KEGG ORTHOLOGY: K07206

ORTHOLOGY: K07206

Entry

K07206                      KO

Symbol

TSC1

Name

tuberous sclerosis 1

Pathway

map04072

Phospholipase D signaling pathway

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04218

Cellular senescence

map04714

Thermogenesis

map04910

Insulin signaling pathway

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05168

Herpes simplex virus 1 infection

map05231

Choline metabolism in cancer

Disease

H00896

Lymphangioleiomyomatosis

H00915

Tuberous sclerosis complex

H01251

Focal cortical dysplasia of Taylor

H01691

Renal angiomyolipoma

H01692

Subependymal giant cell astrocytoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04151 PI3K-Akt signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04152 AMPK signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04150 mTOR signaling pathway
    K07206  TSC1; tuberous sclerosis 1
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07206  TSC1; tuberous sclerosis 1
  09143 Cell growth and death
   04218 Cellular senescence
    K07206  TSC1; tuberous sclerosis 1
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07206  TSC1; tuberous sclerosis 1
  09149 Aging
   04211 Longevity regulating pathway
    K07206  TSC1; tuberous sclerosis 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K07206  TSC1; tuberous sclerosis 1
09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K07206  TSC1; tuberous sclerosis 1
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07206  TSC1; tuberous sclerosis 1
   05163 Human cytomegalovirus infection
    K07206  TSC1; tuberous sclerosis 1
   05165 Human papillomavirus infection
    K07206  TSC1; tuberous sclerosis 1

Genes

HSA:	7248(TSC1)

PTR:	464818(TSC1)

PPS:	100975575(TSC1)

GGO:	101137273(TSC1)

PON:	100147742(TSC1)

NLE:	100587112(TSC1)

HMH:	116475805(TSC1)

MCC:	714645(TSC1)

MCF:	102124229(TSC1)

MTHB:

126936889

MNI:	105464069(TSC1)

CSAB:

103239711(TSC1)

CATY:

105594171(TSC1)

PANU:

101024169(TSC1)

TGE:	112607854(TSC1)

MLEU:

105542939(TSC1)

RRO:	104669743(TSC1)

RBB:	108513580(TSC1)

TFN:	117073735(TSC1)

PTEH:

111523975(TSC1)

CANG:

105503993(TSC1)

CJC:	100407741(TSC1)

SBQ:	101028002(TSC1)

CIMI:

108295422(TSC1)

CSYR:

103250930(TSC1)

MMUR:

105859868(TSC1)

LCAT:

123646562(TSC1)

PCOQ:

105806636(TSC1)

OGA:	100954949(TSC1)

MMU:	64930(Tsc1)

MCAL:

110312162(Tsc1)

MPAH:

110318637(Tsc1)

RNO:	60445(Tsc1)

MCOC:

116089904(Tsc1)

ANU:	117703026(Tsc1)

MUN:	110550703(Tsc1)

CGE:	100767621(Tsc1)

MAUA:

101834514(Tsc1)

PROB:

127222678(Tsc1)

PLEU:

114702777(Tsc1)

MORG:

121462616(Tsc1)

MFOT:

126509247

AAMP:

119818627(Tsc1)

NGI:	103742835(Tsc1)

HGL:	101708424(Tsc1)

CPOC:

100732297(Tsc1)

CCAN:

109691000(Tsc1)

DORD:

105989408(Tsc1)

DSP:	122108951(Tsc1)

PLOP:

125350743(Tsc1)

NCAR:

124964393

MMMA:

107151973(Tsc1)

OCU:

100338695

OPI:	101520687(TSC1)

TUP:	102483474(TSC1)

GVR:	103582022(TSC1)

CFA:	480688(TSC1)

CLUD:

112677368(TSC1)

VVP:	112928006(TSC1)

VLG:	121473130(TSC1)

NPO:	129507605(TSC1)

AML:	100471530(TSC1)

UMR:	103670250(TSC1)

