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ENTRY	nt06038
Name	Folate metabolism
Category	Pathway view; Cofactor/vitamin metabolism
Pathway	hsa00670 One carbon pool by folate hsa00260 Glycine, serine and threonine metabolism
Module	hsa_M00141 C1-unit interconversion, eukaryotes hsa_M00974 Betaine metabolism, animals, betaine => glycine
Display	drug-target relation   disease type

N01725    Dihydrofolate − DHFR → THF     DHFR deficiency     DHFR* N01726    THF − MTHFD1 → MTHF − MTHFR ⇉ MTR → THF     NTDs     MTHFD1*     NTDs             MTHFR*     NTDs                 MTR* N01869    THF − FTCD → 5,10-MTHF     Formiminotransferase deficiency     FTCD*   N01867    THF+DMG − DMGDH → MTHF+Sarcosine     DMGDHD     DMGDH* N01868    THF+Sarcosine − SARDH → MTHF+Gly     Sarcosinemia Sarcosine↗   SARDH*   N01629    THF − SHMT ⇉ MTHFR → 5-MTHF N01630    Hcy+5-MTHF − (BHMT1/2,MTR) → Met+THF N01791    Ser+THF − SHMT → Gly+MTHF

		Disease name	Disease category
DHFR deficiency	H01197	Dihydrofolate reductase deficiency	Inherited metabolic disorder
NTDs	H00262	Neural tube defects, folate-sensitive	Congenital malformation
Formiminotransferase deficiency	H01262	Formiminotransferase deficiency	Inherited metabolic disorder
DMGDHD	H01003	Dimethylglycine dehydrogenase deficiency	Inherited metabolic disorder
Sarcosinemia	H02657	Sarcosinemia	Inherited metabolic disorder