| Date | Map no | Title | Status |
| 2025-4-9 | 04082 | Neuroactive ligand signaling | Newly added |
| 2025-2-25 | 01320 | Sulfur cycle | Newly added |
| 2025-2-25 | 00520 | Amino sugar and nucleotide sugar metabolism | Category rechanged |
| 2025-2-25 | 00541 | Biosynthesis of various nucleotide sugars | Category rechanged |
| 2025-1-15 | 04081 | Hormone signaling | Newly added |
| 2024-12-26 | 00541 | Biosynthesis of various nucleotide sugars | Title and category changed |
| 2024-10-29 | 03264 | Virion - Flavivirus and Alphavirus | Combined with new item |
| 2024-10-29 | 04981 | Folate transport and metabolism | Newly added |
| 2024-9-17 | 03272 | Virion - Hepatitis viruses | Newly added |
| 2024-8-29 | 01310 | Nitrogen cycle | Newly added |
| 2024-6-26 | 00074 | Mycolic acid biosynthesis | Newly added |
| 2024-6-10 | 00710 | Carbon fixation by Calvin cycle | Title changed |
| 2024-6-10 | 00720 | Other carbon fixation pathways | Title changed |
| 2024-12-7 | 03265 | Virion - Ebolavirus, Lyssavirus and Morbillivirus | Combined with new item |
| 2024-4-4 | 04820 | Cytoskeleton in muscle cells | Newly added |
| 2024-3-21 | 04980 | Cobalamin transport and metabolism | Newly added |
| 2024-1-15 | 03271 | Virion - Rotavirus | Newly added |
| 2024-1-9 | 03261 | Virion - Influenza virus | Title changed |
| 2023-12-7 | 03265 | Virion - Ebolavirus and Lyssavirus | Combined with new item |
| 2023-12-7 | 03259 | Virion - Bacteriophage T4 and T7 | Combined with 03269 |
| 2023-12-7 | 03269 | Virion - Bacteriophage T4 | Deleted; merged into 03259 |
| 2023-10-30 | 03258 | Virion - Bacteriophage lambda | Newly added |
| 2023-10-10 | 03259 | Virion - Bacteriophage T7 | Newly added |
| 2023-10-5 | 04148 | Efferocytosis | Newly added |
| 2023-9-14 | 03269 | Virion - Bacteriophage T4 | Newly added |
| 2023-7-10 | 03082 | ATP-dependent chromatin remodeling | Newly added |
| 2023-7-1 | 03083 | Polycomb repressive complex | Newly added |
| 2023-3-30 | 04814 | Motor proteins | Newly added |
| 2023-3-6 | 00903 | Limonene degradation | Title changed |
| 2023-3-6 | 00907 | Pinene, camphor and geraniol degradation | Newly added |
| 2023-3-6 | 00281 | Geraniol degradation | Deleted; merged into 00907 |
| 2022-12-19 | 03262 | Virion - Coronavirus | Newly added |
| 2022-12-5 | 00946 | Degradation of flavonoids | Newly added |
| 2022-11-10 | 03261 | Virion - Influenza A virus | Newly added |
| 2022-10-24 | 03267 | Virion - Adenovirus | Newly added |
| 2022-9-29 | 03260 | Virion - Human immunodeficiency virus | Newly added |
| 2022-9-29 | 03263 | Virion - Enterovirus | Newly added |
| 2022-9-29 | 03264 | Virion - Flavivirus | Newly added |
| 2022-9-29 | 03265 | Virion - Lyssavirus | Newly added |
| 2022-9-29 | 03266 | Virion - Herpesvirus | Newly added |
| 2022-9-29 | 03268 | Virion - Orthopoxvirus | Newly added |
| 2022-8-9 | 00543 | Exopolysaccharide biosynthesis | Newly added |
| 2022-3-24 | 00552 | Teichoic acid biosynthesis | Newly added |
| 2022-3-14 | 03250 | Viral life cycle - HIV-1 | Newly added |
| 2022-3-8 | 01232 | Nucleotide metabolism | Newly added |
| 2021-12-23 | 00996 | Biosynthesis of various alkaloids | Newly added |
| 2021-12-23 | 01058 | Acridone alkaloid biosynthesis | Deleted; merged into 00996 |
| 2021-12-23 | 00997 | Biosynthesis of various other secondary metabolites | Title changed; reorganized |
| 2021-12-23 | 00998 | Biosynthesis of various antibiotics | Title changed; reorganized |
| 2021-12-23 | 00999 | Biosynthesis of various plant secondary metabolites | Title changed; reorganized |
| 2021-12-1 | 00860 | Porphyrin metabolism | Title changed |
| 2021-10-13 | 01250 | Biosynthesis of nucleotide sugars | Newly added |
| 2021-10-6 | 04936 | Alcoholic liver disease | Newly added |
| 2021-10-6 | 03240 | Viral replication | Newly added |
| 2021-9-22 | 00470 | D-Amino acid metabolism | Newly added by merging 00471-3 |
| 2021-9-22 | 00471 | D-Glutamine and D-glutamate metabolism | Deleted; merged into 00470 |
