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Description |
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map04672
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Intestinal immune network for IgA production |
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunit... |
...etinoate), C15493 (9-cis-Retinoic acid) K13375 (TGFB1) K05428 (IL5) K05405 (IL6) K05475 (TNFSF13) K0... |
TGFβ Gut lumen M cell Antigen processing and presentation T cell receptor signaling pathway B c... |
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map05321
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Inflammatory bowel disease |
Inflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is ... |
...4735 (RELA) K03156 (TNF) K05426 (IL23A) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K05405 (IL6) ... |
INFLAMMATORY BOWEL DISEASE APC TLR2 NF-κB DNA NOD2 MDP PGN TLR5 Flagellin TLR2 Peptidoglycans Lipo... |
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map05415
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Diabetic cardiomyopathy |
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients ... |
...962 (RYR2) K05853 (ATP2A) K19722 (AGER) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04441 (P38) ... |
FFA FFA LCFA-CoA DAG PKCα/δ FAT/CD36 Cer PP2A DIABETIC CARDIOMYOPATHY PKCβ Glucose Glucose UDP-GlcNA... |
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map04218
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Cellular senescence |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... |
...K05405 (IL6) K10030 (IL8) K04383 (IL1A) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K13375 (TGFB1... |
CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB... |
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map04659
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Th17 cell differentiation |
Interleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in ep... |
...494 (IL17F) K05434 (IL21) K05445 (IL22) K13375 (TGFB1) K04500 (SMAD2), K23605 (SMAD3), K04501 (SMAD4... |
DAG IκB NFκB IKK PKCθ NFAT CaN ZAP70 TCRβ TCRα Cell adhesion molecules Th17 CELL DIFFERENTIATIO... |
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map04933
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AGE-RAGE signaling pathway in diabetic complications |
Advanced glycation end products (AGEs) are a complex group of compounds produced through the non-enz... |
... (PLCG1), K05859 (PLCG2), K05860 (PLCE) K13375 (TGFB1) K13375 (TGFB1) K04166 (AGTR1) K08008 (NOX1), ... |
AGE-RAGE SIGNALING PATHWAY IN DIABETIC COMPLICATIONS High glucose Aging Inflammation Oxidative... |
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map05200
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Pathways in cancer |
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...482 (RAD51) K08734 (MLH1) K08735 (MSH2) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04674 (TGFBR... |
PATHWAYS IN CANCER DCC CASP3 CASP9 CASP3 ECAD β-catenin Wnt α-catenin β-catenin ITGB Dvl ECM ITGA ... |
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map05211
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Renal cell carcinoma |
Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be risin... |
...marate) C00007 (Oxygen) K07293 (PTPN11) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K05448 (VEGFA... |
SHP2 TGF-β VEGF Glut1 HIF-β p300/CBP CUL2 Rbx1 ElonginB ElonginC VHL HPH HIF-α Malate Fumarate CUL2 ... |
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map04060
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Cytokine-cytokine receptor interaction |
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulat... |
...7 (INHBA) K13377 (TGFB3) K13376 (TGFB2) K13375 (TGFB1) K05156 (RELT), K26541 (RELL) K05155 (TNFRSF19... |
...P7 BMP2 AMH INHBE INHBC INHBB INHBA TGFB3 TGFB2 TGFB1 RELT TROY XEDAR EDAR BAFFR TACI BCMA GITR Ox40... |
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map04148
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Efferocytosis |
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...1 (PTGER4) K11987 (PTGS2) K06259 (CD36) K13375 (TGFB1) K00460 (ALOX15) K05853 (ATP2A) K04515 (CAMK2)... |
... DNMT3 Methionine DUSP4 EP2/4 PTGS2 PGE2 CD36 TGFB1 Anti-inframatory responses ALOX15 25-HC EFFERO... |
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map04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...1R1), K04723 (IL1RAP) K03158 (TNFRSF1A) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04383 (IL1A)... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
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map04068
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FoxO signaling pathway |
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellu... |
...(FOXO3), K12358 (FOXO4), K17847 (FOXO6) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) |
IKKα/β JNK ERK1/2 AMPK INS Glucose FOXO SOS Ras MEK1/2 INSR Raf PEPCK G6PC Akt P13K PDK1/2 IRS PIP F... |
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map04110
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Cell cycle |
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replic... |
...DKN1B), K09993 (CDKN1C) K04685 (CDKN2B) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04501 (SMAD4... |
ARF Cdh1 MCM ORC APC/C APC/C SCF SCF CDK1 BubR1 PCNA Plk1 ATM/ATR Dbf4 Mad2 Bub1 Bub3 Cdc14b 14-3-3 ... |
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map04350
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TGF-beta signaling pathway |
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and... |
...(SMURF) K04388 (TGFBR2) K04674 (TGFBR1) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04660 (DCN) ... |
LTBP1 THBS1 Cul1 Rbx1 TGF-BETA SIGNALING PATHWAY Apoptosis Cell Cycle Ubiquitin mediated proteolys... |
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map04380
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Osteoclast differentiation |
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage... |
...96 (SOCS3) K14380 (FHL2) K08530 (NR1C3) K13375 (TGFB1), K13376 (TGFB2) K04674 (TGFBR1), K04388 (TGFB... |
OSTEOCLAST DIFFERENTIATION c-Fms TRAF2/6 RANK RANKL M-CSF OPG CYLD Gab2 NIK IKKα IKKγ IKKα IKKβ IκB... |
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map04390
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Hippo signaling pathway |
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies... |
...7 (YAP1), K16820 (WWTR1) K06464 (ITGB2) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04674 (TGFBR... |
HIPPO SIGNALING PATHWAY KIBRA Mer FRMD SAV1 Mst1/2 YAP/TAZ Lats1/2 Crb α-Catenin RASSF1A CTGF Bir... |
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map04926
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Relaxin signaling pathway |
Human relaxin-2 ("relaxin"), originally identified as a peptidic hormone of pregnancy, is now known ... |
...240 (NOS1) K01398 (MMP2), K01403 (MMP9) K13375 (TGFB1) K04500 (SMAD2) K12313 (ACTA2) K06236 (COL1A),... |
PIP AKT RELAXIN SIGNALING PATHWAY RXFP1 IκB NF κB NFκB signaling pathway eNOS Vasodilation VEGF si... |
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map04932
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Non-alcoholic fatty liver disease |
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... |
...4 (ATF4) K04452 (DDIT3) K07415 (CYP2E1) K13375 (TGFB1) K03156 (TNF) K10030 (IL8) K04389 (TNFSF6) K08... |
NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos... |
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map05140
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Leishmaniasis |
Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and ... |
...425 (IL12B) K13241 (NOS2) K05443 (IL10) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K03156 (TNF) ... |
Macrophage FNR FcγR C3b PKC p47phox Complement cascade Leishmania promastigote LPG Calcium signa... |
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map05142
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Chagas disease |
Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease, also called Ame... |
...(PIK3CA_B_D) K04456 (AKT) K05443 (IL10) K13375 (TGFB1), K13376 (TGFB2), K13377 (TGFB3) K03456 (PPP2R... |
TLR2 TLR4 IFNγ gp160 TcCRT C3b C1q Complement pathway Toll-like receptor signaling pathway TLR9 ... |