vascular smooth muscle contraction |
...enhancement. The signaling events that mediate relaxation include the removal of a contractile agon... |
C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00165 (Diacylglycerol) C00076 (Calcium cation) C00219 (... |
...GEF VASCULAR SMOOTH MUSCLE CONTRACTION Actin Relaxation ADRA1 Gαq /11 12/13 PLC DAG Sarcoplasmic ... |
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map04920
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Adipocytokine signaling pathway |
...d adipocyte volume and number are positively correlated with leptin production, and negatively corre... |
...C00076 (Calcium cation) K02580 (NFKB1), K04735 (RELA) K02581 (NFKBIB), K04734 (NFKBIA), K05872 (NFKB... |
Ceramide Long-chain fatty acid Retinoic acid NF-κB IκB SHP-2 SOCS3 CPT-1 G6PC PEPCK FACS Diglyceride... |
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map00571
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Lipoarabinomannan (LAM) biosynthesis |
...ipoarabinomannan (LAM), as well as structurally related lipomannan (LM) and phosphatidylinositol man... |
C01194 (1-Phosphatidyl-D-myo-inositol) G11291 (Phosphatidyl-myo-inositol monomannoside) G13108 (Tria... |
PIM PimA PIM PimC PIM PIM PIM PimE /Ac PIM6 Man PimC PimB’ Man Ino-P Man PimA Man Man PimE Man LIPOA... |
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map04136
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Autophagy - other |
... including plants and protists, where autophagy related genes (ATGs) play similar roles in the life ... |
C00350 (Phosphatidylethanolamine) C00350 (Phosphatidylethanolamine) C04549 (1-Phosphatidyl-1D-myo-in... |
AUTOPHAGY - OTHER Nutrient starvation TORC1 complex Raptor TOR LST8 ATG1 complex ATG1 ATG13 ATG11 ... |
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map04392
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Hippo signaling pathway - multiple species |
...nserved over a billion years of evolution, with related forms described in animals and fungi. In Dro... |
K16685 (WWC1) K16684 (NF2) K16821 (FRMD1), K16822 (FRMD6) K16686 (SAV1) K04412 (STK3) K16687 (YAP1),... |
HIPPO SIGNALING PATHWAY - MULTIPLE SPECIES Kibra NF2 FRMD SAV1 Mst1/2 YAP/TAZ Lats1/2 DNA Mob1... |
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map05213
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Endometrial cancer |
...iology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endo... |
C05981 (Phosphatidylinositol-3,4,5-trisphosphate) K02105 (CTNNB1) K02105 (CTNNB1) K02833 (HRAS), K07... |
β-Catenin β-Catenin Ras APC Axin GSK-3β α-Catenin β-Catenin Cell cycle Fkhrl1 BAD Casp9 ILK ErbB sig... |
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map05161
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Hepatitis B |
... virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry in... |
...6 (MAP3K1) K04440 (JNK) K02580 (NFKB1), K04735 (RELA) K04734 (NFKBIA) K04448 (JUN) K04501 (SMAD4) K0... |
Mitochondria VDAC3 CytC CASP9 Apaf-1 CASP12 CASP3 Apoptosis Bax Survivin Ca release PKC Raf MEK E... |
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map04931
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Insulin resistance |
...s suggested that elevated O-GlcNAc level was correlated to high glucose-induced insulin resistance. ... |
...(CPT1B) K04734 (NFKBIA) K02580 (NFKB1), K04735 (RELA) K19662 (PRKCB) K06269 (PPP1C), K07189 (PPP1R3)... |
JNK1 TNFα FFA ER stress TNFR1 FATPs FFA IKKβ mTOR S6K INSR IRS-1 PI3K AKT2 GSK-3 +py LCFA-CoA DAG PK... |
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map05212
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Pancreatic cancer |
...the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple ef... |
...(IKBKB), K07210 (IKBKG) K02580 (NFKB1), K04735 (RELA) K02158 (BAD) K04570 (BCL2L1) K04365 (BRAF), K0... |
HER2/neu K-Ras PI3K RacGEF PKB/Akt Rac IKK NFκB Bad Bcl-xl Raf CASP9 MEK ERK RalGDS Ral RalBP1 PLD1 ... |
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map04024
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cAMP signaling pathway |
...proteins of the Rho family, and phospholipases, relay signaling downstream from Rap. |
...158 (BAD) K06230 (GLI3) K02580 (NFKB1), K04735 (RELA) K07294 (NR1C1) K04446 (NFATC1) K04498 (EP300) ... |
...dation (hepatocyte) Fatty acid degradation MLC Relaxation (endothelial cell, smooth muscle cell) Ap... |
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map01523
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Antifolate resistance |
...roperties of antifolate have been most strongly related to its ability to block the release of pro-i... |
...(IKBKB), K07210 (IKBKG) K02580 (NFKB1), K04735 (RELA) K05405 (IL6) K04519 (IL1B) K03156 (TNF) K00600... |
ANTIFOLATE RESISTANCE RFC ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 GARTF Antifolate Methotrexate (MTX) Pemetre... |
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map04010
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MAPK signaling pathway |
...regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinase... |
... (MAPT) K02580 (NFKB1), K04469 (NFKB2), K04735 (RELA), K09253 (RELB) K04467 (IKBKA), K07209 (IKBKB),... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
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map04210
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Apoptosis |
...set of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves... |
...87 (CASP3) K02158 (BAD) K02580 (NFKB1), K04735 (RELA) K16060 (BIRC2_3), K04725 (XIAP), K08731 (BIRC5... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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map04933
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AGE-RAGE signaling pathway in diabetic complications |
... and TNF-alpha and a variety of atherosclerosis-related genes, including VCAM-1, tissue factor, VEGF... |
...421 (NOX2), K21423 (NOX4) K19722 (AGER) K04735 (RELA), K02580 (NFKB1) K19722 (AGER) K19662 (PRKCB) K... |
AGE-RAGE SIGNALING PATHWAY IN DIABETIC COMPLICATIONS High glucose Aging Inflammation Oxidative... |
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map05030
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Cocaine addiction |
Drug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking beh... |
...29 (FOSB) K02090 (CDK5) K02580 (NFKB1), K04735 (RELA) K05870 (CREB1), K04450 (ATF2), K04374 (ATF4), ... |
COCAINE ADDICTION Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopaminergi... |
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map05130
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Pathogenic Escherichia coli infection |
...nd enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The ... |
...58 (TNFRSF1A) K03156 (TNF) K08007 (EZR) K04735 (RELA) K04734 (NFKBIA), K02581 (NFKBIB) K07209 (IKBKB... |
Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin... |
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map05166
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Human T-cell leukemia virus 1 infection |
...actor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The... |
...377 (MYC) K11126 (TERT) K02580 (NFKB1), K04735 (RELA) K04734 (NFKBIA) K05429 (IL2) K05068 (IL2RA) K0... |
HUMAN T-CELL LEUKEMIA VIRUS 1 INFECTION Human T-lymphotropic virus-I gp21 gp46 NRP1 CD4+ T cell... |
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map04022
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cGMP-PKG signaling pathway |
...2+-desensitization), resulting in smooth muscle relaxation. In cardiac myocyte, PKG directly phospho... |
C00533 (Nitric oxide) C00942 (3',5'-Cyclic GMP) C00076 (Calcium cation) C00238 (Potassium cation) C0... |
...reased calcium release from store Smooth muscle relaxation Hypertrophic response genes Decrease in i... |