| 2021-9-22 | 00472 | D-Arginine and D-ornithine metabolism | Deleted; merged into 00470 |
| 2021-9-22 | 00473 | D-Alanine metabolism | Deleted; merged into 00470 |
| 2021-9-7 | 00072 | Synthesis and degradation of ketone bodies | Deleted; merged into 00650 |
| 2021-8-2 | 03013 | Nucleocytoplasmic transport | Title changed |
| 2021-7-26 | 05208 | Chemical carcinogenesis - reactive oxygen species | Newly added |
| 2021-6-3 | 03230 | Viral genome structure | Newly added |
| 2021-5-31 | 05207 | Chemical carcinogenesis - receptor activation | Newly added |
| 2021-5-31 | 05204 | Chemical carcinogenesis - DNA adducts | Title changed |
| 2021-4-21 | 00542 | O-Antigen repeat unit biosynthesis | Newly added |
| 2021-3-29 | 05417 | Lipid and atherosclerosis | Newly added |
| 2021-2-22 | 05415 | Diabetic cardiomyopathy | Newly added |
| 2021-1-18 | 04613 | Neutrophil extracellular trap formation | Newly added |
| 2020-11-20 | 05171 | Coronavirus disease - COVID-19 | Newly added |
| 2020-11-19 | 01240 | Biosynthesis of cofactors | Newly added |
| 2020-10-19 | 05022 | Pathways of neurodegeneration - multiple diseases | Newly added |
| 2020-9-10 | 00541 | O-Antigen nucleotide sugar biosynthesis | Newly added |
| 2020-3-10 | 01130 | Biosynthesis of antibiotics | Deleted; merged into 01110 |
| 2020-1-14 | 05017 | Spinocerebellar ataxia | Newly added |
| 2019-11-21 | 00231 | Puromycin biosynthesis | Deleted; merged into 00998 |
| 2019-11-19 | 00997 | Biosynthesis of various secondary metabolites - part 3 | Newly added |
| 2019-11-19 | 00998 | Biosynthesis of various secondary metabolites - part 2 | Title changed; reorganized with 00999 |
| 2019-11-19 | 00999 | Biosynthesis of various secondary metabolites - part 1 | Title changed; reorganized with 00998 |
| 2019-10-2 | 04935 | Growth hormone synthesis, secretion and action | Newly added |
| 2019-7-29 | 04929 | GnRH secretion | Newly added |
| 2019-6-25 | 04361 | Axon regeneration | Newly added |
| 2019-6-13 | 05135 | Yersinia infection | Newly added |
| 2019-6-3 | 00998 | Biosynthesis of secondary metabolites - other antibiotics | Newly added |
| 2019-5-31 | 04061 | Viral protein interaction with cytokine and cytokine receptor | Newly added |
| 2019-5-13 | 05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | Newly added |
| 2019-2-25 | 05168 | Herpes simples virus 1 infection | Title changed |
| 2018-8-21 | 00572 | Arabinogalactan biosynthesis - Mycobacterium | Newly added |
| 2018-8-8 | 05170 | Human immunodeficiency virus 1 infection | Newly added |
| 2018-8-8 | 05166 | Human T-cell leukemia virus 1 infection | Title changed |
| 2018-7-9 | 00999 | Biosynthesis of secondary metabolites - unclassified | Newly added |
| 2018-6-21 | 00571 | Lipoarabinomannan (LAM) biosynthesis | Newly added |
| 2018-6-20 | 05163 | Human cytomegalovirus infection | Newly added |
| 2018-5-21 | 00351 | DDT degradation | Deleted; merged into 00621 |
| 2018-4-16 | 04928 | Parathyroid hormone synthesis, secretion and action | Newly added |
| 2018-3-26 | 04625 | C-type lectin receptor signaling pathway | Newly added |
| 2018-3-6 | 04934 | Cushing syndrome | Newly added |
| 2018-2-15 | 04714 | Thermogenesis | Newly added |
| 2018-1-24 | 04927 | Cortisol synthesis and secretion | Newly added |
| 2017-12-7 | 04979 | Cholesterol metabolism | Newly added |
| 2017-11-6 | 05226 | Gastric cancer | Newly added |
| 2017-9-29 | 05225 | Hepatocellular carcinoma | Newly added |
| 2017-8-7 | 04926 | Relaxin signaling pathway | Newly added |
| 2017-6-27 | 00333 | Prodigiosin biosyntheses | Newly added |
| 2017-6-26 | 05165 | Human papillomavirus infection | Newly added |
| 2017-6-20 | 04218 | Cellular senescence | Newly added |
| 2017-5-15 | 05167 | Kaposi sarcoma-associated herpesvirus infection | Newly added |
| 2017-5-11 | 04217 | Necroptosis | Newly added |
| 2017-3-29 | 04216 | Ferroptosis | Newly added |
