| Entry |
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| Symbol |
FTCD, LCHC1
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| Name |
(RefSeq) formimidoyltransferase cyclodeaminase
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| KO |
| K13990 | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] |
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| Organism |
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| Pathway |
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| Module |
| hsa_M00045 | Histidine degradation, histidine => N-formiminoglutamate => glutamate |
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| Network |
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| Element |
| N01869 | THF conversion, THF to 5,10-MTHF |
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| Disease |
| H01262 | Formiminotransferase deficiency |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09105 Amino acid metabolism
00340 Histidine metabolism
10841 (FTCD)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
10841 (FTCD)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
10841 (FTCD)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
10841 (FTCD)
Enzymes [BR:hsa01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.5 glutamate formimidoyltransferase
10841 (FTCD)
4. Lyases
4.3 Carbon-nitrogen lyases
4.3.1 Ammonia-lyases
4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase
10841 (FTCD)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Centriole proteins
10841 (FTCD)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
10841 (FTCD)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
21:complement(46136262..46155579)
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| AA seq |
541 aa
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVE
GALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELD
VPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARK
FLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLD
FEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRI
RLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVA
AAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYL
EAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDL
QVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQ
E |
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| NT seq |
1626 nt +upstreamnt +downstreamnt
atgtcccagctggtggaatgcgtccccaacttttcggaggggaagaaccaggaggtgatc
gacgccatctctggagccatcacacagaccccgggctgcgtgctgctggatgtggacgca
ggcccttccaccaaccgcaccgtgtacaccttcgtggggccgccggagtgcgtggtggag
ggggccctcaacgctgcccgggtagcttcccgacttatcgacatgagcaggcaccaagga
gagcacccccgcatgggggccctagacgtctgccccttcatccccgtgaggggcgtcagc
gtggatgagtgtgtgctctgcgcccaggcctttggccagaggctggcagaggagctggac
gtgccagtttacctgtacggcgaggcagccaggatggacagtcgccggaccctgccggcc
atccgggccggggagtacgaggccctccctaagaagctccagcaggccgactgggcgccc
gactttggtcccagctcctttgtccccagttggggggccacggccacgggggcgaggaag
ttcctcattgcttttaacatcaacctgctcggcacaaaggagcaagcccaccgcatcgcg
ctcaacctgcgggagcagggccgcgggaaggaccagccaggacgtctgaagaaagttcag
ggcattggctggtacctggatgagaagaacctggctcaggtgtccaccaatcttctggac
tttgaggtcacggcactgcacacggtctacgaggagacctgccgagaagcacaggagctg
agcctcccagtggtgggctcacagctggtgggcctggtgcccctgaaggctctgctggat
gcggccgccttctactgcgagaaggagaacctcttcatcctggaggaggagcagcggatc
aggctggtggtgagccggctgggcctggactccctgtgccccttcagccctaaggagcgg
atcatcgagtacctggtccctgagcgcgggcctgagcgaggcctgggcagcaagtccctg
cgcgccttcgtgggggaggtgggtgcccgctctgcggcccccgggggcggctcggtggcg
gcggccgctgcggccatgggtgcggcgctgggctccatggtgggcctcatgacctacggg
cggcgccaattccagtccctggacacgacgatgcggcgcctgatcccgcccttccgcgag
gcttcggccaagctaaccacgctggtggatgccgacgccgaggccttcaccgcctacctg
gaagcaatgaggctccccaagaacacacctgaggaaaaggacaggcgcacggcggcccta
caggagggtctgaggcgggcagtctctgtgccgctgacgctggcggagacggtggcctcg
ctgtggccggccctgcaggaactggcccggtgtgggaacctggcctgccggtcagacctc
caggtggcggccaaagccctggagatgggcgtgtttggcgcatatttcaacgtgctcatc
aacctgagggacatcacagacgaggcatttaaggaccagatccaccatcgtgtttccagc
ctcctgcaggaagccaagacccaggctgcactggtgctggactgcttggagacccggcag
gagtga |
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