How KEGG can be used for genome/metagenome annotation
- the collection of internally annotated gene catalogs for the complete genomes (called KEGG organisms) and additional protein sequences in the KEGG GENES database
- the knowledge base of high-level functions represented as the molecular interaction, reaction and relation networks in the KEGG PATHWAY, BRITE and MODULE databases, and
- the knowledge base of molecular-level functions associated with ortholog groups in the KO database, where most KO entries are defined in a context-dependent manner as nodes of the KEGG molecular networks.
Continuous efforts are being made to expand the repertoire of KO entries and the improved collection of KEGG modules (identified by M numbers) for automated interpretation of high-level funtions.
The ortholog table (OT) has existed from the beginning of the KEGG project. For a given set of K numbers it displays the current assignment of genes in KEGG organisms.
The module table (MT) is a new addition to the KEGG annotation resource. For a given set of M and/or K numbers it identifies organisms that contain complete modules and/or KO groups. The list of organisms may be collapsed into species or genus level.
The KO entry page (such as K08940) contains the Taxonomy button for mapping against the NCBI taxonomy (br08610), while the module entry page (such as M00165) and the show_module page (such as M00165) contain the Taxonomy button for mapping against the KEGG taxonomy (br08601). The following is a more flexible interface that can be used to examine taxonomic distribution of a single K number, a single M number, or a logical expression of M and K numbers.
Comparing subunit structures or gene sets
Signature KOs and Modules
Last updated: May 1, 2021