| 2017-3-28 | 04136 | Autophagy - other | Newly added |
| 2017-3-27 | 00405 | Phenazine biosynthesis | Newly added |
| 2017-3-9 | 04137 | Mitophagy - animal | Newly added |
| 2017-2-22 | 04371 | Apelin signaling pathway | Newly added |
| 2017-2-13 | 05418 | Fluid shear stress and atherosclerosis | Newly added |
| 2017-2-13 | 01059 | Biosynthesis of enediyne antibiotics | Newly added |
| 2017-2-7 | 04140 | Autophagy - animal | New version of 04140 |
| 2017-2-2 | 04138 | Autophagy - yeast | Newly added; split from 04140 |
| 2017-1-11 | 04657 | IL-17 signaling pathway | Newly added |
| 2017-1-6 | 02026 | Biofilm formation - Escherichia coli | Newly added |
| 2016-12-14 | 04659 | Th17 cell differentiation | Newly added |
| 2016-12-7 | 00515 | Mannose type O-glycan biosynthesis | Newly added |
| 2016-11-28 | 02025 | Biofilm formation - Pseudomonas aeruginosa | Newly added |
| 2016-11-14 | 04658 | Th1 and Th2 cell differentiation | Newly added |
| 2016-11-10 | 05111 | Biofilm formation - Vibrio cholerae | Title changed in the new cateogry |
| 2016-10-11 | 01523 | Antifolate resistance | Newly added |
| 2016-10-11 | 04016 | MAPK signaling pathway - plant | Newly added |
| 2016-9-23 | 00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | Title changed |
| 2016-9-12 | 05224 | Breast cancer | Newly added |
| 2016-8-31 | 04624 | Toll and Imd signaling pathway | Newly added |
| 2016-8-9 | 00524 | Neomycin, kanamycin and gentamicin biosynthesis | Title changed |
| 2016-8-5 | 01522 | Endocrine resistance | Newly added |
| 2016-8-1 | 02024 | Quorum sensing | Newly added |
| 2016-7-11 | 01524 | Platinum drug resistance | Newly added |
| 2016-7-11 | 00525 | Acarbose and validamycin biosynthesis | Newly added |
| 2016-6-20 | 01521 | EGFR tyrosine kinase inhibitor resistance | Newly added in the new category |
| 2016-6-1 | 04341 | Hedgehog signaling pathway - fly | Newly added |
| 2016-5-27 | 04392 | Hippo signaling pathway - multiple species | Newly added |
| 2016-4-18 | 04215 | Apoptosis - multiple species | Newly added |
| 2016-4-14 | 00404 | Staurosporine biosynthesis | Newly added |
| 2016-3-31 | 04214 | Apoptosis - fly | Newly added |
| 2016-2-3 | 04213 | Longevity regulating pathway - multiple species | Newly added |
| 2016-1-7 | 04212 | Longevity regulating pathway - worm | Newly added |
| 2015-12-14 | 04211 | Longevity regulating pathway | Newly added |
| 2015-12-14 | 04139 | Mitophagy - yeast | Newly added |
| 2015-12-1 | 04933 | AGE-RAGE signaling pathway in diabetic complications | Newly added |
| 2015-10-28 | 04072 | Phospholipase D signaling pathway | Newly added |
| 2015-9-14 | 04925 | Aldosterone synthesis and secretion | Newly added |
| 2015-8-27 | 04931 | Insulin resistance | Newly added |
| 2015-7-24 | 04924 | Renin secretion | Newly added |
| 2015-7-13 | 00220 | Arginine biosynthesis | Newly added; split from 00330 |
| 2015-6-8 | 04923 | Regulation of lipolysis in adipocytes | Newly added |
| 2015-4-27 | 01503 | Cationic antimicrobial peptide (CAMP) resistance | Newly added |
| 2015-4-6 | 00261 | Monobactam biosynthesis | Newly added |
| 2015-3-27 | 01130 | Biosynthesis of antibiotics | Newly added global map |
| 2015-3-9 | 04922 | Glucagon signaling pathway | Newly added |
| 2015-2-16 | 04071 | Sphingolipid signaling pathway | Newly added |
| 2015-1-20 | 01502 | Vancomycin resistance | Newly added |
| 2014-12-24 | 01501 | beta-Lactam resistance | New map number; changed from 00312 |
| 2014-11-28 | 05231 | Choline metabolism in cancer | Newly added |
| 2014-10-27 | 05230 | Central carbon metabolism in cancer | Newly added |
| 2014-10-2 | 00332 | Carbapenem biosynthesis | Newly added |
| 2014-9-1 | 04550 | Signaling pathways regulating pluripotency of stem cells | Newly added |
| 2014-7-25 | 04024 | cAMP signaling pathway | Newly added |
| 2014-7-10 | 00403 | Indole diterpene alkaloid biosynthesis | Newly added |
| 2014-6-12 | 04152 | AMPK signaling pathway | Newly added |
