KEGG   DRUG: Sunitinib
Entry
D08552                      Drug                                   
Name
Sunitinib (INN)
Formula
C22H27FN4O2
Exact mass
398.2118
Mol weight
398.4738
Structure
Simcomp
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: L01EX01
Chemical structure group: DG00712
Product (DG00712): D06402<JP/US>
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
Target
CSF1R (FMS, CD115) [HSA:1436] [KO:K05090]
FLT3 (CD135) [HSA:2322] [KO:K05092]
PDGFR [HSA:5156 5159] [KO:K04363 K05089]
RET [HSA:5979] [KO:K05126]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07045  Antineoplastics - protein kinase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX01 Sunitinib
      D08552  Sunitinib (INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG00712  Sunitinib
     D08552  Sunitinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00712  Sunitinib
     D08552  Sunitinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFR
     D08552  Sunitinib (INN)
    KIT (CD117)
     D08552  Sunitinib (INN)
    FLT3 (CD135)
     D08552  Sunitinib (INN)
   VEGFR family
    VEGFR1 (FLT1)
     D08552  Sunitinib (INN)
    VEGFR2 (KDR)
     D08552  Sunitinib (INN)
    VEGFR3 (FLT4)
     D08552  Sunitinib (INN)
   RET family
    RET
     D08552  Sunitinib (INN)
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF1R (FMS, CD115)
     D08552  Sunitinib (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08552
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG00712  Sunitinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00712  Sunitinib
Other DBs
CAS: 557795-19-4
PubChem: 96025237
PDB-CCD: B49[PDBj]
LigandBox: D08552
NIKKAJI: J1.942.549E
LinkDB
KCF data

ATOM        29
            1   C8x C    18.1300  -13.6500
            2   C8x C    16.9400  -14.3500
            3   C8y C    16.9400  -15.7500
            4   C8x C    18.1300  -16.4500
            5   C8y C    19.3200  -15.7500
            6   C8y C    19.3200  -14.3500
            7   C2y C    20.7200  -16.1700
            8   C5x C    21.4900  -15.0500
            9   N1x N    20.7200  -13.9300
            10  X   F    15.7500  -16.4500
            11  O5x O    22.8900  -15.0500
            12  C2b C    20.7200  -17.5700
            13  C8y C    21.9100  -18.2700
            14  C8y C    21.9100  -19.6700
            15  C8y C    23.2400  -20.0900
            16  C8y C    24.0100  -18.9700
            17  N4x N    23.2400  -17.8500
            18  C1a C    20.7200  -20.5100
            19  C1a C    25.4800  -18.9700
            20  C5a C    23.2400  -21.5600
            21  O5a O    22.0500  -22.2600
            22  N1b N    24.5000  -22.2600
            23  C1b C    25.6900  -21.5600
            24  C1b C    26.8800  -22.2600
            25  N1c N    28.0700  -21.5600
            26  C1b C    29.2600  -22.2600
            27  C1a C    30.4500  -21.5600
            28  C1b C    28.0700  -20.0900
            29  C1a C    29.2600  -19.4600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   25  28 1
            31   28  29 1

» Japanese version   » Back

DBGET integrated database retrieval system