UAH:	113266547(TSC1)

UAR:	123775611(TSC1)

ELK:

111145731

LLV:

125083259

MPUF:

101676115(TSC1)

MNP:	132024295(TSC1)

MLK:	131812183(TSC1)

NVS:	122917138(TSC1)

ORO:	101363167(TSC1)

EJU:	114198841(TSC1)

ZCA:	113934213(TSC1)

MLX:	118017558(TSC1)

NSU:	110581464(TSC1)

LWW:	102740017(TSC1)

FCA:	101101514(TSC1)

PYU:	121035151(TSC1)

PCOO:

112871843(TSC1)

PBG:	122474995(TSC1)

PVIV:

125150812(TSC1)

LRUF:

124525615

PTG:	102953770(TSC1)

PPAD:

109249982(TSC1)

PUC:

125927652

AJU:

106985348

HHV:	120230192(TSC1)

BTA:	533440(TSC1)

BOM:	102280709(TSC1)

BIU:	109566571(TSC1)

BBUB:

102401735(TSC1)

BBIS:

105000870(TSC1)

CHX:	102178739(TSC1)

OAS:	101119127(TSC1)

BTAX:

128056632(TSC1)

ODA:	120852124(TSC1)

CCAD:

122442300(TSC1)

MBEZ:

129539141(TSC1)

SSC:	100154726(TSC1)

CFR:	102504505(TSC1)

CBAI:

105069721(TSC1)

CDK:	105085191(TSC1)

VPC:	102545424(TSC1)

BACU:

103010162(TSC1)

BMUS:

118896887(TSC1)

LVE:	103088278(TSC1)

OOR:	101275677(TSC1)

DLE:	111177090(TSC1)

PCAD:

102991442(TSC1)

PSIU:

116755497(TSC1)

NASI:

112411342(TSC1)

ECB:	100066615(TSC1)

EPZ:	103553676(TSC1)

EAI:	106845368(TSC1)

MYB:	102245381(TSC1)

MYD:	102752713(TSC1)

MMYO:

118666926(TSC1)

MLF:	102440346(TSC1)

PKL:	118708902(TSC1)

EFUS:

103296157(TSC1)

MNA:	107524632(TSC1)

DRO:	112306281(TSC1)

SHON:

118980068(TSC1)

AJM:	119059019(TSC1)

PDIC:

114502990(TSC1)

PHAS:

123823356(TSC1)

MMF:	118629416(TSC1)

PPAM:

129079187(TSC1)

HAI:	109380979(TSC1)

RFQ:	117031806(TSC1)

PALE:

102878835(TSC1)

PGIG:

120602738(TSC1)

PVP:	105298655(TSC1)

RAY:	107504576(TSC1)

MJV:	108386004(TSC1)

TOD:	119231219(TSC1)

SARA:

101554144(TSC1)

SETR:

126009519(TSC1)

LAV:	100667008(TSC1)

TMU:

101347417

ETF:	101654757(TSC1)

DNM:	101446801(TSC1)

MDO:	100017591(TSC1)

GAS:	123235210(TSC1)

SHR:	100918165(TSC1)

AFZ:

127550929

PCW:	110198888(TSC1)

OAA:	100080641(TSC1)

GGA:	417166(TSC1)

PCOC:

116234278(TSC1)

MGP:	100539473(TSC1)

CJO:	107321823(TSC1)

TPAI:

128073987(TSC1)

LMUT:

125702418(TSC1)

NMEL:

110406741(TSC1)

APLA:

101798545(TSC1)

ACYG:

106044091(TSC1)

CATA:

118252095(TSC1)

AFUL:

116496812(TSC1)

TGU:	100228268(TSC1)

LSR:	110477611(TSC1)

SCAN:

103818978(TSC1)

PMOA:

120507498(TSC1)

OTC:	121336850(TSC1)

PRUF:

121357501(TSC1)

GFR:	102040493(TSC1)