| 2014-5-26 | 04622 | cGMP-PKG signaling pathway | Newly added |
| 2014-4-28 | 04611 | Platelet activation | Newly added |
| 2014-4-4 | 04921 | Oxytocin signaling pathway | Newly added |
| 2014-4-1 | 00312 | beta-Lactam resistance | Newly added in the new category |
| 2014-2-28 | 04750 | Inflammatory mediator regulation of TRP channels | Newly added |
| 2014-1-23 | 04919 | Thyroid hormone signaling pathway | Newly added |
| 2013-12-24 | 04068 | FoxO signaling pathway | Newly added |
| 2013-11-18 | 04261 | Adrenergic signaling in cardiomyocytes | Newly added |
| 2013-10-30 | 04015 | Rap1 signaling pathway | Newly added |
| 2013-10-28 | 00254 | Aflatoxin biosynthesis | Newly added |
| 2013-10-21 | 01212 | Fatty acid metabolism | Newly added |
| 2013-10-7 | 04014 | Ras signaling pathway | Newly added |
| 2013-9-9 | 04932 | Non-alcoholic fatty liver disease (NAFLD) | Newly added |
| 2013-8-28 | 00071 | Fatty acid degradation | Title changed |
| 2013-8-9 | 05206 | MicroRNAs in cancer | Newly added |
| 2013-7-12 | 05321 | Inflammatory bowel disease (IBD) | Newly added |
| 2013-7-2 | 04918 | Thyroid hormone synthesis | Newly added |
| 2013-6-28 | 01200 | Carbon metabolism | Newly added |
| 2013-6-3 | 04917 | Prolactin signaling pathway | Newly added |
| 2013-5-24 | 04668 | TNF signaling pathway | Newly added |
| 2013-5-2 | 04915 | Estrogen signaling pathway | Newly added |
| 2013-4-24 | 01230 | Biosynthesis of amino acids | Newly added |
| 2013-4-22 | 04913 | Ovarian steroidogenesis | Newly added |
| 2013-4-1 | 00365 | Furfural degradation | Newly added |
| 2013-4-1 | 05205 | Proteoglycans in cancer | Newly added |
| 2013-3-15 | 04911 | Insulin secretion | Newly added |
| 2013-2-8 | 04390 | Hippo signaling pathway | Newly added |
| 2013-1-9 | 04391 | Hippo signaling pathway - fly | Newly added |
| 2012-12-27 | 01220 | Degradation of aromatic compounds | Newly added |
| 2012-12-27 | 01210 | 2-Oxocarboxylic acid metabolism | Newly added |
| 2012-11-7 | 04713 | Circadian entrainment | Newly added |
| 2012-10-24 | 04066 | HIF-1 signaling pathway | Newly added |
| 2012-10-16 | 05161 | Hepatitis B | Newly added |
| 2012-10-2 | 04151 | PI3K-Akt signaling pathway | Newly added |
| 2012-9-12 | 05204 | Chemical carcinogenesis | Newly added |
| 2012-8-3 | 05203 | Viral carcinogenesis | Newly added |
| 2012-6-12 | 04064 | NF-kappa B signaling pathway | Newly added |
| 2012-6-5 | 00984 | Steroid degradation | Newly added |
| 2012-4-26 | 05034 | Alcoholism | Newly added |
| 2012-4-23 | 05169 | Epstein-Barr virus infection | Newly added |
| 2012-4-9 | 05033 | Nicotine addiction | Newly added |
| 2012-3-15 | 05032 | Morphine addiction | Newly added |
| 2012-2-21 | 05031 | Amphetamine addiction | Newly added |
| 2012-1-30 | 05030 | Cocaine addiction | Newly added |
| 2012-1-25 | 00909 | Sesquiterpenoid and triterpenoid biosynthesis | Title changed |
| 2011-12-16 | 04723 | Retrograde endocannabinoid signaling | Newly added |
| 2011-11-24 | 04726 | Serotonergic synapse | Newly added |
| 2011-10-30 | 05202 | Transcriptional misregulation in cancers | Newly added |
| 2011-9-5 | 05134 | Legionellosis | Newly added |
| 2011-9-2 | 04728 | Dopaminergic synapse | Newly added |
| 2011-8-12 | 05168 | Herpes simplex infection | Newly added |
| 2011-8-8 | 00073 | Cutin, suberine and wax biosynthesis | Newly added |
| 2011-8-8 | 00062 | Fatty acid elongation | Title changed |
| 2011-8-1 | 03460 | Fanconi anemia pathway | Newly added |
| 2011-8-1 | 04727 | GABAergic synapse | Newly added |
| 2011-7-22 | 05132 | Salmonella infection | Newly added |
| 2011-7-13 | 05166 | HTLV-I infection | Newly added |
| 2011-7-11 | 04721 | Synaptic vesicle cycle | Newly added |
| 2011-6-16 | 05133 | Pertussis | Newly added |
| 2011-6-8 | 04725 | Cholinergic synapse | Newly added |
| 2011-5-30 | 05164 | Influenza A | Newly added |
| 2011-5-16 | 04724 | Glutamatergic synapse | Newly added |
| 2011-5-9 | 05152 | Tuberculosis | Newly added |
| 2011-4-18 | 04961 | Endocrine and other factor-regulated calcium reabsorption | Newly added |
| 2011-4-11 | 05162 | Measles | Newly added |
| 2011-3-31 | 04978 | Mineral absorption | Newly added |
| 2011-3-11 | 00450 | Selenocompound metabolism | Title changed |
| 2011-3-9 | 05323 | Rheumatoid arthritis | Newly added |
| 2011-3-7 | 04977 | Vitamin digestion and absorption | Newly added |
| 2011-3-3 | 03008 | Ribosome biogenesis in eukaryotes | Newly added |
| 2011-2-28 | 00720 | Carbon fixation pathways in prokaryotes | Title changed; newly drawn |
| 2011-2-14 | 04075 | Plant hormone signal transduction | Newly added |
| 2011-2-14 | 00513 | Various types of N-glycan biosynthesis | Title changed |
| 2011-2-9 | 05143 | African trypanosomiasis | Newly added |
| 2011-1-31 | 04975 | Fat digestion and absorption | Newly added |
| 2011-1-24 | 00512 | Mucin type O-glycan biosynthesis | Title changed |
| 2011-1-24 | 00514 | Other types of O-glycan biosynthesis | Title changed |
| 2011-1-17 | 03015 | mRNA surveillance pathway | Newly added |
| 2011-1-13 | 04380 | Osteoclast differentiation | Newly added |
| 2011-1-11 | 04976 | Bile secretion | Newly added |
| 2010-12-28 | 01120 | Microbial metabolism in diverse environments | Newly added global map |
| 2010-12-6 | 03013 | RNA transport | Newly added |
| 2010-12-1 | 00361 | Chlorocyclohexane and chlorobenzene degradation | Title changed; newly drawn |
| 2010-12-1 | 00362 | Benzoate degradation | Title changed; newly drawn |
| 2010-12-1 | 00363 | Bisphenol degradation | Title changed; newly drawn |
| 2010-12-1 | 00621 | Dioxin degradation | Title changed; newly drawn |
| 2010-12-1 | 00622 | Xylene degradation | Title changed; newly drawn |
| 2010-12-1 | 00623 | Toluene degradation | Title changed; newly drawn |
| 2010-12-1 | 00624 | Polycyclic aromatic hydrocarbon degradation | Title changed; newly drawn |
| 2010-12-1 | 00625 | Chloroalkane and chloroalkene degradation | Title changed; newly drawn |
| 2010-12-1 | 00626 | Naphthalene degradation | Title changed; newly drawn |
| 2010-12-1 | 00627 | Aminobenzoate degradation | Title changed; newly drawn |
| 2010-12-1 | 00633 | Nitrotoluene degradation | Title changed; newly drawn |
| 2010-12-1 | 00628 | Fluorene degradation | Deleted; merged into 00621 and 00624 |
| 2010-12-1 | 00629 | Carbazole degradation | Deleted; merged into 00621 and 00627 |
| 2010-12-1 | 00631 | 1,2-Dichloroethane degradation | Deleted; merged into 00625 |
| 2010-12-1 | 00632 | Benzoate degradation via CoA ligation | Deleted; merged into 00362 and 00623 |
| 2010-12-1 | 00641 | 3-Chloroacrylic acid degradation | Deleted; merged into 00625 |
| 2010-11-12 | 05160 | Hepatitis C | Newly added |
| 2010-11-9 | 04974 | Protein digestion and absorption | Newly added |
| 2010-11-8 | 05150 | Staphylococcus aureus infection | Newly added |
| 2010-11-1 | 04122 | Sulfur relay system | Newly added |
| 2010-10-25 | 04973 | Carbohydrate digestion and absorption | Newly added |
| 2010-10-12 | 05145 | Toxoplasmosis | Newly added |
| 2010-9-21 | 04972 | Pancreatic secretion | Newly added |
| 2010-9-2 | 04141 | Protein processing in endoplasmic reticulum | Newly added |
| 2010-8-16 | 05146 | Amoebiasis | Newly added |
| 2010-8-2 | 04971 | Gastric acid secretion | Newly added |
| 2010-7-20 | 04145 | Phagosome | Newly added |
| 2010-7-5 | 04970 | Salivary secretion | Newly added |
| 2010-6-29 | 05144 | Malaria | Newly added |
| 2010-6-14 | 04745 | Phototransduction - fly | Newly added |
| 2010-6-14 | 05131 | Shigellosis | Newly added |
| 2010-5-31 | 01110 | Biosynthesis of secondary metabolites | Newly added global map |
| 2010-5-31 | 04744 | Phototransduction | Newly added |
| 2010-5-31 | 05100 | Bacterial invasion of epithelial cells | Newly added |
| 2010-5-18 | 05142 | Chagas disease | Newly added |
| 2010-5-10 | 04966 | Collecting duct acid secretion | Newly added |
| 2010-4-15 | 04112 | Cell cycle - Caulobacter | Newly added |