FAB:	101806512(TSC1)

OMA:	130260075(TSC1)

PHI:	102103020(TSC1)

PMAJ:

107212076(TSC1)

CCAE:

111937022(TSC1)

CCW:	104688322(TSC1)

CBRC:

103623138(TSC1)

ETL:	114073788(TSC1)

ZAB:	102069656(TSC1)

ACHL:

103798457(TSC1)

SVG:	106851361(TSC1)

MMEA:

130576706(TSC1)

HRT:	120761612(TSC1)

FPG:	101921096(TSC1)

FCH:	102050812(TSC1)

CLV:	102094746(TSC1)

EGZ:	104128282(TSC1)

NNI:	104023182(TSC1)

PCRI:

104024385(TSC1)

PLET:

104617340(TSC1)

EHS:	104511266(TSC1)

PCAO:

104053163(TSC1)

ACUN:

113486658(TSC1)

TALA:

104366662(TSC1)

PADL:

103915274(TSC1)

AFOR:

103905322(TSC1)

ACHC:

115334918(TSC1)

HALD:

104319997(TSC1)

HLE:	104833882(TSC1)

AGEN:

126052272

GCL:

127023806

CCRI:

104165372(TSC1)

CSTI:

104558696(TSC1)

CMAC:

104479773(TSC1)

MUI:	104535819(TSC1)

BREG:

104642858(TSC1)

FGA:	104077738(TSC1)

GSTE:

104265045(TSC1)

LDI:	104351575(TSC1)

MNB:	103774360(TSC1)

OHA:	104329135(TSC1)

NNT:	104399485(TSC1)

SHAB:

115616933(TSC1)

DPUB:

104296397(TSC1)

PGUU:

104466325(TSC1)

ACAR:

104518272(TSC1)

CPEA:

104389825(TSC1)

AVIT:

104267635(TSC1)

CVF:	104292814(TSC1)

RTD:	128917433(TSC1)

CUCA:

104066929(TSC1)

TEO:	104382932(TSC1)

BRHI:

104493433(TSC1)

AAM:	106483762(TSC1)

AROW:

112964238(TSC1)

NPD:	112955817(TSC1)

TGT:	104565745(TSC1)

DNE:	112984141(TSC1)

SCAM:

104138251(TSC1)

ASN:	102383470(TSC1)

AMJ:	102560300(TSC1)

CPOO:

109313966(TSC1)

GGN:	109292989(TSC1)

PSS:	102453047(TSC1)

CMY:	102939516(TSC1)

CCAY:

125623530(TSC1)

DCC:	119844105(TSC1)

CPIC:

101947761(TSC1)

TST:	117867206(TSC1)

CABI:

116824084(TSC1)

MRV:	120386778(TSC1)

ACS:	100560493(tsc1)

ASAO:

132763552(TSC1)

PVT:	110079595(TSC1)

SUND:

121936339(TSC1)

PBI:	103052506(TSC1)

PMUR:

107296501(TSC1)

CTIG:

120298815(TSC1)

TSR:	106554224(TSC1)

PGUT:

117656776(TSC1)

APRI:

131186039(TSC1)

PTEX:

113444049(TSC1)

NSS:	113425248(TSC1)

VKO:	123028227(TSC1)

PMUA:

114589564(TSC1)

PRAF:

128406259(TSC1)

ZVI:	118078373(TSC1)

HCG:	128338909(TSC1)

GJA:	107112796(TSC1)

STOW:

125441757(TSC1)

EMC:	129342094(TSC1)

XLA:	108698219(tsc1.L) 108699932(tsc1.S)

XTR:	100380126(tsc1)

NPR:	108794671(TSC1)

RTEM:

120914013(TSC1)

BBUF:

121009179(TSC1)

BGAR:

122946118(TSC1)

MUO:	115473103(TSC1)

GSH:	117367573(TSC1)

DRE:	100330617(tsc1b) 337167(tsc1a)