| 2010-4-12 | 00524 | Butirosin and neomycin biosynthesis | Newly added |
| 2010-4-5 | 04964 | Proximal tubule bicarbonate reclamation | Newly added |
| 2010-3-30 | 05140 | Leishmaniasis | Newly added |
| 2010-3-8 | 04962 | Vasopressin-regulated water reabsorption | Newly added |
| 2010-3-8 | 00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate | Title changed |
| 2010-3-8 | 00534 | Glycosaminoglycan biosynthesis - heparan sulfate | Title changed |
| 2010-3-8 | 00533 | Glycosaminoglycan biosynthesis - keratan sulfate | Title changed |
| 2010-3-1 | 04626 | Plant-pathogen interaction | Newly added |
| 2010-2-4 | 04146 | Peroxisome | Newly added |
| 2010-1-28 | 00140 | Steroid hormone biosynthesis | Title changed; merging 00140 & 00150 |
| 2010-1-28 | 00150 | Androgen and estrogen metabolism | Deleted; merged into 00140 |
| 2010-1-25 | 04960 | Aldosterone-regulated sodium reabsorption | Newly added |
| 2010-1-6 | 00402 | Benzoxazinoid biosynthesis | Title changed |
| 2009-12-25 | 04672 | Intestinal immune network for IgA production | Newly added |
| 2009-12-10 | 04114 | Oocyte meiosis | Newly added |
| 2009-11-19 | 04623 | Cytosolic DNA-sensing pathway | Newly added |
| 2009-11-9 | 00440 | Phosphonate and phosphinate metabolism | Title changed |
| 2009-11-9 | 05416 | Viral myocarditis | Newly added |
| 2009-11-2 | 03040 | Spliceosome | Newly added |
| 2009-10-27 | 04621 | NOD-like receptor signaling pathway | Newly added |
| 2009-10-26 | 04113 | Meiosis - yeast | Newly added |
| 2009-10-13 | 05414 | Dilated cardiomyopathy | Newly added |
| 2009-9-16 | 04622 | RIG-I-like receptor signaling pathway | Newly added |
| 2009-9-11 | 03018 | RNA degradation | Newly added |
| 2009-9-7 | 05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | Newly added |
| 2009-8-25 | 00945 | Stilbenoid, diarylheptanoid and gingerol biosynthesis | Newly added |
| 2009-8-25 | 00965 | Betalain biosynthesis | Newly added |
| 2009-8-24 | 05410 | Hypertrophic cardiomyopathy (HCM) | Newly added |
| 2009-8-24 | 04666 | Fc gamma R-mediated phagocytosis | Newly added |
| 2009-8-18 | 00901 | Indole alkaloid biosynthesis | Title changed |
| 2009-8-18 | 00950 | Isoquinoline alkaloid biosynthesis | Title changed |
| 2009-8-18 | 00960 | Tropane, piperidine and pyridine alkaloid biosynthesis | Title changed |
| 2009-8-11 | 00121 | Secondary bile acid biosynthesis | Newly added |
| 2009-8-11 | 00270 | Cysteine and methionine metabolism | New number; merging 00272 & 00271 |
| 2009-8-11 | 00272 | Cysteine metabolism | Deleted; merged into 00270 |
| 2009-8-11 | 00271 | Methionine metabolism | Deleted; merged into 00270 |
| 2009-8-7 | 00130 | Ubiquinone and other terpenoid-quinone biosynthesis | Title changed |
| 2009-7-27 | 04144 | Endocytosis | Newly added |
| 2009-7-27 | 00100 | Steroid biosynthesis | Title changed |
| 2009-7-27 | 00900 | Terpenoid backbone biosynthesis | Title changed |
| 2009-7-27 | 00909 | Sesquiterpenoid biosynthesis | Newly added |
| 2009-7-17 | 04722 | Neurotrophin signaling pathway | Newly added |
| 2009-7-17 | 05020 | Prion diseases | Newly added |
| 2009-7-14 | 00520 | Amino sugar and nucleotide sugar metabolism | Title changed |
| 2009-7-14 | 00530 | Aminosugars metabolism | Deleted; merged into 00520 |
| 2009-7-13 | 00250 | Alanine, aspartate and glutamate metabolism | New number; merging 00252 & 00251 |
| 2009-7-13 | 00252 | Alanine and aspartate metabolism | Deleted; merged into 00250 |
| 2009-7-13 | 00251 | Glutamate metabolism | Deleted; merged into 00250 |
| 2009-7-2 | 00120 | Primary bile acid biosynthesis | Title changed |
| 2009-7-2 | 04142 | Lysosome | Newly added |
| 2009-7-1 | 00220 | Urea cycle and metabolism of amino groups | Deleted; merged into 00330 |
| 2009-6-17 | 04062 | Chemokine signaling pathway | Newly added |
| 2009-6-15 | 03070 | Bacterial secretion system | Title changed; category changed |
| 2009-6-15 | 03080 | Type IV secretion system | Deleted; merged into 03070 |
| 2009-6-15 | 03090 | Type II secretion system | Deleted; merged into 03070 |
| 2009-6-8 | 04270 | Vascular smooth muscle contraction | Newly added |
| 2009-5-26 | 00966 | Glucosinolate biosynthesis | Newly added |
| 2009-5-13 | 04710 | Circadian rhythm - mammal | Title changed |
| 2009-5-13 | 04711 | Circadian rhythm - fly | Split from 04710 |
| 2009-5-13 | 04712 | Circadian rhythm - plant | Split from 04710 |
| 2009-5-8 | 00907 | Carotenoid biosynthesis, "Organism-specific" | Deleted; represented by 00906 |
| 2009-4-24 | 01100 | Metabolic pathways | Changed to global map |
| 2009-4-22 | 02011 | ABC transporters, "Organism-specific" | Deleted; represented by 02010 |
| 2009-4-21 | 04260 | Cardiac muscle contraction | Newly added |
| 2009-4-2 | 00031 | Inositol metabolism | Deleted; merged into 00562 |
| 2009-4-2 | 01030 | Glycan structures - biosynthesis 1 | Deleted; merged into 00510 |
| 2009-4-2 | 01031 | Glycan structures - biosynthesis 2 | Deleted; merged into 00510 |
| 2009-4-2 | 01032 | Glycan structures - degradation | Deleted; merged into 00511 |
| 2009-4-1 | 00511 | Other glycan degradation | Title changed |
| 2009-3-31 | 01330 | Signaling molecules and interaction | Deleted |
| 2009-3-31 | 01430 | Cell junctions | Deleted |
| 2009-3-31 | 01510 | Neurodegenerative diseases | Deleted |
| 2009-3-28 | 02021 | Two-component system, "Organism-specific" | Deleted; represented by 02020 |
| 2009-3-24 | 00130 | Ubiquinone and menaquinone biosynthesis | Title changed |
| 2009-3-23 | 05050 | Dentatorubropallidoluysian atrophy (DRPLA) | Deleted; represented by H00060 |
| 2009-3-23 | 05060 | Prion disease | Deleted; represented by H00061 |
| 2009-3-23 | 05016 | Huntington's disease | Newly added |
| 2009-3-23 | 05040 | Huntington's disease | Deleted |
| 2009-2-17 | 00602 | Glycosphingolipid biosynthesis - neo-lactoseries | Deleted; merged into 00601 |
| 2009-2-17 | 00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | Title changed |
| 2009-2-16 | 05010 | Alzheimer's disease | Newly added |
| 2009-2-16 | 05010 | Alzheimer's disease | Deleted |
| 2008-12-23 | 01060 | Biosynthesis of plant secondary metabolites | Newly added |
| 2008-12-23 | 01061 | Biosynthesis of phenylpropanoids | Newly added |
| 2008-12-23 | 01062 | Biosynthesis of terpenoids and steroids | Newly added |
| 2008-12-23 | 01063 | Biosynthesis of alkaloids derived from shikimate pathway | Newly added |
| 2008-12-23 | 01064 | Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid | Newly added |
| 2008-12-23 | 01065 | Biosynthesis of alkaloids derived from histidine and purine | Newly added |
| 2008-12-23 | 01066 | Biosynthesis of alkaloids derived from terpenoid and polyketide | Newly added |
| 2008-12-23 | 01070 | Biosynthesis of plant hormones | Newly added |
| 2008-12-22 | 05014 | Amyotrophic lateral sclerosis (ALS) | Newly added |
| 2008-12-22 | 05030 | Amyotrophic lateral sclerosis (ALS) | Deleted |
| 2008-11-10 | 05012 | Parkinson's disease | Newly added |
| 2008-11-10 | 05020 | Parkinson's disease | Deleted |
| 2008-8-4 | 05322 | Systemic lupus erythematosus | Newly added |
| 2008-7-29 | 03450 | Non-homologous end-joining | Newly added |
| 2008-7-14 | 05340 | Primary immunodeficiency | Newly added |
| 2008-7-8 | 03440 | Homologous recombination | Newly added |
| 2008-7-7 | 05110 | Vibrio cholerae infection | Newly added |
| 2008-7-7 | 05111 | Vibrio cholerae pathogenic cycle | Newly added |
| 2008-7-7 | 05110 | Cholera - infection | Deleted |
| 2008-7-7 | 05111 | Cholera - colonization | Deleted |
| 2008-7-7 | 05112 | Cholera - diarrhea | Deleted |
| 2008-7-7 | 05113 | Cholera - environment | Deleted |
| 2008-7-7 | 05114 | Cholera - life cycle | Deleted |
| 2008-7-4 | 00982 | Drug metabolism - cytochrome P450 | Newly added |
| 2008-7-4 | 00983 | Drug metabolism - other enzymes | Newly added |
| 2008-6-23 | 05332 | Graft-versus-host disease | Newly added |