SRX:	107708349(tsc1) 107709700 107741960 107757977

SANH:

107679850(tsc1) 107681228 107686900 107690665

SGH:	107556942 107587327 107595695 107597815

CCAR:

109045935 109045945

CAUA:

113038695 113049315 113064325 113074311

CGIB:

127941850 127957944 127985909 128008742

PTET:

122326532(tsc1b) 122345163(tsc1a)

LROH:

127152543(tsc1b) 127165149(tsc1a)

OMC:	131529507(tsc1b) 131540183(tsc1a)

PPRM:

120469653(tsc1a) 120490767(tsc1b) 120490776

RKG:	130089808(tsc1a) 130102240(tsc1b)

MAMB:

125252238(tsc1b) 125266734(tsc1a)

CIDE:

127503535 127512701

MASI:

127426723 127428936 127431076 127439107

TROS:

130546551(tsc1a) 130570278(tsc1b)

TDW:	130407983(tsc1b) 130419134(tsc1a)

MANU:

129423239(tsc1b) 129440165(tsc1a)

IPU:	108255875(tsc1a) 108279310(tsc1b)

IFU:	128622311(tsc1b) 128625591(tsc1a)

PHYP:

113535643 113537092

SMEO:

124380586(tsc1a) 124398007(tsc1b)

TFD:	113646434(tsc1b) 113653285(tsc1a)

TVC:	132854499(tsc1a) 132859733(tsc1b)

TRN:	134330158(tsc1b) 134335194(tsc1a)

AMEX:

103023802 103025705(tsc1)

CMAO:

118819985(tsc1b) 118827015(tsc1a)

EEE:	113573747(tsc1) 113577927

CHAR:

105891616(tsc1a) 105902542(tsc1b)

TRU:	101064275(tsc1) 101070860

TFS:	130517172(tsc1b) 130525887

TNG:	GSTEN00001765G001 GSTEN00006133G001 GSTEN00011449G001

LCO:	104923614(tsc1)

NCC:	104947658(tsc1)

TBEN:

117478867(tsc1b)

CGOB:

115004749 115016568(tsc1)

PGEO:

117455927

GACU:

117539972(tsc1b)

EMAC:

134868553(tsc1b) 134873741(tsc1a)

ELY:	117252779(tsc1a) 117269635(tsc1b)

EFO:	125890855(tsc1a) 125905504(tsc1b)

PLEP:

121959984(tsc1b)

SLUC:

116034777(tsc1b) 116051629(tsc1a)

ECRA:

117944830(tsc1a) 117959348(tsc1b)

ESP:	116689998(tsc1) 116704302

PFLV:

114555944 114570521

GAT:	120813988 120831883(tsc1b)

PPUG:

119226595(tsc1b)

AFB:	129101167 129102195(tsc1b)

CLUM:

117736924(tsc1a) 117740320(tsc1b)

PSWI:

130196757(tsc1a) 130205275(tsc1b)

MSAM:

119891527(tsc1a) 119914204(tsc1b)

SCHU:

122865188(tsc1b) 122876153(tsc1a)

CUD:	121509650(tsc1a) 121524985(tsc1b)

ALAT:

119019368(tsc1a) 119029532(tsc1b)

MZE:	101469816 101473939

ONL:	100704495 100705892

OAU:	116319602(tsc1b) 116324075(tsc1a)

OLA:	101174436 101175335(tsc1)

OML:	112137715 112140338(tsc1b) 112148929(tsc1a)

CSAI:

133450761 133455417(tsc1b)

XMA:	102219029 102237756

XCO:	114144509 114149511

XHE:	116724437 116729766

PRET:

103473966(tsc1)

PFOR:

103131447 103154408(tsc1)

PLAI:

106939200 106940026 106942232

PMEI:

106906339 106910681

GAF:	122828597(tsc1a) 122846931(tsc1b)

PPRL:

129366101(tsc1a) 129366403(tsc1b)