| 2008-6-5 | 03430 | Mismatch repair | Newly added |
| 2008-6-2 | 05330 | Allograft rejection | Newly added |
| 2008-5-28 | 03420 | Nucleotide excision repair | Newly added |
| 2008-5-14 | 03410 | Base excision repair | Newly added |
| 2008-4-28 | 05320 | Autoimmune thyroid disease | Newly added |
| 2008-4-22 | 00944 | Flavone and flavonol biosynthesis | Newly added |
| 2008-3-26 | 05200 | Pathways in cancer | Newly added |
| 2008-3-8 | 05310 | Asthma | Newly added |
| 2008-3-6 | 00908 | Zeatin biosynthesis | Newly added |
| 2008-2-27 | 00981 | Insect hormone biosynthesis | Newly added |
| 2008-1-25 | 00281 | Geraniol degradation | Newly added |
| 2008-1-25 | 00364 | Fluorobenzoate degradation | Newly added |
| 2007-12-10 | 00633 | Trinitrotoluene degradation | Newly added |
| 2007-10-17 | 00232 | Caffeine metabolism | Newly added |
| 2007-10-16 | 00942 | Anthocyanin biosynthesis | Newly added |
| 2007-10-16 | 00592 | alpha-Linolenic acid metabolism | Newly added |
| 2007-10-1 | 01040 | Biosynthesis of unsaturated fatty acids | Newly added |
| 2007-8-21 | 05219 | Bladder cancer | Newly added |
| 2007-8-6 | 00943 | Isoflavonoid biosynthesis | Newly added |
| 2007-7-26 | 00785 | Lipoic acid metabolism | Newly added |
| 2007-7-24 | 04115 | p53 signaling pathway | Newly added |
| 2007-7-3 | 05221 | Acute myeloid leukemia | Newly added |
| 2007-5-29 | 05215 | Prostate cancer | Newly added |
| 2007-5-21 | 00906 | Carotenoid biosynthesis | Newly added |
| 2007-5-2 | 05222 | Small cell lung cancer | Newly added |
| 2007-5-2 | 05223 | Non-small cell lung cancer | Newly added |
| 2007-4-9 | 04614 | Renin/angiotensin system | Newly added |
| 2007-4-4 | 05213 | Endometrial cancer | Newly added |
| 2007-4-4 | 04012 | ErbB signaling pathway | Newly added |
| 2007-3-15 | 00905 | Brassinosteroid biosynthesis | Newly added |
| 2007-3-5 | 00402 | Benzoxazinone biosynthesis | Newly added |
| 2007-2-28 | 05211 | Renal cell carcinoma | Newly added |
| 2007-2-8 | 04916 | Melanogenesis | Newly added |
| 2007-1-22 | 05218 | Melanoma | Newly added |
| 2007-1-22 | 01058 | Acridone alkaloid biosynthesis | Newly added |
| 2006-12-25 | 05217 | Basal cell carcinoma | Newly added |
| 2006-11-22 | 05216 | Thyroid cancer | Newly added |
| 2006-10-23 | 05220 | Chronic myeloid leukemia | Newly added |
| 2006-9-26 | 05214 | Glioma | Newly added |
| 2006-9-21 | 00196 | Photosynthesis - antenna proteins | Newly added |
| 2006-9-8 | 00565 | Ether lipid metabolism | Newly added |
| 2006-9-6 | 05212 | Pancreatic cancer | Newly added |
| 2006-8-23 | 03320 | PPAR signaling pathway | Newly added |
| 2006-8-9 | 05210 | Colorectal cancer | Newly added |
| 2006-7-5 | 04914 | Progesterone-mediated oocyte maturation | Newly added |
| 2006-6-14 | 04912 | GnRH signaling pathway | Newly added |
| 2006-5-30 | 05130 | Pathogenic Escherichia coli infection | Newly added |
| 2006-5-24 | 04742 | Taste transduction | Newly added |
| 2006-4-25 | 04140 | Regulation of autophagy | Newly added |
| 2006-4-19 | 04740 | Olfactory transduction | Newly added |
| 2006-3-28 | 04370 | VEGF signaling pathway | Newly added |
| 2006-3-16 | 04150 | mTOR signaling pathway | Newly added |
| 2006-3-10 | 00532 | Chondroitin sulfate biosynthesis | Newly added |
| 2006-3-10 | 00534 | Heparan sulfate biosynthesis | Newly added |
| 2006-2-28 | 05120 | Epithelial cell signaling in Helicobacter pylori infection | Newly added |
| 2006-2-27 | 04664 | Fc epsilon RI signaling pathway | Newly added |
| 2006-2-9 | 04730 | Long-term depression | Newly added |
| 2006-2-8 | 04612 | Antigen processing and presentation | Newly added |
| 2006-2-6 | 00980 | Metabolism of xenobiotics by cytochrome P450 | Newly added |
| 2006-2-2 | 00590 | Arachidonic acid metabolism | Newly added |
| 2006-2-2 | 00591 | Linoleic acid metabolism | Newly added |
| 2006-1-31 | 04720 | Long-term potentiation | Newly added |
| 2006-1-11 | 04950 | Maturity onset diabetes of the young | Newly added |