CVG:	107097901 107102465

CTUL:

119772024(tsc1b) 119776717(tsc1a)

GMU:	124872672(tsc1b) 124877475(tsc1a)

NFU:	107375136 107386302

KMR:	108241421(tsc1b) 108248101(tsc1a)

ALIM:

106513555(tsc1) 106527806

NWH:	119413737(tsc1a) 119424924(tsc1b)

AOCE:

111567968

MCEP:

124996605(tsc1b) 125012374(tsc1a)

CSEM:

103389287(tsc1) 103397967 103398880

POV:	109640306(tsc1) 109645786

SSEN:

122758312(tsc1b) 122769569(tsc1a)

HHIP:

117768560(tsc1a) 117771698(tsc1b)

HSP:	118114670(tsc1a) 118125796(tsc1b)

PPLT:

128424999(tsc1b) 128438804(tsc1a)

SMAU:

118284917(tsc1b) 118314445(tsc1a)

LCF:	108894433 108894795(tsc1a)

SDU:	111236140 111238487

SLAL:

111646396 111650122(tsc1)

XGL:	120804922(tsc1a) 120806376(tsc1b)

HCQ:	109525278 109530634(tsc1)

SSCV:

125979430 125993784

SBIA:

133490791(tsc1b)

PEE:	133399605(tsc1a) 133413608(tsc1b)

PTAO:

133490054(tsc1b)

BPEC:

110161175(tsc1) 110168809

MALB:

109957432 109960754

BSPL:

114861429(tsc1a) 114866608(tsc1b)

SJO:	128354708 128380427(tsc1b)

SASA:

100380649(tsc1) 106565454 106587014(tsc1)

STRU:

115159506 115167676(tsc1) 115204136

OTW:	112219359(tsc1b) 112230526 112248911(tsc1a)

OMY:	110509856 110522917(tsc1b) 110526086(tsc1a)

OGO:	124006965 124033995 124048898

ONE:	115101223 115111984(tsc1) 115123533

OKI:	109868386 109873688 109884041

OKE:	118385245 118387583 118393589(tsc1a)

SALP:

111961557 111964075 111974703(tsc1)

SNH:	120021274 120025722 120044832(tsc1a)

CCLU:

121541720 121582456 121584591(tsc1a)

ELS:	105024185(tsc1) 105027820

SFM:	108922678 108938614(tsc1)

PKI:	111833412 111835364 111842691(tsc1)

AANG:

118212859 118237071(tsc1a)

LOC:

PSPA:

ARUT:

PSEX:

LCM:	102358393(TSC1)

CMK:	103184683(tsc1b)

RTP:	109916041(tsc1b)

CPLA:

122564998(tsc1b)

HOC:	132825947(tsc1b)

LERI:

129712070(tsc1b)

PMRN:

116944861(TSC1)

LRJ:	133341737(TSC1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG6147(Tsc1)

DER:

6554977

DSE:

6607685

DSI:	Dsimw501_GD21066(Dsim_GD21066)

DYA:	Dyak_GE23448

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24168

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119675247 119678491

MDE:	101894607 131800556

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ000640

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204625

VCD:

MCIX:

PXU:

PRAP:

AAGE:

PGW:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM021770

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

LSM:

PPOI:

DSV:

RSAN:

RMP:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

BMY:	BM_BM9251(Bm9251)

LOA:	LOAG_17043

TSP:	Tsp_04213 Tsp_06004

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_53459

AQU:

109586668

» show all

Reference

PMID:9242607

Authors

van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ

Title

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.

Journal

Science 277:805-8 (1997)
DOI:10.1126/science.277.5327.805

Sequence

[hsa:7248]

Reference

PMID:12271141

Authors

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J

Title

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Journal

Proc Natl Acad Sci U S A 99:13571-6 (2002)
DOI:10.1073/pnas.202476899

Sequence

[hsa:7248]

LinkDB

DBGET integrated database retrieval system